{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:25:47Z","timestamp":1789003547091,"version":"build-2803163510"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010590","name":"Tianjin Municipal Health Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010590","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.lfs.2019.116569","type":"journal-article","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T12:31:10Z","timestamp":1560429070000},"page":"116569","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["The IRE1 signaling pathway is involved in the protective effect of low-dose LPS on myocardial ischemia-reperfusion injury"],"prefix":"10.1016","volume":"231","author":[{"given":"Ting","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.lfs.2019.116569_bb0005","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1536\/ihj.51.348","article-title":"BAY 11-7082, a nuclear factor-\u03baB inhibitor, reduces inflammation and apoptosis in a rat cardiac ischemia-reperfusion injury model","volume":"51","author":"Kim","year":"2010","journal-title":"Int. Heart J."},{"issue":"3","key":"10.1016\/j.lfs.2019.116569_bb0010","doi-asserted-by":"crossref","first-page":"81","DOI":"10.15171\/jcvtr.2015.19","article-title":"The effect of lipopolysaccharide on ischemic-reperfusion injury of heart: a double hit model of myocardial ischemia and endotoxemia","volume":"7","author":"Nader","year":"2015","journal-title":"J. Cardiovasc. Thor. Res."},{"issue":"6","key":"10.1016\/j.lfs.2019.116569_bb0015","first-page":"H2470","article-title":"Endotoxin and ischemic preconditioning: TNF-\u03b1 concentration and myocardial infarct development in rabbits","volume":"277","author":"Belosjorow","year":"1999","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"issue":"3","key":"10.1016\/j.lfs.2019.116569_bb0020","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/cvr\/cvn037","article-title":"Lipopolysaccharide-induced myocardial protection against ischaemia\/reperfusion injury is mediated through a PI3K\/Akt-dependent mechanism","volume":"78","author":"Ha","year":"2008","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.lfs.2019.116569_bb0025","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0008-6363(02)00506-0","article-title":"Lipopolysaccharide triggers late preconditioning against myocardial infarction via inducible nitric oxide synthase","volume":"56","author":"Wang","year":"2002","journal-title":"Cardiovasc. Res."},{"issue":"5","key":"10.1016\/j.lfs.2019.116569_bb0030","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/ni.1857","article-title":"TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages","volume":"11","author":"Martinon","year":"2010","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.lfs.2019.116569_bb0035","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1089\/dna.2014.2552","article-title":"Involvement of the IRE1\u03b1-XBP1 pathway and XBP1S-dependent transcriptional reprogramming in metabolic diseases","volume":"34","author":"Wu","year":"2015","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.lfs.2019.116569_bb0040","doi-asserted-by":"crossref","unstructured":"Liu, M. and S.C. Dudley Jr, Targeting the Unfolded Protein Response in Heart Diseases. 2014, Taylor & Francis.","DOI":"10.1517\/14728222.2014.918605"},{"issue":"6","key":"10.1016\/j.lfs.2019.116569_bb0045","doi-asserted-by":"crossref","first-page":"e0179042","DOI":"10.1371\/journal.pone.0179042","article-title":"Unfolded protein response plays a critical role in heart damage after myocardial ischemia\/reperfusion in rats","volume":"12","author":"Zhang","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.lfs.2019.116569_bb0050","doi-asserted-by":"crossref","first-page":"11859","DOI":"10.1038\/s41598-017-12366-8","article-title":"Bisoprolol protects myocardium cells against ischemia\/reperfusion injury by attenuating unfolded protein response in rats","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.lfs.2019.116569_bb0055","doi-asserted-by":"crossref","first-page":"e1219","DOI":"10.1038\/cddis.2014.193","article-title":"Cab 45S inhibits the ER stress-induced IRE1-JNK pathway and apoptosis via GRP78\/BiP","volume":"5","author":"Chen","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.lfs.2019.116569_bb0060","article-title":"The role of micro RNA-1 targeting MAPK3 in myocardial ischemia\/reperfusion injury in rats undergoing sevoflurane preconditioning via the PI3K\/Akt pathway","author":"Hao","year":"2018","journal-title":"Am. J. Phys. Cell Phys."},{"issue":"7","key":"10.1016\/j.lfs.2019.116569_bb0065","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1161\/01.ATV.0000224324.52466.e6","article-title":"Cardiomyocyte-specific overexpression of NO synthase-3 protects against myocardial ischemia-reperfusion injury","volume":"26","author":"Elrod","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"4","key":"10.1016\/j.lfs.2019.116569_bb0070","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3390\/brainsci8040072","article-title":"The GABAA receptor \u03b12 subunit activates a neuronal TLR4 signal in the ventral tegmental area that regulates alcohol and nicotine abuse","volume":"8","author":"Balan","year":"2018","journal-title":"Brain Sci."