{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T01:12:22Z","timestamp":1758417142856,"version":"3.44.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["2014-09861-1"],"award-info":[{"award-number":["2014-09861-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.lfs.2020.117814","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T21:31:10Z","timestamp":1589837470000},"page":"117814","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Effects of amiodarone on rodent ventricular cardiomyocytes: Novel perspectives from a cellular model of Long QT Syndrome Type 3"],"prefix":"10.1016","volume":"255","author":[{"given":"Samuel Santos","family":"Beserra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artur","family":"Santos-Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaqueline Oliveira","family":"Sarmento","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor Martins","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danilo","family":"Roman-Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"year":"2017","series-title":"Organization WH: Fact Sheets on Cardiovascular Diseases","key":"10.1016\/j.lfs.2020.117814_bb0005"},{"key":"10.1016\/j.lfs.2020.117814_bb0010","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1161\/CIRCULATIONAHA.111.023838","article-title":"Epidemiology and genetics of sudden cardiac death","volume":"125","author":"Deo","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2020.117814_bb0015","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1056\/NEJMra000650","article-title":"Sudden death due to cardiac arrhythmias","volume":"345","author":"Huikuri","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2020.117814_bb0020","doi-asserted-by":"crossref","first-page":"e190","DOI":"10.1016\/j.hrthm.2017.10.035","volume":"15","author":"Al-Khatib","year":"2018","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.lfs.2020.117814_bb0025","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.jacc.2006.10.062","article-title":"Mortality trends in patients diagnosed with first atrial fibrillation: a 21-year community-based study","volume":"49","author":"Miyasaka","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"issue":"18","key":"10.1016\/j.lfs.2020.117814_bb0030","first-page":"1609","article-title":"ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS","volume":"2016","author":"Kirchhof","year":"2016","journal-title":"Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology"},{"key":"10.1016\/j.lfs.2020.117814_bb0035","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/0735-1097(89)90525-1","article-title":"Long-term results of amiodarone therapy in patients with recurrent sustained ventricular tachycardia or ventricular fibrillation","volume":"13","author":"Herre","year":"1989","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.lfs.2020.117814_bb0040","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1093\/eurheartj\/ehs253","article-title":"2012 focused update of the ESC Guidelines for the management of atrial fibrillation: an update of the 2010 ESC Guidelines for the management of atrial fibrillation. Developed with the special contribution of the European Heart Rhythm Association","volume":"33","author":"Camm","year":"2012","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.lfs.2020.117814_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104521","article-title":"The role of amiodarone in contemporary management of complex cardiac arrhythmias","volume":"151","author":"Mujovic","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.lfs.2020.117814_bb0050","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1006\/jmcc.2001.1355","article-title":"Late sodium current is a novel target for amiodarone: studies in failing human myocardium","volume":"33","author":"Maltsev","year":"2001","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.lfs.2020.117814_bb0055","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1093\/cvr\/cvm069","article-title":"Augmentation of late sodium current unmasks the proarrhythmic effects of amiodarone","volume":"77","author":"Wu","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2020.117814_bb0060","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1093\/cvr\/24.3.182","article-title":"Negative inotropic effects of amiodarone on isolated guinea pig papillary muscle","volume":"24","author":"Aomine","year":"1990","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2020.117814_bb0065","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/0306-3623(90)91022-J","article-title":"The inhibitory actions of amiodarone on rested-state contraction in isolated guinea-pig ventricular muscle","volume":"21","author":"Aomine","year":"1990","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117814_bb0070","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/j.1476-5381.1992.tb12774.x","article-title":"Effects of long-term oral administration of amiodarone on the electromechanical performance of rabbit ventricular muscle","volume":"107","author":"Kodama","year":"1992","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117814_bb0075","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1111\/j.1440-1681.2007.04676.x","article-title":"Negative inotropic and lusitropic effects of intravenous amiodarone in conscious rats","volume":"34","author":"Salgado","year":"2007","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.lfs.2020.117814_bb0080","first-page":"H2031","article-title":"An increase of late sodium current induces delayed after depolarizations and sustained triggered activity in atrial myocytes","volume":"294","author":"Song","year":"2008","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"key":"10.1016\/j.lfs.2020.117814_bb0085","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/S0022-3565(25)20858-8","article-title":"Amiodarone