{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T06:03:10Z","timestamp":1782021790780,"version":"3.54.5"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Natural Youth Science Foundation of China","award":["81603678"],"award-info":[{"award-number":["81603678"]}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011176","name":"Peking Union Medical College","doi-asserted-by":"publisher","award":["3332014006"],"award-info":[{"award-number":["3332014006"]}],"id":[{"id":"10.13039\/501100011176","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011176","name":"Peking Union Medical College","doi-asserted-by":"publisher","award":["3332015123"],"award-info":[{"award-number":["3332015123"]}],"id":[{"id":"10.13039\/501100011176","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Special Fund for Basic Scientific Research of the Central Public Research Institutes","award":["2016CZ-1"],"award-info":[{"award-number":["2016CZ-1"]}]},{"name":"Special Fund for Basic Scientific Research of the Central Public Research Institutes","award":["2018CZ-8"],"award-info":[{"award-number":["2018CZ-8"]}]},{"DOI":"10.13039\/501100003345","name":"CAMS","doi-asserted-by":"publisher","award":["2016-I2M-3-006"],"award-info":[{"award-number":["2016-I2M-3-006"]}],"id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.lfs.2019.02.010","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T14:12:52Z","timestamp":1549548772000},"page":"47-55","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Systemic microcirculation dysfunction after low thoracic spinal cord injury in mice"],"prefix":"10.1016","volume":"221","author":[{"given":"Xiaochen","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingbin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinshan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingli","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijuan","family":"Xiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2019.02.010_bb0005","first-page":"254","article-title":"Pathology of experimental spinal cord trauma. II. Ultrastructure of axons and myelin","volume":"39","author":"Balentine","year":"1978","journal-title":"Lab. Investig."},{"key":"10.1016\/j.lfs.2019.02.010_bb0010","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s12028-010-9359-9","article-title":"Risk factors for organ dysfunction and failure in patients with acute traumatic cervical spinal cord injury","volume":"13","author":"Stein","year":"2010","journal-title":"Neurocrit. Care."},{"key":"10.1016\/j.lfs.2019.02.010_bb0015","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s12974-016-0736-y","article-title":"Multiple organ dysfunction and systemic inflammation after spinal cord injury: a complex relationship","volume":"13","author":"Sun","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.lfs.2019.02.010_bb0020","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3171\/2014.3.SPINE13784","article-title":"Systemic inflammatory response syndrome in patients with spinal cord injury: does its presence at admission affect patient outcomes? Clinical article","volume":"21","author":"Kesani","year":"2014","journal-title":"J. Neurosurg. Spine"},{"key":"10.1016\/j.lfs.2019.02.010_bb0025","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.expneurol.2014.04.023","article-title":"The paradox of chronic neuroinflammation, systemic immune suppression, autoimmunity after traumatic chronic spinal cord injury","volume":"258","author":"Schwab","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.lfs.2019.02.010_bb0030","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s11910-017-0715-4","article-title":"Systemic complications of spinal cord injury","volume":"17","author":"Sweis","year":"2017","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.lfs.2019.02.010_bb0035","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1007\/s12031-014-0430-4","article-title":"Melatonin treatment protects against acute spinal cord injury-induced disruption of blood spinal cord barrier in mice","volume":"54","author":"Wu","year":"2014","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.lfs.2019.02.010_bb0040","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1161\/01.CIR.101.6.668","article-title":"Microbubble persistence in the microcirculation during ischemia\/reperfusion and inflammation is caused by integrin- and complement-mediated adherence to activated leukocytes","volume":"101","author":"Lindner","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2019.02.010_bb0045","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nri2171","article-title":"Evolving functions of endothelial cells in inflammation","volume":"7","author":"Pober","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.lfs.2019.02.010_bb0050","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1002\/stem.745","article-title":"Concise review: circulating endothelial progenitor cells for vascular medicine","volume":"29","author":"Asahara","year":"2011","journal-title":"Stem Cells"},{"key":"10.1016\/j.lfs.2019.02.010_bb0055","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1056\/NEJMoa022287","article-title":"Circulating endothelial progenitor cells, vascular function, and cardiovascular risk","volume":"348","author":"Hill","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2019.02.010_bb0060","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1113\/jphysiol.2010.201541","article-title":"The microcirculation: physiology at the mesoscale","volume":"589","author":"Secomb","year":"2011","journal-title":"J. Physiol. Lond."},{"key":"10.1016\/j.lfs.2019.02.010_bb0065","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1007\/s00018-015-2021-0","article-title":"Endothelial nitric oxide synthase in the microcirculation","volume":"72","author":"Shu","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.lfs.2019.02.010_bb0070","doi-asserted-by":"crossref","DOI":"10.1111\/and.12692","article-title":"Effects of melatonin on spinal cord injury-induced oxidative damage in mice testis","volume":"49","author":"Yuan","year":"2017","journal-title":"Andrologia"},{"key":"10.1016\/j.lfs.2019.02.010_bb0075","doi-asserted-by":"crossref","first-page":"10819","DOI":"10.1523\/JNEUROSCI.1642-11.2011","article-title":"Peripheral nerve injury alters blood-spinal cord barrier functional and molecular integrity through a selective inflammatory pathway","volume":"31","author":"Echeverry","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2019.02.010_bb0080","first-page":"1","article-title":"A comparison of the cutaneous microvascular properties of the spontaneously hypertensive and the Wistar-Kyoto rats by spectral analysis of laser Doppler","author":"Yuan","year":"2018","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.lfs.2019.02.010_bb0085","first-page":"61","article-title":"Wavelet analysis of the effects of static magnetic field on skin blood flowmotion: investigation using an in vivo rat model","volume":"21","author":"Li","year":"2007","journal-title":"In Vivo."