{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:16:28Z","timestamp":1793344588613,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.lfs.2019.116640","type":"journal-article","created":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T01:44:05Z","timestamp":1562550245000},"page":"116640","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Ocimum kilimandscharicum L. restores ovarian functions in letrozole - induced Polycystic Ovary Syndrome (PCOS) in rats: Comparison with metformin"],"prefix":"10.1016","volume":"232","author":[{"given":"Nada","family":"Khaled","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AlShaymaa Amin","family":"El-Bahy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha","family":"Radwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5552-1725","authenticated-orcid":false,"given":"Heba","family":"Handoussa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"AbdelMaksoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2019.116640_bb0005","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.mehy.2019.01.019","article-title":"Is polycystic ovary syndrome a 20th century phenomenon","volume":"124","author":"Rodgers","year":"2019","journal-title":"Med. Hypotheses"},{"issue":"6","key":"10.1016\/j.lfs.2019.116640_bb0010","first-page":"336","article-title":"Polycystic ovary syndrome: a review of treatment options with a focus on pharmacological approaches","volume":"38","author":"Ndefo","year":"2013","journal-title":"P T"},{"issue":"4","key":"10.1016\/j.lfs.2019.116640_bb0015","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0889-8529(18)30405-5","article-title":"Hyperinsulinemia and ovarian hyperandrogenism: cause and effect","volume":"17","author":"Barbieri","year":"1988","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"issue":"6","key":"10.1016\/j.lfs.2019.116640_bb0020","doi-asserted-by":"crossref","first-page":"974","DOI":"10.3904\/kjim.2017.354","article-title":"Combination therapy of oral hypoglycemic agents in patients with type 2 diabetes mellitus","volume":"32","author":"Moon","year":"2017","journal-title":"Korean J. Intern. Med."},{"issue":"3","key":"10.1016\/j.lfs.2019.116640_bb0025","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1177\/2042018810380215","article-title":"Role of metformin in the management of polycystic ovary syndrome","volume":"1","author":"Lashen","year":"2010","journal-title":"Ther. Adv. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.lfs.2019.116640_bb0030","first-page":"1098","article-title":"The effect of herbal teas on Management of Polycystic Ovary Syndrome: a systematic review","volume":"5","author":"Kolivand","year":"2017","journal-title":"J. Midwifery Reprod. Heal."},{"issue":"3","key":"10.1016\/j.lfs.2019.116640_bb0035","first-page":"1","article-title":"Ocimum kilimand scharicum Guerke: phytochemical and pharmacological aspects: a review","volume":"2","author":"Singh","year":"2014","journal-title":"Res. Rev. J. Pharmacogn. Phytochem."},{"issue":"11","key":"10.1016\/j.lfs.2019.116640_bb0040","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.phymed.2014.07.004","article-title":"Chemical composition and free radical-scavenging, anticancer and anti-inflammatory activities of the essential oil from Ocimum kilimandscharicum","volume":"21","author":"de Lima","year":"2014","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.lfs.2019.116640_bb0045","doi-asserted-by":"crossref","DOI":"10.1095\/biolreprod.115.131631","article-title":"A novel letrozole model recapitulates both the reproductive and metabolic phenotypes of polycystic ovary syndrome in female Mice1","volume":"93","author":"Kauffman","year":"2015","journal-title":"Biol. Reprod."},{"issue":"4","key":"10.1016\/j.lfs.2019.116640_bb0050","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1210\/en.2017-03218","article-title":"Antiandrogen treatment ameliorates reproductive and metabolic phenotypes in the letrozole-induced mouse model of PCOS","volume":"159","author":"Ryan","year":"2018","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.lfs.2019.116640_bb0055","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13048-015-0131-9","article-title":"Use of aromatase inhibitors in practice of gynecology","volume":"8","author":"Usluogullari","year":"2015","journal-title":"J. Ovarian Res."