{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:54:54Z","timestamp":1787068494974,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["16K10962"],"award-info":[{"award-number":["16K10962"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.lfs.2020.118074","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T01:39:30Z","timestamp":1594604370000},"page":"118074","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Sodium thiosulfate prevents doxorubicin-induced DNA damage and apoptosis in cardiomyocytes in mice"],"prefix":"10.1016","volume":"257","author":[{"given":"Yukie","family":"Mizuta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Tokuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayoko","family":"Narahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahito","family":"Kawano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Murata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Yamaura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumio","family":"Hoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Hashizume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Akahoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"13","key":"10.1016\/j.lfs.2020.118074_bb0005","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1056\/NEJM199809243391307","article-title":"Doxorubicin-induced cardiomyopathy","volume":"339","author":"Singal","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2020.118074_bb0010","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ejphar.2017.10.043","article-title":"Molecular mechanism of doxorubicin-induced cardiomyopathy \u2013 an update","volume":"818","author":"Renu","year":"2018","journal-title":"Eur. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.lfs.2020.118074_bb0015","doi-asserted-by":"crossref","first-page":"e445","DOI":"10.1016\/S1470-2045(17)30535-1","article-title":"Cardiotoxic effects of anthracycline-based therapy: what is the evidence and what are the potential harms?","volume":"18","author":"Levis","year":"2017","journal-title":"The Lancet Oncology"},{"issue":"6","key":"10.1016\/j.lfs.2020.118074_bb0020","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.yjmcc.2012.03.006","article-title":"Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategies","volume":"52","author":"Octavia","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"5","key":"10.1016\/j.lfs.2020.118074_bb0025","first-page":"H1466","article-title":"Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro","volume":"296","author":"Mukhopadhyay","year":"2009","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"issue":"4","key":"10.1016\/j.lfs.2020.118074_bb0030","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1161\/CIRCRESAHA.114.300505","article-title":"Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease","volume":"114","author":"Polhemus","year":"2014","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.lfs.2020.118074_bb0035","doi-asserted-by":"crossref","first-page":"16146","DOI":"10.3390\/molecules191016146","article-title":"Hydrogen sulfide and polysulfides as biological mediators","volume":"19","author":"Kimura","year":"2014","journal-title":"Molecules (Basel, Switzerland)"},{"issue":"4","key":"10.1016\/j.lfs.2020.118074_bb0040","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1253\/circj.CJ-08-0636","article-title":"Hydrogen sulfide regulates cardiac function and structure in adriamycin-induced cardiomyopathy","volume":"73","author":"Su","year":"2009","journal-title":"Circ. J."},{"issue":"56","key":"10.1016\/j.lfs.2020.118074_bb0045","doi-asserted-by":"crossref","first-page":"95425","DOI":"10.18632\/oncotarget.20729","article-title":"Gas signaling molecule hydrogen sulfide attenuates doxorubicin-induced dilated cardiomyopathy","volume":"8","author":"Yu","year":"2017","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.lfs.2020.118074_bb0050","first-page":"R297","article-title":"The therapeutic potential of hydrogen sulfide: separating hype from hope","volume":"301","author":"Olson","year":"2011","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"issue":"13","key":"10.1016\/j.lfs.2020.118074_bb0055","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1111\/j.1742-4658.2008.06482.x","article-title":"Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria","volume":"275","author":"Hildebrandt","year":"2008","journal-title":"FEBS J."},{"issue":"5","key":"10.1016\/j.lfs.2020.118074_bb0060","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s10557-017-6751-0","article-title":"Sodium thiosulfate preconditioning ameliorates ischemia\/reperfusion injury in rat hearts via reduction of oxidative stress and apoptosis","volume":"31","author":"Ravindran","year":"2017","journal-title":"Cardiovasc. Drugs Ther."