{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:09:28Z","timestamp":1791835768933,"version":"4.3.4"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000},"content-version":"vor","delay-in-days":296,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["306082\/2014-4"],"award-info":[{"award-number":["306082\/2014-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000770","name":"University of Manchester","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000770","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["1966\/2016"],"award-info":[{"award-number":["1966\/2016"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.lfs.2020.117819","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T11:39:34Z","timestamp":1589888374000},"page":"117819","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Perivascular adipose tissue phenotype and sepsis vascular dysfunction: Differential contribution of NO, ROS and beta 3-adrenergic receptor"],"prefix":"10.1016","volume":"254","author":[{"given":"Clarissa Germano","family":"Barp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Oliveira","family":"Benedet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamil","family":"Assreuy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2020.117819_bb0005","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1056\/NEJMra1208623","article-title":"Severe sepsis and septic shock","volume":"369","author":"Angus","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2020.117819_bb0010","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.lfs.2020.117819_bb0015","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/jac\/41.suppl_1.9","article-title":"Cardiovascular alterations in septic shock","volume":"41","author":"Vincent","year":"1998","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.lfs.2020.117819_bb0020","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/bjaceaccp\/mkv003","article-title":"Pathophysiology of cardiovascular dysfunction in sepsis","volume":"15","author":"Greer","year":"2015","journal-title":"BJA Educ."},{"key":"10.1016\/j.lfs.2020.117819_bb0025","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","article-title":"Nitric oxide: physiology, pathophysiology, and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.lfs.2020.117819_bb0030","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/368850a0","article-title":"Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle","volume":"368","author":"Bolotina","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2020.117819_bb0035","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1161\/ATVBAHA.110.215939","article-title":"Compartmentalized connexin 43 S-nitrosylation\/denitrosylation regulates heterocellular communication in the vessel wall","volume":"31","author":"Straub","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.lfs.2020.117819_bb0040","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0005-2728(99)00031-6","article-title":"Nitric oxide in septic shock","volume":"1411","author":"Titheradge","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.lfs.2020.117819_bb0045","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.bbrc.2010.07.071","article-title":"Role of different nitric oxide synthase isoforms in a murine model of acute lung injury and sepsis","volume":"399","author":"Lange","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2020.117819_bb0050","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1097\/CCM.0000000000000301","article-title":"Neuronal nitric oxide synthase and its interaction with soluble guanylate cyclase is a key factor for the vascular dysfunction of experimental sepsis","volume":"42","author":"Nardi","year":"2014","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.lfs.2020.117819_bb0055","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.phrs.2015.08.001","article-title":"Rapid NOS-1-derived nitric oxide and peroxynitrite formation act as signaling agents for inducible NOS-2 expression in vascular smooth muscle cells","volume":"100","author":"Scheschowitsch","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.lfs.2020.117819_bb0060","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1152\/ajpheart.00052.2016","article-title":"Cardiac hyporesponsiveness in severe sepsis is associated with nitric oxide-dependent activation of G protein receptor kinase","volume":"313","author":"Dal-Secco","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.lfs.2020.117819_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/CS20110151","article-title":"Perivascular adipose tissue: more than just structural support","volume":"122","author":"Szasz","year":"2012","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.lfs.2020.117819_bb0070","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1530\/JOE-16-0211","article-title":"Adipose tissue in control of metabolism","volume":"231","author":"Luo","year":"2016","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.lfs.2020.117819_bb0075","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1677\/JOE-07-0284","article-title":"Comparative expression analysis of the renin\u2013angiotensin system components between white and brown perivascular adipose tissue","volume":"197","author":"G\u00e1lvez-Prieto","year":"2008","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.lfs.2020.117819_bb0080","first-page":"R543","article-title":"Divergent phenotype of rat thoracic and abdominal perivascular adipose tissues","volume":"304","author":"Padilla","year":"2013","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.lfs.2020.117819_bb0085","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.tem.2015.04.003","article-title":"Regional differences in perivascular adipose tissue impacting vascular homeostasis","volume":"26","author":"Gil-Ortega","year":"2015","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2020.117819_bb0090","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3389\/fphys.2016.00295","article-title":"Different anti-contractile function and nitric oxide production of thoracic and abdominal perivascular adipose tissues","volume":"7","author":"Victorio","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.lfs.2020.117819_bb0095","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1161\/ATVBAHA.114.303029","article-title":"Perivascular adipose tissue in vascular function and disease - a review of current research and animal models","volume":"34","author":"Brown","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.lfs.2020.117819_bb0100","first-page":"277","article-title":"Influence of perivascular adipose tissue on rat aortic smooth muscle responsiveness","volume":"13","author":"Soltis","year":"1991","journal-title":"Clin. Exper. Hyper. A"},{"key":"10.1016\/j.lfs.2020.117819_bb0105","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.1111\/bph.13663","article-title":"New actions of an old friend: perivascular adipose tissue\u2019s adrenergic mechanisms","volume":"174","author":"Ayala-Lopez","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117819_bb0110","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1161\/ATVBAHA.118.310777","article-title":"Role of sympathetic nerves and adipocyte catecholamine uptake in the vasorelaxant function of perivascular adipose tissue","volume":"38","author":"Saxton","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.lfs.2020.117819_bb0115","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1161\/ATVBAHA.118.311720","article-title":"Perivascular adipocytes atore norepinephrine by vesicular transport","volume":"39","author":"Ahmad","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.lfs.2020.117819_bb0120","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1161\/CIRCULATIONAHA.108.821181","article-title":"Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients","volume":"119","author":"Greenstein","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2020.117819_bb0125","doi-asserted-by":"crossref","DOI":"10.1111\/1755-5922.12322","article-title":"Vascular dysfunction elicited by a cross talk between periaortic adipose tissue and the vascular wall is reversed by pioglitazone","volume":"36","author":"Quesada","year":"2018","journal-title":"Cardiovasc. Ther."