{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:14:41Z","timestamp":1777626881545,"version":"3.51.4"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010731","name":"Faculty of Medicine, Chiang Mai University","doi-asserted-by":"publisher","award":["001\\u20132561"],"award-info":[{"award-number":["001\\u20132561"]}],"id":[{"id":"10.13039\/501100010731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002842","name":"Chiang Mai University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002842","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","award":["MRG6080226"],"award-info":[{"award-number":["MRG6080226"]}],"id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","award":["TRF-RTA6080003"],"award-info":[{"award-number":["TRF-RTA6080003"]}],"id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004192","name":"National Science and Technology Development Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004192","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.lfs.2019.116878","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T04:44:52Z","timestamp":1572583492000},"page":"116878","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Deferiprone and efonidipine mitigated iron-overload induced neurotoxicity in wild-type and thalassemic mice"],"prefix":"10.1016","volume":"239","author":[{"given":"Jirapas","family":"Sripetchwandee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juthamas","family":"Khamseekaew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saovaros","family":"Svasti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somdet","family":"Srichairatanakool","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suthat","family":"Fucharoen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nipon","family":"Chattipakorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siriporn C.","family":"Chattipakorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2019.116878_bib1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1196\/annals.1345.036","article-title":"Thalassemia and learning: neurocognitive functioning in children","volume":"1054","author":"Armstrong","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.lfs.2019.116878_bib2","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1442-200X.2010.03279.x","article-title":"Neurocognitive function in patients with beta-thalassemia major","volume":"53","author":"Duman","year":"2011","journal-title":"Pediatr. Int."},{"key":"10.1016\/j.lfs.2019.116878_bib3","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1007\/s00277-015-2378-z","article-title":"Neurological complications of beta-thalassemia","volume":"94","author":"Nemtsas","year":"2015","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.lfs.2019.116878_bib4","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0165-0173(98)00012-5","article-title":"Expression of iron transport proteins and excessive iron accumulation in the brain in neurodegenerative disorders","volume":"27","author":"Qian","year":"1998","journal-title":"Brain Res Brain Res Rev"},{"key":"10.1016\/j.lfs.2019.116878_bib5","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jtemb.2014.11.009","article-title":"Age-related changes of brain iron load changes in the frontal cortex in APPswe\/PS1DeltaE9 transgenic mouse model of Alzheimer's disease","volume":"30","author":"Xian-hui","year":"2015","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.lfs.2019.116878_bib6","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1096\/fj.09-135749","article-title":"Divalent metal transporter 1 is involved in amyloid precursor protein processing and Abeta generation","volume":"23","author":"Zheng","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.lfs.2019.116878_bib7","doi-asserted-by":"crossref","first-page":"e85115","DOI":"10.1371\/journal.pone.0085115","article-title":"Combined therapy of iron chelator and antioxidant completely restores brain dysfunction induced by iron toxicity","volume":"9","author":"Sripetchwandee","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2019.116878_bib8","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.neuroscience.2016.07.003","article-title":"A combination of an iron chelator with an antioxidant effectively diminishes the dendritic loss, tau-hyperphosphorylation, amyloids-beta accumulation and brain mitochondrial dynamic disruption in rats with chronic iron-overload","volume":"332","author":"Sripetchwandee","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.lfs.2019.116878_bib9","series-title":"Deferoxamine Inhibits Microglial Activation, Attenuates Blood-Brain Barrier Disruption, Rescues Dendritic Damage and Improves Spatial Memory in a Mouse Model of Microhemorrhages","author":"He","year":"2016"},{"key":"10.1016\/j.lfs.2019.116878_bib10","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/jcbfm.2010.209","article-title":"Iron toxicity in mice with collagenase-induced intracerebral hemorrhage","volume":"31","author":"Wu","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.lfs.2019.116878_bib11","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3389\/fncel.2014.00388","article-title":"Neuroinflammation