{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:43:27Z","timestamp":1790358207238,"version":"4.1.0"},"reference-count":140,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573652"],"award-info":[{"award-number":["81573652"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874354"],"award-info":[{"award-number":["81874354"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.lfs.2020.117909","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T07:48:47Z","timestamp":1591343327000},"page":"117909","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"special_numbering":"C","title":["Activation of Nrf2\/AREs-mediated antioxidant signalling, and suppression of profibrotic TGF-\u03b21\/Smad3 pathway: a promising therapeutic strategy for hepatic fibrosis \u2014 A review"],"prefix":"10.1016","volume":"256","author":[{"given":"Yongfang","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2020.117909_bb0005","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.addr.2017.05.007","article-title":"Hepatic stellate cells as key target in liver fibrosis","volume":"121","author":"Higashi","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.lfs.2020.117909_bb0010","doi-asserted-by":"crossref","first-page":"875","DOI":"10.3390\/cells9040875","article-title":"Liver Fibrosis: mechanistic concepts and therapeutic perspectives","volume":"9","author":"Roehlen","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.lfs.2020.117909_bb0015","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3390\/cells9020461","article-title":"Cellular interplay as a consequence of inflammatory signals leading to liver fibrosis development","volume":"9","author":"Ignat","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.lfs.2020.117909_bb0020","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.taap.2009.10.002","article-title":"Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats","volume":"242","author":"Tsai","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117909_bb0025","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s10620-017-4710-z","article-title":"NF-E2-related factor 2 suppresses intestinal fibrosis by inhibiting reactive oxygen species-dependent TGF-beta1\/SMADs pathway","volume":"63","author":"Guan","year":"2018","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.lfs.2020.117909_bb0030","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.1111\/bph.14831","article-title":"Praziquantel ameliorates CCl4 -induced liver fibrosis in mice by inhibiting TGF-beta\/Smad signalling via up-regulating Smad7 in hepatic stellate cells","volume":"176","author":"Liu","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117909_bb0035","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1369\/0022155415627681","article-title":"TGF-beta\/SMAD pathway and its regulation in hepatic fibrosis","volume":"64","author":"Xu","year":"2016","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.lfs.2020.117909_bb0040","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.crohns.2014.03.008","article-title":"Results of the 4th scientific workshop of the ECCO (I): pathophysiology of intestinal fibrosis in IBD","volume":"8","author":"Latella","year":"2014","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.lfs.2020.117909_bb0045","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1080\/14728222.2017.1351549","article-title":"Nrf2: a potential therapeutic target for naturally occurring anticancer drugs?","volume":"21","author":"Catanzaro","year":"2017","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.lfs.2020.117909_bb0050","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1159\/000475890","article-title":"Targeting the Keap1-Nrf2 system to prevent kidney disease progression","volume":"45","author":"Nezu","year":"2017","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.lfs.2020.117909_bb0055","doi-asserted-by":"crossref","first-page":"10074","DOI":"10.3390\/molecules190710074","article-title":"Molecular and chemical regulation of the Keap1-Nrf2 signaling pathway","volume":"19","author":"Keum","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.lfs.2020.117909_bb0060","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.tiv.2009.03.006","article-title":"Quercetin protects against ethanol-induced oxidative damage in rat primary hepatocytes","volume":"24","author":"Liu","year":"2010","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.lfs.2020.117909_bb0065","first-page":"6321","article-title":"Simvastatin alleviates inflammation and oxidative stress in rats with cerebral hemorrhage through Nrf2-ARE signaling pathway","volume":"23","author":"Zhang","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.lfs.2020.117909_bb0070","doi-asserted-by":"crossref","first-page":"G667","DOI":"10.1152\/ajpgi.00050.2016","article-title":"Dysregulation of redox pathways in liver fibrosis","volume":"311","author":"Torok","year":"2016","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.lfs.2020.117909_bb0075","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1172\/JCI66028","article-title":"Evolving therapies for liver