{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:12:23Z","timestamp":1790691143126,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007787","name":"National Research Centre","doi-asserted-by":"publisher","award":["NRC 2\/1\/4"],"award-info":[{"award-number":["NRC 2\/1\/4"]}],"id":[{"id":"10.13039\/100007787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.lfs.2020.117458","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T02:52:51Z","timestamp":1582253571000},"page":"117458","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["New combination therapy of gliclazide and quercetin for protection against STZ-induced diabetic rats"],"prefix":"10.1016","volume":"247","author":[{"given":"Noha F.","family":"Abdelkader","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hebatollah E.","family":"Eitah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousreya A.","family":"Maklad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina A.","family":"Gamaleldin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal A.","family":"Badawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanaa A.","family":"Kenawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2020.117458_bb0005","first-page":"45","article-title":"Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links","volume":"11","author":"Oguntibeju","year":"2019","journal-title":"Int. J. Physiol. Pathophysiol. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117458_bb0010","series-title":"International Diabetes Federation, IDF Diabetes Atlas","author":"Atlas","year":"2015"},{"key":"10.1016\/j.lfs.2020.117458_bb0015","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.apjtm.2016.07.014","article-title":"Changes of adipocytokine expression after diabetic rats received sitagliptin and the molecular mechanism","volume":"9","author":"Wu","year":"2016","journal-title":"Asian Pac J Trop Med"},{"key":"10.1016\/j.lfs.2020.117458_bb0020","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.biopha.2018.10.130","article-title":"In vitro and in vivo evidence that quercetin protects against diabetes and its complications: a systematic review of the literature","volume":"109","author":"Shi","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.lfs.2020.117458_bb0025","first-page":"e13127","article-title":"Quercetin modulates hyperglycemia by improving the pancreatic antioxidant status and enzymes activities linked with glucose metabolism in type 2 diabetes model of rats: In silico studies of molecular interaction of quercetin with hexokinase and catalase","author":"Oyedemi","year":"2019","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.lfs.2020.117458_bb0030","series-title":"The Islets of Langerhans","first-page":"501","article-title":"The \u03b2-cell in human type 2 diabetes","author":"Marchetti","year":"2010"},{"key":"10.1016\/j.lfs.2020.117458_bb0035","doi-asserted-by":"crossref","first-page":"222","DOI":"10.2119\/2007-00119.Tilg","article-title":"Inflammatory mechanisms in the regulation of insulin resistance","volume":"14","author":"Tilg","year":"2008","journal-title":"Mol. Med."},{"key":"10.1016\/j.lfs.2020.117458_bb0040","doi-asserted-by":"crossref","first-page":"S119","DOI":"10.2337\/diabetes.53.2007.S119","article-title":"\u03b2-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes","volume":"53","author":"Robertson","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.lfs.2020.117458_bb0045","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF02536034","article-title":"Mechanisms of free radical oxidation of unsaturated lipids","volume":"30","author":"Porter","year":"1995","journal-title":"Lipids."},{"key":"10.1016\/j.lfs.2020.117458_bb0050","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.cmet.2016.04.011","article-title":"Adiponectin, leptin, and fatty acids in the maintenance of metabolic homeostasis through adipose tissue crosstalk","volume":"23","author":"Stern","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.lfs.2020.117458_bb0055","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1161\/01.ATV.20.6.1595","article-title":"Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients","volume":"20","author":"Hotta","year":"2000","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.lfs.2020.117458_bb0060","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1503\/cmaj.1031414","article-title":"Oral antihyperglycemic therapy for type 2 diabetes mellitus","volume":"172","author":"Cheng","year":"2005","journal-title":"Cmaj."},{"key":"10.1016\/j.lfs.2020.117458_bb0065","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.2174\/1381612054546879","article-title":"Insulin secretagogues, sulfonylurea receptors and KATP channels","volume":"11","author":"Bryan","year":"2005","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.lfs.2020.117458_bb0070","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.2165\/00003495-200464120-00006","article-title":"The role of sulphonylureas in the management of type 2 diabetes mellitus","volume":"64","author":"Rendell","year":"2004","journal-title":"Drugs."