{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:34:07Z","timestamp":1787906047572,"version":"build-2784847793"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570310"],"award-info":[{"award-number":["81570310"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.lfs.2020.117759","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T02:34:57Z","timestamp":1588905297000},"page":"117759","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Metformin therapy confers cardioprotection against the remodeling of gap junction in tachycardia-induced atrial fibrillation dog model"],"prefix":"10.1016","volume":"254","author":[{"given":"Jiayi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinxu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaozhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9131","key":"10.1016\/j.lfs.2020.117759_bb0005","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/S0140-6736(98)07037-8","volume":"352","year":"1998","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.lfs.2020.117759_bb0010","doi-asserted-by":"crossref","first-page":"601","DOI":"10.7326\/0003-4819-157-9-201211060-00003","article-title":"Comparative effectiveness of sulfonylurea and metformin monotherapy on cardiovascular events in type 2 diabetes mellitus: a cohort study","volume":"157","author":"Roumie","year":"2012","journal-title":"Ann. Intern. Med."},{"issue":"11","key":"10.1016\/j.lfs.2020.117759_bb0015","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1111\/dom.12354","article-title":"Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls","volume":"16","author":"Bannister","year":"2014","journal-title":"Diabetes Obes. Metab."},{"issue":"2","key":"10.1016\/j.lfs.2020.117759_bb0020","first-page":"116","article-title":"A randomized controlled trial of metformin on left ventricular hypertrophy in patients with coronary artery disease without diabetes: the MET-REMODEL trial","volume":"2","author":"Mohan","year":"2019","journal-title":"Eur. Heart J."},{"issue":"21","key":"10.1016\/j.lfs.2020.117759_bb0025","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1001\/archinternmed.2010.409","article-title":"Metformin use and mortality among patients with diabetes and atherothrombosis","volume":"170","author":"Roussel","year":"2010","journal-title":"Arch. Intern. Med."},{"issue":"3","key":"10.1016\/j.lfs.2020.117759_bb0030","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1463-1326.2010.01349.x","article-title":"Effect of metformin on cardiovascular events and mortality: a meta-analysis of randomized clinical trials","volume":"13","author":"Lamanna","year":"2011","journal-title":"Diabetes Obes. Metab."},{"issue":"3","key":"10.1016\/j.lfs.2020.117759_bb0035","doi-asserted-by":"crossref","first-page":"696","DOI":"10.2337\/db07-1098","article-title":"Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling","volume":"57","author":"Calvert","year":"2008","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.lfs.2020.117759_bb0040","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s10557-015-6601-x","article-title":"The effect of metformin use on left ventricular ejection fraction and mortality post-myocardial infarction","volume":"29","author":"Abualsuod","year":"2015","journal-title":"Cardiovasc. Drugs Ther."},{"issue":"19","key":"10.1016\/j.lfs.2020.117759_bb0045","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1161\/CIRCULATIONAHA.108.798561","article-title":"Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase","volume":"119","author":"Sasaki","year":"2009","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.lfs.2020.117759_bb0050","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1007\/s00125-017-4287-2","article-title":"Metformin prevents ischaemic ventricular fibrillation in metabolically normal pigs","volume":"60","author":"Lu","year":"2017","journal-title":"Diabetologia"},{"key":"10.1016\/j.lfs.2020.117759_bb0055","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12933-014-0123-x","article-title":"Association of metformin with lower atrial fibrillation risk among patients with type 2 diabetes mellitus: a population-based dynamic cohort and in vitro studies","volume":"13","author":"Chang","year":"2014","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.lfs.2020.117759_bb0060","doi-asserted-by":"crossref","unstructured":"Jadhav S, Ferrell W, Greer IA, Petrie JR, Cobbe SM, Sattar N: Effects of metformin on microvascular function and exercise tolerance in women with angina and normal coronary arteries: a randomized, double-blind, placebo-controlled study. J. Am. Coll. Cardiol. 2006, 48(5):956\u2013963.","DOI":"10.1016\/j.jacc.2006.04.088"},{"issue":"9","key":"10.1016\/j.lfs.2020.117759_bb0065","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1056\/NEJM199508313330902","article-title":"Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group","volume":"333","author":"DeFronzo","year":"1995","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.lfs.2020.117759_bb0070","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/S0735-1097(01)01129-9","article-title":"Improved endothelial function with metformin in type 2 diabetes mellitus","volume":"37","author":"Mather","year":"2001","journal-title":"J. Am. Coll. Cardiol."