fibrosis","volume":"123","author":"Schuppan","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2020.117909_bb0080","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1038\/ncomms3823","article-title":"Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology","volume":"4","author":"Mederacke","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2020.117909_bb0085","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1172\/JCI66369","article-title":"Hepatic stellate cells in liver development, regeneration, and cancer","volume":"123","author":"Yin","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2020.117909_bb0090","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3892\/ijmm.2017.3015","article-title":"Therapeutic strategies for alcoholic liver disease: focusing on inflammation and fibrosis (review)","volume":"40","author":"Kawaratani","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.lfs.2020.117909_bb0095","doi-asserted-by":"crossref","first-page":"8082","DOI":"10.3748\/wjg.v20.i25.8082","article-title":"Oxidative stress as a crucial factor in liver diseases","volume":"20","author":"Cichoz-Lach","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.lfs.2020.117909_bb0100","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.2174\/092986712803341520","article-title":"Role of oxidative stress and molecular changes in liver fibrosis: a review","volume":"19","author":"Sanchezvalle","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.lfs.2020.117909_bb0105","doi-asserted-by":"crossref","first-page":"4234061","DOI":"10.1155\/2016\/4234061","article-title":"Insights into the role and interdependence of oxidative stress and inflammation in liver diseases","volume":"2016","author":"Li","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.lfs.2020.117909_bb0110","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/112_2018_10","article-title":"Targeting oxidative stress for the treatment of liver fibrosis","volume":"175","author":"Luangmonkong","year":"2018","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117909_bb0115","doi-asserted-by":"crossref","first-page":"26087","DOI":"10.3390\/ijms161125942","article-title":"The role of oxidative stress and antioxidants in liver diseases","volume":"16","author":"Li","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2020.117909_bb0120","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.7314\/APJCP.2014.15.11.4405","article-title":"Oxidative stress and antioxidants in disease and cancer: a review","volume":"15","author":"Gupta","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.lfs.2020.117909_bb0125","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3109\/10715762.2011.647691","article-title":"Ascorbic acid supplementation down-regulates the alcohol induced oxidative stress, hepatic stellate cell activation, cytotoxicity and mRNA levels of selected fibrotic genes in guinea pigs","volume":"46","author":"Abhilash","year":"2012","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.lfs.2020.117909_bb0130","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0168-8278(01)00142-8","article-title":"Oxidative stress-related molecules and liver fibrosis","volume":"35","author":"Parola","year":"2001","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2020.117909_bb0135","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1055\/s-2002-26761","article-title":"Oxidative stress, plant-derived antioxidants and liver fibrosis","volume":"68","author":"Gebhardt","year":"2002","journal-title":"Planta Med."},{"key":"10.1016\/j.lfs.2020.117909_bb0140","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/med.21257","article-title":"Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents","volume":"32","author":"Magesh","year":"2012","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.lfs.2020.117909_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/cells8111419","article-title":"TGF-beta in hepatic stellate cell activation and liver fibrogenesis-updated 2019","volume":"8","author":"Dewidar","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.lfs.2020.117909_bb0150","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.fct.2017.02.016","article-title":"Hepatoprotective effect of 2'-O-galloylhyperin against oxidative stress-induced liver damage through induction of Nrf2\/ARE-mediated antioxidant pathway","volume":"102","author":"Wang","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.lfs.2020.117909_bb0155","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1055\/s-0028-1088302","article-title":"Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals","volume":"74","author":"Surh","year":"2008","journal-title":"Planta Med."},{"key":"10.1016\/j.lfs.2020.117909_bb0160","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3389\/fonc.2012.00200","article-title":"The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism","volume":"2","author":"Mitsuishi","year":"2012","journal-title":"Front. Oncol."},{"key":"10.1016\/j.lfs.2020.117909_bb0165","doi-asserted-by":"crossref","first-page":"10895","DOI":"10.1128\/MCB.25.24.10895-10906.2005","article-title":"The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation","volume":"25","author":"Nioi","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.lfs.2020.117909_bb0170","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1158\/0008-5472.CAN-12-3386","article-title":"RXRalpha inhibits the NRF2-ARE signaling pathway through a direct interaction with the Neh7 domain of NRF2","volume":"73","author":"Wang","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2020.117909_bb0175","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1101\/gad.225680.113","article-title":"The emerging role of the Nrf2-Keap1 signaling pathway in cancer","volume":"27","author":"Jaramillo","year":"2013","journal-title":"Genes Dev."