{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:54:39Z","timestamp":1783468479557,"version":"3.55.0"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Research and Innovation Programme","doi-asserted-by":"publisher","award":["728018 Eat2beNICE"],"award-info":[{"award-number":["728018 Eat2beNICE"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Russian Academic Excellence Project"},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["16-16-10073"],"award-info":[{"award-number":["16-16-10073"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.lfs.2019.117163","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T12:23:43Z","timestamp":1576239823000},"page":"117163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Prefrontal cortex inflammation and liver pathologies accompany cognitive and motor deficits following Western diet consumption in non-obese female mice"],"prefix":"10.1016","volume":"241","author":[{"given":"Ekaterina","family":"Veniaminova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Oplatchikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucien","family":"Bettendorff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Kotenkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Lysko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Vasilevskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan V.","family":"Kalueff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliya","family":"Fedulova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksei","family":"Umriukhin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus-Peter","family":"Lesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"Anthony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana","family":"Strekalova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2019.117163_bb0005","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/ajcn.81.2.341","article-title":"Origins and evolution of the Western diet: health implications for the 21st century","volume":"81","author":"Cordain","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.lfs.2019.117163_bb0010","first-page":"97","article-title":"Health effects of changes in the structure of dietary macronutrients intake in western societies","volume":"66","author":"Okr\u0119glicka","year":"2015","journal-title":"Rocz. Panstw. Zakl. Hig."},{"key":"10.1016\/j.lfs.2019.117163_bb0015","doi-asserted-by":"crossref","unstructured":"F.N. Jacka, J.A. Pasco, A. Mykletun, L.J. Williams, A.M. Hodge, S.L. O'Reilly, G.C. Nicholson, M.A. Kotowicz, M. Berk, Association of western and traditional diets with depression and anxiety in women, Am. J. Psychiatry 167 (2010) 305\u2013311. doi:https:\/\/doi.org\/10.1176\/appi.ajp.2009.09060881","DOI":"10.1176\/appi.ajp.2009.09060881"},{"key":"10.1016\/j.lfs.2019.117163_bb0020","doi-asserted-by":"crossref","first-page":"434","DOI":"10.4306\/pi.2015.12.4.434","article-title":"Healthy and unhealthy dietary patterns are related to depression: a case-control study","volume":"12","author":"Khosravi","year":"2015","journal-title":"Psychiatry Investig."},{"key":"10.1016\/j.lfs.2019.117163_bb0025","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.bbi.2018.01.002","article-title":"Dietary patterns, body mass index and inflammation: pathways to depression and mental health problems in adolescents","volume":"69","author":"Oddy","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.lfs.2019.117163_bb0030","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/aur.1586","article-title":"Maternal metabolic risk factors for autism spectrum disorder-an analysis of electronic medical records and linked birth data","volume":"9","author":"Connolly","year":"2016","journal-title":"Autism Res."},{"key":"10.1016\/j.lfs.2019.117163_bb0035","first-page":"1","article-title":"How nutritional status, diet and dietary supplements can affect autism","volume":"64","author":"Kawicka","year":"2013","journal-title":"A review, Rocz. Panstw. Zakl. Hig."},{"key":"10.1016\/j.lfs.2019.117163_bb0040","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1542\/peds.2011-2199","article-title":"The diet factor in attention-deficit\/hyperactivity disorder","volume":"129","author":"Millichap","year":"2012","journal-title":"Pediatrics"},{"key":"10.1016\/j.lfs.2019.117163_bb0045","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1002\/oby.21441","article-title":"High-fat diet feeding alters olfactory-, social-, and reward-related behaviors of mice independent of obesity","volume":"24","author":"Takase","year":"2016","journal-title":"Obesity."