{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:08:16Z","timestamp":1791979696746,"version":"4.4.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871646"],"award-info":[{"award-number":["81871646"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470851"],"award-info":[{"award-number":["81470851"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.lfs.2019.02.060","type":"journal-article","created":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T16:38:47Z","timestamp":1551458327000},"page":"69-73","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["The relevance of pyroptosis in the pathogenesis of liver diseases"],"prefix":"10.1016","volume":"223","author":[{"given":"Huiting","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjie","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6159-9879","authenticated-orcid":false,"given":"Min","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.lfs.2019.02.060_bb0005","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/imr.12534","article-title":"Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases","volume":"277","author":"Man","year":"2017","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.lfs.2019.02.060_bb0010","doi-asserted-by":"crossref","unstructured":"Kolb, J.P., et al., Programmed cell death and inflammation: winter is coming. Trends Immunol., 2017. 38(10): p. 705\u2013718.","DOI":"10.1016\/j.it.2017.06.009"},{"issue":"2","key":"10.1016\/j.lfs.2019.02.060_bb0015","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrmicro2070","article-title":"Pyroptosis: host cell death and inflammation","volume":"7","author":"Bergsbaken","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.lfs.2019.02.060_bb0020","doi-asserted-by":"crossref","unstructured":"Qiu, T., et al., Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway. Cell Death Dis., 2018. 9(10): p. 946.","DOI":"10.1038\/s41419-018-1004-0"},{"key":"10.1016\/j.lfs.2019.02.060_bb0025","unstructured":"Hilbi, H., et al., The Interleukin 1beta-Converting Enzyme, Caspase 1, Is Activated during Shigella Flexneri-Induced Apoptosis in Human Monocyte-Derived Macrophages. (0019-9567 (Print))."},{"key":"10.1016\/j.lfs.2019.02.060_bb0030","unstructured":"Hilbi, H., et al., Shigella-Induced Apoptosis is Dependent on Caspase-1 Which Binds to IpaB. (0021-9258 (Print))."},{"key":"10.1016\/j.lfs.2019.02.060_bb0035","doi-asserted-by":"crossref","unstructured":"Chen, Y., et al., A bacterial invasin induces macrophage apoptosis by binding directly to ICE. EMBO J., 1996. 15(15): p. 3853\u201360.","DOI":"10.1002\/j.1460-2075.1996.tb00759.x"},{"key":"10.1016\/j.lfs.2019.02.060_bb0040","doi-asserted-by":"crossref","unstructured":"Xu, Y.J., et al., Pyroptosis and its relationship to atherosclerosis. Clin. Chim. Acta, 2018. 476: p. 28\u201337.","DOI":"10.1016\/j.cca.2017.11.005"},{"issue":"13","key":"10.1016\/j.lfs.2019.02.060_bb0045","doi-asserted-by":"crossref","first-page":"R568","DOI":"10.1016\/j.cub.2016.02.019","article-title":"Pyroptosis","volume":"26","author":"Vande Walle","year":"2016","journal-title":"Curr. Biol."},{"issue":"4","key":"10.1016\/j.lfs.2019.02.060_bb0050","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1128\/IAI.73.4.1907-1916.2005","article-title":"Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells","volume":"73","author":"Fink","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.lfs.2019.02.060_bb0055","doi-asserted-by":"crossref","unstructured":"Fernandes-Alnemri, T., et al., The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ., 2007. 14(9): p. 1590\u2013604.","DOI":"10.1038\/sj.cdd.4402194"},{"issue":"11","key":"10.1016\/j.lfs.2019.02.060_bb0060","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1111\/j.1462-5822.2006.00751.x","article-title":"Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages","volume":"8","author":"Fink","year":"2006","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.lfs.2019.02.060_bb0065","doi-asserted-by":"crossref","unstructured":"Sanders, M.G., et al., Single-cell imaging of inflammatory caspase dimerization reveals differential recruitment to inflammasomes. Cell Death Dis., 2015. 