},{"key":"10.1016\/j.lfs.2020.117909_bb0180","doi-asserted-by":"crossref","first-page":"10726","DOI":"10.1038\/s41598-018-29023-3","article-title":"Amelioratory effects of testosterone propionate on age-related renal fibrosis via suppression of TGF-beta1\/Smad signaling and activation of Nrf2-ARE signaling","volume":"8","author":"Zhang","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2020.117909_bb0185","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.2147\/DDDT.S137507","article-title":"Schisandrin B attenuates CCl4-induced liver fibrosis in rats by regulation of Nrf2-ARE and TGF-beta\/Smad signaling pathways","volume":"11","author":"Chen","year":"2017","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.lfs.2020.117909_bb0190","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.freeradbiomed.2011.11.012","article-title":"Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-beta\/Smad signaling","volume":"52","author":"Oh","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.lfs.2020.117909_bb0195","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.freeradbiomed.2013.07.029","article-title":"Sirt1 resists advanced glycation end products-induced expressions of fibronectin and TGF-beta1 by activating the Nrf2\/ARE pathway in glomerular mesangial cells","volume":"65","author":"Huang","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.lfs.2020.117909_bb0200","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1743-7075-10-7","article-title":"Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2\/HO-1 pathway","volume":"10","author":"Kilic","year":"2013","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.lfs.2020.117909_bb0205","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.freeradbiomed.2009.07.035","article-title":"Nrf2:INrf2 (Keap1) signaling in oxidative stress","volume":"47","author":"Kaspar","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.lfs.2020.117909_bb0210","first-page":"277","article-title":"Induction of HO-1 and redox signaling in endothelial cells by advanced glycation end products: a role for Nrf2 in vascular protection in diabetes","volume":"21","author":"He","year":"2011","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.lfs.2020.117909_bb0215","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1007\/s00018-018-2852-6","article-title":"Targeting Nrf-2 is a promising intervention approach for the prevention of ethanol-induced liver disease","volume":"75","author":"Zhao","year":"2018","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.lfs.2020.117909_bb0220","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.tox.2007.10.029","article-title":"The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity","volume":"246","author":"Copple","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.lfs.2020.117909_bb0225","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.bbrc.2003.09.086","article-title":"Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts","volume":"310","author":"Hayashi","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2020.117909_bb0230","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.freeradbiomed.2004.02.074","article-title":"Nrf2 signaling in coordinated activation of antioxidant gene expression","volume":"36","author":"Jaiswal","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.lfs.2020.117909_bb0235","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.advenzreg.2006.01.007","article-title":"Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species","volume":"46","author":"Kobayashi","year":"2006","journal-title":"Adv. Enzym. Regul."},{"key":"10.1016\/j.lfs.2020.117909_bb0240","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.freeradbiomed.2007.05.029","article-title":"Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma cells","volume":"43","author":"Kwak","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.lfs.2020.117909_bb0245","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/toxsci\/kfn177","article-title":"Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid","volume":"106","author":"Maher","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.lfs.2020.117909_bb0250","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1124\/dmd.105.003798","article-title":"Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver","volume":"33","author":"Maher","year":"2005","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.lfs.2020.117909_bb0255","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1002\/hep.21831","article-title":"Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway","volume":"46","author":"Maher","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2020.117909_bb0260","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1124\/mol.105.014571","article-title":"trans-Stilbene oxide induces expression of genes involved in metabolism and transport in mouse liver via CAR and Nrf2 transcription