},{"key":"10.1016\/j.lfs.2019.117163_bb0050","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41398-019-0470-1","article-title":"A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling","volume":"9","author":"Vagena","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.lfs.2019.117163_bb0055","doi-asserted-by":"crossref","unstructured":"T. Strekalova, M. Evans, J. Costa-Nunes, S. Bachurin, N. Yeritsyan, Y. Couch, H.M.W. Steinbusch, S.E. K\u00f6hler, K.-P. Lesch, D.C. Anthony, Tlr4 upregulation in the brain accompanies depression- and anxiety-like behaviors induced by a high-cholesterol diet, Brain. Behav. Immun. 48 (2015). doi:10.1016\/j.bbi.2015.02.015.","DOI":"10.1016\/j.bbi.2015.02.015"},{"key":"10.1016\/j.lfs.2019.117163_bb0060","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jad.2016.02.045","article-title":"Insulin receptor sensitizer, dicholine succinate, prevents both Toll-like receptor 4 (TLR4) upregulation and affective changes induced by a high-cholesterol diet in mice","volume":"196","author":"Strekalova","year":"2016","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.lfs.2019.117163_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/9498247","article-title":"Autism-like behaviours and memory deficits result from a western diet in mice","volume":"2017","author":"Veniaminova","year":"2017","journal-title":"Neural Plast."},{"key":"10.1016\/j.lfs.2019.117163_bb0070","doi-asserted-by":"crossref","unstructured":"E. Veniaminova, R. Cespuglio, N. Markova, N. Mortimer, C. Wai Cheung, H.W. Steinbusch, K.-P. Lesch, T. Strekalova, Behavioral features of mice fed with a cholesterol-enriched diet:Deficient novelty exploration and unaltered aggressive behavior, Transl. Neurosci. Clin. 2 (2016) 87. doi:10.18679\/CN11-6030\/R.2016.014.","DOI":"10.18679\/CN11-6030_R.2016.014"},{"key":"10.1016\/j.lfs.2019.117163_bb0075","doi-asserted-by":"crossref","first-page":"295","DOI":"10.4103\/0256-4947.65261","article-title":"Autism spectrum disorders","volume":"30","author":"Faras","year":"2010","journal-title":"Ann. Saudi Med."},{"key":"10.1016\/j.lfs.2019.117163_bb0080","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1007\/s10608-013-9569-5","article-title":"Depression in adults with attention-deficit\/hyperactivity disorder (ADHD): the mediating role of cognitive-behavioral factors","volume":"37","author":"Knouse","year":"2013","journal-title":"Cogn. Ther. Res."},{"key":"10.1016\/j.lfs.2019.117163_bb0085","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3810\/pgm.2010.09.2206","article-title":"Understanding attention-deficit\/hyperactivity disorder from childhood to adulthood","volume":"122","author":"Wilens","year":"2010","journal-title":"Postgrad. Med."},{"key":"10.1016\/j.lfs.2019.117163_bb0090","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2017.00034","article-title":"Metabolic dysfunction underlying autism spectrum disorder and potential treatment approaches","volume":"10","author":"Cheng","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.lfs.2019.117163_bb0095","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41398-019-0370-4","article-title":"Autism spectrum disorders: let\u2019s talk about glucose?","volume":"9","author":"Hoirisch-Clapauch","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.lfs.2019.117163_bb0100","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s11892-019-1174-x","article-title":"Attention deficit\/hyperactivity, the metabolic syndrome, and type 2 diabetes","volume":"19","author":"Landau","year":"2019","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.lfs.2019.117163_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/6178575","article-title":"Impaired visual motor coordination in obese adults","volume":"2016","author":"Gaul","year":"2016","journal-title":"J. Obes."},{"key":"10.1016\/j.lfs.2019.117163_bb0110","doi-asserted-by":"crossref","unstructured":"A. Stojakovic, C.A. Mastronardi, J. Licinio, M.-L. Wong, Long-term consumption of high-fat diet impairs motor coordination without affecting the general motor activity, J. Transl. Sci. 5 (2018) 1\u201310. doi:10.15761\/JTS.1000295.","DOI":"10.15761\/JTS.1000295"},{"key":"10.1016\/j.lfs.2019.117163_bb0115","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.neuron.2011.10.008","article-title":"Neuroplasticity subserving motor skill learning","volume":"72","author":"Dayan","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.lfs.2019.117163_bb0120","article-title":"Applied machine learning method to predict children with ADHD using prefrontal cortex activity: a multicenter study in Japan","volume":"108705471774063","author":"Yasumura","year":"2017","journal-title":"J. Atten. Disord."