},{"issue":"6","key":"10.1016\/j.lfs.2019.116640_bb0060","first-page":"278","article-title":"Spicatic acid: a 4-carboxygentisic acid from Gentiana spicata extract with potential hepatoprotective activity","volume":"3","author":"Handoussa","year":"2009","journal-title":"Drug Discov. Ther."},{"issue":"3","key":"10.1016\/j.lfs.2019.116640_bb0065","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1258\/la.2012.150312","article-title":"Guide for the care and use of laboratory animals (8th edn)","volume":"46","author":"Albus","year":"2012","journal-title":"Lab. Anim."},{"issue":"2","key":"10.1016\/j.lfs.2019.116640_bb0070","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4103\/0253-7613.178833","article-title":"A novel method of extraction of bamboo seed oil (Bambusa bambos Druce) and its promising effect on metabolic symptoms of experimentally induced polycystic ovarian disease","volume":"48","author":"Soumya","year":"2016","journal-title":"Indian J. Pharmacol."},{"issue":"4","key":"10.1016\/j.lfs.2019.116640_bb0075","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1210\/en.2014-1765","article-title":"Metformin regulates ovarian angiogenesis and follicular development in a female polycystic ovary syndrome rat model","volume":"156","author":"Di Pietro","year":"2015","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.lfs.2019.116640_bb0080","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.apjr.2016.01.006","article-title":"Beneficial effect of curcumin in letrozole induced polycystic ovary syndrome","volume":"5","author":"Reddy","year":"2016","journal-title":"Asian Pacific J. Reprod."},{"key":"10.1016\/j.lfs.2019.116640_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/576584","article-title":"HOMA-AD in assessing insulin resistance in lean noncirrhotic HCV outpatients","volume":"2012","author":"Michalczuk","year":"2012","journal-title":"Int. J. Hepatol."},{"key":"10.1016\/j.lfs.2019.116640_bb0090","unstructured":"Banchroft JD, SA and TD. Theory and Practice of Histological Techniques. Fourth Edition, Churchill Livingstone. New York, London, San Fr Tokyo. 1996."},{"issue":"3","key":"10.1016\/j.lfs.2019.116640_bb0095","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.jff.2013.04.003","article-title":"Anti-inflammatory and cytotoxic activities of dietary phenolics isolated from Corchorus olitorius and Vitis vinifera","volume":"5","author":"Handoussa","year":"2013","journal-title":"J. Funct. Foods"},{"issue":"5","key":"10.1016\/j.lfs.2019.116640_bb0100","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1080\/10826076.2011.606583","article-title":"LC-MS quantification of rosmarinic acid and ursolic acid in the Ocimum sanctum Linn. leaf extract (Holy basil, Tulsi)","volume":"35","author":"Sundaram","year":"2012","journal-title":"J. Liq. Chromatogr. Relat. Technol."},{"key":"10.1016\/j.lfs.2019.116640_bb0105","first-page":"9","article-title":"Rosmarinic acid-rich extracts of summer savory (Satureja hortensis L.) protect jurkat T cells against oxidative stress","author":"Chkhikvishvili","year":"2013","journal-title":"Oxid Med Cell Longev."},{"issue":"11","key":"10.1016\/j.lfs.2019.116640_bb0110","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1021\/jf050024v","article-title":"Distribution of a new rosmarinic acid derivative in Eryngium alpinum L. and other Apiaceae","volume":"53","author":"Le","year":"2005","journal-title":"J. Agric. Food Chem."},{"issue":"7","key":"10.1016\/j.lfs.2019.116640_bb0115","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1080\/13880200308951340","article-title":"A novel 4\u2032-Odiglycoside of decarboxylosmarinic acid from Blepharis ciliaris","volume":"41","author":"Afifi","year":"2003","journal-title":"Pharm. Biol."},{"issue":"6","key":"10.1016\/j.lfs.2019.116640_bb0120","doi-asserted-by":"crossref","first-page":"11490","DOI":"10.3390\/molecules200611490","article-title":"Antioxidant capacities and analysis of phenolic compounds in three endemic nolana species by HPLC-PDA-ESI-MS","volume":"20","author":"Simirgiotis","year":"2015","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.lfs.2019.116640_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0193451","article-title":"Ursolic acid rich ocimum sanctum L leaf extract loaded nanostructured lipid carriers ameliorate adjuvant induced arthritis in rats by inhibition of COX-1, COX-2, TNF-\u03b1 and IL-1: pharmacological and docking