{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T05:54:39Z","timestamp":1769234079124,"version":"3.49.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671856"],"award-info":[{"award-number":["81671856"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.lfs.2019.117253","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T07:22:52Z","timestamp":1578640972000},"page":"117253","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Acid sphingomyelinase\/ceramide mediates structural remodeling of cerebral artery and small mesenteric artery in simulated weightless rats"],"prefix":"10.1016","volume":"243","author":[{"given":"Yu-Ting","family":"Su","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao-Ping","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Ping","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao-Ming","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Xiang","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.lfs.2019.117253_bb0005","article-title":"Mechanisms of post-flight orthostatic intolerance","volume":"1","author":"Blomqvist","year":"1994","journal-title":"J. Gravit. Physiol."},{"issue":"2","key":"10.1016\/j.lfs.2019.117253_bb0010","first-page":"59","article-title":"Consequences of cardiovascular adaptation to spaceflight: implications for the use of pharmacological countermeasures","volume":"18","author":"Convertino","year":"2005","journal-title":"Gravit. Space Biol. Bull."},{"key":"10.1016\/j.lfs.2019.117253_bb0015","series-title":"Space Biology and Medicine. Humans in Spaceflight","first-page":"63","article-title":"Cardiovascular and cardiorespiratory function","author":"Charles","year":"1996"},{"key":"10.1016\/j.lfs.2019.117253_bb0020","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1880-6805-31-32","article-title":"Peripheral and central vascular conductance influence on post-exercise hypotension","volume":"31","author":"Endo","year":"2012","journal-title":"J. Physiol. Anthropol."},{"issue":"2","key":"10.1016\/j.lfs.2019.117253_bb0025","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000158978","article-title":"Mesenteric arcade arteries contribute substantially to vascular resistance in conscious rats","volume":"30","author":"Christensen","year":"1993","journal-title":"J. Vasc. Res."},{"issue":"6","key":"10.1016\/j.lfs.2019.117253_bb0030","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1152\/jappl.1999.87.6.2115","article-title":"Effects of hindlimb unloading on rat cerebral, splenic, and mesenteric resistance artery morphology","volume":"87","author":"Wilkerson","year":"1999","journal-title":"J. Appl. Physiol. (1985)"},{"issue":"6","key":"10.1016\/j.lfs.2019.117253_bb0035","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1152\/jappl.2001.91.6.2415","article-title":"Vascular adaptation to microgravity: what have we learned?","volume":"91","author":"Zhang","year":"2001","journal-title":"J. Appl. Physiol. (1985)"},{"issue":"5","key":"10.1016\/j.lfs.2019.117253_bb0040","doi-asserted-by":"crossref","first-page":"e97737","DOI":"10.1371\/journal.pone.0097737","article-title":"Mechanics and composition of middle cerebral arteries from simulated microgravity rats with and without 1-h\/d -Gx gravitation","volume":"9","author":"Cheng","year":"2014","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.lfs.2019.117253_bb0045","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1007\/s00421-013-2597-8","article-title":"Region-specific vascular remodeling and its prevention by artificial gravity in weightless environment","volume":"113","author":"Zhang","year":"2013","journal-title":"Eur. J. Appl. Physiol."},{"issue":"2","key":"10.1016\/j.lfs.2019.117253_bb0050","article-title":"Microgravity induced cardiovascular deconditioning: peripheral effector mechanism hypothesis and gravity-based countermeasure","volume":"7","author":"Zhang","year":"2000","journal-title":"J. Gravit. Physiol."},{"issue":"9","key":"10.1016\/j.lfs.2019.117253_bb0055","first-page":"852","article-title":"Angiotensinogen and AT1R expression in cerebral and femoral arteries during hindlimb unloading in rats","volume":"78","author":"Bao","year":"2007","journal-title":"Aviat. Space Environ. Med."},{"issue":"1","key":"10.1016\/j.lfs.2019.117253_bb0060","doi-asserted-by":"crossref","first-page":"H691","DOI":"10.1152\/ajpheart.01229.2006","article-title":"Differential regulation of L-type Ca2+ channels in cerebral and mesenteric arteries after simulated microgravity in rats and its intervention by standing","volume":"293","author":"Xue","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"2","key":"10.1016\/j.lfs.2019.117253_bb0065","article-title":"Vasoconstrictor responsiveness of hind body vascular beds is diminished in tail-suspended rats","volume":"7","author":"Ma","year":"2000","journal-title":"J. Gravit. Physiol."