{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T07:05:38Z","timestamp":1784358338410,"version":"3.55.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.lfs.2020.118165","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T07:12:09Z","timestamp":1596006729000},"page":"118165","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["CRISPR\/Cas9 novel therapeutic road for the treatment of neurodegenerative diseases"],"prefix":"10.1016","volume":"259","author":[{"given":"Ansar","family":"Karimian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negar","family":"Gorjizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Forough","family":"Alemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zatollah","family":"Asemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil","family":"Azizian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jafar","family":"Soleimanpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faezeh","family":"Malakouti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niloufar","family":"Targhazeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Majidinia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahman","family":"Yousefi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2020.118165_bb0005","first-page":"653","article-title":"Focus: genome editing: genome editing: past, present, and future","volume":"90","author":"Carroll","year":"2017","journal-title":"Yale J. Biol. Med."},{"key":"10.1016\/j.lfs.2020.118165_bb0010","doi-asserted-by":"crossref","first-page":"76","DOI":"10.5430\/jst.v6n2p76","article-title":"Different strategies of gene delivery for treatment of cancer and other disorders","volume":"6","author":"Agi","year":"2016","journal-title":"J. Solid Tumors"},{"key":"10.1016\/j.lfs.2020.118165_bb0015","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nm.3793","article-title":"Therapeutic genome editing: prospects and challenges","volume":"21","author":"Cox","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.lfs.2020.118165_bb0020","doi-asserted-by":"crossref","first-page":"531","DOI":"10.2174\/1566523215666150929110424","article-title":"Contemporary animal models for human gene therapy applications","volume":"15","author":"Gopinath","year":"2015","journal-title":"Curr. Gene Ther."},{"key":"10.1016\/j.lfs.2020.118165_bb0025","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1016\/j.jacc.2017.10.002","article-title":"Genome editing: the recent history and perspective in cardiovascular diseases","volume":"70","author":"Musunuru","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.lfs.2020.118165_bb0030","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/mt.2016.5","article-title":"Current progress in therapeutic gene editing for monogenic diseases","volume":"24","author":"Prakash","year":"2016","journal-title":"Mol. Ther."},{"key":"10.1016\/j.lfs.2020.118165_bb0035","doi-asserted-by":"crossref","first-page":"591","DOI":"10.15171\/apb.2018.067","article-title":"The impact of crispr-cas system on antiviral therapy","volume":"8","author":"Bayat","year":"2018","journal-title":"Adv. Pharm. Bull."},{"key":"10.1016\/j.lfs.2020.118165_bb0040","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3390\/antibiotics8010018","article-title":"Crispr-cas: converting a bacterial defence mechanism into a state-of-the-art genetic manipulation tool","volume":"8","author":"Loureiro","year":"2019","journal-title":"Antibiotics"},{"key":"10.1016\/j.lfs.2020.118165_bb0045","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/s41591-018-0050-6","article-title":"p53 inhibits CRISPR\u2013Cas9 engineering in human pluripotent stem cells","volume":"24","author":"Ihry","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.lfs.2020.118165_bb0050","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/nbt.4192","article-title":"Repair of double-strand breaks induced by CRISPR\u2013Cas9 leads to large deletions and complex rearrangements","volume":"36","author":"Kosicki","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.lfs.2020.118165_bb0055","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s13059-018-1529-7","article-title":"Manipulating plant RNA-silencing pathways to improve the gene editing efficiency of CRISPR\/Cas9 systems","volume":"19","author":"Mao","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.lfs.2020.118165_bb0060","series-title":"Future Medicine","article-title":"Application of nanoparticle-based siRNA and CRISPR\/Cas9 delivery systems in gene-targeted therapy","author":"Tao","year":"2019"},{"key":"10.1016\/j.lfs.2020.118165_bb0065","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1002\/ijc.29626","article-title":"CRISPR-Cas9 systems: versatile cancer modelling platforms and promising therapeutic strategies","volume":"138","author":"Wen","year":"2016","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.lfs.2020.118165_bb0070","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/pbi.12755","article-title":"High efficient multisites genome editing in allotetraploid cotton (Gossypium hirsutum) using CRISPR\/Cas9 system","volume":"16","author":"Wang","year":"2018","journal-title":"Plant Biotechnol. J."