},{"issue":"1","key":"10.1016\/j.lfs.2020.118074_bb0065","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1089\/ars.2011.4363","article-title":"Inhaled hydrogen sulfide prevents endotoxin-induced systemic inflammation and improves survival by altering sulfide metabolism in mice","volume":"17","author":"Tokuda","year":"2012","journal-title":"Antioxid. Redox Signal."},{"issue":"2","key":"10.1016\/j.lfs.2020.118074_bb0070","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1089\/ars.2013.5354","article-title":"Cystathionine gamma-lyase deficiency protects mice from galactosamine\/lipopolysaccharide-induced acute liver failure","volume":"20","author":"Shirozu","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.lfs.2020.118074_bb0075","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3389\/fphar.2018.00032","article-title":"Protective mechanism of hydrogen sulfide against chemotherapy-induced cardiotoxicity","volume":"9","author":"Du","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.lfs.2020.118074_bb0080","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0041-008X(85)90163-2","article-title":"Antagonism of cyanide poisoning by chlorpromazine and sodium thiosulfate","volume":"81","author":"Pettersen","year":"1985","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"3","key":"10.1016\/j.lfs.2020.118074_bb0085","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1525-139X.2010.00738.x","article-title":"Sodium thiosulfate: new hope for the treatment of calciphylaxis","volume":"23","author":"Hayden","year":"2010","journal-title":"Semin. Dial."},{"issue":"12","key":"10.1016\/j.lfs.2020.118074_bb0090","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3390\/md14120231","article-title":"Alginate oligosaccharide prevents acute doxorubicin cardiotoxicity by suppressing oxidative stress and endoplasmic reticulum-mediated apoptosis","volume":"14","author":"Guo","year":"2016","journal-title":"Marine drugs"},{"issue":"51","key":"10.1016\/j.lfs.2020.118074_bb0095","doi-asserted-by":"crossref","first-page":"E5537","DOI":"10.1073\/pnas.1414665111","article-title":"Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling","volume":"111","author":"Dhingra","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"34","key":"10.1016\/j.lfs.2020.118074_bb0100","doi-asserted-by":"crossref","first-page":"55863","DOI":"10.18632\/oncotarget.10150","article-title":"Cytoplasmic vacuolization in cell death and survival","volume":"7","author":"Shubin","year":"2016","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.lfs.2020.118074_bb0105","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.114.001451","article-title":"Reactive oxygen metabolites are closely associated with the diagnosis and prognosis of coronary artery disease","volume":"4","author":"Hirata","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.lfs.2020.118074_bb0110","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ijcard.2016.07.225","article-title":"Usefulness of the d-ROMs test for prediction of cardiovascular events","volume":"222","author":"Masaki","year":"2016","journal-title":"Int. J. Cardiol."},{"issue":"6","key":"10.1016\/j.lfs.2020.118074_bb0115","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00005-009-0051-8","article-title":"Cardiomyocyte death in doxorubicin-induced cardiotoxicity","volume":"57","author":"Zhang","year":"2009","journal-title":"Arch. Immunol. Ther. Exp."},{"issue":"1","key":"10.1016\/j.lfs.2020.118074_bb0120","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.redox.2013.01.014","article-title":"Teaching the basics of redox biology to medical and graduate students: oxidants, antioxidants and disease mechanisms","volume":"1","author":"Kalyanaraman","year":"2013","journal-title":"Redox Biol."},{"issue":"3","key":"10.1016\/j.lfs.2020.118074_bb0125","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.bbrc.2017.09.153","article-title":"Interleukin-33 attenuates doxorubicin-induced cardiomyocyte apoptosis through suppression of ASK1\/JNK signaling pathway","volume":"493","author":"Yao","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.lfs.2020.118074_bb0130","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.pharmthera.2014.05.013","article-title":"Crosstalk between mitogen-activated protein kinases and mitochondria in cardiac diseases: therapeutic perspectives","volume":"144","author":"Javadov","year":"2014","journal-title":"Pharmacol. Ther."},{"issue":"24","key":"10.1016\/j.lfs.2020.118074_bb0135","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1111\/febs.14122","article-title":"Control of cell death and mitochondrial fission by ERK1\/2 MAP kinase signalling","volume":"284","author":"Cook","year":"2017","journal-title":"FEBS J."