{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:07:56Z","timestamp":1783030076861,"version":"3.54.6"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007688","name":"American University of Beirut","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007688","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007175","name":"Conseil National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007175","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.lfs.2020.117639","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T11:04:17Z","timestamp":1586171057000},"page":"117639","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Thymoquinone synergizes with arsenic and interferon alpha to target human T-cell leukemia\/lymphoma"],"prefix":"10.1016","volume":"251","author":[{"given":"Marwa","family":"Houssein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maamoun","family":"Fatfat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeina","family":"Habli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasab","family":"Ghazal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Moodad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala","family":"Khalife","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala","family":"Gali-Muhtasib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2020.117639_bb0005","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nrc.2016.63","article-title":"The genetics and mechanisms of T cell acute lymphoblastic leukaemia","volume":"16","author":"Belver","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.lfs.2020.117639_bb0010","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S1470-2045(08)70314-0","article-title":"Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia","volume":"10","author":"Coustan-Smith","year":"2009","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.lfs.2020.117639_bb0015","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1136\/jcp.2007.052456","article-title":"Adult T-cell leukaemia\/lymphoma","volume":"60","author":"Matutes","year":"2007","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.lfs.2020.117639_bb0025","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1535-6108(02)00018-1","article-title":"Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia","volume":"11","author":"Ferrando","year":"2002","journal-title":"Cancer Cell"},{"key":"10.1016\/j.lfs.2020.117639_bb0030","author":"Seiter"},{"key":"10.1016\/j.lfs.2020.117639_bb0035","doi-asserted-by":"crossref","first-page":"e517","DOI":"10.1016\/S1470-2045(14)70202-5","article-title":"Human T-cell leukaemia virus type I and adult T-cell leukaemia-lymphoma","volume":"5","author":"Ishitsuka","year":"2014","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.lfs.2020.117639_bb0040","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3389\/fonc.2020.00273","article-title":"The physiopathology of T-cell acute lymphoblastic leukemia: focus on molecular aspects","volume":"10","author":"Fattizzo","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.lfs.2020.117639_bb0045","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1182\/blood-2016-07-692608","article-title":"Management of adults with T-cell lymphoblastic leukemia","volume":"129","author":"Marks","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.lfs.2020.117639_bb0050","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1182\/blood-2011-03-345702","article-title":"How I treat how I treat adult T-cell leukemia \/ lymphoma","volume":"118","author":"Bazarbachi","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.lfs.2020.117639_bb0055","first-page":"2849","article-title":"Arsenic-interferon-alpha-triggered apoptosis in HTLV-I transformed cells is associated with tax down-regulation and reversal of NF-kappa B activation","volume":"96","author":"El-Sabban","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.lfs.2020.117639_bb0060","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1084\/jem.20101095","article-title":"Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemia","volume":"207","author":"El Hajj","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.lfs.2020.117639_bb0065","doi-asserted-by":"crossref","first-page":"6528","DOI":"10.1182\/blood-2009-03-211821","article-title":"Phase 2 study of the efficacy and safety of the combination of arsenic trioxide , interferon alpha , and zidovudine in newly diagnosed chronic adult T-cell leukemia \/ lymphoma ( ATL )","volume":"113","author":"Kchour","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.lfs.2020.117639_bb0070","first-page":"A29","article-title":"Induction of cell cycle arrest and apoptosis in HTLV-I transformed cells by a combination of arsenic trioxide and interferon-\u03b1","volume":"20","author":"El-Sabban","year":"1999","journal-title":"JAIDS"},{"key":"10.1016\/j.lfs.2020.117639_bb0075","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.drudis.2013.08.021","article-title":"Thymoquinone\u202f: fifty years of success in the battle against cancer models","volume":"19","author":"Schneider-stock","year":"2014","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.lfs.2020.117639_bb0080","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.biocel.2005.10.009","article-title":"Thymoquinone\u202f: a promising anti-cancer drug from natural sources","volume":"38","author":"Gali-muhtasib","year":"2006","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.lfs.2020.117639_bb0085","first-page":"709","article-title":"Thymoquinone induces apoptosis in malignant T-cells via generation of ROS","volume":"5","author":"Dergarabetian","year":"2013","journal-title":"Front Biosci (Elite Ed)"},{"key":"10.1016\/j.lfs.2020.117639_bb0090","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0065-2571(84)90007-4","article-title":"Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors","volume":"22","author":"Chou","year":"1984","journal-title":"Adv. Enzym. Regul."