blocks calcium current in single guinea pig ventricular myocytes","volume":"251","author":"Nishimura","year":"1989","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2020.117814_bb0090","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/cvr\/cvt007","article-title":"Atrial selectivity in Na+ channel blockade by acute amiodarone","volume":"98","author":"Suzuki","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2020.117814_bb0095","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1152\/physiolgenomics.00159.2007","article-title":"Evolution of ventricular myocyte electrophysiology","volume":"35","author":"Rosati","year":"2008","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.lfs.2020.117814_bb0100","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1038\/sj.bjp.0705379","article-title":"Action potential changes associated with a slowed inactivation of cardiac voltage-gated sodium channels by KB130015","volume":"139","author":"Macianskiene","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117814_bb0105","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2170\/physiolsci.RP010107","article-title":"A simple technique for isolating healthy heart cells from mouse models","volume":"57","author":"Shioya","year":"2007","journal-title":"The Journal of Physiological Sciences: JPS"},{"key":"10.1016\/j.lfs.2020.117814_bb0110","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.lfs.2010.10.011","article-title":"Investigation of the cardiomyocyte dysfunction in bradykinin type 2 receptor knockout mice","volume":"87","author":"Roman-Campos","year":"2010","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2020.117814_bb0115","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aal2039","article-title":"Fluorescent Ca(2+) indicators directly inhibit the Na,K-ATPase and disrupt cellular functions","volume":"11","author":"Smith","year":"2018","journal-title":"Sci. Signal."},{"key":"10.1016\/j.lfs.2020.117814_bb0120","doi-asserted-by":"crossref","DOI":"10.1038\/srep13287","article-title":"Purkinje cells as sources of arrhythmias in long QT syndrome type 3","volume":"5","author":"Iyer","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2020.117814_bb0125","article-title":"Animal models of cardiovascular diseases","volume":"2011","author":"Zaragoza","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.lfs.2020.117814_bb0130","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1152\/physrev.00002.2005","article-title":"Molecular physiology of cardiac repolarization","volume":"85","author":"Nerbonne","year":"2005","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.lfs.2020.117814_bb0135","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/415198a","article-title":"Cardiac excitation-contraction coupling","volume":"415","author":"Bers","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2020.117814_bb0140","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0022-3565(24)39261-4","article-title":"Effects of mitoxantrone on excitation-contraction coupling in guinea pig ventricular myocytes","volume":"293","author":"Wang","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2020.117814_bb0145","first-page":"H1335","article-title":"Cardiac myocyte calcium transport in phospholamban knockout mouse: relaxation and endogenous CaMKII effects","volume":"274","author":"Li","year":"1998","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.lfs.2020.117814_bb0150","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/S0006-3495(97)78778-2","article-title":"Measurements of Ca2+ entry and sarcoplasmic reticulum Ca2+ content during the cardiac cycle in guinea pig and rat ventricular myocytes","volume":"72","author":"Terracciano","year":"1997","journal-title":"Biophys. J."},{"issue":"Pt 3","key":"10.1016\/j.lfs.2020.117814_bb0155","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1113\/jphysiol.1996.sp021418","article-title":"Comparison of sarcolemmal calcium channel current in rabbit and rat ventricular myocytes","volume":"493","author":"Yuan","year":"1996","journal-title":"J. Physiol."},{"key":"10.1016\/j.lfs.2020.117814_bb0160","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/BF00230179","article-title":"Contractile and calcium regulating capacities of myocardia of different sized mammals scale with resting heart rate","volume":"106","author":"Hamilton","year":"1991","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.lfs.2020.117814_bb0165","first-page":"H477","article-title":"Effects of acidosis on Na+\/Ca2+ exchange and consequences for relaxation in guinea pig cardiac myocytes","volume":"267","author":"Terracciano","year":"1994","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.lfs.2020.117814_bb0170","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1476-5381.1970.tb09891.x","article-title":"The effect of amiodarone, a new anti-anginal drug, on cardiac muscle","volume":"39","author":"Singh","year":"1970","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117814_bb0175","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0008-6363(97)00114-4","article-title":"Cellular electropharmacology of amiodarone","volume":"35","author":"Kodama","year":"1997","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2020.117814_bb0180","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1476-5381.1984.tb10107.x","article-title":"The effects of ryanodine, EGTA and low-sodium on action potentials in rat and guinea-pig ventricular myocytes: evidence for two inward currents during the