},{"issue":"2","key":"10.1016\/j.lfs.2019.117253_bb0070","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s13105-015-0398-8","article-title":"28-Day hindlimb unweighting reduces expression of Rho kinase and inhibits its effects in femoral artery of rat","volume":"71","author":"Wang","year":"2015","journal-title":"J. Physiol. Biochem."},{"issue":"5","key":"10.1016\/j.lfs.2019.117253_bb0075","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/1440-1681.12381","article-title":"Simulated microgravity promotes monocyte adhesion to rat aortic endothelium via nuclear factor-kappaB activation","volume":"42","author":"Liu","year":"2015","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"3","key":"10.1016\/j.lfs.2019.117253_bb0080","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrm.2017.107","article-title":"Sphingolipids and their metabolism in physiology and disease","volume":"19","author":"Hannun","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"15","key":"10.1016\/j.lfs.2019.117253_bb0085","article-title":"Meeting report - the 2019 FEBS special meeting on sphingolipid biology: sphingolipids in physiology and pathology","volume":"132","author":"D\u2019Angelo","year":"2019","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.lfs.2019.117253_bb0090","first-page":"1","article-title":"Risky lipids: refining the ceramide score that measures cardiovascular health","volume":"0","author":"Poss","year":"2019","journal-title":"Eur. Heart J."},{"issue":"2","key":"10.1016\/j.lfs.2019.117253_bb0095","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20020411","article-title":"Ceramide and regulation of vascular tone","volume":"20","author":"Cogolludo","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.lfs.2019.117253_bb0100","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.healun.2019.02.008","article-title":"Acid sphingomyelinase deficiency (Niemann-Pick disease type B) as an inflammatory disease","volume":"38","author":"Lidove","year":"2019","journal-title":"J. Heart Lung Transplant."},{"issue":"11","key":"10.1016\/j.lfs.2019.117253_bb0105","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.13065","article-title":"Solving the secretory acid sphingomyelinase puzzle: insights from lysosome-mediated parasite invasion and plasma membrane repair","volume":"21","author":"Andrews","year":"2019","journal-title":"Cell. Microbiol."},{"issue":"1","key":"10.1016\/j.lfs.2019.117253_bb0110","doi-asserted-by":"crossref","first-page":"e30387","DOI":"10.1371\/journal.pone.0030387","article-title":"Lysosome-membrane fusion mediated superoxide production in hyperglycaemia-induced endothelial dysfunction","volume":"7","author":"Bao","year":"2012","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.lfs.2019.117253_bb0115","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1097\/00005768-199608000-00007","article-title":"Cardiovascular adaptation to spaceflight","volume":"28","author":"Hargens","year":"1996","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.lfs.2019.117253_bb0120","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau8650","article-title":"The NASA twins study: a multidimensional analysis of a year-long human spaceflight","volume":"364","author":"Garrett-Bakelman","year":"2019","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.lfs.2019.117253_bb0125","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3357\/AMHP.4493.2016","article-title":"Carotid and femoral artery intima-media thickness during 6 months of spaceflight","volume":"87","author":"Arbeille","year":"2016","journal-title":"Aerosp. Med. Hum. Perform."},{"issue":"5","key":"10.1016\/j.lfs.2019.117253_bb0130","doi-asserted-by":"crossref","first-page":"H628","DOI":"10.1152\/ajpheart.00802.2015","article-title":"Increased postflight carotid artery stiffness and inflight insulin resistance resulting from 6-mo spaceflight in male and female astronauts","volume":"310","author":"Hughson","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"5","key":"10.1016\/j.lfs.2019.117253_bb0135","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1152\/jappl.1998.85.5.1615","article-title":"Simulated microgravity increases myogenic tone in rat cerebral arteries","volume":"85","author":"Geary","year":"1998","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.1016\/j.lfs.2019.117253_bb0140","series-title":"Handbook of Physiology. Environmental Physiology","first-page":"631","article-title":"The cardiovascular system in microgravity","volume":"vol. I","author":"Watenpaugh","year":"1996"},{"issue":"1","key":"10.1016\/j.lfs.2019.117253_bb0145","article-title":"Human cardiovascular acclimation to microgravity","volume":"5","author":"Watenpaugh","year":"1998","journal-title":"J. Gravit. Physiol."},{"issue":"6","key":"10.1016\/j.lfs.2019.117253_bb0150","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1096\/fj.12-222687","article-title":"Spaceflight-induced alterations in cerebral artery vasoconstrictor, mechanical, and structural properties: implications for elevated cerebral perfusion and intracranial pressure","volume":"27","author":"Taylor","year":"2013","journal-title":"FASEB J."