},{"key":"10.1016\/j.lfs.2020.117458_bb0075","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/dmrr.770","article-title":"Marchetti, \u00df-cell function and anti-diabetic pharmacotherapy","volume":"23","author":"Del Prato","year":"2007","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.lfs.2020.117458_bb0080","first-page":"108736","article-title":"Antidiabetic effect of quercetin: a systematic review and meta-analysis of animal studies","volume":"127","author":"Bule","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.lfs.2020.117458_bb0085","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.3390\/nu11102288","article-title":"Dietary Quercetin and Kaempferol: bioavailability and potential cardiovascular-related bioactivity in humans","volume":"11","author":"Dabeek","year":"2019","journal-title":"Nutrients."},{"key":"10.1016\/j.lfs.2020.117458_bb0090","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.lfs.2010.07.004","article-title":"Quercetin: a potential drug to reverse multidrug resistance","volume":"87","author":"Chen","year":"2010","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2020.117458_bb0095","first-page":"701","article-title":"Quercetin and metabolic syndrome","volume":"3","author":"Kumar","year":"2016","journal-title":"EJPMR."},{"key":"10.1016\/j.lfs.2020.117458_bb0100","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.taap.2018.12.011","article-title":"Modulating impacts of quercetin\/sitagliptin combination on streptozotocin-induced diabetes mellitus in rats","volume":"365","author":"Eitah","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117458_bb0105","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.phrs.2004.06.002","article-title":"Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and \u03b2-cell damage in rat pancreas","volume":"51","author":"Coskun","year":"2005","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.lfs.2020.117458_bb0110","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1124\/jpet.106.109702","article-title":"Nicotinamide reverses neurological and neurovascular deficits in streptozotocin diabetic rats","volume":"320","author":"Stevens","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2020.117458_bb0115","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1258\/la.2010.010090","article-title":"Single dose streptozotocin-induced diabetes: considerations for study design in islet transplantation models","volume":"45","author":"Deeds","year":"2011","journal-title":"Lab. Anim."},{"key":"10.1016\/j.lfs.2020.117458_bb0120","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/0002-9343(91)90413-R","article-title":"Improvement in glucose-induced insulin secretion in diabetic rats after long-term gliclazide treatment: a comparative study using different models of non-insulin-dependent diabetes mellitus induced by neonatal streptozotocin","volume":"90","author":"Portha","year":"1991","journal-title":"Am. J. Med."},{"key":"10.1016\/j.lfs.2020.117458_bb0125","first-page":"123","article-title":"Quercetin allievates oxidative stress in streptozotocin-induced diabetic rats","volume":"18","author":"Mahesh","year":"2004","journal-title":"Phyther. Res. An Int. J. Devoted to Pharmacol. Toxicol. Eval. Nat. Prod. Deriv."},{"key":"10.1016\/j.lfs.2020.117458_bb0130","series-title":"Simple Assay for the Level of Total Lipid Peroxides in Serum or Plasma, in: Free Radic","first-page":"101","author":"Yagi","year":"1998"},{"key":"10.1016\/j.lfs.2020.117458_bb0135","series-title":"Carleton\u2019s Histological Technique","author":"Carleton","year":"1980"},{"key":"10.1016\/j.lfs.2020.117458_bb0140","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1124\/pr.58.3.10","article-title":"Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies","volume":"58","author":"Chou","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.lfs.2020.117458_bb0145","first-page":"1751","article-title":"Study of the effect of gliclazide and garlic extract on blood sugar level in STZ-induced diabetic male mice","author":"Khayatnouri","year":"2011","journal-title":"Adv. Environ. Biol."},{"key":"10.1016\/j.lfs.2020.117458_bb0150","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1055\/s-2007-979838","article-title":"Characterization of the molecular mode of action of the sulfonylurea, glimepiride, at \u03b2-cells","volume":"28","author":"Kramer","year":"1996","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.lfs.2020.117458_bb0155","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.2337\/diabetes.50.8.1778","article-title":"Acute and short-term administration of a sulfonylurea (gliclazide) increases pulsatile insulin secretion in type 2 diabetes","volume":"50","author":"Juhl","year":"2001","journal-title":"Diabetes."