6: p. e1813.","DOI":"10.1038\/cddis.2015.186"},{"key":"10.1016\/j.lfs.2019.02.060_bb0070","first-page":"15","article-title":"Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives","volume":"8","author":"Ozaki","year":"2015","journal-title":"J. Inflamm. Res."},{"issue":"5","key":"10.1016\/j.lfs.2019.02.060_bb0075","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","article-title":"Mechanisms and functions of inflammasomes","volume":"157","author":"Lamkanfi","year":"2014","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.lfs.2019.02.060_bb0080","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.tcb.2014.12.009","article-title":"Mechanisms of inflammasome activation: recent advances and novel insights","volume":"25","author":"Vanaja","year":"2015","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.lfs.2019.02.060_bb0085","doi-asserted-by":"crossref","unstructured":"Hornung, V., et al., AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature, 2009. 458(7237): p. 514\u20138.","DOI":"10.1038\/nature07725"},{"key":"10.1016\/j.lfs.2019.02.060_bb0090","doi-asserted-by":"crossref","unstructured":"Miao, E.A., et al., Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome. Proc. Natl. Acad. Sci. U. S. A., 2010. 107(7): p. 3076\u20133080.","DOI":"10.1073\/pnas.0913087107"},{"key":"10.1016\/j.lfs.2019.02.060_bb0095","doi-asserted-by":"crossref","unstructured":"Kovarova, M., et al., NLRP1-dependent Pyroptosis leads to acute lung injury and morbidity in mice. J. Immunol., 2012. 189(4): p. 2006\u20132016.","DOI":"10.4049\/jimmunol.1201065"},{"key":"10.1016\/j.lfs.2019.02.060_bb0100","doi-asserted-by":"crossref","unstructured":"Miao, E.A., et al., Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. Nat. Immunol., 2006. 7(6): p. 569\u201375.","DOI":"10.1038\/ni1344"},{"key":"10.1016\/j.lfs.2019.02.060_bb0105","doi-asserted-by":"crossref","unstructured":"Aachoui, Y., et al., Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection. Curr. Opin. Microbiol., 2013. 16(3): p. 319\u2013326.","DOI":"10.1016\/j.mib.2013.04.004"},{"issue":"4","key":"10.1016\/j.lfs.2019.02.060_bb0110","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00117-11","article-title":"Asc modulates the function of NLRC4 in response to infection of macrophages by legionella pneumophila","volume":"2","author":"Case","year":"2011","journal-title":"MBio"},{"key":"10.1016\/j.lfs.2019.02.060_bb0115","doi-asserted-by":"crossref","unstructured":"Broz, P., et al., Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing. Cell Host Microbe, 2010. 8(6): p. 471\u201383.","DOI":"10.1016\/j.chom.2010.11.007"},{"key":"10.1016\/j.lfs.2019.02.060_bb0120","doi-asserted-by":"crossref","unstructured":"Kayagaki, N., et al., Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature, 2015. 526(7575): p. 666\u2013671.","DOI":"10.1038\/nature15541"},{"issue":"4","key":"10.1016\/j.lfs.2019.02.060_bb0125","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/cdd.2017.24","article-title":"'Hints' in the killer protein gasdermin D: unveiling the secrets of gasdermins driving cell death","volume":"24","author":"Qiu","year":"2017","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.lfs.2019.02.060_bb0130","doi-asserted-by":"crossref","unstructured":"Shi, J.J., et al., Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature, 2015. 526(7575): p. 660\u2013665.","DOI":"10.1038\/nature15514"},{"key":"10.1016\/j.lfs.2019.02.060_bb0135","doi-asserted-by":"crossref","unstructured":"Sborgi, L., et al., GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death. EMBO J., 2016. 35(16): p. 1766\u201378.","DOI":"10.15252\/embj.201694696"},{"key":"10.1016\/j.lfs.2019.02.060_bb0140","doi-asserted-by":"crossref","unstructured":"Ding, J., et al., Pore-forming activity and structural autoinhibition of the gasdermin family. Nature, 2016. 535(7610): p. 111\u20136.","DOI":"10.1038\/nature18590"},{"key":"10.1016\/j.lfs.2019.02.060_bb0145","doi-asserted-by":"crossref","unstructured":"Kayagaki, N., et al., Noncanonical inflammasome activation by intracellular LPS independent of TLR4. Science, 2013. 