},{"key":"10.1016\/j.lfs.2019.117163_bb0125","first-page":"589","article-title":"The medial prefrontal cortex and integration in autism","volume":"15","author":"Ben Shalom","year":"2009","journal-title":"Neurosci."},{"key":"10.1016\/j.lfs.2019.117163_bb0130","doi-asserted-by":"crossref","unstructured":"B. Lizarbe, A.F. Soares, S. Larsson, J.M.N. Duarte, Neurochemical Modifications in the Hippocampus, Cortex and Hypothalamus of Mice Exposed to Long-Term High-Fat Diet, Front. Neurosci. 12 (2019). doi:https:\/\/doi.org\/10.3389\/fnins.2018.00985.","DOI":"10.3389\/fnins.2018.00985"},{"key":"10.1016\/j.lfs.2019.117163_bb0135","doi-asserted-by":"crossref","unstructured":"T.M. Comhair, S.C. Garcia Caraballo, C.H. Dejong, W.H. Lamers, S.E. Koehler, Dietary cholesterol, female gender and n-3 fatty acid deficiency are more important factors in the development of non-alcoholic fatty liver disease than the saturation index of the fat, Nutr. Metab. (Lond). 8 (2011) 4. doi:https:\/\/doi.org\/10.1186\/1743-7075-8-4.","DOI":"10.1186\/1743-7075-8-4"},{"key":"10.1016\/j.lfs.2019.117163_bb0140","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2174\/1745017901814010177","article-title":"The prevalence of autism spectrum disorders in adult psychiatric inpatients: a systematic review","volume":"14","author":"Tromans","year":"2018","journal-title":"Clin. Pract. Epidemiol. Ment. Health"},{"key":"10.1016\/j.lfs.2019.117163_bb0145","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1210\/en.2010-0377","article-title":"A western diet increases serotonin availability in rat small intestine","volume":"152","author":"Bertrand","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.lfs.2019.117163_bb0150","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2202-14-128","article-title":"The expression of platelet serotonin transporter (SERT) in human obesity","volume":"14","author":"Giannaccini","year":"2013","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.lfs.2019.117163_bb0155","doi-asserted-by":"crossref","first-page":"4924","DOI":"10.1038\/s41598-018-22814-8","article-title":"The effect of obesity on the availabilities of dopamine and serotonin transporters","volume":"8","author":"Nam","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2019.117163_bb0160","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/hbm.23418","article-title":"Altered interregional molecular associations of the serotonin transporter in attention deficit\/hyperactivity disorder assessed with PET","volume":"38","author":"Vanicek","year":"2017","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.lfs.2019.117163_bb0165","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jfma.2016.07.012","article-title":"Abnormal serotonin transporter availability in the brains of adults with conduct disorder","volume":"116","author":"Chang","year":"2017","journal-title":"J. Formos. Med. Assoc."},{"key":"10.1016\/j.lfs.2019.117163_bb0170","doi-asserted-by":"crossref","unstructured":"J. de Munter, I. Schafarevich, A. Liundup, D. Pavlov, E. Wolters, A. Gorlova, E. Veniaminova, A. Umriukhin, A. Kalueff, A. Svistunov, B.W. Kramer, K.-P. Lesch, T. Strekalova, CNS and Therapeutics, Neuro-Cell therapy improves motor outcomes and suppresses inflammation during experimental syndrome of amyotrophic lateral sclerosis in mice, CNS Neurosci. Ther. (2019). (in press).","DOI":"10.1111\/cns.13280"},{"key":"10.1016\/j.lfs.2019.117163_bb0175","doi-asserted-by":"crossref","DOI":"10.3791\/2610-v","article-title":"Measuring the strength of mice","author":"Deacon","year":"2013","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.lfs.2019.117163_bb0180","first-page":"277","article-title":"A new method for the measurement of muscle relaxation in white mice","volume":"152","author":"Kondziella","year":"1964","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.lfs.2019.117163_bb0185","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bbr.2013.02.015","article-title":"The differential effects of chronic imipramine or citalopram administration on physiological and behavioral outcomes in na\u00efve