{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T05:05:52Z","timestamp":1793336752025,"version":"4.5.0"},"reference-count":109,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31600852"],"award-info":[{"award-number":["31600852"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771202"],"award-info":[{"award-number":["81771202"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873101"],"award-info":[{"award-number":["81873101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971056"],"award-info":[{"award-number":["81971056"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["2018SHZDZX01"],"award-info":[{"award-number":["2018SHZDZX01"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFB0403803"],"award-info":[{"award-number":["2017YFB0403803"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.lfs.2020.118198","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T08:09:45Z","timestamp":1596442185000},"page":"118198","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["The role of connexins and pannexins in orofacial pain"],"prefix":"10.1016","volume":"258","author":[{"given":"Qian","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Xia","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.lfs.2020.118198_bb0005","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1097\/j.pain.0000000000001009","article-title":"Defining chronic pain in epidemiological studies: a systematic review and meta-analysis","volume":"158","author":"Steingr\u00edmsd\u00f3ttir","year":"2017","journal-title":"Pain"},{"key":"10.1016\/j.lfs.2020.118198_bb0010","doi-asserted-by":"crossref","first-page":"100070","DOI":"10.1016\/j.wnsx.2020.100070","article-title":"Treatment outcomes in trigeminal neuralgia-a systematic review of domains, dimensions and measures","volume":"6","author":"Nova","year":"2020","journal-title":"World Neurosurg X"},{"key":"10.1016\/j.lfs.2020.118198_bb0015","first-page":"h1238","article-title":"Trigeminal neuralgia","volume":"350","author":"Zakrzewska","year":"2015","journal-title":"BMJ (Clinical research ed.)"},{"issue":"7","key":"10.1016\/j.lfs.2020.118198_bb0020","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1002\/j.1532-2149.2013.00441.x","article-title":"Etanercept reduces thermal and mechanical orofacial hyperalgesia following inflammation and neuropathic injury","volume":"18","author":"Coelho","year":"2014","journal-title":"European journal of pain (London, England)"},{"issue":"1\u20132","key":"10.1016\/j.lfs.2020.118198_bb0025","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jpain.2019.08.012","article-title":"Calcium Channel alpha2delta1 subunit mediates secondary Orofacial Hyperalgesia through PKC-TRPA1\/gap junction signaling","volume":"21","author":"Cui","year":"2020","journal-title":"The journal of pain"},{"key":"10.1016\/j.lfs.2020.118198_bb0030","doi-asserted-by":"crossref","DOI":"10.1177\/1744806916633704","article-title":"Connexin 43 contributes to ectopic orofacial pain following inferior alveolar nerve injury","volume":"12","author":"Kaji","year":"2016","journal-title":"Mol. Pain"},{"issue":"2","key":"10.1016\/j.lfs.2020.118198_bb0035","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1001\/archneur.1968.00480020015001","article-title":"Carbamazepine in the treatment of neuralgia. Use of side effects","volume":"19","author":"Killian","year":"1968","journal-title":"Arch. Neurol."},{"issue":"1","key":"10.1016\/j.lfs.2020.118198_bb0040","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1526-4610.1969.hed0901054.x","article-title":"A four year double-blind study of tegretol in facial pain","volume":"9","author":"Nicol","year":"1969","journal-title":"Headache"},{"issue":"4","key":"10.1016\/j.lfs.2020.118198_bb0045","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1600-0404.1970.tb05803.x","article-title":"Facial pain treated with carbamazepin (Tegretol)","volume":"46","author":"Rasmussen","year":"1970","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.lfs.2020.118198_bb0050","article-title":"Carbamazepine for acute and chronic pain in adults","volume":"1","author":"Wiffen","year":"2011","journal-title":"The Cochrane Database of Systematic Reviews"},{"issue":"9","key":"10.1016\/j.lfs.2020.118198_bb0055","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1111\/j.1468-1331.2010.02999.x","article-title":"EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision","volume":"17","author":"Attal","year":"2010","journal-title":"Eur. J. Neurol."},{"issue":"3","key":"10.1016\/j.lfs.2020.118198_bb0060","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.neuron.2015.06.005","article-title":"Nociception, pain, negative moods, and behavior selection","volume":"87","author":"Baliki","year":"2015","journal-title":"Neuron"},{"issue":"7","key":"10.1016\/j.lfs.2020.118198_bb0065","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1177\/0333102417704187","article-title":"Mechanisms of craniofacial pain","volume":"37","author":"Chichorro","year":"2017","journal-title":"Cephalalgia"},{"key":"10.1016\/j.lfs.2020.118198_bb0070","article-title":"The role of peripheral opioid receptors in orofacial pain","author":"Liu","year":"2020","journal-title":"Oral Dis."