factors","volume":"69","author":"Slitt","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117909_bb0265","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1080\/03602530600971974","article-title":"Mechanistic studies of the Nrf2-Keap1 signaling pathway","volume":"38","author":"Zhang","year":"2006","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.lfs.2020.117909_bb0270","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.biopha.2017.03.079","article-title":"Metformin mitigates carbon tetrachloride-induced TGF-beta1\/Smad3 signaling and liver fibrosis in mice","volume":"90","author":"Fan","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.lfs.2020.117909_bb0275","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1124\/mol.112.084269","article-title":"Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model","volume":"84","author":"Shimozono","year":"2013","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117909_bb0280","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ejphar.2009.08.022","article-title":"Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide","volume":"620","author":"Shin","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117909_bb0285","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1007\/s00125-010-2001-8","article-title":"Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 [corrected](NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL\/6J mice","volume":"54","author":"Yu","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/j.lfs.2020.117909_bb0290","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bbagen.2013.09.018","article-title":"Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis","volume":"1840","author":"Zhou","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.lfs.2020.117909_bb0295","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1749-6632.2011.06092.x","article-title":"Regulation of the Keap1\/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications","volume":"1229","author":"Keum","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.lfs.2020.117909_bb0300","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.taap.2012.05.010","article-title":"Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation","volume":"262","author":"Wu","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117909_bb0305","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/labinvest.2008.75","article-title":"The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis","volume":"88","author":"Xu","year":"2008","journal-title":"Lab. Invest."},{"key":"10.1016\/j.lfs.2020.117909_bb0310","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1093\/carcin\/bgn095","article-title":"Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2","volume":"29","author":"Wang","year":"2008","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.lfs.2020.117909_bb0315","doi-asserted-by":"crossref","first-page":"11580","DOI":"10.1158\/0008-5472.CAN-06-3562","article-title":"Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis","volume":"66","author":"Khor","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2020.117909_bb0320","doi-asserted-by":"crossref","first-page":"E791","DOI":"10.3390\/biom10050791","article-title":"The NRF2\/KEAP1 axis in the regulation of tumor metabolism: mechanisms and therapeutic perspectives","volume":"10","author":"Panieri","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.lfs.2020.117909_bb0325","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1089\/ars.2007.1901","article-title":"Oxidative stress and antioxidants in the pathogenesis of pulmonary fibrosis: a potential role for Nrf2","volume":"10","author":"Walters","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.lfs.2020.117909_bb0330","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/bbrc.1997.6943","article-title":"An Nrf2\/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements","volume":"236","author":"Itoh","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2020.117909_bb0335","doi-asserted-by":"crossref","first-page":"13079","DOI":"10.3748\/wjg.v20.i36.13079","article-title":"Role of Nrf2 in chronic liver disease","volume":"20","author":"Tang","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.lfs.2020.117909_bb0340","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/clpt.2012.110","article-title":"Nrf2: a potential target for new therapeutics in liver disease","volume":"92","author":"Bataille","year":"2012","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.lfs.2020.117909_bb0345","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1089\/152308602753666307","article-title":"Activation of the mouse heme oxygenase-1 gene by 15-deoxy-delta(12,14)-prostaglandin J(2) is mediated by the stress response elements and transcription factor Nrf2","volume":"4","author":"Gong","year":"2002","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.lfs.2020.117909_bb0350","first-page":"1","article-title":"Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms, is raised by health promoting factors","volume":"67","author":"Pall","year":"2015","journal-title":"Acta Phys. Sin."