{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T05:30:05Z","timestamp":1768282205885,"version":"3.49.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81702578"],"award-info":[{"award-number":["81702578"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.lfs.2019.116549","type":"journal-article","created":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T23:59:51Z","timestamp":1560297591000},"page":"116549","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Long noncoding RNA TUSC7 inhibits cell proliferation, migration and invasion by regulating SOCS4 (SOCS5) expression through targeting miR-616 in endometrial carcinoma"],"prefix":"10.1016","volume":"231","author":[{"given":"Xiaoling","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongge","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuyuan","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.lfs.2019.116549_bb0005","first-page":"7","article-title":"Cancer statistics, 2018","volume":"68","author":"Siegel","year":"2018","journal-title":"CA Cancer J. Clin."},{"issue":"9823","key":"10.1016\/j.lfs.2019.116549_bb0010","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/S0140-6736(12)60442-5","article-title":"Contemporary management of endometrial cancer","volume":"379","author":"Wright","year":"2012","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.lfs.2019.116549_bb0015","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ygyno.2015.07.108","article-title":"Prediction of concurrent endometrial carcinoma in women with endometrial hyperplasia","volume":"139","author":"Matsuo","year":"2015","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.lfs.2019.116549_bb0020","series-title":"Loss of p27 Expression in Endometrial Carcinoma Patients With Recurrent Tumor is Significantly Associated With Poor Survival","first-page":"119","volume":"39(1)","author":"Al-Maghrabi","year":"2018"},{"issue":"2","key":"10.1016\/j.lfs.2019.116549_bb0025","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/02648725.2018.1471566","article-title":"Long noncoding RNAs: regulation, function and cancer","volume":"34","author":"Rafiee","year":"2018","journal-title":"Biotechnol Genet Eng Rev"},{"issue":"10","key":"10.1016\/j.lfs.2019.116549_bb0030","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cancergen.2015.07.006","article-title":"Overexpression of the LSAMP and TUSC7 genes in acute myeloid leukemia following microdeletion\/duplication of chromosome 3","volume":"208","author":"Coccaro","year":"2015","journal-title":"Cancer Genet"},{"issue":"35","key":"10.1016\/j.lfs.2019.116549_bb0035","doi-asserted-by":"crossref","first-page":"59518","DOI":"10.18632\/oncotarget.18496","article-title":"Prognostic value of decreased long non-coding RNA TUSC7 expression in some solid tumors: a systematic review and meta-analysis","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.lfs.2019.116549_bb0040","doi-asserted-by":"crossref","DOI":"10.21037\/tcr.2017.08.19","article-title":"LncRNA TUSC7 affects malignant tumor prognosis by regulating protein ubiquitination: a genome-wide analysis from 10,237 pan-cancer patients","volume":"6","author":"Shi","year":"2017","journal-title":"Transl. Cancer Res."},{"issue":"8","key":"10.1016\/j.lfs.2019.116549_bb0045","doi-asserted-by":"crossref","first-page":"11429","DOI":"10.1007\/s13277-016-4892-6","article-title":"Long non-coding RNA TUSC7 acts a molecular sponge for miR-10a and suppresses EMT in hepatocellular carcinoma","volume":"37","author":"Wang","year":"2016","journal-title":"Tumour Biol."},{"issue":"16","key":"10.1016\/j.lfs.2019.116549_bb0050","first-page":"3605","article-title":"Long non-coding RNA TUSC7 expression is independently predictive of outcome in glioma","volume":"21","author":"Ma","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"6","key":"10.1016\/j.lfs.2019.116549_bb0055","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1002\/ijc.29516","article-title":"Reciprocal repression between TUSC7 and miR-23b in gastric cancer","volume":"137","author":"Qi","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.lfs.2019.116549_bb0060","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3389\/fncel.2016.00235","article-title":"Long non-coding RNA TUSC7, a target of miR-23b, plays tumor-suppressing roles in human gliomas","volume":"10","author":"Shang","year":"2016","journal-title":"Front. Cell. Neurosci."