mice","volume":"245","author":"Strekalova","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.lfs.2019.117163_bb0190","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1038\/sj.npp.1300532","article-title":"Stress-induced anhedonia in mice is associated with deficits in forced swimming and exploration","volume":"29","author":"Strekalova","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.lfs.2019.117163_bb0195","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.exger.2012.04.010","article-title":"Anhedonic-like traits and lack of affective deficits in 18-month-old C57BL\/6 mice: implications for modeling elderly depression","volume":"47","author":"Malatynska","year":"2012","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.lfs.2019.117163_bb0200","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2015.00037","article-title":"Dicholine succinate, the neuronal insulin sensitizer, normalizes behavior, REM sleep, hippocampal pGSK3 beta and mRNAs of NMDA receptor subunits in mouse models of depression","volume":"9","author":"Cline","year":"2015","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.lfs.2019.117163_bb0205","doi-asserted-by":"crossref","first-page":"596126","DOI":"10.1155\/2015\/596126","article-title":"Animal models of depression and drug delivery with food as an effective dosing method: evidences from studies with celecoxib and dicholine succinate","volume":"2015","author":"Costa-Nunes","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.lfs.2019.117163_bb0210","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1242\/dmm.006239","article-title":"NIH mouse metabolic phenotyping center consortium, standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice","volume":"3","author":"Ayala","year":"2010","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.lfs.2019.117163_bb0215","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s12974-016-0572-0","article-title":"Low-dose lipopolysaccharide (LPS) inhibits aggressive and augments depressive behaviours in a chronic mild stress model in mice","volume":"13","author":"Couch","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.lfs.2019.117163_bb0220","doi-asserted-by":"crossref","unstructured":"D. Pavlov, L. Bettendorff, A. Gorlova, A. Olkhovik, A. V Kalueff, E.D. Ponomarev, A. Inozemtsev, V. Chekhonin, K.-P. Les\u0441h, D.C. Anthony, T. Strekalova, Neuroinflammation and aberrant hippocampal plasticity in a mouse model of emotional stress evoked by exposure to ultrasound of alternating frequencies., Prog. Neuropsychopharmacol. Biol. Psychiatry. 90 (2019) 104\u2013116. doi:https:\/\/doi.org\/10.1016\/j.pnpbp.2018.11.014.","DOI":"10.1016\/j.pnpbp.2018.11.014"},{"key":"10.1016\/j.lfs.2019.117163_bb0225","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/nprot.2013.055","article-title":"Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease","volume":"8","author":"Mehlem","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.lfs.2019.117163_bb0230","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.bbi.2012.12.017","article-title":"Microglial activation, increased TNF and SERT expression in the prefrontal cortex define stress-altered behaviour in mice susceptible to anhedonia","volume":"29","author":"Couch","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.lfs.2019.117163_bb0235","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.3945\/ajcn.117.158089","article-title":"Neuromodulation directed at the prefrontal cortex of subjects with obesity reduces snack food intake and hunger in a randomized trial","volume":"106","author":"Heinitz","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.lfs.2019.117163_bb0240","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/ajcn\/84.4.725","article-title":"Less activation of the left dorsolateral prefrontal cortex in response to a meal: a feature of obesity","volume":"84","author":"Le","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.lfs.2019.117163_bb0245","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.biopsych.2010.07.005","article-title":"Prefrontal cortex and impulsive decision making","volume":"69","author":"Kim","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.lfs.2019.117163_bb0250","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s00429-017-1526-8","article-title":"Maternal high-fat diet and early life stress differentially modulate spine density and dendritic morphology in the medial prefrontal cortex of juvenile and adult rats","volume":"223","author":"Rincel","year":"2018","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.lfs.2019.117163_bb0255","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.biopsych.2010.09.024","article-title":"Looking on the bright side of serotonin transporter gene variation","volume":"69","author":"Homberg","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.lfs.2019.117163_bb0260","first-page":"137","article-title":"Serotonin transporter deficiency increases abdominal fat in female","volume":"18","author":"Homberg","year":"2010","journal-title":"But Not Male Rats, Obesity."