{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:09:06Z","timestamp":1791515346899,"version":"4.3.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.lfs.2019.116868","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T18:21:05Z","timestamp":1572632465000},"page":"116868","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["The therapeutic effect of dexmedetomidine on protection from renal failure via inhibiting KDM5A in lipopolysaccharide-induced sepsis of mice"],"prefix":"10.1016","volume":"239","author":[{"given":"Yan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanming","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jicheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2019.116868_bib1","doi-asserted-by":"crossref","first-page":"5985209","DOI":"10.1155\/2017\/5985209","article-title":"Role of oxidative stress and mitochondrial dysfunction in sepsis and potential therapies","volume":"2017","author":"Mantzarlis","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.lfs.2019.116868_bib2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/bja\/aer093","article-title":"Oxidative stress and mitochondrial dysfunction in sepsis","volume":"107","author":"Galley","year":"2011","journal-title":"Br. J. Anaesth."},{"issue":"4","key":"10.1016\/j.lfs.2019.116868_bib3","doi-asserted-by":"crossref","first-page":"e159","DOI":"10.1097\/PCC.0000000000000668","article-title":"Acute kidney injury in neonates in the PICU. Pediatric critical care medicine","volume":"17","author":"Kriplani","year":"2016","journal-title":"Pediatr. Crit. Care Med."},{"issue":"8","key":"10.1016\/j.lfs.2019.116868_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/antiox7080105","article-title":"Mechanisms of LPS-induced acute kidney injury in neonatal and adult rats","volume":"7","author":"Plotnikov","year":"2018","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.lfs.2019.116868_bib5","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jcrc.2015.09.017","article-title":"Recent knowledge on the pathophysiology of septic acute kidney injury: a narrative review","volume":"31","author":"Shum","year":"2016","journal-title":"J. Crit. Care"},{"key":"10.1016\/j.lfs.2019.116868_bib6","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.biopha.2018.06.059","article-title":"Dexmedetomidine protects against lipopolysaccharide-induced sepsis-associated acute kidney injury via an alpha7 nAChR-dependent pathway","volume":"106","author":"Kang","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"10","key":"10.1016\/j.lfs.2019.116868_bib7","doi-asserted-by":"crossref","first-page":"F1443","DOI":"10.1152\/ajprenal.00143.2012","article-title":"alpha2-Adrenoceptor agonist dexmedetomidine protects septic acute kidney injury through increasing BMP-7 and inhibiting HDAC2 and HDAC5","volume":"303","author":"Hsing","year":"2012","journal-title":"Am. J. Physiol. Renal. Physiol."},{"issue":"3","key":"10.1016\/j.lfs.2019.116868_bib8","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/s41419-019-1416-5","article-title":"Dexmedetomidine inhibits astrocyte pyroptosis and subsequently protects the brain in in vitro and in vivo models of sepsis","volume":"10","author":"Sun","year":"2019","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.lfs.2019.116868_bib9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cr.2018.11.001","article-title":"Nuclear-cytoplasmic shuttling of class IIa histone deacetylases regulates somatic cell reprogramming","volume":"8","author":"Luo","year":"2019","journal-title":"Cell Regen."},{"key":"10.1016\/j.lfs.2019.116868_bib10","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.biocel.2018.07.002","article-title":"DNMT and HDAC inhibitors together abrogate endotoxemia mediated macrophage death by STAT3-JMJD3 signaling","volume":"102","author":"Samanta","year":"2018","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.lfs.2019.116868_bib11","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.intimp.2018.03.027","article-title":"JMJD3 is involved in neutrophil membrane proteinase 3 overexpression during the hyperinflammatory response in early sepsis","volume":"59","author":"Chen","year":"2018","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.lfs.2019.116868_bib12","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.molcel.2018.01.002","article-title":"PKCalpha-LSD1-NF-kappaB-Signaling cascade is crucial for epigenetic control of the inflammatory response","volume":"69","author":"Kim","year":"2018","journal-title":"Mol. Cell"},{"issue":"2","key":"10.1016\/j.lfs.2019.116868_bib13","doi-asserted-by":"crossref","first-page":"E244","DOI":"10.1073\/pnas.1718759114","article-title":"Histone demethylase LSD1 regulates hematopoietic stem cells homeostasis and protects from death by endotoxic shock","volume":"115","author":"Wang","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.lfs.2019.116868_bib14","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nchembio.2085","article-title":"An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells","volume":"12","author":"Vinogradova","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.lfs.2019.116868_bib15","unstructured":"Lai KW, Liang J, Zhang B, Labadie S, Ortwine D, Dragovich P, Kiefer J, Gehling VS, Harmange J-C: Pyrrolidine Amide Compounds as Histone Demethylase Inhibitors. In.: Google Patents; 2017."},{"issue":"13","key":"10.1016\/j.lfs.2019.116868_bib16","doi-asserted-by":"crossref","first-page":"9408","DOI":"10.1074\/jbc.M112.419861","article-title":"Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen","volume":"288","author":"Sayegh","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2019.116868_bib17","doi-asserted-by":"crossref","DOI":"10.1111\/jphp.13103","article-title":"S-nitrosoglutathione protects lipopolysaccharide-induced acute kidney injury by inhibiting toll-like receptor 4-nuclear factor-kappaB signal pathway","author":"Fan","year":"2019","journal-title":"J. Pharm. Pharmacol."