},{"issue":"7","key":"10.1016\/j.lfs.2019.116549_bb0065","doi-asserted-by":"crossref","first-page":"9441","DOI":"10.1007\/s13277-015-4414-y","article-title":"Long non-coding RNA tumor suppressor candidate 7 functions as a tumor suppressor and inhibits proliferation in osteosarcoma","volume":"37","author":"Cong","year":"2016","journal-title":"Tumour Biol."},{"issue":"9","key":"10.1016\/j.lfs.2019.116549_bb0070","first-page":"4026","article-title":"TUSC7 acts as a tumor suppressor in colorectal cancer","volume":"9","author":"Ren","year":"2017","journal-title":"Am. J. Transl. Res."},{"issue":"2","key":"10.1016\/j.lfs.2019.116549_bb0075","first-page":"680","article-title":"Downregulation of the long non-coding RNA TUSC7 promotes NSCLC cell proliferation and correlates with poor prognosis","volume":"8","author":"Wang","year":"2016","journal-title":"Am. J. Transl. Res."},{"issue":"6","key":"10.1016\/j.lfs.2019.116549_bb0080","doi-asserted-by":"crossref","DOI":"10.1177\/1010428317707883","article-title":"Long non-coding RNA tumor suppressor candidate 7 advances chemotherapy sensitivity of endometrial carcinoma through targeted silencing of miR-23b","volume":"39","author":"Shang","year":"2017","journal-title":"Tumour Biol."},{"issue":"2","key":"10.1016\/j.lfs.2019.116549_bb0085","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1158\/0008-5472.CAN-10-2587","article-title":"MicroRNA-616 induces androgen-independent growth of prostate cancer cells by suppressing expression of tissue factor pathway inhibitor TFPI-2","volume":"71","author":"Ma","year":"2011","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.lfs.2019.116549_bb0090","first-page":"963","article-title":"MicroRNA profiling of human gastric cancer","volume":"2","author":"Yao","year":"2009","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.lfs.2019.116549_bb0095","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/nm.2577","article-title":"EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers","volume":"18","author":"Garofalo","year":"2011","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.lfs.2019.116549_bb0100","doi-asserted-by":"crossref","first-page":"366","DOI":"10.3892\/or.2015.4334","article-title":"MicroRNA-616 promotes the migration, invasion and epithelial-mesenchymal transition of HCC by targeting PTEN","volume":"35","author":"Zhang","year":"2016","journal-title":"Oncol. Rep."},{"issue":"4","key":"10.1016\/j.lfs.2019.116549_bb0105","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.3892\/or.2017.5854","article-title":"MicroRNA-616 promotes the growth and metastasis of non-small cell lung cancer by targeting SOX7","volume":"38","author":"Wang","year":"2017","journal-title":"Oncol. Rep."},{"issue":"24","key":"10.1016\/j.lfs.2019.116549_bb0110","first-page":"5630","article-title":"MiR-616 promotes proliferation and inhibits apoptosis in glioma cells by suppressing expression of SOX7 via the Wnt signaling pathway","volume":"21","author":"Bai","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"6","key":"10.1016\/j.lfs.2019.116549_bb0115","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/nri818","article-title":"Suppressors of cytokine signalling (SOCS) in the immune system","volume":"2","author":"Alexander","year":"2002","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"10.1016\/j.lfs.2019.116549_bb0120","first-page":"1","article-title":"SOCS proteins in development and disease","volume":"2","author":"Trengove","year":"2013","journal-title":"Am J Clin Exp Immunol"},{"issue":"50","key":"10.1016\/j.lfs.2019.116549_bb0125","doi-asserted-by":"crossref","first-page":"35553","DOI":"10.1074\/jbc.274.50.35553","article-title":"SOCS\/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms","volume":"274","author":"Ram","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.lfs.2019.116549_bb0130","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0968-0004(02)02085-6","article-title":"The SOCS box: a tale of destruction and degradation","volume":"27","author":"Kile","year":"2002","journal-title":"Trends Biochem. Sci."