},{"key":"10.1016\/j.lfs.2020.117909_bb0355","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2147\/DDDT.S68501","article-title":"Schisandra chinensis regulates drug metabolizing enzymes and drug transporters via activation of Nrf2-mediated signaling pathway","author":"Zhou","year":"2014","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.lfs.2020.117909_bb0360","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1080\/01926230701311344","article-title":"Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease","volume":"35","author":"Aleksunes","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.lfs.2020.117909_bb0365","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1096\/fj.04-2591hyp","article-title":"Nrf2, a multi-organ protector?","volume":"19","author":"Lee","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.lfs.2020.117909_bb0370","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.freeradbiomed.2013.02.008","article-title":"Regulation of Nrf2-an update","volume":"66","author":"Niture","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.lfs.2020.117909_bb0375","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1146\/annurev.pharmtox.43.100901.140229","article-title":"Regulatory mechanisms controlling gene expression mediated by the antioxidant response element","volume":"43","author":"Nguyen","year":"2003","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.lfs.2020.117909_bb0380","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1111\/j.1745-7254.2007.00688.x","article-title":"Keap1 eye on the target: chemoprevention of liver cancer","volume":"28","author":"Yates","year":"2007","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.lfs.2020.117909_bb0385","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1096\/fj.03-1273rev","article-title":"TGF-beta signaling and the fibrotic response","volume":"18","author":"Leask","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.lfs.2020.117909_bb0390","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nrd3810","article-title":"Targeting the TGFbeta signalling pathway in disease","volume":"11","author":"Akhurst","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.lfs.2020.117909_bb0395","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1111\/febs.13665","article-title":"TGF-beta signalling and liver disease","volume":"283","author":"Fabregat","year":"2016","journal-title":"FEBS J."},{"key":"10.1016\/j.lfs.2020.117909_bb0400","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.cbi.2014.10.005","article-title":"Sauchinone attenuates liver fibrosis and hepatic stellate cell activation through TGF-beta\/Smad signaling pathway","volume":"224","author":"Lee","year":"2014","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.lfs.2020.117909_bb0405","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1021\/mp9000469","article-title":"TGF-beta1 gene silencing for treating liver fibrosis","volume":"6","author":"Cheng","year":"2009","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.lfs.2020.117909_bb0410","doi-asserted-by":"crossref","first-page":"d793","DOI":"10.2741\/gressner","article-title":"Roles of TGF-beta in hepatic fibrosis","volume":"7","author":"Gressner","year":"2002","journal-title":"Front. Biosci."},{"key":"10.1016\/j.lfs.2020.117909_bb0415","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1582-4934.2006.tb00292.x","article-title":"Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets","volume":"10","author":"Gressner","year":"2006","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.lfs.2020.117909_bb0420","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00441-011-1246-y","article-title":"TGF-beta in progression of liver disease","volume":"347","author":"Dooley","year":"2012","journal-title":"Cell Tissue Res."},{"issue":"Suppl. 1","key":"10.1016\/j.lfs.2020.117909_bb0425","first-page":"S122","article-title":"Transforming growth factor-beta and hepatocyte transdifferentiation in liver fibrogenesis","volume":"23","author":"Meindl-Beinker","year":"2008","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.lfs.2020.117909_bb0430","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lfs.2016.04.023","article-title":"Diosmetin prevents TGF-beta1-induced epithelial-mesenchymal transition via ROS\/MAPK signaling pathways","volume":"153","author":"Ge","year":"2016","journal-title":"Life Sci."},{"issue":"Pt A","key":"10.1016\/j.lfs.2020.117909_bb0435","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jep.2014.10.028","article-title":"Mistletoe alkaloid fractions alleviates carbon tetrachloride-induced liver fibrosis through inhibition of hepatic stellate cell activation via TGF-beta\/Smad interference","volume":"158","author":"Jiang","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.lfs.2020.117909_bb0440","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.7150\/ijbs.7.1056","article-title":"Diverse roles of TGF-beta\/Smads in renal fibrosis and inflammation","volume":"7","author":"Lan","year":"2011","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.lfs.2020.117909_bb0445","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ejphar.2016.04.042","article-title":"Isorhamnetin attenuates liver fibrosis by inhibiting TGF-beta\/Smad signaling and relieving oxidative stress","volume":"783","author":"Yang","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117909_bb0450","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00441-011-1190-x","article-title":"Role of Smads in TGFbeta signaling","volume":"347","author":"Heldin","year":"2012","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.lfs.2020.117909_bb0455","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1136\/gut.2005.088690","article-title":"Emerging insights into transforming growth factor beta Smad signal in hepatic fibrogenesis","volume":"56","author":"Inagaki","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.lfs.2020.117909_bb0460","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1139\/o02-161","article-title":"TGF-beta and the Smad signal transduction pathway","volume":"80","author":"Mehra","year":"2002","journal-title":"Biochem. Cell Biol."