},{"key":"10.1016\/j.lfs.2019.117163_bb0265","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrn2284","article-title":"Targeting the murine serotonin transporter: insights into human neurobiology","volume":"9","author":"Murphy","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.lfs.2019.117163_bb0270","doi-asserted-by":"crossref","first-page":"420","DOI":"10.2174\/1567205014666171004113537","article-title":"Reduced serotonin transporter levels and inflammation in the midbrain raphe of 12 month old APPswe\/PSEN1dE9 mice","volume":"15","author":"Metaxas","year":"2018","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.lfs.2019.117163_bb0275","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/2040-2392-4-37","article-title":"A review of the serotonin transporter and prenatal cortisol in the development of autism spectrum disorders","volume":"4","author":"Rose\u2019Meyer","year":"2013","journal-title":"Mol. Autism"},{"key":"10.1016\/j.lfs.2019.117163_bb0280","doi-asserted-by":"crossref","DOI":"10.1002\/ajpa.23896","article-title":"Serotonergic innervation of the human amygdala and evolutionary implications","author":"Lew","year":"2019","journal-title":"Am. J. Phys. Anthropol."},{"key":"10.1016\/j.lfs.2019.117163_bb0285","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1001\/jamapsychiatry.2017.0659","article-title":"Association between medication use for attention-deficit\/hyperactivity disorder and risk of motor vehicle crashes","volume":"74","author":"Chang","year":"2017","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.lfs.2019.117163_bb0290","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/oby.2007.65","article-title":"Genes implicated in serotonergic and dopaminergic functioning predict BMI categories","volume":"16","author":"Fuemmeler","year":"2008","journal-title":"Obesity"},{"key":"10.1016\/j.lfs.2019.117163_bb0295","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/oby.2007.519","article-title":"Short allele of serotonin transporter gene promoter is a risk factor for obesity in adolescents*","volume":"15","author":"Sookoian","year":"2007","journal-title":"Obesity"},{"key":"10.1016\/j.lfs.2019.117163_bb0300","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cca.2009.10.022","article-title":"The serotonin transporter promoter polymorphism (5-HTTLPR) is associated with type 2 diabetes","volume":"411","author":"Iordanidou","year":"2010","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.lfs.2019.117163_bb0305","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/01.psy.0000195746.52074.63","article-title":"Investigation of the serotonin transporter regulatory region polymorphism in bulimia nervosa: relationships to harm avoidance, nutritional parameters, and psychiatric comorbidity","volume":"68","author":"Monteleone","year":"2006","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.lfs.2019.117163_bb0310","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2014.10.002","article-title":"Integrating the monoamine, neurotrophin and cytokine hypotheses of depression \u2014 a central role for the serotonin transporter?","volume":"147","author":"Haase","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.lfs.2019.117163_bb0315","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1515\/hsz-2013-0241","article-title":"The role of oxidative stress during inflammatory processes","volume":"395","author":"Lugrin","year":"2014","journal-title":"Biol. Chem."