},{"issue":"24","key":"10.1016\/j.lfs.2019.116549_bb0135","doi-asserted-by":"crossref","first-page":"14133","DOI":"10.1073\/pnas.2232790100","article-title":"SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer","volume":"100","author":"He","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.lfs.2019.116549_bb0140","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1038\/sj.bjc.6602133","article-title":"Constitutional activation of IL-6-mediated JAK\/STAT pathway through hypermethylation of SOCS-1 in human gastric cancer cell line","volume":"91","author":"To","year":"2004","journal-title":"Br. J. Cancer"},{"issue":"44","key":"10.1016\/j.lfs.2019.116549_bb0145","doi-asserted-by":"crossref","first-page":"6699","DOI":"10.1038\/sj.onc.1208818","article-title":"SOCS-3 is frequently methylated in head and neck squamous cell carcinoma and its precursor lesions and causes growth inhibition","volume":"24","author":"Weber","year":"2005","journal-title":"Oncogene"},{"issue":"2\u20133","key":"10.1016\/j.lfs.2019.116549_bb0150","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1159\/000086781","article-title":"Prognostic and predictive relevance of DNAM-1, SOCS6 and CADH-7 genes on chromosome 18q in colorectal cancer","volume":"68","author":"Storojeva","year":"2005","journal-title":"Oncology"},{"issue":"2","key":"10.1016\/j.lfs.2019.116549_bb0155","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s00268-011-1358-2","article-title":"Suppressor of cytokine signaling 4 detected as a novel gastric cancer suppressor gene using double combination array analysis","volume":"36","author":"Kobayashi","year":"2012","journal-title":"World J. Surg."},{"issue":"1","key":"10.1016\/j.lfs.2019.116549_bb0160","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s13277-011-0264-4","article-title":"SOCS5 and SOCS6 have similar expression patterns in normal and cancer tissues","volume":"33","author":"Yoon","year":"2012","journal-title":"Tumour Biol."},{"issue":"10","key":"10.1016\/j.lfs.2019.116549_bb0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0139456","article-title":"Interleukin-23 facilitates thyroid cancer cell migration and invasion by inhibiting SOCS4 expression via microRNA-25","volume":"10","author":"Mei","year":"2015","journal-title":"PLoS One"},{"issue":"20","key":"10.1016\/j.lfs.2019.116549_bb0170","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects","volume":"310","author":"World Medical","year":"2013","journal-title":"JAMA"},{"issue":"12","key":"10.1016\/j.lfs.2019.116549_bb0175","first-page":"5141","article-title":"LncRNAs and miRNAs: potential biomarkers and therapeutic targets for prostate cancer","volume":"8","author":"Ma","year":"2016","journal-title":"Am. J. Transl. Res."},{"issue":"12","key":"10.1016\/j.lfs.2019.116549_bb0180","first-page":"1072","article-title":"Guide for the care and use of laboratory animals","volume":"103","author":"Alleva","year":"1997","journal-title":"Ethology"},{"issue":"5","key":"10.1016\/j.lfs.2019.116549_bb0185","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1161\/ATVBAHA.110.207464","article-title":"Suppressors of cytokine signaling (SOCS) proteins and JAK\/STAT pathways: regulation of T-cell inflammation by SOCS1 and SOCS3","volume":"31","author":"Tamiya","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.lfs.2019.116549_bb0190","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3109\/08977194.2012.660936","article-title":"Biology and significance of the JAK\/STAT signalling pathways","volume":"30","author":"Kiu","year":"2012","journal-title":"Growth Factors"},{"key":"10.1016\/j.lfs.2019.116549_bb0195","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.biopha.2018.05.046","article-title":"LncRNA MIR22HG negatively regulates miR-141-3p to enhance DAPK1 expression and inhibits endometrial carcinoma cells proliferation","volume":"104","author":"Cui","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.lfs.2019.116549_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2018.07.008","article-title":"Long non-coding RNA PVT1 promotes malignancy in human endometrial carcinoma cells through negative regulation of miR-195-5p","author":"Kong","year":"2018","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"issue":"15","key":"10.1016\/j.lfs.2019.116549_bb0205","first-page":"4820","article-title":"LncRNA