},{"key":"10.1016\/j.lfs.2019.02.010_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0173805","article-title":"Rat retinal vasomotion assessed by laser speckle imaging","volume":"12","author":"Neganova","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2019.02.010_bb0095","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1088\/0967-3334\/35\/10\/1983","article-title":"Multiresolution analysis of pathological changes in cerebral venous dynamics in newborn mice with intracranial hemorrhage: adrenorelated vasorelaxation","volume":"35","author":"Pavlov","year":"2014","journal-title":"Physiol. Meas."},{"key":"10.1016\/j.lfs.2019.02.010_bb0100","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nprot.2007.111","article-title":"A protocol for phenotypic detection and enumeration of circulating endothelial cells and circulating progenitor cells in human blood","volume":"2","author":"Duda","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.lfs.2019.02.010_bb0105","article-title":"Validation of a standardized method for enumerating circulating endothelial cells and progenitors: flow cytometry and molecular and ultrastructural analyses (vol 15, pg 267, 2009)","volume":"21","author":"Mancuso","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.lfs.2019.02.010_bb0110","doi-asserted-by":"crossref","DOI":"10.5301\/jbm.5000156","article-title":"Absolute circulating pericyte progenitor cell counts in mice by flow cytometry: comparison of 2 single-platform technologies","volume":"30","author":"Yuan","year":"2015","journal-title":"Int. J. Biol. Markers"},{"key":"10.1016\/j.lfs.2019.02.010_bb0115","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1161\/01.RES.0000255691.76142.4a","article-title":"Phenotypic heterogeneity of the endothelium I. Structure, function, and mechanisms","volume":"100","author":"Aird","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2019.02.010_bb0120","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006429","article-title":"Endothelial cell heterogeneity","volume":"2","author":"Aird","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.lfs.2019.02.010_bb0125","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/B978-0-12-386037-8.00001-6","article-title":"New insights into the regulation of vascular permeability","volume":"290","author":"Chavez","year":"2011","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.lfs.2019.02.010_bb0130","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1152\/physrev.00035.2003","article-title":"Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis","volume":"84","author":"Bazzoni","year":"2004","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.lfs.2019.02.010_bb0135","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1089\/neu.2013.3034","article-title":"Characterization of vascular disruption and blood-spinal cord barrier permeability following traumatic spinal cord injury","volume":"31","author":"Figley","year":"2014","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.lfs.2019.02.010_bb0140","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1097\/WNR.0000000000000686","article-title":"Meliorating microcirculatory with melatonin in rat model of spinal cord injury using laser Doppler flowmetry","volume":"27","author":"Jing","year":"2016","journal-title":"Neuroreport"},{"key":"10.1016\/j.lfs.2019.02.010_bb0145","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.mvr.2010.05.012","article-title":"Excellent reproducibility of laser speckle contrast imaging to assess skin microvascular reactivity","volume":"80","author":"Roustit","year":"2010","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.lfs.2019.02.010_bb0150","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.biopha.2006.07.012","article-title":"The investigation of skin blood flowmotion: a new approach to study the microcirculatory impairment in vascular diseases?","volume":"60","author":"Rossi","year":"2006","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.lfs.2019.02.010_bb0155","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/j.1440-1681.2007.04588.x","article-title":"Identification of blood pressure control mechanisms by power spectral analysis","volume":"34","author":"Stauss","year":"2007","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.lfs.2019.02.010_bb0160","article-title":"Power spectral analysis in mice: what are the appropriate frequency bands?","volume":"292","author":"Stauss","year":"2007","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.lfs.2019.02.010_bb0165","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.jacc.2006.02.078","article-title":"Circulating endothelial cells in cardiovascular disease","volume":"48","author":"Boos","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.lfs.2019.02.010_bb0170","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1160\/TH04-09-0578","article-title":"Circulating endothelial cells - biomarker of vascular disease","volume":"93","author":"Blann","year":"2005","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.lfs.2019.02.010_bb0175","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1582-4934.2008.00639.x","article-title":"Circulating endothelial cells, microparticles and progenitors: key players towards the definition of vascular competence","volume":"13","author":"Sabatier","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.lfs.2019.02.010_bb0180","article-title":"Factors affecting circulating endothelial progenitor cells (EPCs) and endothelial microparticles (EdMPs) in patients with type 2 diabetes","volume":"66","author":"Giusti","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.lfs.2019.02.010_bb0185","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1097\/HJH.0b013e32833bcfe9","article-title":"Circulating endothelial progenitor cells, microparticles and vascular disease","volume":"28","author":"Mehta","year":"2010","journal-title":"J. Hypertens."