after intracerebral hemorrhage","volume":"8","author":"Mracsko","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.lfs.2019.116878_bib12","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/03630260600642518","article-title":"Effect of deferiprone on liver iron overload and fibrosis in hepatitis-C-virus-infected thalassemia","volume":"30","author":"Chen","year":"2006","journal-title":"Hemoglobin"},{"key":"10.1016\/j.lfs.2019.116878_bib13","doi-asserted-by":"crossref","first-page":"3738","DOI":"10.1182\/blood-2005-07-2948","article-title":"Randomized controlled trial of deferiprone or deferoxamine in beta-thalassemia major patients with asymptomatic myocardial siderosis","volume":"107","author":"Pennell","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.lfs.2019.116878_bib14","first-page":"489","article-title":"Comparative effects of deferiprone and deferoxamine on survival and cardiac disease in patients with thalassemia major: a retrospective analysis","volume":"88","author":"Piga","year":"2003","journal-title":"Haematologica"},{"key":"10.1016\/j.lfs.2019.116878_bib15","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ejphar.2017.02.015","article-title":"Effects of iron overload, an iron chelator and a T-Type calcium channel blocker on cardiac mitochondrial biogenesis and mitochondrial dynamics in thalassemic mice","volume":"799","author":"Khamseekaew","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2019.116878_bib16","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ejphar.2018.01.015","article-title":"Combined iron chelator and T-type calcium channel blocker exerts greater efficacy on cardioprotection than monotherapy in iron-overload thalassemic mice","volume":"822","author":"Kumfu","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2019.116878_bib17","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.ygeno.2004.11.016","article-title":"A humanized mouse model for a common beta0-thalassemia mutation","volume":"85","author":"Jamsai","year":"2005","journal-title":"Genomics"},{"key":"10.1016\/j.lfs.2019.116878_bib18","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ygeno.2006.03.009","article-title":"A humanized BAC transgenic\/knockout mouse model for HbE\/beta-thalassemia","volume":"88","author":"Jamsai","year":"2006","journal-title":"Genomics"},{"key":"10.1016\/j.lfs.2019.116878_bib19","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ijcard.2006.08.076","article-title":"Heart rate variability in beta-thalassemic mice","volume":"121","author":"Incharoen","year":"2007","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.lfs.2019.116878_bib20","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1600-0609.2012.01779.x","article-title":"T-type calcium channel blockade improves survival and cardiovascular function in thalassemic mice","volume":"88","author":"Kumfu","year":"2012","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.lfs.2019.116878_bib21","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2147\/JBM.S27400","article-title":"Treating thalassemia major-related iron overload: the role of deferiprone","volume":"3","author":"Berdoukas","year":"2012","journal-title":"J. Blood Med."},{"key":"10.1016\/j.lfs.2019.116878_bib22","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1042\/BJ20140795","article-title":"A novel method for non-transferrin-bound iron quantification by chelatable fluorescent beads based on flow cytometry","volume":"463","author":"MA","year":"2014","journal-title":"Biochem. J."},{"key":"10.1016\/j.lfs.2019.116878_bib23","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.expneurol.2008.05.004","article-title":"BK channel openers inhibit ROS production of isolated rat brain mitochondria","volume":"212","author":"Kulawiak","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.lfs.2019.116878_bib24","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.lfs.2013.01.004","article-title":"Mitochondrial calcium uniporter blocker effectively prevents brain mitochondrial dysfunction caused by iron overload","volume":"92","author":"Sripetchwandee","year":"2013","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2019.116878_bib25","first-page":"5","article-title":"The bicinchoninic acid (BCA) assay for protein quantitation","volume":"32","author":"Walker","year":"1994","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.lfs.2019.116878_bib26","doi-asserted-by":"crossref","first-page":"e0141629","DOI":"10.1371\/journal.pone.0141629","article-title":"Deficiency of calcium-independent phospholipase A2 beta induces brain iron accumulation through upregulation of divalent metal transporter 1","volume":"10","author":"Beck","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2019.116878_bib27","first-page":"19","article-title":"Divalent metal transporter 1 (DMT1) in the brain: implications for a role in iron transport at the blood-brain barrier, and neuronal and glial pathology","volume":"8","author":"Skjorringe","year":"2015","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.lfs.2019.116878_bib28","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1124\/mol.105.017756","article-title":"Increased