},{"issue":"3","key":"10.1016\/j.lfs.2020.118198_bb0075","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/0306-4522(84)90096-4","article-title":"The subnuclei and primary afferents of the descending trigeminal system in the mallard (Anas platyrhynchos L.)","volume":"13","author":"Arends","year":"1984","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.lfs.2020.118198_bb0080","first-page":"238","article-title":"Part 2a: trigeminal anatomy related to pain, dent update","volume":"42","author":"Renton","year":"2015","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.lfs.2020.118198_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1042-3680(18)30333-4","article-title":"The trigeminal complex. Anatomy and physiology","volume":"8","author":"Brown","year":"1997","journal-title":"Neurosurg. Clin. N. Am."},{"issue":"01","key":"10.1016\/j.lfs.2020.118198_bb0090","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.pain.2013.06.022","article-title":"Glia and pain: is chronic pain a gliopathy?","volume":"154 Suppl 1","author":"Ji","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.lfs.2020.118198_bb0095","doi-asserted-by":"crossref","first-page":"412","DOI":"10.3389\/fncel.2015.00412","article-title":"Role of satellite glial cells in gastrointestinal pain","volume":"9","author":"Hanani","year":"2015","journal-title":"Front. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.lfs.2020.118198_bb0100","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neuron.2009.09.033","article-title":"Current challenges in glia-pain biology","volume":"64","author":"McMahon","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.lfs.2020.118198_bb0105","doi-asserted-by":"crossref","first-page":"374","DOI":"10.3389\/fnmol.2017.00374","article-title":"Connexin43 hemichannels in satellite glial cells, can they influence sensory neuron activity?","volume":"10","author":"Retamal","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.lfs.2020.118198_bb0110","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.3389\/fnins.2019.01227","article-title":"Peripheral and central mechanisms of persistent orofacial pain","volume":"13","author":"Shinoda","year":"2019","journal-title":"Front. Neurosci."},{"issue":"2","key":"10.1016\/j.lfs.2020.118198_bb0115","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/glia.20748","article-title":"Connexin43 is involved in the effect of endothelin-1 on astrocyte proliferation and glucose uptake","volume":"57","author":"Herrero-Gonzalez","year":"2009","journal-title":"Glia"},{"issue":"4","key":"10.1016\/j.lfs.2020.118198_bb0120","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1152\/physrev.1981.61.4.829","article-title":"Junctional intercellular communication: the cell-to-cell membrane channel","volume":"61","author":"Loewenstein","year":"1981","journal-title":"Physiol. Rev."},{"issue":"3","key":"10.1016\/j.lfs.2020.118198_bb0125","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0092-8674(00)81282-9","article-title":"The gap junction communication channel","volume":"84","author":"Kumar","year":"1996","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.lfs.2020.118198_bb0130","doi-asserted-by":"crossref","first-page":"193","DOI":"10.4161\/chan.5.3.15765","article-title":"Pannexin channels are not gap junction hemichannels","volume":"5","author":"Sosinsky","year":"2011","journal-title":"Channels (Austin, Tex.)"},{"issue":"2","key":"10.1016\/j.lfs.2020.118198_bb0135","doi-asserted-by":"crossref","first-page":"124","DOI":"10.4161\/chan.27422","article-title":"Diverse post-translational modifications of the pannexin family of channel-forming proteins","volume":"8","author":"Penuela","year":"2014","journal-title":"Channels (Austin, Tex.)"},{"issue":"1","key":"10.1016\/j.lfs.2020.118198_bb0140","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/glia.20435","article-title":"Pannexin1 is expressed by neurons and glia but does not form functional gap junctions","volume":"55","author":"Huang","year":"2007","journal-title":"Glia"},{"issue":"1","key":"10.1016\/j.lfs.2020.118198_bb0145","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/jnr.24088","article-title":"Connexins and pannexins: at the junction of neuro-glial homeostasis & disease","volume":"96","author":"Lapato","year":"2018","journal-title":"J. Neurosci. Res."},{"issue":"12","key":"10.1016\/j.lfs.2020.118198_bb0150","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.tcb.2016.06.003","article-title":"Next-generation connexin and pannexin cell biology","volume":"26","author":"Esseltine","year":"2016","journal-title":"Trends Cell Biol."