},{"key":"10.1016\/j.lfs.2019.02.010_bb0190","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1002\/jnr.23113","article-title":"Contribution of bone marrow-derived endothelial progenitor cells to neovascularization and astrogliosis following spinal cord injury","volume":"90","author":"Kamei","year":"2012","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.lfs.2019.02.010_bb0195","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1179\/2045772314Y.0000000227","article-title":"Evidence for proangiogenic cellular and humoral systemic response in patients with acute onset of spinal cord injury","volume":"38","author":"Paczkowska","year":"2015","journal-title":"J Spinal Cord Med."},{"key":"10.1016\/j.lfs.2019.02.010_bb0200","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1002\/ijc.25816","article-title":"Circulating perivascular progenitors: a target of PDGFR inhibition","volume":"129","author":"Mancuso","year":"2011","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.lfs.2019.02.010_bb0205","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1002\/jnr.23113","article-title":"Contribution of bone marrow-derived endothelial progenitor cells to neovascularization and astrogliosis following spinal cord injury","volume":"90","author":"Kamei","year":"2012","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.lfs.2019.02.010_bb0210","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0079-6123(06)61009-1","article-title":"Progressive damage after brain and spinal cord injury: pathomechanisms and treatment strategies","volume":"161","author":"Bramlett","year":"2007","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.lfs.2019.02.010_bb0215","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1093\/brain\/awl296","article-title":"The cellular inflammatory response in human spinal cords after injury","volume":"129","author":"Fleming","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.lfs.2019.02.010_bb0220","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/jbmr.5650100617","article-title":"Interleukin-6 and the acute-phase response during treatment of patients with Pagets-disease with the nitrogen-containing bisphosphonate Dimethylaminohydroxypropylidene bisphosphonate","volume":"10","author":"Schweitzer","year":"1995","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.lfs.2019.02.010_bb0225","article-title":"Lung pericyte-like cells are functional interstitial immune sentinel cells","volume":"312","author":"Hung","year":"2017","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.lfs.2019.02.010_bb0230","doi-asserted-by":"crossref","first-page":"144","DOI":"10.4049\/jimmunol.142.1.144","article-title":"Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells","volume":"142","author":"Jirik","year":"1989","journal-title":"J. Immunol."},{"issue":"Suppl. 3","key":"10.1016\/j.lfs.2019.02.010_bb0235","doi-asserted-by":"crossref","first-page":"S233","DOI":"10.1186\/ar565","article-title":"The paradigm of IL-6: from basic science to medicine","volume":"4","author":"Naka","year":"2002","journal-title":"Arthritis Res."},{"key":"10.1016\/j.lfs.2019.02.010_bb0240","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fasebj.9.8.7768358","article-title":"Soluble interleukin-6 (IL-6) receptor augments central effects of IL-6 in vivo","volume":"9","author":"Schobitz","year":"1995","journal-title":"FASEB J."},{"key":"10.1016\/j.lfs.2019.02.010_bb0245","doi-asserted-by":"crossref","first-page":"799","DOI":"10.4049\/jimmunol.154.2.799","article-title":"IL-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells","volume":"154","author":"Bochner","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.lfs.2019.02.010_bb0250","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bbi.2017.07.003","article-title":"Interplay of inflammatory gene expression in pericytes following Japanese encephalitis virus infection","volume":"66","author":"Chang","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.lfs.2019.02.010_bb0255","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.ejcb.2008.06.005","article-title":"HIV-1 Tat protein induces IL-10 production in monocytes by classical and alternative NF-kappaB pathways","volume":"87","author":"Leghmari","year":"2008","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.lfs.2019.02.010_bb0260","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.cardiores.2005.10.018","article-title":"Downregulated CD36 and oxLDL uptake and stimulated ABCA1\/G1 and cholesterol efflux as anti-atherosclerotic mechanisms of interleukin-10","volume":"69","author":"Rubic","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2019.02.010_bb0265","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.3390\/ijms12021306","article-title":"The effects of G-CSF on proliferation of mouse myocardial microvascular endothelial cells","volume":"12","author":"Li","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2019.02.010_bb0270","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.yjmcc.2008.07.002","article-title":"G-CSF exerts dual effects on endothelial cells\u2013opposing actions of direct eNOS induction versus indirect CRP elevation","volume":"45","author":"Park","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.lfs.2019.02.010_bb0275","article-title":"G-CSF protects human brain vascular endothelial cells injury induced by high glucose, free fatty acids and hypoxia through MAPK and Akt signaling","volume":"10","author":"Su","year":"2015","journal-title":"PLoS One"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320519300888?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320519300888?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:18:52Z","timestamp":1758399532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320519300888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":55,"alternative-id":["S0024320519300888"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2019.02.010","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systemic microcirculation dysfunction after low thoracic spinal cord injury in mice","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2019.02.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}