},{"key":"10.1016\/j.lfs.2020.118165_bb0075","doi-asserted-by":"crossref","first-page":"5615","DOI":"10.1093\/nar\/gkw159","article-title":"Repurposing the CRISPR-Cas9 system for targeted DNA methylation","volume":"44","author":"Vojta","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.lfs.2020.118165_bb0080","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nature14136","article-title":"Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex","volume":"517","author":"Konermann","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2020.118165_bb0085","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/nature24049","article-title":"RNA targeting with CRISPR\u2013Cas13","volume":"550","author":"Abudayyeh","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2020.118165_bb0090","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1756-6606-4-3","article-title":"APP processing in Alzheimer\u2019s disease","volume":"4","author":"Zhang","year":"2011","journal-title":"Mol. Brain"},{"key":"10.1016\/j.lfs.2020.118165_bb0095","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/s41593-019-0352-0","article-title":"In vivo neuronal gene editing via CRISPR\u2013Cas9 amphiphilic nanocomplexes alleviates deficits in mouse models of Alzheimer\u2019s disease","volume":"22","author":"Park","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.lfs.2020.118165_bb0100","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nature09325","article-title":"Gamma-secretase activating protein is a therapeutic target for Alzheimer\u2019s disease","volume":"467","author":"He","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2020.118165_bb0105","doi-asserted-by":"crossref","first-page":"6385","DOI":"10.1073\/pnas.1820160116","article-title":"GSAP modulates \u03b3-secretase specificity by inducing conformational change in PS1","volume":"116","author":"Wong","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.lfs.2020.118165_bb0110","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.omtn.2018.03.007","article-title":"CRISPR\/Cas9 mediated disruption of the Swedish APP allele as a therapeutic approach for early-onset Alzheimer\u2019s disease","volume":"11","author":"Gy\u00f6rgy","year":"2018","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.lfs.2020.118165_bb0115","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1038\/s41467-018-04238-0","article-title":"Generation of App knock-in mice reveals deletion mutations protective against Alzheimer\u2019s disease-like pathology","volume":"9","author":"Nagata","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2020.118165_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.scr.2018.11.010","article-title":"Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line","volume":"34","author":"Schmid","year":"2019","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.lfs.2020.118165_bb0125","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/ana.25455","article-title":"Neuronal apolipoprotein E4 increases cell death and phosphorylated tau release in alzheimer disease","volume":"85","author":"Wadhwani","year":"2019","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.lfs.2020.118165_bb0130","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.3390\/molecules22081287","article-title":"Recent advances in the inhibition of p38 MAPK as a potential strategy for the treatment of Alzheimer\u2019s disease","volume":"22","author":"Lee","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.lfs.2020.118165_bb0135","first-page":"1","article-title":"Targeted gene editing of glia maturation factor in microglia: a novel Alzheimer\u2019s disease therapeutic target","author":"Raikwar","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.lfs.2020.118165_bb0140","article-title":"Parkinson\u2019s disease as a system-level disorder","volume":"2","author":"Caligiore","year":"2016","journal-title":"npj Park. Dis."