},{"key":"10.1016\/j.lfs.2020.117819_bb0130","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nprot.2008.214","article-title":"Immunodesign of experimental sepsis by cecal ligation and puncture","volume":"4","author":"Rittirsch","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.lfs.2020.117819_bb0135","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1152\/ajpheart.00697.2012","article-title":"Perivascular adipose tissue-derived adiponectin activates BKCa channels to induce anticontractile responses","volume":"304","author":"Lynch","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.lfs.2020.117819_bb0140","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.bbadis.2017.10.029","article-title":"The therapeutic value of protein (de)nitrosylation in experimental septic shock","volume":"1864","author":"Benedet","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.lfs.2020.117819_bb0145","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1111\/bph.14433","article-title":"\u03b23-Adrenoceptor stimulation of perivascular adipocytes leads to increased fat cell-derived NO and vascular relaxation in small arteries","volume":"175","author":"Bussey","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117819_bb0150","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/joim.12331","article-title":"Endothelial barrier dysfunction in septic shock","volume":"277","author":"Opal","year":"2015","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.lfs.2020.117819_bb0155","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/0883-9441(94)90006-X","article-title":"Endothelial and vascular smooth muscle function in sepsis","volume":"9","author":"Hollenberg","year":"1994","journal-title":"J. Crit. Care"},{"key":"10.1016\/j.lfs.2020.117819_bb0160","series-title":"Handb. Exp. Pharmacol","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/3-540-32967-6_7","article-title":"Nitric oxide and the vascular endothelium","volume":"176","author":"Moncada","year":"2006"},{"key":"10.1016\/j.lfs.2020.117819_bb0165","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4161\/viru.26482","article-title":"Pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock","volume":"5","author":"Backer","year":"2014","journal-title":"Virulence"},{"key":"10.1016\/j.lfs.2020.117819_bb0170","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.jtcvs.2005.05.028","article-title":"Perivascular adipose tissue modulates vascular function in the human internal thoracic artery","volume":"130","author":"Gao","year":"2005","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.lfs.2020.117819_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172706","article-title":"Perivascular adipose tissue contributes to lethal sepsis-induced vasoplegia in rats","volume":"863","author":"Awata","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117819_bb0180","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.cardiores.2006.03.013","article-title":"Perivascular adipose tissue promotes vasoconstriction: the role of superoxide anion","volume":"71","author":"Gao","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2020.117819_bb0185","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nri1937","article-title":"Adipocytokines: mediators linking adipose tissue, inflammation and immunity","volume":"6","author":"Tilg","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.lfs.2020.117819_bb0190","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1161\/ATVBAHA.115.306263","article-title":"Uncoupling of endothelial nitric oxide synthase in perivascular adipose tissue of diet-induced obese mice","volume":"36","author":"Xia","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.lfs.2020.117819_bb0195","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ejphar.2011.05.065","article-title":"NOS-1-derived NO is an essential triggering signal for the development of systemic inflammatory responses","volume":"668","author":"Duma","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117819_bb0200","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrd4623","article-title":"Strategies to increase nitric oxide signalling in cardiovascular disease","volume":"14","author":"Lundberg","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.lfs.2020.117819_bb0205","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1124\/mol.63.5.1148","article-title":"Role of S-nitrosation of cysteine residues in longlasting inhibitory effect of nitric oxide on arterial tone","volume":"63","author":"Alencar","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117819_bb0210","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1472-8206.1995.tb00268.x","article-title":"Regulation of beta 3-adrenoceptor expression in white fat cells","volume":"9","author":"Langin","year":"1995","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117819_bb0215","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/s41598-017-01047-1","article-title":"The role of the brown adipose tissue in \u03b23-adrenergic receptor activation-induced sleep, metabolic and feeding responses","volume":"7","author":"Szentirmai","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2020.117819_bb0220","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1046\/j.1523-1755.2000.00212.x","article-title":"Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat","volume":"58","author":"Chatterjee","year":"2000","journal-title":"Kidney Int."},{"key":"10.1016\/j.lfs.2020.117819_bb0225","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/bja\/aer093","article-title":"Oxidative stress and mitochondrial dysfunction in sepsis","volume":"107","author":"Galley","year":"2011","journal-title":"Br. J. Anaesth."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520305683?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520305683?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:47:06Z","timestamp":1775062026000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320520305683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":45,"alternative-id":["S0024320520305683"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.117819","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perivascular adipose tissue phenotype and sepsis vascular dysfunction: Differential contribution of NO, ROS and beta 3-adrenergic receptor","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.117819","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117819"}}