{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T11:44:37Z","timestamp":1782906277165,"version":"3.54.5"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571217"],"award-info":[{"award-number":["81571217"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.lfs.2020.117360","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T11:10:30Z","timestamp":1580123430000},"page":"117360","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Progesterone attenuates A\u03b225\u201335-induced neuronal toxicity by activating the Ras signalling pathway through progesterone receptor membrane component 1"],"prefix":"10.1016","volume":"253","author":[{"given":"Zhigang","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghai","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengpeng","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanning","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2020.117360_bb0005","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1017\/S135561771700100X","article-title":"Alzheimer\u2019s disease: past, present, and future","volume":"23","author":"Bondi","year":"2017","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10.1016\/j.lfs.2020.117360_bb0010","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neubiorev.2016.04.012","article-title":"Alzheimer, mitochondria and gender","volume":"67","author":"Grimm","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.lfs.2020.117360_bb0015","first-page":"383","article-title":"Neurosteroids: biosynthesis and function","volume":"9","author":"Robel","year":"1995","journal-title":"Crit. Rev. Neurobiol."},{"key":"10.1016\/j.lfs.2020.117360_bb0020","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.yhbeh.2012.06.003","article-title":"Progesterone and neuroprotection","volume":"63","author":"Singh","year":"2013","journal-title":"Horm. Behav."},{"key":"10.1016\/j.lfs.2020.117360_bb0025","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1002\/jnr.21370","article-title":"Progesterone increases brain-derived neuroptrophic factor expression and protects against glutamate toxicity in a mitogen-activated protein kinase- and phosphoinositide-3 kinase-dependent manner in cerebral cortical explants","volume":"85","author":"Kaur","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.lfs.2020.117360_bb0030","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1097\/00001756-200205070-00018","article-title":"Impact of progestins on estradiol potentiation of the glutamate calcium response","volume":"13","author":"Nilsen","year":"2002","journal-title":"Neuroreport"},{"key":"10.1016\/j.lfs.2020.117360_bb0035","doi-asserted-by":"crossref","first-page":"10506","DOI":"10.1073\/pnas.1334098100","article-title":"Divergent impact of progesterone and medroxyprogesterone acetate (provera) on nuclear mitogen-activated protein kinase signaling","volume":"100","author":"Nilsen","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2020.117360_bb0040","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1046\/j.1471-4159.1996.66051836.x","article-title":"Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid beta-peptide toxicity in hippocampal neurons","volume":"66","author":"Goodman","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/j.lfs.2020.117360_bb0045","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.1016\/j.jmb.2016.06.020","article-title":"Progesterone receptor signaling mechanisms","volume":"428","author":"Grimm","year":"2016","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.lfs.2020.117360_bb0050","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.yfrne.2008.02.001","article-title":"Progesterone receptors: form and function in brain","volume":"29","author":"Brinton","year":"2008","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.lfs.2020.117360_bb0055","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1210\/en.2007-1050","volume":"149","author":"Peluso","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.lfs.2020.117360_bb0060","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1095\/biolreprod.112.103036","article-title":"Plasminogen activator inhibitor 1 RNA-binding protein interacts with progesterone receptor membrane component 1 to regulate progesterone\u2019s ability to maintain the viability of spontaneously immortalized granulosa cells and rat granulosa cells","volume":"88","author":"Peluso","year":"2013","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.lfs.2020.117360_bb0065","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/j.ajog.2010.10.057","article-title":"Progesterone receptor membrane component 1 (Pgrmc1) inhibits Ca2+ mediated cell death in human cytotrophoblast cells","volume":"204","author":"Murtha","year":"2011","journal-title":"Am. J. Obst. Gynecol."},{"key":"10.1016\/j.lfs.2020.117360_bb0070","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neuroscience.2012.09.056","article-title":"Progesterone, brain-derived neurotrophic factor and neuroprotection","volume":"239","author":"Singh","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.lfs.2020.117360_bb0075","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1210\/en.2015-1610","article-title":"Pgrmc1\/BDNF signaling plays a critical role in mediating glia-neuron cross talk","volume":"157","author":"Sun","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.lfs.2020.117360_bb0080","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jsbmb.2015.01.002","article-title":"Progesterone attenuates A\u03b225-35-induced neuronal toxicity via JNK inactivation and progesterone receptor membrane component 1-dependent inhibition of mitochondrial apoptotic pathway","volume":"154","author":"Qin","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.lfs.2020.117360_bb0085","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1021\/cb100294v","article-title":"Identification of direct protein targets of small molecules","volume":"6","author":"Lomenick","year":"2011","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.lfs.2020.117360_bb0090","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1039\/C6NP00001K","article-title":"Chemical proteomics approaches for identifying the