studies","volume":"13","author":"Ahmad","year":"2018","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.lfs.2019.116640_bb0130","doi-asserted-by":"crossref","first-page":"8402","DOI":"10.3390\/molecules18078402","article-title":"Characterization of flavonoids and phenolic acids in Myrcia bella Cambess. using FIA-ESI-IT-MS(n) and HPLC-PAD-ESI-IT-MS combined with NMR","volume":"18","author":"Saldanha","year":"2013","journal-title":"Molecules"},{"issue":"8","key":"10.1016\/j.lfs.2019.116640_bb0135","doi-asserted-by":"crossref","first-page":"9757","DOI":"10.3390\/molecules17089754","article-title":"Antioxidative properties of defatted dabai pulp and peel prepared by solid phase extraction","volume":"17","author":"Khoo","year":"2012","journal-title":"Molecules"},{"issue":"11","key":"10.1016\/j.lfs.2019.116640_bb0140","doi-asserted-by":"crossref","first-page":"17400","DOI":"10.3390\/molecules191117400","article-title":"HPLC-UV-MS profiles of phenolic compounds and antioxidant activity of fruits from three citrus species consumed in Northern Chile","volume":"19","author":"Brito","year":"2014","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.lfs.2019.116640_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0093149","article-title":"Metabolomics as a potential chemotaxonomical tool: application in the genus Vernonia Schreb","volume":"9","author":"Martucci","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2019.116640_bb0150","series-title":"A Closer Insight into the Role of Vitamin D in Polycystic Ovary Syndrome (Pcos)","volume":"vol. 6(4)","author":"El-bahya","year":"2018"},{"key":"10.1016\/j.lfs.2019.116640_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/7801543","article-title":"Medicinal plants of the family Lamiaceae in pain therapy: a review","volume":"2018","author":"Uritu","year":"2018","journal-title":"Pain Res. Manag."},{"issue":"5","key":"10.1016\/j.lfs.2019.116640_bb0160","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1210\/er.2015-1104","article-title":"The pathogenesis of polycystic ovary syndrome (PCOS): the hypothesis of PCOS as functional ovarian hyperandrogenism revisited","volume":"37","author":"Rosenfield","year":"2016","journal-title":"Endocr. Rev."},{"issue":"1","key":"10.1016\/j.lfs.2019.116640_bb0165","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1080\/13880209.2016.1258425","article-title":"Soy isoflavones exert beneficial effects on letrozole-induced rat polycystic ovary syndrome (PCOS) model through anti-androgenic mechanism","volume":"55","author":"Rajan","year":"2017","journal-title":"Pharm. Biol."},{"issue":"1","key":"10.1016\/j.lfs.2019.116640_bb0170","doi-asserted-by":"crossref","DOI":"10.1186\/s13048-017-0359-7","article-title":"Ameliorative effects of rutin against metabolic, biochemical and hormonal disturbances in polycystic ovary syndrome in rats","volume":"9","author":"Ullah","year":"2016","journal-title":"J. Ovarian Res."},{"issue":"5","key":"10.1016\/j.lfs.2019.116640_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/nu8050305","article-title":"Apigenin ameliorates dyslipidemia, hepatic steatosis and insulin resistance by modulating metabolic and transcriptional profiles in the liver of high-fat diet-induced obese mice","volume":"8","author":"Jung","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2019.116640_bb0180","doi-asserted-by":"crossref","unstructured":"Yokozawa T, Kim HY, Cho EJ, Choi JS, Chung and HY. Antioxidant effects of Isorhamnetin 3, 7-Di- O - D -glucopyranoside isolated from mustard leaf (Brassica juncea) in rats with streptozotocin-induced diabetes. J. Agric. Food Chem. 2002;50(19):5490\u20135.","DOI":"10.1021\/jf0202133"},{"issue":"7","key":"10.1016\/j.lfs.2019.116640_bb0185","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.tem.2007.07.004","article-title":"Pathophysiology and types of dyslipidemia in PCOS","volume":"18","author":"Diamanti-Kandarakis","year":"2007","journal-title":"Trends Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.lfs.2019.116640_bb0190","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.rbmo.2010.01.007","article-title":"Role of vascular endothelial growth factor in women with PCO and PCOS: a systematic review","volume":"20","author":"Peitsidis","year":"2010","journal-title":"Reprod. BioMed. Online"},{"issue":"1","key":"10.1016\/j.lfs.2019.116640_bb0195","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1080\/14647270802621358","article-title":"Vascular endothelial growth factor and its soluble receptor in patients with polycystic ovary syndrome undergoing IVF","volume":"12","author":"Artini","year":"2009","journal-title":"Hum. Fertil."