H19 regulates the expression of its target gene HOXA10 in endometrial carcinoma through competing with miR-612","volume":"22","author":"Zhang","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"2","key":"10.1016\/j.lfs.2019.116549_bb0210","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1159\/000457938","article-title":"The novel long noncoding RNA TUSC7 inhibits proliferation by sponging MiR-211 in colorectal cancer","volume":"41","author":"Xu","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"issue":"19","key":"10.1016\/j.lfs.2019.116549_bb0215","doi-asserted-by":"crossref","first-page":"27538","DOI":"10.18632\/oncotarget.8485","article-title":"The role of glycogen synthase kinase-3beta (GSK-3beta) in endometrial carcinoma: a carcinogenesis, progression, prognosis, and target therapy marker","volume":"7","author":"Chen","year":"2016","journal-title":"Oncotarget"},{"issue":"12","key":"10.1016\/j.lfs.2019.116549_bb0220","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.18632\/oncotarget.667","article-title":"Down-regulation of Sox7 is associated with aberrant activation of Wnt\/b-catenin signaling in endometrial cancer","volume":"3","author":"Chan","year":"2012","journal-title":"Oncotarget"},{"key":"10.1016\/j.lfs.2019.116549_bb0225","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.gene.2018.02.051","article-title":"PTEN negative correlates with miR-181a in tumour tissues of non-obese endometrial cancer patients","volume":"655","author":"Geletina","year":"2018","journal-title":"Gene"},{"issue":"15","key":"10.1016\/j.lfs.2019.116549_bb0230","doi-asserted-by":"crossref","first-page":"11977","DOI":"10.18632\/oncotarget.24046","article-title":"miR-1290 promotes lung adenocarcinoma cell proliferation and invasion by targeting SOCS4","volume":"9","author":"Xiao","year":"2018","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.lfs.2019.116549_bb0235","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1086\/653212","article-title":"MicroRNA-98 and let-7 regulate expression of suppressor of cytokine signaling 4 in biliary epithelial cells in response to Cryptosporidium parvum infection","volume":"202","author":"Hu","year":"2010","journal-title":"J. Infect. Dis."},{"issue":"316","key":"10.1016\/j.lfs.2019.116549_bb0240","doi-asserted-by":"crossref","first-page":"ra25","DOI":"10.1126\/scisignal.2004824","article-title":"MeCP2 reinforces STAT3 signaling and the generation of effector CD4+ T cells by promoting miR-124-mediated suppression of SOCS5","volume":"7","author":"Jiang","year":"2014","journal-title":"Sci. Signal."},{"key":"10.1016\/j.lfs.2019.116549_bb0245","article-title":"BRM transcriptionally regulates miR-302a-3p to target SOCS5\/STAT3 signaling axis to potentiate pancreatic cancer metastasis","author":"Zhang","year":"2019","journal-title":"Cancer Lett."},{"key":"10.1016\/j.lfs.2019.116549_bb0250","doi-asserted-by":"crossref","DOI":"10.1038\/srep27685","article-title":"Japanese encephalitis virus exploits the microRNA-432 to regulate the expression of suppressor of cytokine signaling (SOCS) 5","volume":"6","author":"Sharma","year":"2016","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.lfs.2019.116549_bb0255","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.yexmp.2018.10.002","article-title":"Upregulation of miR-132 contributes to the pathophysiology of COPD via targeting SOCS5","volume":"105","author":"Diao","year":"2018","journal-title":"Exp. Mol. Pathol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320519304758?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320519304758?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:28:26Z","timestamp":1758400106000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320519304758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":51,"alternative-id":["S0024320519304758"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2019.116549","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long noncoding RNA TUSC7 inhibits cell proliferation, migration and invasion by regulating SOCS4 (SOCS5) expression through targeting miR-616 in endometrial carcinoma","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2019.116549","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116549"}}