{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:43:22Z","timestamp":1782276202821,"version":"3.54.5"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Natural Science Fund of China","award":["81703100"],"award-info":[{"award-number":["81703100"]}]},{"name":"National Natural Science Fund of China","award":["81673462"],"award-info":[{"award-number":["81673462"]}]},{"name":"National Natural Science Fund of China","award":["81473293"],"award-info":[{"award-number":["81473293"]}]},{"name":"National Natural Science Fund of China","award":["81403347"],"award-info":[{"award-number":["81403347"]}]},{"name":"National Natural Science Fund of China","award":["81573604"],"award-info":[{"award-number":["81573604"]}]},{"name":"National Natural Science Fund of China","award":["91540119"],"award-info":[{"award-number":["91540119"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010014","name":"Six Talent Peaks Project in Jiangsu Province","doi-asserted-by":"publisher","award":["YY-012"],"award-info":[{"award-number":["YY-012"]}],"id":[{"id":"10.13039\/501100010014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013058","name":"Key Research and Development Project of Jiangsu Province","doi-asserted-by":"publisher","award":["BE2017712"],"award-info":[{"award-number":["BE2017712"]}],"id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["2017NJMUZD065"],"award-info":[{"award-number":["2017NJMUZD065"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.lfs.2019.116674","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T01:37:03Z","timestamp":1563759423000},"page":"116674","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Endogenous peptide LYENRL prevents the activation of hypertrophic scar-derived fibroblasts by inhibiting the TGF-\u03b21\/Smad pathway"],"prefix":"10.1016","volume":"231","author":[{"given":"Xiaojun","family":"Ji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Shuai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhirui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5041-0134","authenticated-orcid":false,"given":"Wu","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2019.116674_bb0005","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/S0140-6736(16)31406-4","article-title":"Hypertrophic scarring: the greatest unmet challenge after burn injury","volume":"388","author":"Finnerty","year":"2016","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.lfs.2019.116674_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2011.05.055","article-title":"Cutaneous scarring: pathophysiology, molecular mechanisms, and scar reduction therapeutics part I. the molecular basis of scar formation","volume":"66","author":"Profyris","year":"2012","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.lfs.2019.116674_bb0015","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1524-4725.2008.34406.x","article-title":"Hypertrophic scars and keloids\u2013a review of their pathophysiology, risk factors, and therapeutic management","volume":"35","author":"Wolfram","year":"2009","journal-title":"Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al]"},{"key":"10.1016\/j.lfs.2019.116674_bb0020","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1002\/pmic.201400310","article-title":"Current peptidomics: applications, purification, identification, quantification, and functional analysis","volume":"15","author":"Dallas","year":"2015","journal-title":"Proteomics"},{"key":"10.1016\/j.lfs.2019.116674_bb0025","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1001\/archneur.59.11.1729","article-title":"Cerebrospinal fluid tau and beta-amyloid 42 proteins identify Alzheimer disease in subjects with mild cognitive impairment","volume":"59","author":"Riemenschneider","year":"2002","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.lfs.2019.116674_bb0030","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1074\/mcp.M110.001917","article-title":"Naturally occurring human urinary peptides for use in diagnosis of chronic kidney disease","volume":"9","author":"Good","year":"2010","journal-title":"Molecular & Cellular Proteomics: MCP"},{"key":"10.1016\/j.lfs.2019.116674_bb0035","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1038\/ki.2010.322","article-title":"Urinary excretion of twenty peptides forms an early and accurate diagnostic pattern of acute kidney injury","volume":"78","author":"Metzger","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.lfs.2019.116674_bb0040","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1523-1755.2005.00394.x","article-title":"Impact of diabetic nephropathy and angiotensin II receptor blockade on urinary polypeptide patterns","volume":"68","author":"Rossing","year":"2005","journal-title":"Kidney Int."},{"key":"10.1016\/j.lfs.2019.116674_bb0045","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/prca.200780082","article-title":"Discovery and validation of urinary biomarkers for prostate cancer","volume":"2","author":"Theodorescu","year":"2008","journal-title":"Proteomics Clin. Appl."