341(6151): p. 1246\u20131249.","DOI":"10.1126\/science.1240248"},{"issue":"1","key":"10.1016\/j.lfs.2019.02.060_bb0150","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/imr.12287","article-title":"Pyroptotic cell death defends against intracellular pathogens","volume":"265","author":"Jorgensen","year":"2015","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.lfs.2019.02.060_bb0155","doi-asserted-by":"crossref","unstructured":"Vanaja, S.K., et al., Bacterial outer membrane vesicles mediate cytosolic localization of LPS and Caspase-11 activation. Cell, 2016. 165(5): p. 1106\u20131119.","DOI":"10.1016\/j.cell.2016.04.015"},{"key":"10.1016\/j.lfs.2019.02.060_bb0160","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.coi.2016.10.005","article-title":"Early innate immune responses to bacterial LPS","volume":"44","author":"Rosadini","year":"2017","journal-title":"Curr. Opin. Immunol."},{"issue":"4","key":"10.1016\/j.lfs.2019.02.060_bb0165","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.jhep.2018.01.017","article-title":"Pyroptosis: an inflammatory link between NAFLD and NASH with potential therapeutic implications","volume":"68","author":"Beier","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2019.02.060_bb0170","doi-asserted-by":"crossref","unstructured":"Chalasani, N., et al., The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology, 2012. 142(7): p. 1592\u2013609.","DOI":"10.1053\/j.gastro.2012.04.001"},{"key":"10.1016\/j.lfs.2019.02.060_bb0175","doi-asserted-by":"crossref","unstructured":"Vandanmagsar, B., et al., The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat. Med., 2011. 17(2): p. 179\u201388.","DOI":"10.1038\/nm.2279"},{"key":"10.1016\/j.lfs.2019.02.060_bb0180","doi-asserted-by":"crossref","unstructured":"Xu, B., et al., Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice. J. Hepatol., 2018. 68(4): p. 773\u2013782.","DOI":"10.1016\/j.jhep.2017.11.040"},{"key":"10.1016\/j.lfs.2019.02.060_bb0185","doi-asserted-by":"crossref","unstructured":"Wree, A., et al., NLRP3 inflammasome activation is required for fibrosis development in NAFLD. J. Mol. Med., 2014. 92(10): p. 1069\u20131082.","DOI":"10.1007\/s00109-014-1170-1"},{"key":"10.1016\/j.lfs.2019.02.060_bb0190","doi-asserted-by":"crossref","unstructured":"Mridha, A.R., et al., NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice. J. Hepatol., 2017. 66(5): p. 1037\u20131046.","DOI":"10.1016\/j.jhep.2017.01.022"},{"key":"10.1016\/j.lfs.2019.02.060_bb0195","doi-asserted-by":"crossref","unstructured":"Ye, X., et al., ROS\/TXNIP pathway contributes to thrombin induced NLRP3 inflammasome activation and cell apoptosis in microglia. Biochem. Biophys. Res. Commun., 2017. 485(2): p. 499\u2013505.","DOI":"10.1016\/j.bbrc.2017.02.019"},{"key":"10.1016\/j.lfs.2019.02.060_bb0200","doi-asserted-by":"crossref","unstructured":"Liu, Y., et al., AMSC-derived exosomes alleviate lipopolysaccharide\/d-galactosamine-induced acute liver failure by miR-17-mediated reduction of TXNIP\/NLRP3 inflammasome activation in macrophages. EBioMedicine, 2018. 36: p. 140\u2013150.","DOI":"10.1016\/j.ebiom.2018.08.054"},{"key":"10.1016\/j.lfs.2019.02.060_bb0205","doi-asserted-by":"crossref","unstructured":"He, K., et al., Inhibition of NLRP3 inflammasome by thioredoxin-interacting protein in mouse Kupffer cells as a regulatory mechanism for non-alcoholic fatty liver disease development. Oncotarget, 2017. 8(23): p. 37657\u201337672.","DOI":"10.18632\/oncotarget.17489"},{"key":"10.1016\/j.lfs.2019.02.060_bb0210","doi-asserted-by":"crossref","unstructured":"Khanova, E., et al., Pyroptosis by caspase11\/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients. Hepatology, 2018. 67(5): p. 1737\u20131753.","DOI":"10.1002\/hep.29645"},{"key":"10.1016\/j.lfs.2019.02.060_bb0215","doi-asserted-by":"crossref","unstructured":"Heo, M.J., et al., Alcohol dysregulates miR-148a in hepatocytes through FoxO1, facilitating pyroptosis via TXNIP overexpression. Gut, 2018.","DOI":"10.1136\/gutjnl-2017-315123"},{"key":"10.1016\/j.lfs.2019.02.060_bb0220","doi-asserted-by":"crossref","unstructured":"Fu, X., et al., The protective effects of selenium-enriched Spirulina platensis on chronic alcohol-induced liver injury in mice. Food Funct., 2018. 