divalent metal transporter 1 expression might be associated with the neurotoxicity of L-DOPA","volume":"69","author":"Chang","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.lfs.2019.116878_bib29","doi-asserted-by":"crossref","first-page":"876","DOI":"10.3109\/00207454.2013.813510","article-title":"Blocking of L-type calcium channels protects hippocampal and nigral neurons against iron neurotoxicity. The role of L-type calcium channels in iron-induced neurotoxicity","volume":"123","author":"Bostanci","year":"2013","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.lfs.2019.116878_bib30","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1007\/s11064-007-9313-1","article-title":"Voltage-gated calcium channels provide an alternate route for iron uptake in neuronal cell cultures","volume":"32","author":"Gaasch","year":"2007","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.lfs.2019.116878_bib31","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s11064-011-0591-2","article-title":"Differential effect of nimodipine in attenuating iron-induced toxicity in brain- and blood-brain barrier-associated cell types","volume":"37","author":"Lockman","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.lfs.2019.116878_bib32","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1600-0609.2010.01549.x","article-title":"T-type calcium channel as a portal of iron uptake into cardiomyocytes of beta-thalassemic mice","volume":"86","author":"Kumfu","year":"2011","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.lfs.2019.116878_bib33","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.nurt.2010.05.014","article-title":"Microglial activation and chronic neurodegeneration","volume":"7","author":"Lull","year":"2010","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.lfs.2019.116878_bib34","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1128\/CMR.17.4.942-964.2004","article-title":"Role of microglia in central nervous system infections","volume":"17","author":"Rock","year":"2004","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.lfs.2019.116878_bib35","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/0166-2236(96)10049-7","article-title":"Microglia: a sensor for pathological events in the CNS","volume":"19","author":"Kreutzberg","year":"1996","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.lfs.2019.116878_bib36","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/0014-5793(87)80305-8","article-title":"Production of superoxide anions by a CNS macrophage, the microglia","volume":"223","author":"Colton","year":"1987","journal-title":"FEBS Lett."},{"key":"10.1016\/j.lfs.2019.116878_bib37","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/(SICI)1098-1136(19990201)25:3<304::AID-GLIA10>3.0.CO;2-W","article-title":"Cytokine transcripts expressed by microglia in vitro are not expressed by ameboid microglia of the developing rat central nervous system","volume":"25","author":"Hurley","year":"1999","journal-title":"Glia"},{"key":"10.1016\/j.lfs.2019.116878_bib38","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrn2038","article-title":"Microglia-mediated neurotoxicity: uncovering the molecular mechanisms","volume":"8","author":"Block","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.lfs.2019.116878_bib39","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.4049\/jimmunol.149.8.2736","article-title":"Activated microglia mediate neuronal cell injury via a nitric oxide mechanism","volume":"149","author":"Chao","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.lfs.2019.116878_bib40","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s13311-016-0477-8","article-title":"Integrative regulators of neuroinflammation in stroke and other neurological diseases","volume":"13","author":"Cekanaviciute","year":"2016","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.lfs.2019.116878_bib41","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3389\/fnmol.2017.00427","article-title":"Involvement of astrocytes in alzheimer's disease from a neuroinflammatory and oxidative stress perspective","volume":"10","author":"Gonzalez-Reyes","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.lfs.2019.116878_bib42","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.neubiorev.2016.06.014","article-title":"Insights on the pathophysiology of Alzheimer's disease: the crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system","volume":"68","author":"Da Mesquita","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.lfs.2019.116878_bib43","doi-asserted-by":"crossref","first-page":"309129","DOI":"10.1155\/2014\/309129","article-title":"Chronic neuroinflammation in Alzheimer's disease: new perspectives on animal models and promising candidate drugs","volume":"2014","author":"Millington","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.lfs.2019.116878_bib44","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12974-017-0871-0","article-title":"Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity","volume":"14","author":"Kirkley","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.lfs.2019.116878_bib45","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2019.116878_bib46","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cell.2009.01.038","article-title":"A