{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:05:28Z","timestamp":1773306328972,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Rajaie Cardiovascular, Medical and Research Center","award":["1393.28"],"award-info":[{"award-number":["1393.28"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.lfs.2019.02.045","type":"journal-article","created":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T11:23:04Z","timestamp":1550834584000},"page":"319-326","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["High-intensity interval training increase GATA4, CITED4 and c-Kit and decreases C\/EBP\u03b2 in rats after myocardial infarction"],"prefix":"10.1016","volume":"221","author":[{"given":"Nasim","family":"Naderi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Hemmatinafar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas Ali","family":"Gaeini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Bahramian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5075-2225","authenticated-orcid":false,"given":"Alireza","family":"Ghardashi-Afousi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Reza","family":"Kordi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Darbandi-Azar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fariba","family":"Karimzade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid","family":"Mohebbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmood","family":"Barati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2019.02.045_bb0005","doi-asserted-by":"crossref","first-page":"8819","DOI":"10.1039\/c0jm00805b","article-title":"Multimodal biomaterial strategies for regeneration of infarcted myocardium","volume":"20","author":"Mukherjee","year":"2010","journal-title":"J. Mater. Chem."},{"key":"10.1016\/j.lfs.2019.02.045_bb0010","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nature11682","article-title":"Mammalian heart renewal by pre-existing cardiomyocytes","volume":"493","author":"Senyo","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2019.02.045_bb0015","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1136\/heartjnl-2011-300639","article-title":"Physiological cardiac remodelling in response to endurance exercise training: cellular and molecular mechanisms","volume":"98","author":"Ellison","year":"2012","journal-title":"Heart"},{"key":"10.1016\/j.lfs.2019.02.045_bb0020","article-title":"Targeting necroptotic cell death pathway by high-intensity interval training (HIIT) decreases development of post-ischemic adverse remodelling after myocardial ischemia \/ reperfusion injury","author":"Ghardashi Afousi","year":"2018","journal-title":"J Cell Commun Signal"},{"key":"10.1016\/j.lfs.2019.02.045_bb0025","first-page":"e6","article-title":"Heart disease and stroke statistics \u2013 2013 update: a report from the American Heart Association","volume":"127","author":"Go","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2019.02.045_bb0030","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s12265-010-9210-x","article-title":"Delivering regenerative cues to the heart: cardiac drug delivery by microspheres and peptide nanofibers","volume":"3","author":"Sy","year":"2010","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.lfs.2019.02.045_bb0035","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.cell.2013.07.039","article-title":"Adult c-kit pos cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair","volume":"154","author":"Ellison","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2019.02.045_bb0040","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.scr.2015.05.011","article-title":"Endogenous resident c-Kit cardiac stem cells increase in mice with an exercise-induced, physiologically hypertrophied heart","volume":"15","author":"Leite","year":"2015","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.lfs.2019.02.045_bb0045","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.cell.2010.11.036","article-title":"C\/EBP\u03b2 controls exercise-induced cardiac growth and protects against pathological cardiac remodeling","volume":"143","author":"Bostr\u00f6m","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2019.02.045_bb0050","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1161\/CIRCULATIONAHA.112.131110","article-title":"Enhanced effect of human cardiac stem cells and bone marrow mesenchymal stem cells to reduce infarct size and restore cardiac function after myocardial infarction","volume":"127","author":"Williams","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2019.02.045_bb0055","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nature08899","article-title":"Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation","volume":"464","author":"Jopling","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2019.02.045_bb0060","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1073\/pnas.1208863110","article-title":"Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family","volume":"110","author":"Porrello","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2019.02.045_bb0065","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1164680","article-title":"Evidence for cardiomyocyte renewal in humans","volume":"324","author":"Bergmann","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.lfs.2019.02.045_bb0070","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1056\/NEJM200106073442303","article-title":"Evidence that human cardiac myocytes divide after myocardial infarction","volume":"344","author":"Beltrami","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2019.02.045_bb0075","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1111\/j.1582-4934.2012.01589.x","article-title":"Local activation of cardiac stem cells for post-myocardial infarction cardiac repair","volume":"16","author":"Wen","year":"2012","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.lfs.2019.02.045_bb0080","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.drudis.2014.03.010","article-title":"Mechanisms of exercise-induced cardiac growth","volume":"19","author":"Lerchenm\u00fcller","year":"2014","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.lfs.2019.02.045_bb0085","first-page":"663","article-title":"Exercise-induced physiological hypertrophy initiates activation of cardiac progenitor cells","volume":"7","author":"Xiao","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.lfs.2019.02.045_bb0090","doi-asserted-by":"crossref","first-page":"262","DOI":"10.2174\/157340311799960618","article-title":"Transcription factors in heart: promising therapeutic targets in cardiac hypertrophy","volume":"7","author":"Kohli","year":"2011","journal-title":"Curr. Cardiol. Rev."