},{"issue":"6","key":"10.1016\/j.lfs.2019.116868_bib18","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.ccr.2004.10.012","article-title":"Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth","volume":"6","author":"Fei","year":"2004","journal-title":"Cancer Cell"},{"issue":"15","key":"10.1016\/j.lfs.2019.116868_bib19","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.lfs.2019.116868_bib20","series-title":"FastQC A Quality Control Tool for High Throughput Sequence Data","author":"Andrews","year":"2013"},{"issue":"4","key":"10.1016\/j.lfs.2019.116868_bib21","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"issue":"9","key":"10.1016\/j.lfs.2019.116868_bib22","doi-asserted-by":"crossref","first-page":"R137","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based analysis of ChIP-seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol."},{"issue":"7381","key":"10.1016\/j.lfs.2019.116868_bib23","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nature10730","article-title":"Differential oestrogen receptor binding is associated with clinical outcome in breast cancer","volume":"481","author":"Ross-Innes","year":"2012","journal-title":"Nature"},{"issue":"43","key":"10.1016\/j.lfs.2019.116868_bib24","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.lfs.2019.116868_bib25","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s12539-016-0198-z","article-title":"CAsubtype: an R package to identify gene sets predictive of cancer subtypes and clinical outcomes","volume":"10","author":"Kong","year":"2018","journal-title":"Interdiscip. Sci."},{"issue":"11","key":"10.1016\/j.lfs.2019.116868_bib26","first-page":"5020","article-title":"Effect of dexmedetomidine on kidney injury in sepsis rats through TLR4\/MyD88\/NF-kappaB\/iNOS signaling pathway","volume":"23","author":"Jin","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.lfs.2019.116868_bib27","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12871-015-0042-8","article-title":"The effect of dexmedetomidine on inflammatory response of septic rats","volume":"15","author":"Zhang","year":"2015","journal-title":"BMC Anesthesiol."},{"key":"10.1016\/j.lfs.2019.116868_bib28","doi-asserted-by":"crossref","first-page":"172401","DOI":"10.1016\/j.ejphar.2019.05.030","article-title":"Dexmedetomidine effects in different experimental sepsis in vivo models","volume":"856","author":"Dardalas","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2019.116868_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.28539","article-title":"Dexmedetomidine ameliorates lipopolysaccharide-induced acute kidney injury in rats by inhibiting inflammation and oxidative stress via the GSK-3beta\/Nrf2 signaling pathway","author":"Feng","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"12","key":"10.1016\/j.lfs.2019.116868_bib30","first-page":"5245","article-title":"Dexmedetomidine mitigates CLP-stimulated acute lung injury via restraining the RAGE pathway","volume":"9","author":"Hu","year":"2017","journal-title":"Am. J. Transl. Res."},{"issue":"1","key":"10.1016\/j.lfs.2019.116868_bib31","first-page":"533","article-title":"Dexmedetomidine attenuates the toxicity of beta amyloid on neurons and astrocytes by increasing BDNF production under the regulation of HDAC2 and HDAC5","volume":"19","author":"Wang","year":"2019","journal-title":"Mol. Med. Rep."},{"issue":"5","key":"10.1016\/j.lfs.2019.116868_bib32","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1177\/0960327116652458","article-title":"Dexmedetomidine increases acetylation level of histone through ERK1\/2 pathway in dopamine neuron","volume":"36","author":"Hu","year":"2017","journal-title":"Hum. Exp. Toxicol."},{"issue":"3","key":"10.1016\/j.lfs.2019.116868_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001354","article-title":"H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylation","volume":"7","author":"Guillemette","year":"2011","journal-title":"PLoS Genet."},{"issue":"5","key":"10.1016\/j.lfs.2019.116868_bib34","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S1369-5266(02)00287-X","article-title":"Acetylated, methylated, remodeled: chromatin states for gene regulation","volume":"5","author":"Lusser","year":"2002","journal-title":"Curr. Opin. Plant Biol."},{"issue":"5","key":"10.1016\/j.lfs.2019.116868_bib35","doi-asserted-by":"crossref","first-page":"302","DOI":"10.4161\/epi.4.5.9369","article-title":"Histone H3 lysine 4 di-methylation: a novel mark for transcriptional fidelity?","volume":"4","author":"Pinskaya","year":"2009","journal-title":"Epigenetics"},{"key":"10.1016\/j.lfs.2019.116868_bib36","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.molimm.2017.12.008","article-title":"The protective effect of dexmedetomidine on LPS-induced acute lung injury through the HMGB1-mediated TLR4\/NF-kappaB and PI3K\/Akt\/mTOR pathways","volume":"94","author":"Meng","year":"2018","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.lfs.2019.116868_bib37","doi-asserted-by":"crossref","first-page":"105717","DOI":"10.1016\/j.intimp.2019.105717","article-title":"Dexmedetomidine ameliorates LPS induced acute lung injury via GSK-3beta\/STAT3-NF-kappaB signaling pathway in rats","volume":"74","author":"Zhang","year":"2019","journal-title":"Int. Immunopharmacol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320519307957?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320519307957?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:34:12Z","timestamp":1758400452000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320519307957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":37,"alternative-id":["S0024320519307957"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2019.116868","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The therapeutic effect of dexmedetomidine on protection from renal failure via inhibiting KDM5A in lipopolysaccharide-induced sepsis of mice","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2019.116868","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116868"}}