},{"issue":"1","key":"10.1016\/j.lfs.2019.116640_bb0200","doi-asserted-by":"crossref","DOI":"10.1186\/1476-4598-12-7","article-title":"Androgen up-regulates vascular endothelial growth factor expression in prostate cancer cells via an Sp1 binding site","volume":"12","author":"Eisermann","year":"2013","journal-title":"Mol. Cancer"},{"issue":"3","key":"10.1016\/j.lfs.2019.116640_bb0205","first-page":"1444","article-title":"Selecting bioactive phenolic compounds as potential agents to inhibit proliferation and VEGF expression in human ovarian cancer cells","volume":"9","author":"Rojanasakul","year":"2014","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.lfs.2019.116640_bb0210","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jnutbio.2017.04.012","article-title":"Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat","volume":"47","author":"Hu","year":"2017","journal-title":"J. Nutr. Biochem."},{"issue":"4","key":"10.1016\/j.lfs.2019.116640_bb0215","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3390\/antibiotics6040037","article-title":"LC-MS\/MS tandem mass spectrometry for analysis of phenolic compounds and pentacyclic triterpenes in antifungal extracts of Terminalia brownii (Fresen)","volume":"6","author":"Salih","year":"2017","journal-title":"Antibiotics"},{"issue":"3","key":"10.1016\/j.lfs.2019.116640_bb0220","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/jms.995","article-title":"Structural characterization of flavonol 3,7-di-O-glycosides and determination of the glycosylation position by using negative ion electrospray ionization tandem mass spectrometry","volume":"41","author":"Ablajan","year":"2006","journal-title":"J. Mass Spectrom."},{"issue":"1","key":"10.1016\/j.lfs.2019.116640_bb0225","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jpha.2011.09.009","article-title":"Characterization of flavonoids in Millettia nitida var. hirsutissima by HPLC\/DAD\/ESI-MSn","volume":"2","author":"Ye","year":"2012","journal-title":"J. Pharm. Anal."},{"issue":"2","key":"10.1016\/j.lfs.2019.116640_bb0230","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jasms.2004.11.007","article-title":"Analysis of homoisoflavonoids in Ophiopogon japonicus by HPLC-DAD-ESI-MSn","volume":"16","author":"Ye","year":"2005","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"4","key":"10.1016\/j.lfs.2019.116640_bb0235","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1016\/j.foodchem.2013.06.071","article-title":"Characterisation of phenolic compounds in wild fruits from Northeastern Portugal","volume":"141","author":"Guimar\u00e3es","year":"2013","journal-title":"Food Chem."},{"issue":"1","key":"10.1016\/j.lfs.2019.116640_bb0240","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1590\/S1679-45082016AO3386","article-title":"Phytochemical analysis of hydroethanolic extract of Turnera diffusa Willd and evaluation of its effects on astrocyte cell death","volume":"14","author":"Bezerra","year":"2016","journal-title":"Einstein (S\u00e3o Paulo)"},{"issue":"2","key":"10.1016\/j.lfs.2019.116640_bb0245","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.3390\/molecules18021672","article-title":"The Passiflora tripartita (banana passion) fruit: a source of bioactive flavonoid C-glycosides isolated by HSCCC and characterized by HPLC-DAD-ESI\/MS\/MS","volume":"18","author":"Simirgiotis","year":"2013","journal-title":"Molecules"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320519305661?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320519305661?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:41:15Z","timestamp":1793036475000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320519305661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":49,"alternative-id":["S0024320519305661"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2019.116640","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ocimum kilimandscharicum L. restores ovarian functions in letrozole - induced Polycystic Ovary Syndrome (PCOS) in rats: Comparison with metformin","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2019.116640","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116640"}}