},{"issue":"5","key":"10.1016\/j.lfs.2020.117759_bb0075","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1161\/CIRCRESAHA.116.308445","article-title":"Anti-inflammatory effects of metformin irrespective of diabetes status","volume":"119","author":"Cameron","year":"2016","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.lfs.2020.117759_bb0080","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/cvr\/cvv212","article-title":"LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation","volume":"108","author":"Kim","year":"2015","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.lfs.2020.117759_bb0085","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/cvr\/cvv166","article-title":"AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism","volume":"107","author":"Sung","year":"2015","journal-title":"Cardiovasc. Res."},{"issue":"10","key":"10.1016\/j.lfs.2020.117759_bb0090","doi-asserted-by":"crossref","first-page":"17999","DOI":"10.1002\/jcp.28432","article-title":"Theaflavin 3,3\u2032-digallate reverses the downregulation of connexin 43 and autophagy induced by high glucose via AMPK activation in cardiomyocytes","volume":"234","author":"Shen","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"8","key":"10.1016\/j.lfs.2020.117759_bb0095","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1172\/JCI13505","article-title":"Role of AMP-activated protein kinase in mechanism of metformin action","volume":"108","author":"Zhou","year":"2001","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.lfs.2020.117759_bb0100","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1007\/s00125-017-4342-z","article-title":"The mechanisms of action of metformin","volume":"60","author":"Rena","year":"2017","journal-title":"Diabetologia"},{"issue":"2","key":"10.1016\/j.lfs.2020.117759_bb0105","doi-asserted-by":"crossref","first-page":"496","DOI":"10.2337\/diabetes.55.02.06.db05-1064","article-title":"Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase","volume":"55","author":"Davis","year":"2006","journal-title":"Diabetes"},{"issue":"Suppl. 2","key":"10.1016\/j.lfs.2020.117759_bb0110","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.33549\/physiolres.931546","article-title":"Myocardial gap junctions: targets for novel approaches in the prevention of life-threatening cardiac arrhythmias","volume":"57","author":"Tribulova","year":"2008","journal-title":"Physiol. Res."},{"issue":"5","key":"10.1016\/j.lfs.2020.117759_bb0115","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1161\/01.CIR.101.5.547","article-title":"Accelerated onset and increased incidence of ventricular arrhythmias induced by ischemia in Cx43-deficient mice","volume":"101","author":"Lerner","year":"2000","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.lfs.2020.117759_bb0120","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1093\/cvr\/cvr209","article-title":"Connexin 43 gene therapy prevents persistent atrial fibrillation in a porcine model","volume":"92","author":"Bikou","year":"2011","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.lfs.2020.117759_bb0125","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/cvr\/cvp028","article-title":"Human cardiac gap-junction coupling: effects of antiarrhythmic peptide AAP10","volume":"83","author":"Hagen","year":"2009","journal-title":"Cardiovasc. Res."},{"issue":"25","key":"10.1016\/j.lfs.2020.117759_bb0130","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1161\/01.CIR.0000101926.43759.10","article-title":"Pharmacological modulation of cardiac gap junctions to enhance cardiac conduction: evidence supporting a novel target for antiarrhythmic therapy","volume":"108","author":"Eloff","year":"2003","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.lfs.2020.117759_bb0135","doi-asserted-by":"crossref","first-page":"e001733","DOI":"10.1161\/JAHA.114.001733","article-title":"LKB1 knockout mouse develops spontaneous atrial fibrillation and provides mechanistic insights into human disease process","volume":"4","author":"Ozcan","year":"2015","journal-title":"J. Am. Heart Assoc."},{"issue":"7","key":"10.1016\/j.lfs.2020.117759_bb0140","doi-asserted-by":"crossref","first-page":"698","DOI":"10.7150\/ijms.19800","article-title":"Autophagy was involved in the protective effect of metformin on hyperglycemia-induced cardiomyocyte apoptosis and Connexin43 downregulation in H9c2 cells","volume":"14","author":"Wang","year":"2017","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.lfs.2020.117759_bb0145","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.exger.2013.12.016","article-title":"AMPK-mediated downregulation of connexin43 and premature senescence of mesangial cells under high-glucose conditions","volume":"51","author":"Guo","year":"2014","journal-title":"Exp. Gerontol."