{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T19:06:27Z","timestamp":1782759987236,"version":"3.54.5"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.lfs.2019.04.024","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T10:35:56Z","timestamp":1554978956000},"page":"149-155","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Knockdown of Delta-like 3 restricts lipopolysaccharide-induced inflammation, migration and invasion of A2058 melanoma cells via blocking Twist1-mediated epithelial-mesenchymal transition"],"prefix":"10.1016","volume":"226","author":[{"given":"Xiaojie","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuyao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.lfs.2019.04.024_bb0005","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/toxsci\/kfx147","article-title":"Editor's highlight: PPAR\u03b2\/\u03b4 and PPAR\u03b3 inhibit melanoma Tumorigenicity by modulating inflammation and apoptosis","volume":"159","author":"Borland","year":"2017","journal-title":"Toxicol. Sci."},{"issue":"10","key":"10.1016\/j.lfs.2019.04.024_bb0010","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1093\/carcin\/bgv123","article-title":"Immunosuppression associated with chronic inflammation in the tumor microenvironment","volume":"36","author":"Wang","year":"2015","journal-title":"Carcinogenesis"},{"issue":"5","key":"10.1016\/j.lfs.2019.04.024_bb0015","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1002\/ijc.25764","article-title":"Interleukin-6 promotes tumorigenesis by altering DNA methylation in oral cancer cells","volume":"129","author":"Gasche","year":"2011","journal-title":"Int. J. Cancer"},{"issue":"10","key":"10.1016\/j.lfs.2019.04.024_bb0020","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/iub.1435","article-title":"Paeonol inhibits B16F10 melanoma metastasis in vitro and in vivo via disrupting proinflammatory cytokines-mediated NF-kappaB and STAT3 pathways","volume":"67","author":"Zhang","year":"2015","journal-title":"IUBMB Life"},{"issue":"12","key":"10.1016\/j.lfs.2019.04.024_bb0025","doi-asserted-by":"crossref","first-page":"e2515","DOI":"10.1038\/cddis.2016.408","article-title":"Inflammation and notch signaling: a crosstalk with opposite effects on tumorigenesis","volume":"7","author":"Fazio","year":"2016","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.lfs.2019.04.024_bb0030","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1590\/1414-431X20143368","article-title":"Notch ligand Delta-like 1 promotes the metastasis of melanoma by enhancing tumor adhesion","volume":"47","author":"Zhang","year":"2014","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"10","key":"10.1016\/j.lfs.2019.04.024_bb0035","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s12032-017-1039-6","article-title":"Notch signaling pathway networks in cancer metastasis: a new target for cancer therapy","volume":"34","author":"Li","year":"2017","journal-title":"Med. Oncol."},{"key":"10.1016\/j.lfs.2019.04.024_bb0040","doi-asserted-by":"crossref","first-page":"20670","DOI":"10.1038\/srep20670","article-title":"Inflammation increases NOTCH1 activity via MMP9 and is counteracted by Eicosapentaenoic acid-free fatty acid in colon cancer cells","volume":"6","author":"Fazio","year":"2016","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.lfs.2019.04.024_bb0045","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1002\/ptr.5612","article-title":"Embelin inhibits invasion and migration of MDA-MB-231 breast cancer cells by suppression of CXC chemokine receptor 4, matrix metalloproteinases-9\/2, and epithelial-mesenchymal transition","volume":"30","author":"Lee","year":"2016","journal-title":"Phytother. Res."},{"issue":"3","key":"10.1016\/j.lfs.2019.04.024_bb0050","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/cbin.10726","article-title":"Cyclophosphamide promotes breast cancer cell migration through CXCR4 and matrix metalloproteinases","volume":"41","author":"Hung","year":"2017","journal-title":"Cell Biol. Int."},{"issue":"3","key":"10.1016\/j.lfs.2019.04.024_bb0055","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s10238-012-0190-9","article-title":"The involvement of notch signaling in melanoma vasculogenic mimicry","volume":"13","author":"Vartanian","year":"2013","journal-title":"Clin. Exp. Med."},{"issue":"1","key":"10.1016\/j.lfs.2019.04.024_bb0060","doi-asserted-by":"crossref","first-page":"e176-e","DOI":"10.1016\/j.jdermsci.2016.08.519","article-title":"Delta-like protein 3 promotes proliferation and migration of melanoma via MAPK activation","volume":"84","author":"Kiniwa","year":"2016","journal-title":"J. Dermatol. Sci."},{"issue":"3","key":"10.1016\/j.lfs.2019.04.024_bb0065","doi-asserted-by":"crossref","first-page":"817","DOI":"10.3892\/ijo.2013.1778","article-title":"Delta-like 3 is silenced by methylation and induces apoptosis in human hepatocellular carcinoma","volume":"42","author":"Maemura","year":"2013","journal-title":"Int. J. Oncol."},{"issue":"1","key":"10.1016\/j.lfs.2019.04.024_bb0070","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.bbrc.2016.12.117","article-title":"The notch ligand delta-like 3 promotes tumor growth and inhibits notch signaling in lung cancer cells in mice","volume":"483","author":"Deng","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2019.04.024_bb0075","doi-asserted-by":"crossref","first-page":"350209","DOI":"10.1155\/2012\/350209","article-title":"Notch signaling mediates TNF-alpha-induced IL-6 production in cultured fibroblast-like synoviocytes from rheumatoid arthritis","volume":"2012","author":"Jiao","year":"2012","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.lfs.2019.04.024_bb0080","unstructured":"Zhang L, et al. Paeonol inhibits B16F10 melanoma metastasis In vitro and In Vivo via disrupting proinflammatory cytokines-mediated NF-\u03baediated NFL, et al. Paeonol inhibits B16F10 melanom"},{"issue":"7225","key":"10.1016\/j.lfs.2019.04.024_bb0085","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/457036b","article-title":"Cancer: inflaming metastasis","volume":"457","author":"Mantovani","year":"2009","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.lfs.2019.04.024_bb0090","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10555-006-9005-3","article-title":"TNF-\u03b1 in promotion and progression of cancer","volume":"25","author":"Balkwill","year":"2006","journal-title":"Cancer Metastasis Rev."