},{"key":"10.1016\/j.lfs.2020.117458_bb0160","doi-asserted-by":"crossref","first-page":"577","DOI":"10.4103\/2230-8210.163171","article-title":"Place of sulfonylureas in the management of type 2 diabetes mellitus in South Asia: a consensus statement","volume":"19","author":"Kalra","year":"2015","journal-title":"Indian J. Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2020.117458_bb0165","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4162\/nrp.2011.5.2.107","article-title":"Quercetin attenuates fasting and postprandial hyperglycemia in animal models of diabetes mellitus","volume":"5","author":"Kim","year":"2011","journal-title":"Nutr. Res. Pract."},{"key":"10.1016\/j.lfs.2020.117458_bb0170","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3177\/jnsv.53.166","article-title":"Characterization of inhibitors of postprandial hyperglycemia from the leaves of Nerium indicum","volume":"53","author":"Ishikawa","year":"2007","journal-title":"J. Nutr. Sci. Vitaminol. (Tokyo)"},{"key":"10.1016\/j.lfs.2020.117458_bb0175","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1517\/14728222.2016.1086752","article-title":"The AMPK enzyme-complex: from the regulation of cellular energy homeostasis to a possible new molecular target in the management of chronic inflammatory disorders","volume":"20","author":"Antonioli","year":"2016","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.lfs.2020.117458_bb0180","series-title":"Antidiabetic effects of quercetin in streptozocin-induced diabetic rats","first-page":"357","volume":"135","author":"Vessal","year":"2003"},{"key":"10.1016\/j.lfs.2020.117458_bb0185","first-page":"1723","article-title":"Effects of metformin plus gliclazide versus metformin plus glimepiride on cardiovascular risk factors in patients with type 2 diabetes mellitus","volume":"28","author":"Hassan","year":"2015","journal-title":"Pak. J. Pharm. Sci."},{"key":"10.1016\/j.lfs.2020.117458_bb0190","first-page":"42","article-title":"The efficacy of quercetin in alloxan diabetes","volume":"55","author":"Nuraliev","year":"1992","journal-title":"Eksp. Klin. Farmakol."},{"key":"10.1016\/j.lfs.2020.117458_bb0195","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1038\/oby.2008.315","article-title":"Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats","volume":"16","author":"Rivera","year":"2008","journal-title":"Obesity."},{"key":"10.1016\/j.lfs.2020.117458_bb0200","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jnutbio.2006.01.001","article-title":"Effects of dietary factors on oxidation of low-density lipoprotein particles","volume":"17","author":"Lapointe","year":"2006","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.lfs.2020.117458_bb0205","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s11130-010-0192-2","article-title":"Beneficial effect of S-allylcysteine (SAC) on blood glucose and pancreatic antioxidant system in streptozotocin diabetic rats","volume":"65","author":"Saravanan","year":"2010","journal-title":"Plant Foods Hum. Nutr."},{"key":"10.1016\/j.lfs.2020.117458_bb0210","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.ejphar.2011.02.044","article-title":"Effects of gliclazide on endothelial function in patients with newly diagnosed type 2 diabetes","volume":"659","author":"Chen","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117458_bb0215","first-page":"51","article-title":"Anti-diabetic activity of the petroleum ether extract of Guar gum in streptozotocin-induced diabetic rats: a comparative study","volume":"2","author":"Nasry","year":"2013","journal-title":"Beni-Suef Univ. J. Basic Appl. Sci."},{"key":"10.1016\/j.lfs.2020.117458_bb0220","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S1056-8727(00)00084-2","article-title":"In vitro and in vivo antioxidant properties of gliclazide","volume":"14","author":"O\u2019Brien","year":"2000","journal-title":"J. Diabetes Complicat."},{"key":"10.1016\/j.lfs.2020.117458_bb0225","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/S0026-0495(97)90208-0","article-title":"Gliclazide decreases cell-mediated low-density lipoprotein (LDL) oxidation and reduces monocyte adhesion to endothelial cells induced by oxidatively modified LDL","volume":"46","author":"Desfaits","year":"1997","journal-title":"Metabolism."},{"key":"10.1016\/j.lfs.2020.117458_bb0230","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3844\/ajptsp.2014.84.95","article-title":"quercetin ameliorates diabetic nephropathy in rats via modulation of renal NA+, K+-ATPase expression and oxidative stress","volume":"9","author":"Bashir","year":"2014","journal-title":"Am. J. Pharmacol. Toxicol."},{"key":"10.1016\/j.lfs.2020.117458_bb0235","first-page":"52","article-title":"Quercetin and exercise treatment on the morphology of pancreatic \u03b2-cells of streptozotocin-treated diabetic rats","volume":"5","author":"Adewole","year":"2006","journal-title":"Ann. Biomed. Sci."