},{"key":"10.1016\/j.lfs.2019.116674_bb0050","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1074\/mcp.M700394-MCP200","article-title":"Urinary proteomic biomarkers in coronary artery disease","volume":"7","author":"Zimmerli","year":"2008","journal-title":"Molecular & Cellular Proteomics: MCP"},{"key":"10.1016\/j.lfs.2019.116674_bb0055","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/jms.744","article-title":"Peptidomic analysis of the larval Drosophila melanogaster central nervous system by two-dimensional capillary liquid chromatography quadrupole time-of-flight mass spectrometry","volume":"40","author":"Baggerman","year":"2005","journal-title":"Journal of Mass Spectrometry: JMS"},{"key":"10.1016\/j.lfs.2019.116674_bb0060","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.4314\/ahs.v18i4.50","article-title":"The immunomodulatory peptide bursopentin (BP5) enhances proliferation and induces sIgM expression in DT40 cells","volume":"18","author":"Ji","year":"2018","journal-title":"Afr. Health Sci."},{"key":"10.1016\/j.lfs.2019.116674_bb0065","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.npep.2009.07.003","article-title":"Endogenous peptide: met-enkephalin-Arg-Phe, differently regulate expression of opioid receptors on chronic treatment","volume":"43","author":"Vats","year":"2009","journal-title":"Neuropeptides"},{"key":"10.1016\/j.lfs.2019.116674_bb0070","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/j.yexcr.2010.02.005","article-title":"Neuroprotective effect of the endogenous neural peptide apelin in cultured mouse cortical neurons","volume":"316","author":"Zeng","year":"2010","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.lfs.2019.116674_bb0075","doi-asserted-by":"crossref","first-page":"5962","DOI":"10.1002\/jcp.26407","article-title":"Comparative peptidomic profile between human hypertrophic scar tissue and matched normal skin for identification of endogenous peptides involved in scar pathology","volume":"233","author":"Li","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.lfs.2019.116674_bb0080","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0021-9258(19)51149-8","article-title":"The determination of hydroxyproline","volume":"184","author":"Neuman","year":"1950","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2019.116674_bb0085","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.phrs.2015.06.006","article-title":"Quercetin inhibits the mTORC1\/p70S6K signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in diabetic nephropathy","volume":"99","author":"Lu","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.lfs.2019.116674_bb0090","doi-asserted-by":"crossref","first-page":"140","DOI":"10.15252\/emmm.201404797","article-title":"Modulation of TNF-alpha mRNA stability by human antigen R and miR181s in sepsis-induced immunoparalysis","volume":"7","author":"Dan","year":"2015","journal-title":"EMBO Molecular Medicine"},{"key":"10.1016\/j.lfs.2019.116674_bb0095","article-title":"Recent understandings of biology, prophylaxis and treatment strategies for hypertrophic scars and keloids","volume":"19","author":"Lee","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2019.116674_bb0100","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0021-9258(18)56248-7","article-title":"The determination of collagen and elastin in tissues","volume":"186","author":"Neuman","year":"1950","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2019.116674_bb0105","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/wrr.12432","article-title":"Current concepts related to hypertrophic scarring in burn injuries","volume":"24","author":"Chiang","year":"2016","journal-title":"Wound Repair and Regeneration: Official Publication of the Wound Healing Society [and] the European Tissue Repair Society"},{"key":"10.1016\/j.lfs.2019.116674_bb0110","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/00005373-199502000-00030","article-title":"Histomorphologic changes in keloids treated with Kenacort","volume":"38","author":"Boyadjiev","year":"1995","journal-title":"J. Trauma"},{"key":"10.1016\/j.lfs.2019.116674_bb0115","first-page":"1355","article-title":"Lasers for scars: a review and evidence-based appraisal","volume":"9","author":"Elsaie","year":"2010","journal-title":"Journal of Drugs in Dermatology: JDD"},{"key":"10.1016\/j.lfs.2019.116674_bb0120","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20150405","article-title":"Radiotherapy for benign disease; assessing the risk of radiation-induced cancer following exposure to intermediate dose radiation","volume":"88","author":"McKeown","year":"2015","journal-title":"Br. J. Radiol."},{"key":"10.1016\/j.lfs.2019.116674_bb0125","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1272\/jnms.83.46","article-title":"Keloids and hypertrophic scars can now be cured completely: recent progress in our understanding of the pathogenesis of keloids and hypertrophic scars and the most promising current therapeutic strategy","volume":"83","author":"Ogawa","year":"2016","journal-title":"Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi"},{"key":"10.1016\/j.lfs.2019.116674_bb0130","first-page":"591","article-title":"Cryotherapy in the treatment of keloids","volume":"5","author":"Rusciani","year":"2006","journal-title":"Journal of Drugs in Dermatology: JDD"},{"key":"10.1016\/j.lfs.2019.116674_bb0135","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0039-6109(05)70576-4","article-title":"Hypertrophic scars, keloids, and contractures. The cellular and molecular basis for therapy","volume":"77","author":"Tredget","year":"1997","journal-title":"Surg. Clin. North Am."