},{"key":"10.1016\/j.lfs.2020.117909_bb0465","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s10555-012-9375-7","article-title":"TGF-beta signalling and its role in cancer progression and metastasis","volume":"31","author":"Drabsch","year":"2012","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.lfs.2020.117909_bb0470","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1242\/dev.030338","article-title":"The regulation of TGFbeta signal transduction","volume":"136","author":"Moustakas","year":"2009","journal-title":"Development (Camb. Engl.)"},{"key":"10.1016\/j.lfs.2020.117909_bb0475","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s003350010032","article-title":"Genomic locus and promoter region of rat Smad7, an important antagonist of TGF beta signaling","volume":"11","author":"Stopa","year":"2000","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.lfs.2020.117909_bb0480","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1053\/j.gastro.2008.04.038","article-title":"Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage","volume":"135","author":"Dooley","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2020.117909_bb0485","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1042\/CS20140606","article-title":"Smad7 regulates compensatory hepatocyte proliferation in damaged mouse liver and positively relates to better clinical outcome in human hepatocellular carcinoma","volume":"128","author":"Feng","year":"2015","journal-title":"Clin. Sci. (Lond. Engl.: 1979)"},{"key":"10.1016\/j.lfs.2020.117909_bb0490","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000324949","article-title":"Transforming growth factor-beta and Smads","volume":"170","author":"Lan","year":"2011","journal-title":"Contrib. Nephrol."},{"key":"10.1016\/j.lfs.2020.117909_bb0495","volume":"50","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2020.117909_bb0500","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0016-5085(03)00666-8","article-title":"Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats","volume":"125","author":"Dooley","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2020.117909_bb0505","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3390\/cancers10060183","article-title":"Clinico-pathological importance of TGF-\u03b2\/Phospho-Smad signaling during human hepatic fibrocarcinogenesis","volume":"10","author":"Yoshida","year":"2018","journal-title":"Cancers"},{"key":"10.1016\/j.lfs.2020.117909_bb0510","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11010-014-2258-1","article-title":"Smad2 protects against TGF-\u03b21\/Smad3-mediated collagen synthesis in human hepatic stellate cells during hepatic fibrosis","volume":"400","author":"Zhang","year":"2015","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.lfs.2020.117909_bb0515","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1369\/0022155415627681","article-title":"TGF\/SMAD pathways and its regulation in hepatic fibrosis","volume":"64","author":"Xu","year":"2016","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.lfs.2020.117909_bb0520","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1111\/jgh.12490","article-title":"Compound Astragalus and Salvia miltiorrhiza extracts suppress hepatocarcinogenesis by modulating TGF-\u03b2\/Smad signaling","volume":"29","author":"Hu","year":"2013","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.lfs.2020.117909_bb0525","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/j.1478-3231.2009.02011.x","article-title":"Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice","volume":"29","author":"Latella","year":"2009","journal-title":"Liver Int."},{"issue":"14","key":"10.1016\/j.lfs.2020.117909_bb0530","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.2741\/3423","article-title":"Modulation of TGF-beta signaling during progression of chronic liver diseases","author":"Matsuzaki","year":"2009","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"10.1016\/j.lfs.2020.117909_bb0535","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0092-8674(00)81696-7","article-title":"Smads: transcriptional activators of TGF-beta responses","volume":"95","author":"Derynck","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2020.117909_bb0540","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.cytogfr.2013.06.002","article-title":"Smad phospho-isoforms direct context-dependent TGF-beta signaling","volume":"24","author":"Matsuzaki","year":"2013","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.lfs.2020.117909_bb0545","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.3892\/ijo.2014.2552","article-title":"TGF-beta\/Smad signaling during hepatic fibro-carcinogenesis (review)","volume":"45","author":"Yoshida","year":"2014","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.lfs.2020.117909_bb0550","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s00535-013-0910-2","article-title":"TGF-beta signal shifting between tumor suppression and fibro-carcinogenesis in human chronic liver diseases","volume":"49","author":"Matsuzaki","year":"2014","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.lfs.2020.117909_bb0555","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1093\/carcin\/bgr172","article-title":"Smad phosphoisoform signaling specificity: the right place at the right time","volume":"32","author":"Matsuzaki","year":"2011","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.lfs.2020.117909_bb0560","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/hep.21672","article-title":"Chronic inflammation associated with hepatitis C virus infection perturbs hepatic transforming growth factor beta signaling, promoting cirrhosis and hepatocellular carcinoma","volume":"46","author":"Matsuzaki","year":"2007","journal-title":"Hepatology (Baltimore, Md.)"},{"key":"10.1016\/j.lfs.2020.117909_bb0565","doi-asserted-by":"crossref","DOI":"10.3390\/jcm5010007","article-title":"Reversible human TGF-beta signal shifting between tumor suppression and fibro-carcinogenesis: implications of Smad phospho-isoforms for hepatic epithelial-mesenchymal transitions","volume":"5","author":"Yoshida","year":"2016","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.lfs.2020.117909_bb0570","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3389\/fphys.2012.00053","article-title":"Differential regulation of TGF-beta\/Smad signaling in hepatic stellate cells between acute and chronic liver injuries","volume":"3","author":"Yoshida","year":"2012","journal-title":"Front. Physiol."},{"key":"10.1016\/j.lfs.2020.117909_bb0575","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.15385","article-title":"Smad3 gene C-terminal phosphorylation site mutation aggravates CCl4-induced inflammation in mice","author":"Ding","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.lfs.2020.117909_bb0580","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3748\/wjg.v12.i4.509","article-title":"Molecular therapy for hepatic injury and fibrosis: where are we?","volume":"12","author":"Prosser","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.lfs.2020.117909_bb0585","doi-asserted-by":"crossref","first-page":"D1121","DOI":"10.1093\/nar\/gkx1076","article-title":"Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics","volume":"46","author":"Li","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.lfs.2020.117909_bb0590","first-page":"223","article-title":"Hepatic stellate cells and oxidative stress","volume":"99","author":"Urtasun","year":"2007","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"10.1016\/j.lfs.2020.117909_bb0595","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1177\/0748233714532996","article-title":"Phyllanthin inhibits CCl4-mediated oxidative stress and hepatic fibrosis by down-regulating TNF-alpha\/NF-kappaB, and pro-fibrotic factor TGF-beta1 mediating inflammatory signaling","volume":"32","author":"Krithika","year":"2016","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.lfs.2020.117909_bb0600","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jhep.2015.08.026","article-title":"Hic-5 deficiency attenuates the activation of hepatic stellate cells and liver fibrosis through upregulation of Smad7 in mice","volume":"64","author":"Lei","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2020.117909_bb0605","doi-asserted-by":"crossref","first-page":"5090","DOI":"10.1158\/0008-5472.CAN-06-4629","article-title":"Reversible Smad-dependent signaling between tumor suppression and oncogenesis","volume":"67","author":"Sekimoto","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2020.117909_bb0610","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1111\/hepr.12082","article-title":"Phosphorylated Smad2 and Smad3 signaling: shifting between tumor suppression and fibro-carcinogenesis in chronic hepatitis C","volume":"43","author":"Yamaguchi","year":"2013","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.lfs.2020.117909_bb0615","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00441-011-1178-6","article-title":"Smad phosphoisoform signals in acute and chronic liver injury: similarities and differences between epithelial and mesenchymal cells","volume":"347","author":"Matsuzaki","year":"2012","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.lfs.2020.117909_bb0620","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s10620-017-4887-1","article-title":"Redox imbalance in intestinal fibrosis: beware of the TGFbeta-1, ROS, and Nrf2 connection","volume":"63","author":"Latella","year":"2018","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.lfs.2020.117909_bb0625","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1164\/rccm.201011-1780OC","article-title":"Transforming growth factor-beta and nuclear factor E2-related factor 2 regulate antioxidant responses in airway smooth muscle cells: role in asthma","volume":"184","author":"Michaeloudes","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.lfs.2020.117909_bb0630","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1165\/rcmb.2010-0338OC","article-title":"Attenuation