},{"issue":"1","key":"10.1016\/j.lfs.2019.04.024_bb0095","first-page":"1","article-title":"The role of TWIST1 in epithelial-mesenchymal transition and cancers","volume":"8","author":"Zhu","year":"2015","journal-title":"Tumour Biol."},{"issue":"1","key":"10.1016\/j.lfs.2019.04.024_bb0100","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0006-291X(87)90730-3","article-title":"Pertussis toxin inhibits stimulated motility independently of the adenylate cyclase pathway in human melanoma cells","volume":"146","author":"Stracke","year":"1987","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"8","key":"10.1016\/j.lfs.2019.04.024_bb0105","doi-asserted-by":"crossref","first-page":"e0182584","DOI":"10.1371\/journal.pone.0182584","article-title":"Total glucosides of paeony inhibits lipopolysaccharide-induced proliferation, migration and invasion in androgen insensitive prostate cancer cells","volume":"12","author":"Zhang","year":"2017","journal-title":"PLoS One"},{"issue":"25","key":"10.1016\/j.lfs.2019.04.024_bb0110","doi-asserted-by":"crossref","first-page":"40190","DOI":"10.18632\/oncotarget.15360","article-title":"Role of TOPK in lipopolysaccharide-induced breast cancer cell migration and invasion","volume":"8","author":"Seol","year":"2017","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.lfs.2019.04.024_bb0115","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1177\/1753425912436589","article-title":"Resveratrol inhibits LPS-induced epithelial-mesenchymal transition in mouse melanoma model","volume":"18","author":"Chen","year":"2012","journal-title":"Innate Immun."},{"issue":"30","key":"10.1016\/j.lfs.2019.04.024_bb0120","doi-asserted-by":"crossref","first-page":"49064","DOI":"10.18632\/oncotarget.17093","article-title":"Interleukin-37 mediates the antitumor activity in colon cancer through beta-catenin suppression","volume":"8","author":"Yan","year":"2017","journal-title":"Oncotarget"},{"issue":"11","key":"10.1016\/j.lfs.2019.04.024_bb0125","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s12032-015-0695-7","article-title":"IL-37 mediates the antitumor activity in renal cell carcinoma","volume":"32","author":"Jiang","year":"2015","journal-title":"Med. Oncol."},{"issue":"115","key":"10.1016\/j.lfs.2019.04.024_bb0130","first-page":"189","article-title":"Notch \u2014 a goldilocks signaling pathway in disease and cancer therapy [J]","volume":"21","author":"Braune","year":"2016","journal-title":"Discov. Med."},{"issue":"1","key":"10.1016\/j.lfs.2019.04.024_bb0135","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1470-2045(16)30575-7","article-title":"Rovalpituzumab tesirine and DLL3: a new challenge for small-cell lung cancer","volume":"18","author":"Rossi","year":"2017","journal-title":"Lancet Oncol."},{"issue":"3","key":"10.1016\/j.lfs.2019.04.024_bb0140","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.18632\/oncotarget.6560","article-title":"Quinomycin a targets notch signaling pathway in pancreatic cancer stem cells","volume":"7","author":"Ponnurangam","year":"2016","journal-title":"Oncotarget"},{"issue":"14","key":"10.1016\/j.lfs.2019.04.024_bb0145","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1158\/0008-5472.CAN-17-0299","article-title":"Noninvasive interrogation of DLL3 expression in metastatic small cell lung cancer","volume":"77","author":"Sharma","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2019.04.024_bb0150","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.mce.2015.10.021","article-title":"The role of FSCN1 in migration and invasion of pituitary adenomas","volume":"419","author":"Liu","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"issue":"7","key":"10.1016\/j.lfs.2019.04.024_bb0155","doi-asserted-by":"crossref","DOI":"10.1177\/1010428317706203","article-title":"EGFL7 participates in regulating biological behavior of growth hormone-secreting pituitary adenomas via Notch2\/DLL3 signaling pathway","volume":"39","author":"Wang","year":"2017","journal-title":"Tumour Biol."},{"issue":"11","key":"10.1016\/j.lfs.2019.04.024_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18112354","article-title":"miRNAs, melanoma and microenvironment: an intricate network","volume":"18","author":"Romano","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.lfs.2019.04.024_bb0165","doi-asserted-by":"crossref","first-page":"e0171512","DOI":"10.1371\/journal.pone.0171512","article-title":"Deep-proteome mapping of WM-266-4 human metastatic melanoma cells: from oncogenic addiction to druggable targets","volume":"12","author":"Konstantakou","year":"2017","journal-title":"PLoS One"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320519302802?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320519302802?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:20:57Z","timestamp":1758399657000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320519302802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":33,"alternative-id":["S0024320519302802"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2019.04.024","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Knockdown of Delta-like 3 restricts lipopolysaccharide-induced inflammation, migration and invasion of A2058 melanoma cells via blocking Twist1-mediated epithelial-mesenchymal transition","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2019.04.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}