},{"key":"10.1016\/j.lfs.2019.116674_bb0140","article-title":"Current and upcoming therapies to modulate skin scarring and fibrosis","author":"Coentro","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2","key":"10.1016\/j.lfs.2019.116674_bb0145","article-title":"The molecular basis of hypertrophic scars","volume":"4","author":"Zhu","year":"2016","journal-title":"Burns & Trauma"},{"key":"10.1016\/j.lfs.2019.116674_bb0150","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jcma.2017.11.002","article-title":"Wound healing","volume":"81","author":"Wang","year":"2018","journal-title":"Journal of the Chinese Medical Association: JCMA"},{"key":"10.1016\/j.lfs.2019.116674_bb0155","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s12079-013-0195-5","article-title":"The molecular mechanism of hypertrophic scar","volume":"7","author":"Zhu","year":"2013","journal-title":"Journal of Cell Communication and Signaling"},{"key":"10.1016\/j.lfs.2019.116674_bb0160","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s12010-014-1316-1","article-title":"Expression, purification, and characterization of scar tissue neovasculature endothelial cell-targeted rhIL10 in Escherichia coli","volume":"175","author":"Shi","year":"2015","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.lfs.2019.116674_bb0165","first-page":"1189","article-title":"Inhibitory effect of TGF-beta peptide antagonist on the fibrotic phenotype of human hypertrophic scar fibroblasts","volume":"54","author":"Wang","year":"2016","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.lfs.2019.116674_bb0170","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.neuropharm.2016.02.006","article-title":"(I) Pharmacological profiling of a novel modulator of the alpha7 nicotinic receptor: blockade of a toxic acetylcholinesterase-derived peptide increased in Alzheimer brains","volume":"105","author":"Garcia-Rates","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.lfs.2019.116674_bb0175","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3389\/fphar.2014.00070","article-title":"N\u2011acetyl\u2011seryl\u2011aspartyl\u2011lysyl\u2011proline: a valuable endogenous anti-fibrotic peptide for combating kidney fibrosis in diabetes","volume":"5","author":"Kanasaki","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2019.116674_bb0180","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1163\/156856208784909435","article-title":"The human tri-peptide GHK and tissue remodeling","volume":"19","author":"Pickart","year":"2008","journal-title":"Journal of Biomaterials Science Polymer Edition"},{"key":"10.1016\/j.lfs.2019.116674_bb0185","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/ni1108","article-title":"Upregulation of the CLIP self peptide on mature dendritic cells antagonizes T helper type 1 polarization","volume":"5","author":"Rohn","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.lfs.2019.116674_bb0190","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.drudis.2014.10.003","article-title":"Peptide therapeutics: current status and future directions","volume":"20","author":"Fosgerau","year":"2015","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.lfs.2019.116674_bb0195","doi-asserted-by":"crossref","first-page":"542","DOI":"10.4314\/ahs.v16i2.23","article-title":"Recombinant human endostatin reduces hypertrophic scar formation in rabbit ear model through down-regulation of VEGF and TIMP-1","volume":"16","author":"Wang","year":"2016","journal-title":"Afr. Health Sci."},{"key":"10.1016\/j.lfs.2019.116674_bb0200","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1096\/fj.03-1273rev","article-title":"TGF-beta signaling and the fibrotic response","volume":"18","author":"Leask","year":"2004","journal-title":"FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology"},{"key":"10.1016\/j.lfs.2019.116674_bb0205","first-page":"18","article-title":"The role of the TGF-beta family in wound healing, burns and scarring: a review","volume":"2","author":"Penn","year":"2012","journal-title":"International Journal of Burns and Trauma"},{"key":"10.1016\/j.lfs.2019.116674_bb0210","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.immuni.2015.06.010","article-title":"Smad2 and Smad3 inversely regulate TGF-beta autoinduction in Clostridium butyricum-activated dendritic cells","volume":"43","author":"Kashiwagi","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.lfs.2019.116674_bb0215","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1038\/jid.2011.150","article-title":"Transcriptional inhibition of hypertrophic scars by a gene silencer, pyrrole-imidazole polyamide, targeting the TGF-beta1 promoter","volume":"131","author":"Washio","year":"2011","journal-title":"The Journal of Investigative Dermatology"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320519306009?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320519306009?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:28:59Z","timestamp":1758400139000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320519306009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":43,"alternative-id":["S0024320519306009"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2019.116674","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endogenous peptide LYENRL prevents the activation of hypertrophic scar-derived fibroblasts by inhibiting the TGF-\u03b21\/Smad pathway","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2019.116674","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116674"}}