{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:47:19Z","timestamp":1789984039141,"version":"4.0.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"Shenzhen Science and Technology Plan","award":["jcyj2016042170251848"],"award-info":[{"award-number":["jcyj2016042170251848"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.lfs.2020.117811","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T22:00:20Z","timestamp":1589580020000},"page":"117811","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["LncRNA Kcnq1ot1 renders cardiomyocytes apoptosis in acute myocardial infarction model by up-regulating Tead1"],"prefix":"10.1016","volume":"256","author":[{"given":"Bihong","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenglei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suihao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijuan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2020.117811_bb0005","first-page":"298","article-title":"Investigation of ischemia modified albumin, oxidant and antioxidant markers in acute myocardial infarction","volume":"11","author":"Hazini","year":"2015","journal-title":"Postepy W Kardiologii Interwencyjnej = Advances in Interventional Cardiology"},{"key":"10.1016\/j.lfs.2020.117811_bb0010","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.disamonth.2012.12.004","article-title":"Acute myocardial infarction","volume":"59","author":"Boateng","year":"2013","journal-title":"Disease-a-Month: DM"},{"key":"10.1016\/j.lfs.2020.117811_bb0015","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1161\/CIRCULATIONAHA.114.015134","article-title":"Prevalence, clinical features, and prognosis of acute myocardial infarction attributable to coronary artery embolism","volume":"132","author":"Shibata","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2020.117811_bb0020","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/7018393","article-title":"Ischemia\/reperfusion injury following acute myocardial infarction: A critical issue for clinicians and forensic pathologists","volume":"2017","author":"Neri","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.lfs.2020.117811_bb0025","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.ahj.2015.08.005","article-title":"Reperfusion therapy for acute myocardial infarction: concepts and controversies from inception to acceptance","volume":"170","author":"Rentrop","year":"2015","journal-title":"Am. Heart J."},{"key":"10.1016\/j.lfs.2020.117811_bb0030","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/S0140-6736(08)61237-4","article-title":"Acute myocardial infarction","volume":"372","author":"White","year":"2008","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.lfs.2020.117811_bb0035","first-page":"435","article-title":"Identification of potential molecular mechanisms and candidate genes involved in the acute phase of myocardial infarction","volume":"20","author":"Yang","year":"2018","journal-title":"Cell J."},{"key":"10.1016\/j.lfs.2020.117811_bb0040","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1161\/CIRCRESAHA.116.302521","article-title":"Long noncoding RNAs in cardiovascular diseases","volume":"116","author":"Uchida","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2020.117811_bb0045","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/ng.3192","article-title":"The landscape of long noncoding RNAs in the human transcriptome","volume":"47","author":"Iyer","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.lfs.2020.117811_bb0050","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1080\/15384101.2019.1678965","article-title":"LncRNA ANRIL knockdown relieves myocardial cell apoptosis in acute myocardial infarction by regulating IL-33\/ST2","volume":"18","author":"J","year":"2019","journal-title":"Cell Cycle (Georgetown, Tex)"},{"key":"10.1016\/j.lfs.2020.117811_bb0055","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1080\/21691401.2019.1652630","article-title":"Long non-coding RNA UCA1 relieves cardiomyocytes H9c2 injury aroused by oxygen-glucose deprivation via declining miR-122","volume":"47","author":"Z.","year":"2019","journal-title":"Artificial Cells, Nanomedicine, and Biotechnology"},{"key":"10.1016\/j.lfs.2020.117811_bb0060","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1080\/21691401.2020.1725026","article-title":"Long non-coding RNA DANCR alleviates hypoxia-caused H9c2 cells damage through up regulation of HIF-1\u03b1","volume":"48","author":"L","year":"2020","journal-title":"Artificial Cells, Nanomedicine, and Biotechnology"},{"key":"10.1016\/j.lfs.2020.117811_bb0065","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/jcp.29031","article-title":"lncRNA ANRIL protects H9c2 cells against hypoxia-induced injury through targeting the miR-7-5p\/SIRT1 axis","volume":"235","author":"L S","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.lfs.2020.117811_bb0070","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/s41419-018-1029-4","article-title":"Silencing long non-coding RNA Kcnq1ot1 alleviates pyroptosis and fibrosis in diabetic cardiomyopathy","volume":"9","author":"Yang","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.lfs.2020.117811_bb0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002956","article-title":"The Kcnq1ot1 long non-coding RNA affects chromatin conformation and expression