},{"issue":"4","key":"10.1016\/j.lfs.2019.117253_bb0155","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1152\/jappl.2000.88.4.1199","article-title":"Rat small mesenteric artery function after hindlimb suspension","volume":"88","author":"Looft-Wilson","year":"2000","journal-title":"J. Appl. Physiol. (1985)"},{"issue":"6","key":"10.1016\/j.lfs.2019.117253_bb0160","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1152\/japplphysiol.00493.2009","article-title":"Contrasting effects of simulated microgravity with and without daily -Gx gravitation on structure and function of cerebral and mesenteric small arteries in rats","volume":"107","author":"Lin","year":"2009","journal-title":"J. Appl. Physiol. (1985)"},{"issue":"2","key":"10.1016\/j.lfs.2019.117253_bb0165","first-page":"107","article-title":"Mechanical properties and composition of mesenteric small arteries of simulated microgravity rats with and without daily -G(x) gravitation","volume":"64","author":"Gao","year":"2012","journal-title":"Sheng Li Xue Bao"},{"issue":"1","key":"10.1016\/j.lfs.2019.117253_bb0170","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1096\/fj.12-218503","article-title":"Effects of spaceflight and ground recovery on mesenteric artery and vein constrictor properties in mice","volume":"27","author":"Behnke","year":"2013","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.lfs.2019.117253_bb0175","first-page":"5","article-title":"Effects of simulated weightlessness on arterial vasculature (an experimental study on vascular deconditioning)","volume":"3","author":"Zhang","year":"1996","journal-title":"J. Gravit. Physiol."},{"issue":"9","key":"10.1016\/j.lfs.2019.117253_bb0180","doi-asserted-by":"crossref","first-page":"14636","DOI":"10.1002\/jcb.28725","article-title":"Promotion of PTEN on apoptosis through PI3K\/Akt signal in vascular smooth muscle cells of mice model of coronary heart disease","volume":"120","author":"Wang","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"5","key":"10.1016\/j.lfs.2019.117253_bb0185","first-page":"4457","article-title":"MicroRNA-494 inhibits apoptosis of murine vascular smooth muscle cells in vitro","volume":"19","author":"Cui","year":"2019","journal-title":"Mol. Med. Rep."},{"issue":"8","key":"10.1016\/j.lfs.2019.117253_bb0190","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1139\/cjpp-2017-0665","article-title":"Focal adhesions are involved in simulated-microgravity-induced basilar and femoral arterial remodelling in rats","volume":"96","author":"Jiang","year":"2018","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"5","key":"10.1016\/j.lfs.2019.117253_bb0195","doi-asserted-by":"crossref","first-page":"e19775","DOI":"10.1371\/journal.pone.0019775","article-title":"Differential regulation and recovery of intracellular Ca2+ in cerebral and small mesenteric arterial smooth muscle cells of simulated microgravity rat","volume":"6","author":"Xue","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.lfs.2019.117253_bb0200","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s12013-012-9460-0","article-title":"Simulated microgravity exposure modulates the phenotype of cultured vascular smooth muscle cells","volume":"66","author":"Kang","year":"2013","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.lfs.2019.117253_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113299","article-title":"Distribution, partitioning, and seasonal variation of lipophilic marine algal toxins in aquatic environments of a typical semi-closed mariculture bay","volume":"255","author":"Wu","year":"2019","journal-title":"Environ. Pollut."},{"issue":"2","key":"10.1016\/j.lfs.2019.117253_bb0210","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1556\/APhysiol.96.2009.2.3","article-title":"Regional specificity of adaptation change in large elastic arteries of simulated microgravity rats","volume":"96","author":"Gao","year":"2009","journal-title":"Acta Physiol. Hung."},{"issue":"8","key":"10.1016\/j.lfs.2019.117253_bb0215","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1139\/cjpp-2014-0066","article-title":"Simulated microgravity induces an inflammatory response in the common carotid artery of rats","volume":"92","author":"Liu","year":"2014","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"6","key":"10.1016\/j.lfs.2019.117253_bb0220","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1096\/fj.13-245654","article-title":"Simulated microgravity-induced mitochondrial dysfunction in rat cerebral arteries","volume":"28","author":"Zhang","year":"2014","journal-title":"FASEB J."