},{"issue":"9","key":"10.1016\/j.lfs.2020.117759_bb0150","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.jacc.2013.10.081","article-title":"c-Src kinase inhibition reduces arrhythmia inducibility and connexin43 dysregulation after myocardial infarction","volume":"63","author":"Rutledge","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.lfs.2020.117759_bb0155","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1097-2765(01)00432-4","article-title":"PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1","volume":"9","author":"Schmitt","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.lfs.2020.117759_bb0160","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10856","article-title":"AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B","volume":"7","author":"Johanns","year":"2016","journal-title":"Nat. Commun."},{"issue":"22","key":"10.1016\/j.lfs.2020.117759_bb0165","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1016\/j.jacc.2011.07.048","article-title":"Inhibition of c-Src tyrosine kinase prevents angiotensin II-mediated connexin-43 remodeling and sudden cardiac death","volume":"58","author":"Sovari","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"issue":"5","key":"10.1016\/j.lfs.2020.117759_bb0170","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1161\/01.CIR.91.5.1588","article-title":"Chronic rapid atrial pacing. Structural, functional, and electrophysiological characteristics of a new model of sustained atrial fibrillation","volume":"91","author":"Morillo","year":"1995","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.lfs.2020.117759_bb0175","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.jacc.2010.09.034","article-title":"Prevention and reversal of atrial fibrillation inducibility and autonomic remodeling by low-level vagosympathetic nerve stimulation","volume":"57","author":"Sheng","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"issue":"9","key":"10.1016\/j.lfs.2020.117759_bb0180","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1161\/CIRCRESAHA.111.253120","article-title":"Differential protein kinase C isoform regulation and increased constitutive activity of acetylcholine-regulated potassium channels in atrial remodeling","volume":"109","author":"Makary","year":"2011","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.lfs.2020.117759_bb0185","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/FJC.0000000000000309","article-title":"Left-sided noninvasive vagus nerve stimulation suppresses atrial fibrillation by upregulating atrial gap junctions in canines","volume":"66","author":"Chen","year":"2015","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"3","key":"10.1016\/j.lfs.2020.117759_bb0190","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1161\/CIRCEP.108.784272","article-title":"Atrial fibrillation begets atrial fibrillation: autonomic mechanism for atrial electrical remodeling induced by short-term rapid atrial pacing","volume":"1","author":"Lu","year":"2008","journal-title":"Circ. Arrhythm. Electrophysiol."},{"issue":"1","key":"10.1016\/j.lfs.2020.117759_bb0195","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jacc.2015.04.056","article-title":"Atrial fibrillation activates AMP-dependent protein kinase and its regulation of cellular calcium handling: potential role in metabolic adaptation and prevention of progression","volume":"66","author":"Harada","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"issue":"14","key":"10.1016\/j.lfs.2020.117759_bb0200","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1111\/bph.14348","article-title":"The opioid oxycodone use-dependently inhibits the cardiac sodium channel NaV 1.5","volume":"175","author":"Meents","year":"2018","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.lfs.2020.117759_bb0205","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1161\/CIRCHEARTFAILURE.112.968321","article-title":"Irregular rhythm adversely influences calcium handling in ventricular myocardium: implications for the interaction between heart failure and atrial fibrillation","volume":"5","author":"Ling","year":"2012","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.lfs.2020.117759_bb0210","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.vascn.2016.04.006","article-title":"Safety pharmacology studies using EFP and impedance","volume":"81","author":"Obergrussberger","year":"2016","journal-title":"J. Pharmacol. Toxicol. Methods"},{"issue":"9","key":"10.1016\/j.lfs.2020.117759_bb0215","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1161\/CIRCRESAHA.108.190454","article-title":"Structural and molecular mechanisms of gap junction remodeling in epicardial border zone myocytes following myocardial