{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:19:17Z","timestamp":1790680757942,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81073063"],"award-info":[{"award-number":["81073063"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573612"],"award-info":[{"award-number":["81573612"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2015A030313357"],"award-info":[{"award-number":["2015A030313357"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2017A020211013"],"award-info":[{"award-number":["2017A020211013"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.lfs.2019.116557","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T11:04:38Z","timestamp":1560164678000},"page":"116557","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Saikosaponin b2 enhances the hepatotargeting effect of anticancer drugs through inhibition of multidrug resistance-associated drug transporters"],"prefix":"10.1016","volume":"231","author":[{"given":"Ya","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9554-3897","authenticated-orcid":false,"given":"Ruizhi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2019.116557_bb0005","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/487919","article-title":"Chinese medicines as an adjuvant therapy for unresectable hepatocellular carcinoma during transarterial chemoembolization: a meta-analysis of randomized controlled trials","volume":"2013","author":"Cheung","year":"2013","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.lfs.2019.116557_bb0010","series-title":"Bioinformatics and Biomedicine Workshops (BIBMW), 2011 IEEE International Conference on","first-page":"740","article-title":"Liver targeting effect of vinegar-baked Radix Bupleuri on oxymatrine in mice","author":"Zhao","year":"2011"},{"key":"10.1016\/j.lfs.2019.116557_bb0015","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jep.2010.08.021","article-title":"Liver targeting effect of vinegar-baked Radix Bupleuri on rhein in rats","volume":"132","author":"Zhao","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.lfs.2019.116557_bb0020","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jep.2009.09.023","article-title":"Study on liver targeting effect of vinegar-baked Radix Bupleuri on resveratrol in mice","volume":"126","author":"Zhao","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.lfs.2019.116557_bb0025","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3109\/00498254.2016.1171932","article-title":"Saikosaponin A, an active glycoside from Radix bupleuri, reverses P-glycoprotein-mediated multidrug resistance in MCF-7\/ADR cells and HepG2\/ADM cells","volume":"47","author":"Ye","year":"2017","journal-title":"Xenobiotica"},{"key":"10.1016\/j.lfs.2019.116557_bb0030","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.neulet.2016.12.019","article-title":"Suppressing effect of saikosaponin A, an active ingredient of Bupleurum falcatum, on chocolate self-administration and reinstatement of chocolate seeking in rats","volume":"638","author":"Lorrai","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.lfs.2019.116557_bb0035","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.3892\/mmr.2017.6765","article-title":"Effects of Saikosaponin D on apoptosis in human U87 glioblastoma cells","volume":"16","author":"Li","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.lfs.2019.116557_bb0040","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.prp.2017.01.022","article-title":"Reversal of P-glycoprotein-mediated multidrug resistance is induced by saikosaponin D in breast cancer MCF-7\/adriamycin cells","volume":"213","author":"Li","year":"2017","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.lfs.2019.116557_bb0045","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.bbrc.2014.02.046","article-title":"Saikosaponin C inhibits lipopolysaccharide-induced apoptosis by suppressing caspase-3 activation and subsequent degradation of focal adhesion kinase in human umbilical vein endothelial cells","volume":"445","author":"Lee","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2019.116557_bb0050","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jep.2015.02.024","article-title":"Chemical and biological comparison of raw and vinegar-baked Radix Bupleuri","volume":"165","author":"Li","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.lfs.2019.116557_bb0055","first-page":"1618","article-title":"Influence of processing on four saikosaponins in Radix Bupleuri","volume":"44","author":"Jiang","year":"2009","journal-title":"Chin. Pharm. J."},{"key":"10.1016\/j.lfs.2019.116557_bb0060","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1186\/s12906-016-1333-4","article-title":"Vinegar amount in the process affected the components of vinegar-baked Radix Bupleuri and its hepatoprotective effect","volume":"16","author":"Zhao","year":"2016","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.lfs.2019.116557_bb0065","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ejps.2005.12.003","article-title":"Transporters as a determinant of drug clearance and tissue distribution","volume":"27","author":"Shitara","year":"2006","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.lfs.2019.116557_bb0070","doi-asserted-by":"crossref","first-page":"21351","DOI":"10.18632\/oncotarget.15212","article-title":"Clerosterol from vinegar-baked Radix Bupleuri modifies drug