cellular targets of natural products","volume":"33","author":"Wright","year":"2016","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.lfs.2020.117360_bb0095","article-title":"Revealing the inhibitory effect of ginseng on mitochondrial respiration through synaptosomal proteomics","volume":"18","author":"Kong","year":"2018","journal-title":"Proteomics"},{"key":"10.1016\/j.lfs.2020.117360_bb0100","doi-asserted-by":"crossref","first-page":"116979","DOI":"10.1016\/j.lfs.2019.116979","article-title":"Effects of progesterone on glucose uptake in neurons of Alzheimer\u2019s disease animals and cell models","volume":"238","author":"Wu","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2020.117360_bb0105","first-page":"2800","article-title":"Metabolic alteration of neuroactive steroids and protective effect of progesterone in Alzheimer\u2019s disease-like rats","volume":"8","author":"Liu","year":"2013","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.lfs.2020.117360_bb0110","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1476-5381.2012.02057.x","article-title":"Alzheimer\u2019s disease, beta-amyloid, glutamate, NMDA receptors and memantine-searching for the connections","volume":"167","author":"Danysz","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117360_bb0115","doi-asserted-by":"crossref","first-page":"20504","DOI":"10.1073\/pnas.0908083106","article-title":"Glun2b subunit-containing NMDA receptor antagonists prevent A\u03b2-mediated synaptic plasticity disruption in vivo","volume":"106","author":"Hu","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2020.117360_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18081813","article-title":"Towards a better understanding of GABAergic remodeling in Alzheimer\u2019s disease","volume":"18","author":"Govindpani","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2020.117360_bb0125","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/jnc.14325","article-title":"GABA-A receptor subunit expression changes in the human Alzheimer\u2019s disease hippocampus, subiculum, entorhinal cortex and superior temporal gyrus","volume":"145","author":"Kwakowsky","year":"2018","journal-title":"J. Neurochem."},{"key":"10.1016\/j.lfs.2020.117360_bb0130","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neuroscience.2017.03.041","article-title":"Impaired expression of GABA transporters in the human Alzheimer\u2019s disease hippocampus, subiculum, entorhinal cortex and superior temporal gyrus","volume":"351","author":"Fuhrer","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.lfs.2020.117360_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jsbmb.2012.12.013","article-title":"Allopregnanolone-mediated protective effects of progesterone on tributyltin-induced neuronal injury in rat hippocampal slices","volume":"135","author":"Ishihara","year":"2013","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.lfs.2020.117360_bb0140","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1126\/science.2422758","article-title":"Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor","volume":"232","author":"Majewska","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.lfs.2020.117360_bb0145","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0028-3908(02)00172-7","article-title":"The influence of subunit composition on the interaction of neurosteroids with GABA-A receptors","volume":"43","author":"Belelli","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.lfs.2020.117360_bb0150","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S0166-2236(99)01399-5","article-title":"Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives","volume":"22","author":"Rupprecht","year":"1999","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.lfs.2020.117360_bb0155","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0165-0173(01)00127-8","article-title":"The role of GABAergic neuroactive steroids in ethanol action, tolerance and dependence","volume":"37","author":"Morrow","year":"2001","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.lfs.2020.117360_bb0160","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.1523\/JNEUROSCI.16-13-04047.1996","article-title":"Regulation of neuromodulatory actions of angiotensin II in the brain neurons by the Ras-dependent mitogen-activated protein kinase pathway","volume":"16","author":"Yang","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2020.117360_bb0165","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.mehy.2017.10.012","article-title":"Neuroprotective potential of high-dose biotin","volume":"109","author":"McCarty","year":"2017","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.lfs.2020.117360_bb0170","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.tig.2008.07.005","article-title":"Oncogenes on my mind: ERK and MTOR signaling in cognitive diseases","volume":"24","author":"Krab","year":"2008","journal-title":"Trends Genet."},{"key":"10.1016\/j.lfs.2020.117360_bb0175","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1523\/JNEUROSCI.20-07-02504.2000","article-title":"Regulation of long-term potentiation by H-Ras through NMDA receptor phosphorylation","volume":"20","author":"Manabe","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2020.117360_bb0180","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuroscience.2012.02.002","article-title":"Ovarian steroids increase spinogenetic proteins in the macaque dorsal raphe","volume":"208","author":"Rivera","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.lfs.2020.117360_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.2006.04208.x","article-title":"Regulation of mitogen-activated protein kinases by glutamate receptors","volume":"100","author":"Wang","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.lfs.2020.117360_bb0190","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1042\/BST0331033","article-title":"Insulin and cholesterol pathways in neuronal function, memory and neurodegeneration","volume":"33","author":"Nelson","year":"2005","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.lfs.2020.117360_bb0195","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.neuint.2016.08.011","article-title":"The