},{"key":"10.1016\/j.lfs.2019.117163_bb0320","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12974-018-1055-2","article-title":"Decreased microglial activation through gut-brain axis by prebiotics, probiotics, or synbiotics effectively restored cognitive function in obese-insulin resistant rats","volume":"15","author":"Chunchai","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.lfs.2019.117163_bb0325","doi-asserted-by":"crossref","first-page":"8889","DOI":"10.1523\/JNEUROSCI.0789-18.2018","article-title":"Microglia play an active role in obesity-associated cognitive decline","volume":"38","author":"Cope","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2019.117163_bb0330","article-title":"Obesity diminishes synaptic markers, alters microglial morphology, and impairs cognitive function","volume":"201511593","author":"Bocarsly","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.lfs.2019.117163_bb0335","first-page":"17","article-title":"Hormones and diet, but not body weight","volume":"62","author":"Gao","year":"2014","journal-title":"control hypothalamic microglial activity, Glia."},{"key":"10.1016\/j.lfs.2019.117163_bb0340","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1172\/JCI59660","article-title":"Obesity is associated with hypothalamic injury in rodents and humans","volume":"122","author":"Thaler","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2019.117163_bb0345","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/sj.ijo.0803177","article-title":"Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans","volume":"30","author":"Vincent","year":"2006","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.lfs.2019.117163_bb0350","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.numecd.2010.02.007","article-title":"Effects of the association of aging and obesity on lipids, lipoproteins and oxidative stress biomarkers: a comparison of older with young men","volume":"21","author":"Karaouzene","year":"2011","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.lfs.2019.117163_bb0355","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/oby.2008.536","article-title":"Oxidative stress in severely obese persons is greater in those with insulin resistance","volume":"17","author":"Tinahones","year":"2009","journal-title":"Obesity"},{"key":"10.1016\/j.lfs.2019.117163_bb0360","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1111\/j.1471-4159.2008.05798.x","article-title":"Effects of short-term Western diet on cerebral oxidative stress and diabetes related factors in APP \u00d7 PS1 knock-in mice","volume":"108","author":"Studzinski","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.lfs.2019.117163_bb0365","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1476-511X-10-74","article-title":"The relation of high fat diet, metabolic disturbances and brain oxidative dysfunction: modulation by hydroxy citric acid","volume":"10","author":"Amin","year":"2011","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.lfs.2019.117163_bb0370","doi-asserted-by":"crossref","unstructured":"C.C. de Aquino, R.A. Leit\u00e3o, L.A. Oliveira Alves, V. Coelho-Santos, R.L. Guerrant, C.F. Ribeiro, J.O. Malva, A.P. Silva, R.B. Ori\u00e1, Effect of Hypoproteic and High-Fat Diets on Hippocampal Blood-Brain Barrier Permeability and Oxidative Stress, Front. Nutr. 5 (2019). doi:https:\/\/doi.org\/10.3389\/fnut.2018.00131.","DOI":"10.3389\/fnut.2018.00131"},{"key":"10.1016\/j.lfs.2019.117163_bb0375","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1179\/1476830513Y.0000000092","article-title":"Damaging effects of a high-fat diet to the brain and cognition: a review of proposed mechanisms","volume":"17","author":"Freeman","year":"2014","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.lfs.2019.117163_bb0380","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.lfs.2014.07.018","article-title":"Mitochondrial dysfunction and oxidative damage in the brain of diet-induced obese rats but not in diet-resistant rats","volume":"110","author":"Ma","year":"2014","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2019.117163_bb0385","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrn2652","article-title":"Tests to assess motor phenotype in mice: a user\u2019s guide","volume":"10","author":"Brooks","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.lfs.2019.117163_bb0390","article-title":"Motor skills of obese and severely obese children and adolescents \u2013 a CIRCUIT study","volume":"1","author":"H\u00e4cker","year":"2017","journal-title":"J. Strength Cond. Res."