},{"issue":"5","key":"10.1016\/j.lfs.2020.118074_bb0140","first-page":"H1956","article-title":"ERKs\/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes","volume":"295","author":"Liu","year":"2008","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"issue":"9","key":"10.1016\/j.lfs.2020.118074_bb0145","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1002\/cbin.10478","article-title":"Effect of alteration of caveolin-1 expression on doxorubicin-induced apoptosis in H9c2 cardiac cells","volume":"39","author":"Takaguri","year":"2015","journal-title":"Cell Biol. Int."},{"issue":"7","key":"10.1016\/j.lfs.2020.118074_bb0150","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/embr.201338213","article-title":"S-sulfhydration of MEK1 leads to PARP-1 activation and DNA damage repair","volume":"15","author":"Zhao","year":"2014","journal-title":"EMBO Rep."},{"issue":"3","key":"10.1016\/j.lfs.2020.118074_bb0155","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1038\/srep01814","article-title":"S-nitrosylation of ERK inhibits ERK phosphorylation and induces apoptosis","author":"Feng","year":"2013","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.lfs.2020.118074_bb0160","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0006-2952(03)00255-7","article-title":"The JNK, ERK and p53 pathways play distinct roles in apoptosis mediated by the antitumor agents vinblastine, doxorubicin, and etoposide","volume":"66","author":"Brantley-Finley","year":"2003","journal-title":"Biochem. Pharmacol."},{"issue":"4","key":"10.1016\/j.lfs.2020.118074_bb0165","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s00424-007-0321-4","article-title":"Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K\/Akt pathways","volume":"455","author":"Hu","year":"2008","journal-title":"Pflugers Arch. - Eur. J. Physiol."},{"issue":"6","key":"10.1016\/j.lfs.2020.118074_bb0170","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1097\/ALN.0000000000000456","article-title":"Sodium thiosulfate attenuates acute lung injury in mice","volume":"121","author":"Sakaguchi","year":"2014","journal-title":"Anesthesiology"},{"issue":"3","key":"10.1016\/j.lfs.2020.118074_bb0175","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000156486","article-title":"Cardioprotective role of sodium thiosulfate on chronic heart failure by modulating endogenous H2S generation","volume":"82","author":"Sen","year":"2008","journal-title":"Pharmacology"},{"issue":"6","key":"10.1016\/j.lfs.2020.118074_bb0180","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1111\/bph.12825","article-title":"Exogenous administration of thiosulfate, a donor of hydrogen sulfide, attenuates angiotensin II-induced hypertensive heart disease in rats","volume":"172","author":"Snijder","year":"2015","journal-title":"Br. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.lfs.2020.118074_bb0185","first-page":"H1925","article-title":"Involvement of mitogen-activated protein kinases in adriamycin-induced cardiomyopathy","volume":"288","author":"Lou","year":"2005","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"key":"10.1016\/j.lfs.2020.118074_bb0190","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3389\/fncel.2017.00338","article-title":"Mechanisms of cisplatin-induced ototoxicity and otoprotection","volume":"11","author":"Sheth","year":"2017","journal-title":"Front. Cell. Neurosci."},{"issue":"25","key":"10.1016\/j.lfs.2020.118074_bb0195","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1056\/NEJMoa1801109","article-title":"Sodium thiosulfate for protection from cisplatin-induced hearing loss","volume":"378","author":"Brock","year":"2018","journal-title":"N. Engl. J. Med."},{"issue":"20","key":"10.1016\/j.lfs.2020.118074_bb0200","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1093\/jnci\/81.20.1552","article-title":"Effect of sodium thiosulfate on the pharmacokinetics and toxicity of cisplatin","volume":"81","author":"Goel","year":"1989","journal-title":"JNCI: Journal of the National Cancer Institute"},{"issue":"10","key":"10.1016\/j.lfs.2020.118074_bb0205","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1002\/1097-0142(19851115)56:10<2364::AID-CNCR2820561003>3.0.CO;2-4","article-title":"High-dose intracavitary cisplatin with intravenous thiosulfate. Low incidence of serious neurotoxicity","volume":"56","author":"Markman","year":"1985","journal-title":"Cancer"},{"issue":"2","key":"10.1016\/j.lfs.2020.118074_bb0210","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J Basic Clin Pharm."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520308250?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520308250?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T21:15:54Z","timestamp":1765228554000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320520308250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":42,"alternative-id":["S0024320520308250"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118074","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sodium thiosulfate prevents doxorubicin-induced DNA damage and apoptosis in cardiomyocytes in mice","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"118074"}}