},{"key":"10.1016\/j.lfs.2020.118165_bb0145","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.stem.2014.04.020","article-title":"Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing","volume":"15","author":"Veres","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.lfs.2020.118165_bb0150","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nature17939","article-title":"Parkinson-associated risk variant in distal enhancer of \u03b1-synuclein modulates target gene expression","volume":"533","author":"Soldner","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2020.118165_bb0155","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.stemcr.2017.08.026","article-title":"FACS-assisted CRISPR-Cas9 genome editing facilitates Parkinson\u2019s disease modeling","volume":"9","author":"Arias-Fuenzalida","year":"2017","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.lfs.2020.118165_bb0160","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.scr.2017.08.013","article-title":"CRISPR\/cas9 and piggyBac-mediated footprint-free LRRK2-G2019S knock-in reveals neuronal complexity phenotypes and \u03b1-Synuclein modulation in dopaminergic neurons","volume":"24","author":"Qing","year":"2017","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.lfs.2020.118165_bb0165","doi-asserted-by":"crossref","first-page":"E180","DOI":"10.1073\/pnas.1711023115","article-title":"Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy","volume":"115","author":"Potting","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2020.118165_bb0170","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/toxsci\/kfz049","article-title":"Mechanistic interplay between autophagy and apoptotic signaling in Endosulfan-induced dopaminergic neurotoxicity: relevance to the adverse outcome pathway in pesticide neurotoxicity","volume":"169","author":"Song","year":"2019","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.lfs.2020.118165_bb0175","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12932","article-title":"Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration","volume":"7","author":"Gordon","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2020.118165_bb0180","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fnmol.2016.00030","article-title":"CRISPR\/Cas9: implications for modeling and therapy of neurodegenerative diseases","volume":"9","author":"Yang","year":"2016","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.lfs.2020.118165_bb0185","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/ejn.14286","article-title":"Engineering synucleinopathy-resistant human dopaminergic neurons by CRISPR-mediated deletion of the SNCA gene","volume":"49","author":"Chen","year":"2019","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.lfs.2020.118165_bb0190","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s11481-013-9439-7","article-title":"Glia maturation factor induces interleukin-33 release from astrocytes: implications for neurodegenerative diseases","volume":"8","author":"Kempuraj","year":"2013","journal-title":"J. NeuroImmune Pharmacol."},{"key":"10.1016\/j.lfs.2020.118165_bb0195","first-page":"1","article-title":"CRISPR\/Cas9 editing of glia maturation factor regulates mitochondrial dynamics by attenuation of the NRF2\/HO-1 dependent ferritin activation in glial cells","author":"Selvakumar","year":"2019","journal-title":"J. NeuroImmune Pharmacol."},{"key":"10.1016\/j.lfs.2020.118165_bb0200","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/B978-0-12-801893-4.00001-8","article-title":"Genetics of Huntington disease","volume":"144","author":"Nance","year":"2017","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.lfs.2020.118165_bb0205","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S1474-4422(17)30280-6","article-title":"Therapies targeting DNA and RNA in Huntington\u2019s disease","volume":"16","author":"Wild","year":"2017","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.lfs.2020.118165_bb0210","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ymthe.2016.11.010","article-title":"CRISPR\/Cas9 editing of the mutant huntingtin allele in vitro and in vivo","volume":"25","author":"Monteys","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.lfs.2020.118165_bb0215","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0896-6273(03)00366-0","article-title":"Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1, 4, 5) triphosphate receptor type 1","volume":"39","author":"Tang","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.lfs.2020.118165_bb0220","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3233\/JHD-170266","article-title":"Inhibition of TRPC1-dependent store-operated calcium entry improves synaptic stability and motor performance in a mouse model of Huntington\u2019s disease","volume":"7","author":"Wu","year":"2018","journal-title":"J. Huntingt. Dis."},{"key":"10.1016\/j.lfs.2020.118165_bb0225","doi-asserted-by":"crossref","first-page":"5110","DOI":"10.1093\/nar\/gkf664","article-title":"An upstream open reading frame impedes translation of the huntingtin gene","volume":"30","author":"Lee","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.lfs.2020.118165_bb0230","doi-asserted-by":"crossref","first-page":"754","DOI":"10.3390\/ijms18040754","article-title":"CRISPR-Cas9 mediated gene-silencing of the mutant huntingtin gene in an in vitro model of Huntington\u2019s disease","volume":"18","author":"Kolli","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2020.118165_bb0235","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1002\/humu.23580","article-title":"Detailed analysis