},{"key":"10.1016\/j.lfs.2020.117639_bb0095","doi-asserted-by":"crossref","first-page":"486","DOI":"10.3324\/haematol.2017.169987","article-title":"Clinicopathological characteristics of T-cell non-Hodgkin lymphoma arising in patients with immunodeficiencies: a single-center case series of 25 patients and a review of the literature","volume":"103","author":"Nijland","year":"2018","journal-title":"Haematologica"},{"key":"10.1016\/j.lfs.2020.117639_bb0100","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2298\/SARH0804187S","article-title":"Molecular mechanisms involved in chemoresistance in paediatric acute lymphoblastic leukaemia","volume":"136","author":"Stankovic","year":"2008","journal-title":"Srp. Arh. Celok. Lek."},{"key":"10.1016\/j.lfs.2020.117639_bb0105","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/carcin\/bgm294","article-title":"Activation of the JNK pathway promotes phosphorylation and degradation of BimEL\u2014a novel mechanism of chemoresistance in T-cell acute lymphoblastic leukemia","volume":"29","author":"Leung","year":"2008","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.lfs.2020.117639_bb0110","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1038\/onc.2013.106","article-title":"Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells","volume":"33","author":"Masciarelli","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.lfs.2020.117639_bb0115","doi-asserted-by":"crossref","first-page":"59950","DOI":"10.18632\/oncotarget.19048","article-title":"The molecular mechanisms of chemoresistance in cancers","volume":"8","author":"Zheng","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.lfs.2020.117639_bb0120","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2174\/1573395511666150923234547","article-title":"Acute lymphoblastic leukemia and regulatory T cells: biomarkers and immunopathogenesis","volume":"12","author":"Hiroki","year":"2016","journal-title":"Cur Immunol Rev"},{"key":"10.1016\/j.lfs.2020.117639_bb0125","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/ni723","article-title":"Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self","volume":"2","author":"Derbinski","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.lfs.2020.117639_bb0130","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1073\/pnas.0408197102","article-title":"Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo","volume":"102","author":"Chen","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.lfs.2020.117639_bb0135","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/imm.12237","article-title":"Critical stoichiometric ratio of CD4(+) CD25(+) FoxP3(+) regulatory T cells and CD4(+) CD25(\u2212) responder T cells influence immunosuppression in patients with B-cell acute lymphoblastic leukaemia","volume":"142","author":"Bhattacharya","year":"2014","journal-title":"Immunology"},{"key":"10.1016\/j.lfs.2020.117639_bb0140","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1158\/1535-7163.MCT-12-0278","article-title":"Humanization of an anti-CCR4 antibody that kills cutaneous T-cell lymphoma cells and abrogates suppression by T-regulatory cells","volume":"11","author":"Chang","year":"2012","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.lfs.2020.117639_bb0145","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3892\/ol.2011.499","article-title":"Immunophenotype and increased presence of CD4(+)CD25(+) regulatory T cells in patients with acute lymphoblastic leukemia","volume":"3","author":"Wu","year":"2012","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.lfs.2020.117639_bb0150","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1158\/0008-5472.CAN-11-3687","article-title":"T regulatory cells: key players in tumor immune escape and angiogenesis","volume":"72","author":"Facciabene","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2020.117639_bb0155","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1002\/eji.200425274","article-title":"Interleukin-2 is essential for CD4+CD25+ regulatory T cell function","volume":"34","author":"de la Rosa","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.lfs.2020.117639_bb0160","first-page":"439","article-title":"Expression of CD4+ CD25+ regulatory T cells in the patients with acute lymphocytic leukemia","volume":"23","author":"Li","year":"2007","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"},{"key":"10.1016\/j.lfs.2020.117639_bb0165","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1182\/blood.V93.1.278","article-title":"Arsenic trioxide and interferon-alpha synergize to induce cell cycle arrest and apoptosis in human T-cell lymphotropic virus type I-transformed cells","volume":"93","author":"Bazarbachi","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.lfs.2020.117639_bb0170","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.bcp.2009.12.015","article-title":"Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1","volume":"79","author":"Alhosin","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117639_bb0175","doi-asserted-by":"crossref","first-page":"821","DOI":"10.3892\/or.2014.3223","article-title":"Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and SRC-mediated phosphorylation of EGF receptor tyrosine kinase","volume":"32","author":"Kundu","year":"2014","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.lfs.2020.117639_bb0180","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.toxlet.2013.08.018","article-title":"Thymoquinone inhibits cell proliferation through regulation of G1\/S phase cell cycle transition in N-nitrosodiethylamine-induced experimental rat hepatocellular