},{"key":"10.1016\/j.lfs.2020.117458_bb0240","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7683051","article-title":"Nanoencapsulated quercetin improves cardioprotection during hypoxia-reoxygenation injury through preservation of mitochondrial function","volume":"2019","author":"Lozano","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.lfs.2020.117458_bb0245","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2754","article-title":"Quercetin activates AMP-activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity","volume":"222","author":"Lu","year":"2010","journal-title":"J. Pathol."},{"key":"10.1016\/j.lfs.2020.117458_bb0250","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S0026-0495(98)90354-7","article-title":"Gliclazide inhibits diabetic neuropathy irrespective of blood glucose levels in streptozotocin-induced diabetic rats","volume":"47","author":"Qiang","year":"1998","journal-title":"Metabolism."},{"key":"10.1016\/j.lfs.2020.117458_bb0255","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0922-4106(91)90069-T","article-title":"Gliclazide: a general free radical scavenger","volume":"208","author":"Scott","year":"1991","journal-title":"Eur. J. Pharmacol. Mol. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117458_bb0260","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0063784","article-title":"Quercetin protects against diabetes-induced exaggerated vasoconstriction in rats: effect on low grade inflammation","volume":"8","author":"Mahmoud","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2020.117458_bb0265","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1093\/jn\/135.10.2299","article-title":"Quercetin decreases oxidative stress, NF-\u03baB activation, and iNOS overexpression in liver of streptozotocin-induced diabetic rats","volume":"135","author":"Dias","year":"2005","journal-title":"J. Nutr."},{"key":"10.1016\/j.lfs.2020.117458_bb0270","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.diabres.2008.01.031","article-title":"Effects of sulfonylurea drugs on adiponectin production from 3T3-L1 adipocytes: implication of different mechanism from pioglitazone","volume":"81","author":"Kanda","year":"2008","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.lfs.2020.117458_bb0275","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.5897\/AJPP12.644","article-title":"Flaxseed and quercetin improves anti-inflammatory cytokines level and insulin sensitivity in animal model of metabolic syndrome fructose-fed rats","volume":"7","author":"Abdelkarem","year":"2013","journal-title":"Afr. J. Pharm. Pharmacol"},{"key":"10.1016\/j.lfs.2020.117458_bb0280","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ejps.2010.05.004","article-title":"Quercetin enhances adiponectin secretion by a PPAR-\u03b3 independent mechanism","volume":"41","author":"Wein","year":"2010","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.lfs.2020.117458_bb0285","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s12020-012-9866-x","article-title":"Fisetin averts oxidative stress in pancreatic tissues of streptozotocin-induced diabetic rats","volume":"44","author":"Prasath","year":"2013","journal-title":"Endocrine."},{"key":"10.1016\/j.lfs.2020.117458_bb0290","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12986-019-0363-6","article-title":"Whole blueberry protects pancreatic beta-cells in diet-induced obese mouse","volume":"16","author":"Liu","year":"2019","journal-title":"Nutr. Metab. (Lond)."},{"key":"10.1016\/j.lfs.2020.117458_bb0295","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4172\/2155-6156.1000182","article-title":"Effect of quercetin on the endocrine pancreas of the experimentally induced diabetes in male albino rats: a histological and immunohistochemical study","volume":"3","author":"Rifaai","year":"2012","journal-title":"J. Diabetes Metab."},{"key":"10.1016\/j.lfs.2020.117458_bb0300","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/bio.3312","article-title":"Influence of quercetin on the interaction of gliclazide with human serum albumin\u2013spectroscopic and docking approaches","volume":"32","author":"Kamen\u00edkov\u00e1","year":"2017","journal-title":"Luminescence."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002432052030206X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002432052030206X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:31:37Z","timestamp":1758400297000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002432052030206X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":60,"alternative-id":["S002432052030206X"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.117458","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New combination therapy of gliclazide and quercetin for protection against STZ-induced diabetic rats","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.117458","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117458"}}