Nurr1\/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death","volume":"137","author":"Saijo","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2019.116878_bib47","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13018-017-0578-z","article-title":"In vivo evaluation of microglia activation by intracranial iron overload in central pain after spinal cord injury","volume":"12","author":"Meng","year":"2017","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.lfs.2019.116878_bib48","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s11011-013-9446-7","article-title":"Glia activation and its role in oxidative stress","volume":"29","author":"Ogundele","year":"2014","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.lfs.2019.116878_bib49","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3389\/fnmol.2017.00455","article-title":"New progress on the role of glia in iron metabolism and iron-induced degeneration of dopamine neurons in Parkinson's disease","volume":"10","author":"Xu","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.lfs.2019.116878_bib50","series-title":"Single Mild Traumatic Brain Injury Results in Transiently Impaired Spatial Long-Term Memory and Altered Search Strategies","author":"Marschner","year":"2018"},{"key":"10.1016\/j.lfs.2019.116878_bib51","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.freeradbiomed.2014.07.033","article-title":"NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: a bipartisan affair?","volume":"76","author":"Bordt","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.lfs.2019.116878_bib52","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1016\/j.neurobiolaging.2015.03.015","article-title":"P2X7 receptor is critical in alpha-synuclein--mediated microglial NADPH oxidase activation","volume":"36","author":"Jiang","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.lfs.2019.116878_bib53","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/glia.22479","article-title":"NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration","volume":"61","author":"Qin","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.lfs.2019.116878_bib54","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/S0891-5849(02)00804-3","article-title":"The relationship between oxidative\/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseases","volume":"32","author":"Giasson","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.lfs.2019.116878_bib55","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s00702-010-0433-4","article-title":"The role of microglia in amyloid clearance from the AD brain","volume":"117","author":"Lee","year":"2010","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.lfs.2019.116878_bib56","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fphar.2012.00014","article-title":"Microglia function in Alzheimer's disease","volume":"3","author":"Solito","year":"2012","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2019.116878_bib57","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1523\/JNEUROSCI.4042-03.2004","article-title":"Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase","volume":"24","author":"Abramov","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2019.116878_bib58","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1053\/beha.2002.0209","article-title":"Oral iron chelators--development and application","volume":"15","author":"Liu","year":"2002","journal-title":"Best Pract. Res. Clin. Haematol."},{"key":"10.1016\/j.lfs.2019.116878_bib59","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1527-3466.2002.tb00084.x","article-title":"Efonidipine hydrochloride: a dual blocker of L- and T-type ca(2+) channels","volume":"20","author":"Tanaka","year":"2002","journal-title":"Cardiovasc. Drug Rev."},{"key":"10.1016\/j.lfs.2019.116878_bib60","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/0306-3623(94)90173-2","article-title":"Effects of efonidipine hydrochloride (NZ-105), a new calcium antagonist, against acute renal failure in rats","volume":"25","author":"Shudo","year":"1994","journal-title":"Gen. Pharmacol."}],"updated-by":[{"DOI":"10.1016\/j.lfs.2023.121401","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000}}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320519308057?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320519308057?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:42:59Z","timestamp":1777423379000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320519308057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":60,"alternative-id":["S0024320519308057"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2019.116878","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deferiprone and efonidipine mitigated iron-overload induced neurotoxicity in wild-type and thalassemic mice","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2019.116878","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116878"}}