transport","volume":"8","author":"Zhao","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.lfs.2019.116557_bb0075","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1111\/j.1440-1681.2006.04415.x","article-title":"Antiviral effects of saikosaponins on human coronacirus 299E in vitro","volume":"33","author":"Cheng","year":"2006","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.lfs.2019.116557_bb0080","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jhep.2014.10.040","article-title":"Saikosaponin b2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry","volume":"62","author":"Lin","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2019.116557_bb0085","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1080\/01635581.2017.1285407","article-title":"Chemosensitizing effect of saikosaponin B on B16F10 melanoma cells","volume":"69","author":"Ma","year":"2017","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.lfs.2019.116557_bb0090","article-title":"Identification of a specific agonist of human TAS2R14 from Radix Bupleuri through virtual screening, functional evaluation and binding studies","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2019.116557_bb0095","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.1016\/S0016-5085(17)30576-0","article-title":"Hepatocyte nuclear factor 1 beta upregulates P-glycoprotein expression in human intestinal epithelial cells","volume":"152","author":"Priyamvada","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2019.116557_bb0100","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1111\/j.1476-5381.2010.01101.x","article-title":"Metformin inhibits P-glycoprotein expression via the NF-kappaB pathway and CRE transcriptional activity through AMPK activation","volume":"162","author":"Kim","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2019.116557_bb0105","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/1476-4598-9-199","article-title":"TRAIL sensitize MDR cells to MDR-related drugs by down-regulation of P-glycoprotein through inhibition of DNA-PKcs\/Akt\/GSK-3beta pathway and activation of caspases","volume":"9","author":"Seo","year":"2010","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.lfs.2019.116557_bb0110","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0005-2736(99)00168-6","article-title":"Structural, mechanistic and clinical aspects of MRP1","volume":"1461","author":"Hipfner","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.lfs.2019.116557_bb0115","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3816\/CLC.2009.n.078","article-title":"Expression of MRP1, BCRP, LRP, and ERCC1 in advanced non-small-cell lung cancer: correlation with response to chemotherapy and survival","volume":"10","author":"Li","year":"2009","journal-title":"Clin. Lung Cancer"},{"key":"10.1016\/j.lfs.2019.116557_bb0120","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1365-2559.2009.03297.x","article-title":"Expression of multidrug resistance-associated protein 1 in invasive ovarian carcinoma: implication for prognosis","volume":"54","author":"Faggad","year":"2009","journal-title":"Histopathology"},{"key":"10.1016\/j.lfs.2019.116557_bb0125","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1179\/joc.2008.20.6.734","article-title":"Role of ABCB1 and ABCC1 gene induction on survival in locally advanced breast cancer","volume":"20","author":"Atalay","year":"2008","journal-title":"J. Chemother."},{"key":"10.1016\/j.lfs.2019.116557_bb0130","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1200\/JCO.2005.01.6196","article-title":"Association of high-level MRP1 expression with poor clinical outcome in a large prospective study of primary neuroblastoma","volume":"24","author":"Haber","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.lfs.2019.116557_bb0135","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1046\/j.0007-1048.2002.03344.x","article-title":"Multidrug resistance mechanisms in chronic lymphocytic leukaemia","volume":"116","author":"Consoli","year":"2002","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.lfs.2019.116557_bb0140","first-page":"1393","article-title":"The expression of drug resistance gene products during the progression of human prostate cancer","volume":"4","author":"Sullivan","year":"1998","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.lfs.2019.116557_bb0145","doi-asserted-by":"crossref","first-page":"328","DOI":"10.2133\/dmpk.DMPK-10-RG-004","article-title":"Elevated systemic elimination of cimetidine in rats with acute biliary obstruction: the role of renal organic cation transporter OCT2","volume":"25","author":"Kurata","year":"2010","journal-title":"Drug Metab. Pharmacokinet."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320519304837?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320519304837?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:22:41Z","timestamp":1758399761000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320519304837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":29,"alternative-id":["S0024320519304837"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2019.116557","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Saikosaponin b2 enhances the hepatotargeting effect of anticancer drugs through inhibition of multidrug resistance-associated drug transporters","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2019.116557","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116557"}}