},{"issue":"15","key":"10.1016\/j.lfs.2019.116569_bb0075","doi-asserted-by":"crossref","first-page":"7368","DOI":"10.1158\/0008-5472.CAN-07-0515","article-title":"Dual role of mitochondrial reactive oxygen species in hypoxia signaling: activation of nuclear factor-\u03baB via c-SRC\u2013and oxidant-dependent cell death","volume":"67","author":"Lluis","year":"2007","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.lfs.2019.116569_bb0080","first-page":"101","article-title":"Effect of HEMADO on level of CK-MB and LDH enzymes after ischemia\/reperfusion injury in isolated rat heart","volume":"3","author":"Amani","year":"2013","journal-title":"Bio Impacts: BI"},{"issue":"1","key":"10.1016\/j.lfs.2019.116569_bb0085","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bbrc.2017.01.061","article-title":"PINK1 alleviates myocardial hypoxia-reoxygenation injury by ameliorating mitochondrial dysfunction","volume":"484","author":"Li","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.lfs.2019.116569_bb0090","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/aps.2012.204","article-title":"The PI3K\/Akt pathway mediates the protection of SO 2 preconditioning against myocardial ischemia\/reperfusion injury in rats","volume":"34","author":"Zhao","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"issue":"8","key":"10.1016\/j.lfs.2019.116569_bb0095","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0968-0004(97)01085-2","article-title":"Caspases: killer proteases","volume":"22","author":"Nicholson","year":"1997","journal-title":"Trends Biochem. Sci."},{"issue":"3","key":"10.1016\/j.lfs.2019.116569_bb0100","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cardiores.2003.12.023","article-title":"Role of apoptosis in reperfusion injury","volume":"61","author":"Eefting","year":"2004","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.lfs.2019.116569_bb0105","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0925-4439(01)00062-X","article-title":"Release of mitochondrial cytochrome c and activation of cytosolic caspases induced by myocardial ischaemia","volume":"1537","author":"Borutaite","year":"2001","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"issue":"3","key":"10.1016\/j.lfs.2019.116569_bb0110","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/jb\/mvh122","article-title":"Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II","volume":"136","author":"Yamamoto","year":"2004","journal-title":"J. Biochem."},{"issue":"18","key":"10.1016\/j.lfs.2019.116569_bb0115","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1038\/emboj.2013.183","article-title":"Toll-like receptor-mediated IRE1\u03b1 activation as a therapeutic target for inflammatory arthritis","volume":"32","author":"Qiu","year":"2013","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.lfs.2019.116569_bb0120","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1038\/s41467-018-05763-8","article-title":"Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy","volume":"9","author":"Logue","year":"2018","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.lfs.2019.116569_bb0125","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/35014014","article-title":"Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response","volume":"2","author":"Bertolotti","year":"2000","journal-title":"Nat. Cell Biol."},{"issue":"5453","key":"10.1016\/j.lfs.2019.116569_bb0130","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1126\/science.287.5453.664","article-title":"Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1","volume":"287","author":"Urano","year":"2000","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.lfs.2019.116569_bb0135","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/s41419-018-0696-5","article-title":"Inhibition of the ER stress IRE1\u03b1 inflammatory pathway protects against cell death in mitochondrial complex I mutant cells","volume":"9","author":"Soustek","year":"2018","journal-title":"Cell Death Dis."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320519304953?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320519304953?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:26:13Z","timestamp":1758399973000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320519304953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":27,"alternative-id":["S0024320519304953"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2019.116569","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The IRE1 signaling pathway is involved in the protective effect of low-dose LPS on myocardial ischemia-reperfusion injury","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2019.116569","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116569"}}