infarction","volume":"104","author":"Kieken","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2020.117759_bb0220","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.bbi.2016.05.010","article-title":"The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise","volume":"57","author":"Cai","year":"2016","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.lfs.2020.117759_bb0225","first-page":"812","article-title":"Spironolactone ameliorates PIT1-dependent vascular osteoinduction in klotho-hypomorphic mice","volume":"123","author":"Voelkl","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.lfs.2020.117759_bb0230","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.biopsych.2018.12.013","article-title":"Male-specific cAMP signaling in the hippocampus controls spatial memory deficits in a mouse model of autism and intellectual disability","volume":"85","author":"Zamarbide","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.lfs.2020.117759_bb0235","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.vascn.2016.06.004","article-title":"Multi-parametric assessment of cardiomyocyte excitation-contraction coupling using impedance and field potential recording: a tool for cardiac safety assessment","volume":"81","author":"Zhang","year":"2016","journal-title":"J. Pharmacol. Toxicol. Methods"},{"issue":"3","key":"10.1016\/j.lfs.2020.117759_bb0240","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1093\/europace\/euv028","article-title":"Low P-wave amplitude (<0.1 mV) in lead I is associated with displaced inter-atrial conduction and clinical recurrence of paroxysmal atrial fibrillation after radiofrequency catheter ablation","volume":"18","author":"Park","year":"2016","journal-title":"Europace"},{"issue":"5","key":"10.1016\/j.lfs.2020.117759_bb0245","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.114.001581","article-title":"Left atrial appendage ligation in patients with atrial fibrillation leads to a decrease in atrial dispersion","volume":"4","author":"Kawamura","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.lfs.2020.117759_bb0250","doi-asserted-by":"crossref","unstructured":"Lee AM, Aziz A, Didesch J, Clark KL, Schuessler RB, Damiano RJ, Jr.: Importance of atrial surface area and refractory period in sustaining atrial fibrillation: testing the critical mass hypothesis. J. Thorac. Cardiovasc. Surg. 2013, 146(3):593\u2013598.","DOI":"10.1016\/j.jtcvs.2012.04.021"},{"issue":"4","key":"10.1016\/j.lfs.2020.117759_bb0255","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1172\/JCI200422683","article-title":"AMP-activated protein kinase: the guardian of cardiac energy status","volume":"114","author":"Hardie","year":"2004","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.lfs.2020.117759_bb0260","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1161\/01.CIR.0000151291.32974.D5","article-title":"Transgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome","volume":"111","author":"Sidhu","year":"2005","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.lfs.2020.117759_bb0265","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1253\/circj.CJ-13-1365","article-title":"Quantitative proteomics of changes in energy metabolism-related proteins in atrial tissue from valvular disease patients with permanent atrial fibrillation","volume":"78","author":"Tu","year":"2014","journal-title":"Circ. J."},{"issue":"15","key":"10.1016\/j.lfs.2020.117759_bb0270","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1161\/01.CIR.0000069269.60167.02","article-title":"Constitutively active adenosine monophosphate-activated protein kinase regulates voltage-gated sodium channels in ventricular myocytes","volume":"107","author":"Light","year":"2003","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.lfs.2020.117759_bb0275","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1074\/jbc.M210621200","article-title":"Regulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cells","volume":"278","author":"Hallows","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.lfs.2020.117759_bb0280","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1161\/CIRCULATIONAHA.111.053272","article-title":"Connexin gene transfer preserves conduction velocity and prevents atrial fibrillation","volume":"125","author":"Igarashi","year":"2012","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.lfs.2020.117759_bb0285","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1161\/01.CIR.88.3.864","article-title":"Reduced content of connexin43 gap junctions in ventricular myocardium from hypertrophied and ischemic human hearts","volume":"88","author":"Peters","year":"1993","journal-title":"Circulation"},{"issue":"14","key":"10.1016\/j.lfs.2020.117759_bb0290","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1093\/cvr\/cvz136","article-title":"An N-\/L-type calcium channel blocker, cilnidipine, suppresses autonomic, electrical and structural remodeling associated with atrial fibrillation","volume":"115","author":"Tajiri","year":"2019","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.lfs.2020.117759_bb0295","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/cvr\/cvu202","article-title":"The role of gap junctions in stretch-induced atrial fibrillation","volume":"104","author":"Ueda","year":"2014","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.lfs.2020.117759_bb0300","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0008-6363(02)00273-0","article-title":"Structural correlate of atrial fibrillation in human patients","volume":"54","author":"Kostin","year":"2002","journal-title":"Cardiovasc. Res."