of Kcnq1, but does not regulate its imprinting in the developing heart","volume":"8","author":"Korostowski","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.lfs.2020.117811_bb0080","doi-asserted-by":"crossref","first-page":"5064","DOI":"10.12659\/MSM.909348","article-title":"Circulating Long noncoding RNA LIPCAR acts as a novel biomarker in patients with ST-segment elevation myocardial infarction","volume":"24","author":"Li","year":"2018","journal-title":"Medical Science Monitor: International Medical Journal of Experimental and Clinical Research"},{"key":"10.1016\/j.lfs.2020.117811_bb0085","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1161\/CIRCRESAHA.115.303836","article-title":"Long noncoding RNAs in patients with acute myocardial infarction","volume":"115","author":"Vausort","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2020.117811_bb0090","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.bbrc.2017.08.005","article-title":"Down-regulation of lncRNA KCNQ1OT1 protects against myocardial ischemia\/reperfusion injury following acute myocardial infarction","volume":"491","author":"Li","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2020.117811_bb0095","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.gpb.2016.12.005","article-title":"Transcriptional and post-transcriptional gene regulation by Long non-coding RNA","volume":"15","author":"Dykes","year":"2017","journal-title":"Genomics, Proteomics & Bioinformatics"},{"key":"10.1016\/j.lfs.2020.117811_bb0100","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.bbrc.2018.09.064","article-title":"YY1-induced upregulation of lncRNA KCNQ1OT1 regulates angiotensin II-induced atrial fibrillation by modulating miR-384b\/CACNA1C axis","volume":"505","author":"Shen","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2020.117811_bb0105","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0140-6736(74)91367-1","article-title":"Letter: hypoxia, saffron, and cardiovascular disease","volume":"2","author":"Grisolia","year":"1974","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.lfs.2020.117811_bb0110","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/4579806","article-title":"MicroRNA-155 promotes myocardial infarction-induced apoptosis by targeting RNA-binding protein QKI","volume":"2019","author":"Guo","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.lfs.2020.117811_bb0115","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1161\/CIRCRESAHA.115.306300","article-title":"MicroRNA regulation of atherosclerosis","volume":"118","author":"Feinberg","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2020.117811_bb0120","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nrneph.2016.51","article-title":"Long noncoding RNAs in kidney and cardiovascular diseases","volume":"12","author":"Lorenzen","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.lfs.2020.117811_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20123079","article-title":"Long noncoding competing endogenous RNA networks in age-associated cardiovascular diseases","volume":"20","author":"Greco","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2020.117811_bb0130","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1161\/CIRCRESAHA.114.302476","article-title":"The long noncoding RNA CHRF regulates cardiac hypertrophy by targeting miR-489","volume":"114","author":"Wang","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2020.117811_bb0135","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.93343","article-title":"Tead1 is required for maintaining adult cardiomyocyte function, and its loss results in lethal dilated cardiomyopathy","volume":"2","author":"Liu","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.lfs.2020.117811_bb0140","doi-asserted-by":"crossref","first-page":"13721","DOI":"10.1074\/jbc.M109.063057","article-title":"TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction","volume":"285","author":"Tsika","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2020.117811_bb0145","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.jacbts.2019.05.006","article-title":"Yes-associated protein (YAP) facilitates pressure overload-induced dysfunction in the diabetic heart","volume":"4","author":"Ikeda","year":"2019","journal-title":"JACC Basic to Translational Science"},{"key":"10.1016\/j.lfs.2020.117811_bb0150","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.yexmp.2017.11.006","article-title":"Activation of Yap1\/Taz signaling in ischemic heart disease and dilated cardiomyopathy","volume":"103","author":"Hou","year":"2017","journal-title":"Exp. Mol. Pathol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520305609?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520305609?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:32:43Z","timestamp":1777426363000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320520305609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":30,"alternative-id":["S0024320520305609"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.117811","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LncRNA Kcnq1ot1 renders cardiomyocytes apoptosis in acute myocardial infarction model by up-regulating Tead1","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.117811","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117811"}}