},{"key":"10.1016\/j.lfs.2019.02.045_bb0095","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/nature08804","article-title":"Primary contribution to zebrafish heart regeneration by GATA4 (+) cardiomyocytes","volume":"464","author":"Kikuchi","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2019.02.045_bb0100","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.cmet.2015.02.014","article-title":"MiR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling","volume":"21","author":"Liu","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.lfs.2019.02.045_bb0105","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.yjmcc.2014.02.013","article-title":"Phenotypic screen quantifying differential regulation of cardiac myocyte hypertrophy identifies CITED4 regulation of myocyte elongation","volume":"72","author":"Ryall","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.lfs.2019.02.045_bb0110","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1152\/japplphysiol.00518.2014","article-title":"High-intensity interval training vs. moderate-intensity continuous exercise training in heart failure with preserved ejection fraction: a pilot study","volume":"119","author":"Angadi","year":"2015","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.lfs.2019.02.045_bb0115","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1093\/eurheartj\/ehs338","article-title":"The adult heart responds to increased workload with physiologic hypertrophy, cardiac stem cell activation, and new myocyte formation","volume":"35","author":"Waring","year":"2014","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.lfs.2019.02.045_bb0120","doi-asserted-by":"crossref","first-page":"52","DOI":"10.4330\/wjc.v7.i2.52","article-title":"Cardiac remodeling and physical training post myocardial infarction","volume":"7","author":"Garza","year":"2015","journal-title":"World J. Cardiol."},{"key":"10.1016\/j.lfs.2019.02.045_bb0125","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1745-6215-12-92","article-title":"A meta-analysis of the effects of exercise training on left ventricular remodeling following myocardial infarction: start early and go longer for greatest exercise benefits on remodeling","volume":"12","author":"Haykowsky","year":"2011","journal-title":"Trials"},{"key":"10.1016\/j.lfs.2019.02.045_bb0130","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1177\/2047487316675823","article-title":"Longer-term effects of home-based exercise interventions on exercise capacity and physical activity in coronary artery disease patients: a systematic review and meta-analysis","volume":"24","author":"Claes","year":"2017","journal-title":"Eur. J. Prev. Cardiol."},{"key":"10.1016\/j.lfs.2019.02.045_bb0135","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/MRR.0000000000000232","article-title":"Effects of exercise training on exercise capacity, cardiac function, BMI, and quality of life in patients with atrial fibrillation: a meta-analysis of randomized-controlled trials","volume":"40","author":"Kato","year":"2017","journal-title":"Int. J. Rehabil. Res."},{"key":"10.1016\/j.lfs.2019.02.045_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lfs.2016.02.055","article-title":"Exercise training activates neuregulin 1\/ErbB signaling and promotes cardiac repair in a rat myocardial infarction model","volume":"149","author":"Cai","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2019.02.045_bb0145","doi-asserted-by":"crossref","unstructured":"Bahramian, A., Mirzaei., B, Karimzadeh, F., Ramhmaninia, F., Gaeini, A.A, Naderi, N. et al, The effects of exercise training intensity on the expression of C\/EBP_ and CITED4 in rats with myocardial infarction, Asian J Sports Med, 9 (2018) e59300.","DOI":"10.5812\/asjsm.59300"},{"key":"10.1016\/j.lfs.2019.02.045_bb0150","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1540-8175.2006.00356.x","article-title":"Echocardiographic evaluation of ventricular function in mice","volume":"24","author":"Rottman","year":"2007","journal-title":"Echocardiography"},{"key":"10.1016\/j.lfs.2019.02.045_bb0155","doi-asserted-by":"crossref","first-page":"42","DOI":"10.17221\/4971-VETMED","article-title":"Basic values of M-mode echocardiographic parameters of the left ventricle in outbreed Wistar rats","volume":"57","author":"Scheer","year":"2012","journal-title":"Vete Med"},{"key":"10.1016\/j.lfs.2019.02.045_bb0160","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1097\/HJR.0b013e3281eacef1","article-title":"Running speed and maximal oxygen uptake in rats and mice: practical implications for exercise training","volume":"14","author":"H\u00f8ydal","year":"2007","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"10.1016\/j.lfs.2019.02.045_bb0165","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/cvr\/cvt080","article-title":"Aerobic interval training attenuates remodelling and mitochondrial dysfunction in the post-infarction failing rat heart","volume":"99","author":"Kraljevic","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2019.02.045_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2172-5-3","article-title":"Rat pro-inflammatory cytokine and cytokine related mRNA quantification by real-time polymerase chain reaction using SYBR green","volume":"5","author":"Peinnequin","year":"2004","journal-title":"BMC Immunol."},{"key":"10.1016\/j.lfs.2019.02.045_bb0175","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.lfs.2019.02.045_bb0180","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0008-6363(01)00565-X","article-title":"Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractility, Ca2+ sensitivity and SERCA-2 in rat after myocardial infarction","volume":"54","author":"Wisloff","year":"2002","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2019.02.045_bb0185","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1161\/01.RES.0000262655.16373.37","article-title":"Early exercise training normalizes myofilament function and attenuates left ventricular pump dysfunction in mice with a large myocardial infarction","volume":"100","author":"de Waard","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2019.02.045_bb0190","first-page":"60","article-title":"Resistance training after myocardial infarction in rats: its role on cardiac and autonomic function","volume":"103","author":"Grans","year":"2014","journal-title":"Arq. Bras. Cardiol."},{"key":"10.1016\/j.lfs.2019.02.045_bb0195","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1161\/CIRCULATIONAHA.106.675041","article-title":"Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study","volume":"115","author":"Wisl\u00f8ff","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2019.02.045_bb0200","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1161\/CIRCULATIONAHA.111.060376","article-title":"Can exercise teach us how to treat heart disease?","volume":"126","author":"Mann","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2019.02.045_bb0205","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.pcad.2007.03.005","article-title":"Endogenous cardiac stem cells","volume":"50","author":"Barile","year":"2007","journal-title":"Prog. Cardiovasc. Dis."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320519301353?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320519301353?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:23:03Z","timestamp":1758399783000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320519301353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":41,"alternative-id":["S0024320519301353"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2019.02.045","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-intensity interval training increase GATA4, CITED4 and c-Kit and decreases C\/EBP\u03b2 in rats after myocardial infarction","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2019.02.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}