plateau","volume":"81","author":"Mitchell","year":"1984","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117814_bb0185","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1161\/01.RES.69.2.519","article-title":"Suppression of time-dependent outward current in guinea pig ventricular myocytes. Actions of quinidine and amiodarone","volume":"69","author":"Balser","year":"1991","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2020.117814_bb0190","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1046\/j.1540-8167.2004.04099.x","article-title":"Comparative pharmacology of guinea pig cardiac myocyte and cloned hERG (I(Kr)) channel","volume":"15","author":"Davie","year":"2004","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"10.1016\/j.lfs.2020.117814_bb0195","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1097\/00005344-199106000-00006","article-title":"Voltage- and use-dependent modulation of calcium channel current in guinea pig ventricular cells by amiodarone and des-oxo-amiodarone","volume":"17","author":"Valenzuela","year":"1991","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117814_bb0200","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41569-019-0179-0","article-title":"Animal models of arrhythmia: classic electrophysiology to genetically modified large animals","volume":"16","author":"Clauss","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.lfs.2020.117814_bb0205","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF03349178","article-title":"Uptake of amiodarone by thyroidal and non-thyroidal cell lines","volume":"29","author":"Bogazzi","year":"2006","journal-title":"J. Endocrinol. Investig."},{"key":"10.1016\/j.lfs.2020.117814_bb0210","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1111\/j.1476-5381.2009.00320.x","article-title":"Intracellular sequestration of amiodarone: role of vacuolar ATPase and macroautophagic transition of the resulting vacuolar cytopathology","volume":"157","author":"Morissette","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117814_bb0215","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1161\/01.RES.55.3.278","article-title":"Block of inactivated sodium channels and of depolarization-induced automaticity in guinea pig papillary muscle by amiodarone","volume":"55","author":"Mason","year":"1984","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2020.117814_bb0220","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/j.hrthm.2014.04.042","article-title":"Novel SCN5A mutation in amiodarone-responsive multifocal ventricular ectopy-associated cardiomyopathy","volume":"11","author":"Beckermann","year":"2014","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.lfs.2020.117814_bb0225","doi-asserted-by":"crossref","first-page":"C601","DOI":"10.1152\/ajpcell.00452.2005","article-title":"Beta-adrenergic stimulation does not activate Na+\/Ca2+ exchange current in guinea pig, mouse, and rat ventricular myocytes","volume":"290","author":"Lin","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.lfs.2020.117814_bb0230","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s004240000512","article-title":"Intracellular sodium and contractile function in hypertrophied human and guinea-pig myocardium","volume":"442","author":"Gray","year":"2001","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.lfs.2020.117814_bb0235","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1161\/01.RES.82.6.657","article-title":"Effects of overexpression of the Na+-Ca2+ exchanger on [Ca2+]i transients in murine ventricular myocytes","volume":"82","author":"Yao","year":"1998","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2020.117814_bb0240","first-page":"C813","article-title":"Rat vs. rabbit ventricle: Ca flux and intracellular Na assessed by ion-selective microelectrodes","volume":"256","author":"Shattock","year":"1989","journal-title":"Am. J. Phys."},{"issue":"Suppl. 4","key":"10.1016\/j.lfs.2020.117814_bb0245","first-page":"iv6","article-title":"Inhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazine","volume":"92","author":"Belardinelli","year":"2006","journal-title":"Heart"},{"key":"10.1016\/j.lfs.2020.117814_bb0250","first-page":"1","article-title":"Impaired sarcoplasmic reticulum calcium uptake and release promote electromechanically and spatially discordant alternans: a computational study","volume":"10","author":"Weinberg","year":"2016","journal-title":"Clin Med Insights Cardiol"},{"key":"10.1016\/j.lfs.2020.117814_bb0255","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1161\/01.RES.87.10.910","article-title":"Distribution of a persistent sodium current across the ventricular wall in guinea pigs","volume":"87","author":"Sakmann","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2020.117814_bb0260","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1540-8167.1996.tb00557.x","article-title":"Evidence for the presence of M cells in the guinea pig ventricle","volume":"7","author":"Sicouri","year":"1996","journal-title":"J. Cardiovasc. Electrophysiol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520305634?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520305634?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:40:47Z","timestamp":1758400847000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320520305634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":52,"alternative-id":["S0024320520305634"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.117814","relation":{},"ISSN":["0024-3205"],"issn-type":[{"type":"print","value":"0024-3205"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of amiodarone on rodent ventricular cardiomyocytes: Novel perspectives from a cellular model of Long QT Syndrome Type 3","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.117814","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117814"}}