9(6): p. 3155\u20133165.","DOI":"10.1039\/C8FO00477C"},{"key":"10.1016\/j.lfs.2019.02.060_bb0225","doi-asserted-by":"crossref","unstructured":"Yu, X., et al., HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1beta production via suppressing the NF-kappaB pathway and ROS production. J. Hepatol., 2017. 66(4): p. 693\u2013702.","DOI":"10.1016\/j.jhep.2016.12.018"},{"key":"10.1016\/j.lfs.2019.02.060_bb0230","doi-asserted-by":"crossref","unstructured":"Miyakawa, K., et al., Molecular dissection of HBV evasion from restriction factor tetherin: a new perspective for antiviral cell therapy. Oncotarget, 2015. 6(26): p. 21840\u201352.","DOI":"10.18632\/oncotarget.4808"},{"key":"10.1016\/j.lfs.2019.02.060_bb0235","doi-asserted-by":"crossref","unstructured":"Kofahi, H.M., et al., Hepatitis C virus infection of cultured human hepatoma cells causes apoptosis and pyroptosis in both infected and bystander cells. Sci. Rep., 2016. 6.","DOI":"10.1038\/srep37433"},{"key":"10.1016\/j.lfs.2019.02.060_bb0240","doi-asserted-by":"crossref","unstructured":"Luan, J.Y., et al., NOD-like receptor protein 3 inflammasome-dependent IL-1 beta accelerated ConA-induced hepatitis. Front. Immunol., 2018. 9.","DOI":"10.3389\/fimmu.2018.00758"},{"key":"10.1016\/j.lfs.2019.02.060_bb0245","doi-asserted-by":"crossref","unstructured":"Lan, P.X., et al., TNF superfamily receptor OX40 triggers invariant NKT cell pyroptosis and liver injury. J. Clin. Investig., 2017. 127(6): p. 2222\u20132234.","DOI":"10.1172\/JCI91075"},{"key":"10.1016\/j.lfs.2019.02.060_bb0250","doi-asserted-by":"crossref","unstructured":"Wei, Q., et al., Deregulation of the NLRP3 inflammasome in hepatic parenchymal cells during liver cancer progression. Lab. Investig., 2014. 94(1): p. 52\u201362.","DOI":"10.1038\/labinvest.2013.126"},{"key":"10.1016\/j.lfs.2019.02.060_bb0255","doi-asserted-by":"crossref","unstructured":"Chu, Q., et al., Pyroptosis is involved in the pathogenesis of human hepatocellular carcinoma. Oncotarget, 2016. 7(51): p. 84658\u201384665.","DOI":"10.18632\/oncotarget.12384"},{"issue":"1","key":"10.1016\/j.lfs.2019.02.060_bb0260","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1055\/s-0035-1571272","article-title":"Targeting cell death and sterile inflammation loop for the treatment of nonalcoholic steatohepatitis","volume":"36","author":"Wree","year":"2016","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.lfs.2019.02.060_bb0265","doi-asserted-by":"crossref","unstructured":"Yaping, Z., et al., Mechanism of interleukin-1beta-induced proliferation in rat hepatic stellate cells from different levels of signal transduction. APMIS, 2014. 122(5): p. 392\u20138.","DOI":"10.1111\/apm.12155"},{"key":"10.1016\/j.lfs.2019.02.060_bb0270","doi-asserted-by":"crossref","unstructured":"Wree, A., et al., NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice. Hepatology, 2014. 59(3): p. 898\u2013910.","DOI":"10.1002\/hep.26592"},{"key":"10.1016\/j.lfs.2019.02.060_bb0275","doi-asserted-by":"crossref","unstructured":"Palacios-Macapagal, D., et al., Cutting edge: eosinophils undergo caspase-1-mediated pyroptosis in response to necrotic liver cells. J. Immunol., 2017. 199(3): p. 847\u2013853.","DOI":"10.4049\/jimmunol.1601162"},{"key":"10.1016\/j.lfs.2019.02.060_bb0280","doi-asserted-by":"crossref","unstructured":"Wu, X.Q., et al., Relevance of the NLRP3 inflammasome in the pathogenesis of chronic liver disease. Front. Immunol., 2017. 8.","DOI":"10.3389\/fimmu.2017.01728"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002432051930150X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002432051930150X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:42:37Z","timestamp":1777423357000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002432051930150X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":56,"alternative-id":["S002432051930150X"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2019.02.060","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The relevance of pyroptosis in the pathogenesis of liver diseases","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2019.02.060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}