},{"issue":"10","key":"10.1016\/j.lfs.2019.117253_bb0225","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1440-1681.2011.05565.x","article-title":"Nitric oxide synthase activity in the abdominal aorta of rats is decreased after 4 weeks of simulated microgravity","volume":"38","author":"Ren","year":"2011","journal-title":"Clin. Exp. Pharmacol. P"},{"key":"10.1016\/j.lfs.2019.117253_bb0230","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.2741\/4448","article-title":"Vascular sphingolipids in physiological and pathological adaptation","volume":"21","author":"Bao","year":"2016","journal-title":"Front. Biosci. (Landmark Ed)"},{"issue":"6","key":"10.1016\/j.lfs.2019.117253_bb0235","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1042\/CS20180911","article-title":"Potential therapeutic targets for atherosclerosis in sphingolipid metabolism","volume":"133","author":"Yu","year":"2019","journal-title":"Clin. Sci. (Lond.)"},{"issue":"12","key":"10.1016\/j.lfs.2019.117253_bb0240","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1161\/ATVBAHA.116.307497","article-title":"Circulating ceramides predict cardiovascular outcomes in the population-based FINRISK 2002 cohort","volume":"36","author":"Havulinna","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"5","key":"10.1016\/j.lfs.2019.117253_bb0245","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1111\/acel.12491","article-title":"Circulating ceramides are inversely associated with cardiorespiratory fitness in participants aged 54\u201396 years from the Baltimore Longitudinal Study of Aging","volume":"15","author":"Fabbri","year":"2016","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.lfs.2019.117253_bb0250","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1038\/s41467-019-09654-4","article-title":"Ceramides bind VDAC2 to trigger mitochondrial apoptosis","volume":"10","author":"Dadsena","year":"2019","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.lfs.2019.117253_bb0255","doi-asserted-by":"crossref","first-page":"280","DOI":"10.33594\/000000021","article-title":"Acid sphingomyelinase-ceramide system in bacterial infections","volume":"52","author":"Li","year":"2019","journal-title":"Cell. Physiol. Biochem."},{"issue":"7","key":"10.1016\/j.lfs.2019.117253_bb0260","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021817","article-title":"Hypertension is associated with marked alterations in sphingolipid biology: a potential role for ceramide","volume":"6","author":"Spijkers","year":"2011","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.lfs.2019.117253_bb0265","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.5551\/jat.32383","article-title":"Acid sphingomyelinase mediates oxidized-LDL induced apoptosis in macrophage via endoplasmic reticulum stress","volume":"23","author":"Zhao","year":"2016","journal-title":"J. Atheroscler. Thromb."},{"issue":"10","key":"10.1016\/j.lfs.2019.117253_bb0270","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1002\/jcp.25939","article-title":"Sphingolipids metabolism in the salivary glands of rats with obesity and streptozotocin induced diabetes","volume":"232","author":"Garbowska","year":"2017","journal-title":"J. Cell. Physiol."},{"issue":"25","key":"10.1016\/j.lfs.2019.117253_bb0275","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1093\/eurheartj\/ehw148","article-title":"Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol","volume":"37","author":"Laaksonen","year":"2016","journal-title":"Eur. Heart J."},{"issue":"5\u20136","key":"10.1016\/j.lfs.2019.117253_bb0280","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00424-017-1969-z","article-title":"Acid sphingomyelinase\/ceramide regulates carotid intima-media thickness in simulated weightless rats","volume":"469","author":"Cheng","year":"2017","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.lfs.2019.117253_bb0285","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3389\/fphys.2014.00331","article-title":"Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons","volume":"5","author":"Beckmann","year":"2014","journal-title":"Front. Physiol."},{"issue":"10","key":"10.1016\/j.lfs.2019.117253_bb0290","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/tra.12587","article-title":"Mechanisms of lysosomal positioning and movement","volume":"19","author":"Cabukusta","year":"2018","journal-title":"Traffic"},{"issue":"23","key":"10.1016\/j.lfs.2019.117253_bb0295","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1242\/jcs.196287","article-title":"Mechanisms and functions of lysosome positioning","volume":"129","author":"Pu","year":"2016","journal-title":"J. Cell Sci."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320519311816?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320519311816?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T13:32:33Z","timestamp":1726061553000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320519311816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":59,"alternative-id":["S0024320519311816"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2019.117253","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acid sphingomyelinase\/ceramide mediates structural remodeling of cerebral artery and small mesenteric artery in simulated weightless rats","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2019.117253","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117253"}}