},{"issue":"15","key":"10.1016\/j.lfs.2020.117759_bb0305","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1161\/01.CIR.0000062689.04037.3F","article-title":"Reverse structural and gap-junctional remodeling after prolonged atrial fibrillation in the goat","volume":"107","author":"Ausma","year":"2003","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.lfs.2020.117759_bb0310","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1161\/hc3601.093990","article-title":"Heterogeneous expression of Gap junction channels in the heart leads to conduction defects and ventricular dysfunction","volume":"104","author":"Gutstein","year":"2001","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.lfs.2020.117759_bb0315","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1084\/jem.20080897","article-title":"The tight junction protein CAR regulates cardiac conduction and cell-cell communication","volume":"205","author":"Lisewski","year":"2008","journal-title":"J. Exp. Med."},{"issue":"7","key":"10.1016\/j.lfs.2020.117759_bb0320","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1161\/CIRCRESAHA.107.154252","article-title":"Connexin43 remodeling caused by inhibition of plakophilin-2 expression in cardiac cells","volume":"101","author":"Oxford","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2020.117759_bb0325","doi-asserted-by":"crossref","first-page":"761","DOI":"10.3389\/fphar.2018.00761","article-title":"Activating AMPK to restore tight junction assembly in intestinal epithelium and to attenuate experimental colitis by metformin","volume":"9","author":"Chen","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.lfs.2020.117759_bb0330","doi-asserted-by":"crossref","first-page":"66","DOI":"10.14336\/AD.2017.0426","article-title":"Apelin ameliorates high glucose-induced downregulation of connexin 43 via AMPK-dependent pathway in neonatal rat cardiomyocytes","volume":"9","author":"Li","year":"2018","journal-title":"Aging Dis."},{"key":"10.1016\/j.lfs.2020.117759_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116876","article-title":"A role of AMPK and connexin 43 in the suppression of CoCl2-induced apoptosis of spiral modiolar artery smooth muscle cells by adiponectin","volume":"238","author":"Xiao","year":"2019","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.lfs.2020.117759_bb0340","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.celrep.2013.10.009","article-title":"Autoregulation of connexin43 gap junction formation by internally translated isoforms","volume":"5","author":"Smyth","year":"2013","journal-title":"Cell Rep."},{"issue":"9","key":"10.1016\/j.lfs.2020.117759_bb0345","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1161\/CIRCRESAHA.117.311955","article-title":"GJA1-20k arranges actin to guide Cx43 delivery to cardiac intercalated discs","volume":"121","author":"Basheer","year":"2017","journal-title":"Circ. Res."},{"issue":"20","key":"10.1016\/j.lfs.2020.117759_bb0350","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.121900","article-title":"Stress response protein GJA1-20k promotes mitochondrial biogenesis, metabolic quiescence, and cardioprotection against ischemia\/reperfusion injury","volume":"3","author":"Basheer","year":"2018","journal-title":"JCI Insight"},{"issue":"9","key":"10.1016\/j.lfs.2020.117759_bb0355","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1681\/ASN.2018010050","article-title":"Phosphorylation of acetyl-CoA carboxylase by AMPK reduces renal fibrosis and is essential for the anti-fibrotic effect of metformin","volume":"29","author":"Lee","year":"2018","journal-title":"J. Am. Soc. Nephrol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520305075?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520305075?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:53:41Z","timestamp":1775062421000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320520305075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":71,"alternative-id":["S0024320520305075"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.117759","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metformin therapy confers cardioprotection against the remodeling of gap junction in tachycardia-induced atrial fibrillation dog model","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.117759","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117759"}}