of transforming growth factor-beta-stimulated collagen production in fibroblasts by quercetin-induced heme oxygenase-1","volume":"44","author":"Nakamura","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.lfs.2020.117909_bb0635","doi-asserted-by":"crossref","first-page":"469","DOI":"10.21037\/atm.2017.09.03","article-title":"Nrf2: a promising trove for diabetic wound healing","volume":"5","author":"Jindam","year":"2017","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.lfs.2020.117909_bb0640","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.fct.2007.09.095","article-title":"Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1","volume":"46","author":"Farombi","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.lfs.2020.117909_bb0645","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.fct.2013.02.033","article-title":"Platycodi radix attenuates dimethylnitrosamine-induced liver fibrosis in rats by inducing Nrf2-mediated antioxidant enzymes","volume":"56","author":"Choi","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.lfs.2020.117909_bb0650","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.freeradbiomed.2004.07.021","article-title":"Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals","volume":"37","author":"Chen","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.lfs.2020.117909_bb0655","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ejphar.2017.12.013","article-title":"Rosuvastatin improves myocardial hypertrophy after hemodynamic pressure overload via regulating the crosstalk of Nrf2\/ARE and TGF-beta\/smads pathways in rat heart","volume":"820","author":"Wang","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117909_bb0660","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1152\/japplphysiol.00721.2015","article-title":"Sulforaphane mitigates muscle fibrosis in mdx mice via Nrf2-mediated inhibition of TGF-beta\/Smad signaling","volume":"120","author":"Sun","year":"2016","journal-title":"J. Appl. Physiol. (Bethesda, Md.: 1985)"},{"key":"10.1016\/j.lfs.2020.117909_bb0665","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045870","article-title":"Dimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-beta\/Smad signaling","volume":"7","author":"Oh","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2020.117909_bb0670","doi-asserted-by":"crossref","first-page":"21015","DOI":"10.18632\/oncotarget.15472","article-title":"Imidazoline I2 receptor inhibitor idazoxan regulates the progression of hepatic fibrosis via Akt-Nrf2-Smad2\/3 signaling pathway","volume":"8","author":"Xuanfei","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.lfs.2020.117909_bb0675","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.4161\/cc.29298","article-title":"Keap1 modulates the redox cycle and hepatocyte cell cycle in regenerating liver","volume":"13","author":"Hu","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.lfs.2020.117909_bb0680","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1124\/jpet.115.231316","article-title":"Nuclear factor erythroid 2-related factor 2 deficiency results in amplification of the liver fat-lowering effect of estrogen","volume":"358","author":"Rui","year":"2016","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2020.117909_bb0685","first-page":"44","article-title":"Salvianolic acid B exerts anti-hepatic fibrosis-carcinoma effect via mediation of pSmad3C\/pSmad3L","volume":"34","author":"Ma","year":"2018","journal-title":"Chin. Pharmacol. Bull."},{"key":"10.1016\/j.lfs.2020.117909_bb0690","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1139\/cjpp-2019-0349","article-title":"Salvianolic acid B exerts a protective effect in acute liver injury by regulating the Nrf2\/HO-1 signaling pathway","volume":"98","author":"Jin","year":"2020","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.lfs.2020.117909_bb0695","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116881","article-title":"Salvianolic acid B exerts anti-liver fibrosis effects via inhibition of MAPK-mediated phospho-Smad2\/3at linker regions in vivo and in vitro","volume":"239","author":"Wu","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2020.117909_bb0700","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jep.2008.04.012","article-title":"Compound Astragalus and Salvia miltiorrhiza extract exerts anti-fibrosis by mediating TGF-beta\/Smad signaling in myofibroblasts","volume":"118","author":"Yang","year":"2008","journal-title":"J. Ethnopharmacol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520306597?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520306597?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T19:18:50Z","timestamp":1735413530000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320520306597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":140,"alternative-id":["S0024320520306597"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.117909","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of Nrf2\/AREs-mediated antioxidant signalling, and suppression of profibrotic TGF-\u03b21\/Smad3 pathway: a promising therapeutic strategy for hepatic fibrosis \u2014 A review","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.117909","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117909"}}