of HTT repeat elements in human blood using targeted amplification-free long-read sequencing","volume":"39","author":"H\u00f6ijer","year":"2018","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.lfs.2020.118165_bb0240","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.molcel.2015.02.032","article-title":"Expanding the biologist\u2019s toolkit with CRISPR-Cas9","volume":"58","author":"Sternberg","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.lfs.2020.118165_bb0245","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1136\/jmedgenet-2014-102968","article-title":"CRISPR-Cas9: a new and promising player in gene therapy","volume":"52","author":"Xiao-Jie","year":"2015","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.lfs.2020.118165_bb0250","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.1172\/JCI72992","article-title":"Expanding the genetic editing tool kit: ZFNs, TALENs, and CRISPR-Cas9","volume":"124","author":"Gupta","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2020.118165_bb0255","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1039\/C8NP00081F","article-title":"Editing streptomycete genomes in the CRISPR\/Cas9 age","volume":"36","author":"Alberti","year":"2019","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.lfs.2020.118165_bb0260","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3390\/cells8010075","article-title":"Development of a bicistronic vector for the expression of a CRISPR\/Cas9-mCherry system in fish cell lines","volume":"8","author":"Escobar-Aguirre","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.lfs.2020.118165_bb0265","doi-asserted-by":"crossref","first-page":"12267","DOI":"10.1002\/jcp.27972","article-title":"CRISPR\/Cas9 technology as a potent molecular tool for gene therapy","volume":"234","author":"Karimian","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.lfs.2020.118165_bb0270","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1101\/gr.162339.113","article-title":"Analysis of off-target effects of CRISPR\/Cas-derived RNA-guided endonucleases and nickases","volume":"24","author":"Cho","year":"2014","journal-title":"Genome Res."},{"key":"10.1016\/j.lfs.2020.118165_bb0275","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/rmb2.12067","article-title":"Revolutionizing male fertility factor research in mice by using the genome editing tool CRISPR\/Cas9","volume":"17","author":"Abbasi","year":"2018","journal-title":"Reprod. Med. Biol."},{"key":"10.1016\/j.lfs.2020.118165_bb0280","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/s12035-018-1068-y","article-title":"Targeted gene editing of glia maturation factor in microglia: a novel Alzheimer\u2019s disease therapeutic target","volume":"56","author":"Raikwar","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.lfs.2020.118165_bb0285","doi-asserted-by":"crossref","first-page":"20620","DOI":"10.1038\/srep20620","article-title":"One-step generation of triple gene-targeted pigs using CRISPR\/Cas9 system","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2020.118165_bb0290","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s00018-014-1744-7","article-title":"Generation of CRISPR\/Cas9-mediated gene-targeted pigs via somatic cell nuclear transfer","volume":"72","author":"Zhou","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.lfs.2020.118165_bb0295","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1016\/j.ymthe.2018.08.019","article-title":"Downregulation of SNCA expression by targeted editing of DNA methylation: a potential strategy for precision therapy in PD","volume":"26","author":"Kantor","year":"2018","journal-title":"Mol. Ther."},{"key":"10.1016\/j.lfs.2020.118165_bb0300","first-page":"4566","article-title":"Permanent inactivation of Huntington\u2019s disease mutation by personalized allele-specific CRISPR\/Cas9","volume":"25","author":"Shin","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.lfs.2020.118165_bb0305","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1172\/JCI92087","article-title":"CRISPR\/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington\u2019s disease","volume":"127","author":"Yang","year":"2017","journal-title":"J. Clin. Invest."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520309176?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520309176?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T10:18:05Z","timestamp":1717237085000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320520309176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":61,"alternative-id":["S0024320520309176"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118165","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CRISPR\/Cas9 novel therapeutic road for the treatment of neurodegenerative diseases","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118165","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"118165"}}