carcinoma","volume":"223","author":"Raghunandhakumar","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.lfs.2020.117639_bb0185","doi-asserted-by":"crossref","first-page":"34453","DOI":"10.18632\/oncotarget.16431","article-title":"Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells","volume":"8","author":"Pang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.lfs.2020.117639_bb0190","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1158\/1541-7786.MCR-07-2088","article-title":"Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis","volume":"6","author":"Sethi","year":"2008","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.lfs.2020.117639_bb0195","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.intimp.2006.02.004","article-title":"Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation","volume":"6","author":"El Gazzar","year":"2006","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.lfs.2020.117639_bb0200","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/j.intimp.2005.06.008","article-title":"Immunomodulatory and therapeutic properties of the Nigella sativa L. seed","volume":"5","author":"Salem","year":"2005","journal-title":"Int. J. Immunopharmacol."},{"key":"10.1016\/j.lfs.2020.117639_bb0205","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nrc2809","article-title":"Eicosanoids and cancer","volume":"10","author":"Wang","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.lfs.2020.117639_bb0210","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1182\/blood.V98.5.1632","article-title":"Cardiac toxicity of arsenic trioxide","volume":"98","author":"Barbey","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.lfs.2020.117639_bb0215","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.envres.2005.08.003","article-title":"Maternal exposure to arsenic, cadmium, lead, and mercury and neural tube defects in offspring","volume":"101","author":"Brender","year":"2006","journal-title":"Environ. Res."},{"key":"10.1016\/j.lfs.2020.117639_bb0220","doi-asserted-by":"crossref","first-page":"7146","DOI":"10.1038\/sj.onc.1204762","article-title":"Arsenic trioxide, a therapeutic agent for APL","volume":"20","author":"Zhang","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.lfs.2020.117639_bb0225","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1182\/blood-2016-09-692574","article-title":"Adult T-cell leukemia: molecular basis for clonal expansion and transformation of HTLV-1\u2013infected T cells","volume":"129","author":"Watanabe","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.lfs.2020.117639_bb0230","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.3892\/or.2016.5019","article-title":"Thymoquinone induces apoptosis through downregulation of c-FLIP and Bcl-2 in renal carcinoma Caki cells","volume":"36","author":"Park","year":"2016","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.lfs.2020.117639_bb0235","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1097\/IGC.0000000000001064","article-title":"The effect of thymoquinone on apoptosis of SK-OV-3 ovarian cancer cell by regulation of Bcl-2 and Bax","volume":"27","author":"Liu","year":"2017","journal-title":"Int. J. Gynecol. Cancer"},{"key":"10.1016\/j.lfs.2020.117639_bb0240","doi-asserted-by":"crossref","first-page":"116628","DOI":"10.1016\/j.lfs.2019.116628","article-title":"Thymoquinone enhances the anticancer activity of doxorubicin against adult T-cell leukemia in vitro and in vivo through ROS-dependent mechanisms","volume":"232","author":"Fatfat","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2020.117639_bb0245","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/carcin\/bgi274","article-title":"Functional inactivation of p53 by human T-cell leukemia virus type 1 tax protein: mechanisms and clinical implications","volume":"27","author":"Tabakin-Fix","year":"2006","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.lfs.2020.117639_bb0250","first-page":"857","article-title":"Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism","volume":"25","author":"Gali-Muhtasib","year":"2004","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.lfs.2020.117639_bb0255","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4161\/cbt.6.2.3575","article-title":"Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells","volume":"6","author":"Roepke","year":"2007","journal-title":"Cancer Biology & Therapy"},{"key":"10.1016\/j.lfs.2020.117639_bb0260","doi-asserted-by":"crossref","first-page":"6348","DOI":"10.1128\/JVI.72.8.6348-6355.1998","article-title":"Phosphorylation of p53: a novel pathway for p53 inactivation in human T-cell lymphotropic virus type 1-transformed cells","volume":"72","author":"Pise-Masison","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.lfs.2020.117639_bb0265","doi-asserted-by":"crossref","unstructured":"SJ. Ullrich, K. Sakaguchi, SP Lees-Miller, M. Fiscella, WE. Mercer, CW. Anderson, E. Appella, Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53, PNAS. 90 (13), 5954\u20135958.","DOI":"10.1073\/pnas.90.13.5954"},{"key":"10.1016\/j.lfs.2020.117639_bb0270","series-title":"In Silico Analysis and Docking Study on a Potential Wild-Type, Tumor Suppressor Protein P53 Activator Using Thymoquinone, NHSJS","author":"Khan","year":"2017"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520303878?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520303878?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T23:01:15Z","timestamp":1762210875000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320520303878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":53,"alternative-id":["S0024320520303878"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.117639","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thymoquinone synergizes with arsenic and interferon alpha to target human T-cell leukemia\/lymphoma","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.117639","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117639"}}