},{"key":"10.1016\/j.lfs.2019.117163_bb0395","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1093\/cercor\/12.12.1254","article-title":"The frontal cortex of the rat and visual attentional performance: dissociable functions of distinct medial prefrontal subregions","volume":"12","author":"Passetti","year":"2002","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.lfs.2019.117163_bb0400","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/hep.20149","article-title":"Body fat distribution, relative weight, and liver enzyme levels: a population-based study","volume":"39","author":"Stranges","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2019.117163_bb0405","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3164\/jcbn.09-83","article-title":"A mouse model of metabolic syndrome: insulin resistance, fatty liver and non-alcoholic fatty pancreas disease (NAFPD) in C57BL\/6 mice fed a high fat diet","volume":"46","author":"Fraulob","year":"2010","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.lfs.2019.117163_bb0410","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1755-1536-6-19","article-title":"Experimental liver fibrosis research: update on animal models, legal issues and translational aspects","volume":"6","author":"Liedtke","year":"2013","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1016\/j.lfs.2019.117163_bb0415","doi-asserted-by":"crossref","unstructured":"M.V. Machado, G.A. Michelotti, G. Xie, T. Almeida Pereira, T.P. de Almeida, J. Boursier, B. Bohnic, C.D. Guy, A.M. Diehl, Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease, PLoS One. 10 (2015) e0127991. doi:https:\/\/doi.org\/10.1371\/journal.pone.0127991.","DOI":"10.1371\/journal.pone.0127991"},{"key":"10.1016\/j.lfs.2019.117163_bb0420","doi-asserted-by":"crossref","unstructured":"G. Goliasch, F. Wiesbauer, H. Blessberger, S. Demyanets, J. Wojta, K. Huber, G. Maurer, M. Schillinger, W.S. Speidl, Premature myocardial infarction is strongly associated with increased levels of remnant cholesterol, J. Clin. Lipidol. 9 (2015) 801\u2013806.e1. doi:https:\/\/doi.org\/10.1016\/j.jacl.2015.08.009.","DOI":"10.1016\/j.jacl.2015.08.009"},{"key":"10.1016\/j.lfs.2019.117163_bb0425","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1373\/clinchem.2017.279463","article-title":"Remnant cholesterol and myocardial infarction in normal weight, overweight, and obese individuals from the Copenhagen general population study","volume":"64","author":"Varbo","year":"2018","journal-title":"Clin. Chem."},{"key":"10.1016\/j.lfs.2019.117163_bb0430","doi-asserted-by":"crossref","DOI":"10.1111\/cns.12866","article-title":"Insulin receptor in the brain: mechanisms of activation and the role in the CNS pathology and treatment","author":"Pomytkin","year":"2018","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.lfs.2019.117163_bb0435","doi-asserted-by":"crossref","unstructured":"I. San Mauro Martin, S. Sanz Rojo, E. Garicano Vilar, L. Gonz\u00e1lez Cosano, R. Conty de la Campa, J.A. Blumenfeld Olivares, Lifestyle factors, diet and attention-deficit\/hyperactivity disorder in Spanish children \u2013 an observational study, Nutr. Neurosci. (2019) 1\u201310. doi:https:\/\/doi.org\/10.1080\/1028415X.2019.1660486.","DOI":"10.1080\/1028415X.2019.1660486"},{"key":"10.1016\/j.lfs.2019.117163_bb0440","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s11920-017-0754-1","article-title":"Attention-deficit\/hyperactivity disorder (ADHD) and obesity: update 2016","volume":"19","author":"Cortese","year":"2017","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.lfs.2019.117163_bb0445","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1177\/1087054710365990","article-title":"ADHD is associated with a \u201cWestern\u201d dietary pattern in adolescents","volume":"15","author":"Howard","year":"2011","journal-title":"J. Atten. Disord."},{"key":"10.1016\/j.lfs.2019.117163_bb0450","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.euroneuro.2018.08.001","article-title":"Live fast, die young? A review on the developmental trajectories of ADHD across the lifespan","volume":"28","author":"Franke","year":"2018","journal-title":"Eur. Neuropsychopharmacol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320519310914?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320519310914?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:29:49Z","timestamp":1758400189000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320519310914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":90,"alternative-id":["S0024320519310914"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2019.117163","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prefrontal cortex inflammation and liver pathologies accompany cognitive and motor deficits following Western diet consumption in non-obese female mice","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2019.117163","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117163"}}