therapeutic potential of sulforaphane on light-induced photoreceptor degeneration through antiapoptosis and antioxidant protection","volume":"100","author":"Kong","year":"2016","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.lfs.2020.117360_bb0200","doi-asserted-by":"crossref","first-page":"G673","DOI":"10.1152\/ajpgi.00584.2006","article-title":"PGE2 inhibits apoptosis in human adenocarcinoma Caco-2 cell line through Ras-PI3K association and cAMP-dependent kinase a activation","volume":"293","author":"Leone","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.lfs.2020.117360_bb0205","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1021\/jf505275s","article-title":"Blockade of the Ras\/Raf\/ERK and Ras\/PI3K\/Akt pathways by Monacolin K reduces the expression of Glo1 and induces apoptosis in U937 cells","volume":"63","author":"Chen","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.lfs.2020.117360_bb0210","first-page":"611","article-title":"Src homology phosphotyrosyl phosphatase 2 mediates cisplatin-related drug resistance by inhibiting apoptosis and activating the Ras\/PI3K\/Akt1\/survivin pathway in lung cancer cells","volume":"39","author":"Tang","year":"2018","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.lfs.2020.117360_bb0215","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1093\/emboj\/17.7.2008","article-title":"Activation of the Src\/p21ras\/ERK pathway by progesterone receptor via cross-talk with estrogen receptor","volume":"17","author":"Migliaccio","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.lfs.2020.117360_bb0220","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1385\/ENDO:14:3:407","article-title":"Ovarian hormones elicit phosphorylation of Akt and extracellular-signal regulated kinase in explants of the cerebral cortex","volume":"14","author":"Singh","year":"2001","journal-title":"Endocrine"},{"key":"10.1016\/j.lfs.2020.117360_bb0225","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1210\/endo.143.1.8582","article-title":"Impact of Progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-Norprogesterone and antagonism by medroxyprogesterone acetate","volume":"143","author":"Nilsen","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.lfs.2020.117360_bb0230","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1530\/JOE-14-0576","article-title":"Role of Pgrmc1 in estrogen maintenance of meiotic arrest in zebrafish oocytes through GPER\/EGFR","volume":"225","author":"Aizen","year":"2015","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.lfs.2020.117360_bb0235","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1158\/0008-5472.CAN-16-0938","article-title":"The Ras-effector interaction as a drug target","volume":"77","author":"Keeton","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2020.117360_bb0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0196232","article-title":"FTI-277 inhibits smooth muscle cell calcification by up-regulating PI3K\/Akt signaling and inhibiting apoptosis","volume":"13","author":"Ponnusamy","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2020.117360_bb0245","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/sj.leu.2402832","article-title":"The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells","volume":"17","author":"Bolick","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.lfs.2020.117360_bb0250","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.bbrc.2010.10.123","article-title":"Long-term treatment of farnesyltransferase inhibitor FTI-277 induces neurotoxicity of hippocampal neurons from rat embryo in a ROS-dependent manner","volume":"403","author":"Kim","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2020.117360_bb0255","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1016\/j.chembiol.2014.09.018","article-title":"Rational design of small molecule inhibitors targeting the Ras Gef, Sos1","volume":"21","author":"Evelyn","year":"2014","journal-title":"Chem. Biol."},{"key":"10.1016\/j.lfs.2020.117360_bb0260","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/s41598-017-01364-5","article-title":"Grb2 carboxyl-terminal SH3 domain can bivalently associate with two ligands, in an SH3 dependent manner","volume":"7","author":"Arya","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2020.117360_bb0265","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1021\/acs.molpharmaceut.6b00952","article-title":"Targeted covalent inhibition of Grb2-Sos1 interaction through proximity-induced conjugation in breast cancer cells","volume":"14","author":"Yu","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.lfs.2020.117360_bb0270","series-title":"Signaling Mechanisms Regulating T Cell Diversity and Function","first-page":"147","article-title":"Transmission of T cell receptor-mediated signaling via the Grb2 family of adaptor proteins","author":"Bilal","year":"2018"},{"key":"10.1016\/j.lfs.2020.117360_bb0275","doi-asserted-by":"crossref","first-page":"11166","DOI":"10.1021\/acs.jpcb.8b06320","article-title":"Folding mechanism of the SH3 domain from Grb2","volume":"122","author":"Troilo","year":"2018","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.lfs.2020.117360_bb0280","first-page":"339","article-title":"The emerging role of progesterone receptor membrane component 1 (Pgrmc1) in cancer biology","volume":"1866","author":"Cahill","year":"2016","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520301077?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520301077?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:35:24Z","timestamp":1758400524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320520301077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":56,"alternative-id":["S0024320520301077"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.117360","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Progesterone attenuates A\u03b225\u201335-induced neuronal toxicity by activating the Ras signalling pathway through progesterone receptor membrane component 1","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.117360","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117360"}}