},{"issue":"6","key":"10.1016\/j.lfs.2020.118198_bb0155","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1248\/bpb.b19-00195","article-title":"Role of connexins in chronic pain and their potential as therapeutic targets for next-generation analgesics","volume":"42","author":"Morioka","year":"2019","journal-title":"Biol. Pharm. Bull."},{"issue":"4\u20136","key":"10.1016\/j.lfs.2020.118198_bb0160","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/cac.10.4-6.173.180","article-title":"An update on connexin genes and their nomenclature in mouse and man","volume":"10","author":"Sohl","year":"2003","journal-title":"Cell Commun. Adhes."},{"issue":"2","key":"10.1016\/j.lfs.2020.118198_bb0165","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/jnr.22764","article-title":"Role of gap junctions in chronic pain","volume":"90","author":"Wu","year":"2012","journal-title":"J. Neurosci. Res."},{"issue":"3","key":"10.1016\/j.lfs.2020.118198_bb0170","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nrn1627","article-title":"Expression and functions of neuronal gap junctions","volume":"6","author":"Sohl","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"issue":"2","key":"10.1016\/j.lfs.2020.118198_bb0175","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nrn2757","article-title":"Astroglial networks: a step further in neuroglial and gliovascular interactions","volume":"11","author":"Giaume","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"issue":"4","key":"10.1016\/j.lfs.2020.118198_bb0180","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/cne.1414","article-title":"Connexin26 in adult rodent central nervous system: demonstration at astrocytic gap junctions and colocalization with connexin30 and connexin43","volume":"441","author":"Nagy","year":"2001","journal-title":"J. Comp. Neurol."},{"issue":"1","key":"10.1016\/j.lfs.2020.118198_bb0185","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bbamem.2012.01.024","article-title":"Gap junction communication in myelinating glia","volume":"1828","author":"Nualart-Marti","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"7","key":"10.1016\/j.lfs.2020.118198_bb0190","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1073\/pnas.051634298","article-title":"Microglia at brain stab wounds express connexin 43 and in vitro form functional gap junctions after treatment with interferon-gamma and tumor necrosis factor-alpha","volume":"98","author":"Eugenin","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2020.118198_bb0195","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fnmol.2019.00023","article-title":"Connexin hemichannels in astrocytes: role in CNS disorders","volume":"12","author":"Xing","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.lfs.2020.118198_bb0200","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.3389\/fphys.2017.01060","article-title":"Connexins in the central nervous system: physiological traits and neuroprotective targets","volume":"8","author":"Vicario","year":"2017","journal-title":"Front. Physiol."},{"issue":"7","key":"10.1016\/j.lfs.2020.118198_bb0205","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/glia.22989","article-title":"Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis","volume":"64","author":"Almad","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.lfs.2020.118198_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2017.10.016","article-title":"Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice","volume":"300","author":"Tonkin","year":"2018","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.lfs.2020.118198_bb0215","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.bbi.2015.06.015","article-title":"Tumor necrosis factor-mediated downregulation of spinal astrocytic connexin43 leads to increased glutamatergic neurotransmission and neuropathic pain in mice","volume":"49","author":"Morioka","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.lfs.2020.118198_bb0220","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3389\/fncel.2018.00129","article-title":"Inhibition of connexin 43 and phosphorylated NR2B in spinal astrocytes attenuates bone cancer pain in mice","volume":"12","author":"Yang","year":"2018","journal-title":"Front. Cell. Neurosci."},{"issue":"3","key":"10.1016\/j.lfs.2020.118198_bb0225","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.acthis.2017.11.005","article-title":"Neurons and satellite glial cells in adult rat lumbar dorsal root ganglia express connexin 36","volume":"120","author":"Perez Armendariz","year":"2018","journal-title":"Acta Histochem."},{"issue":"6","key":"10.1016\/j.lfs.2020.118198_bb0230","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/abbs\/gmz038","article-title":"The role of connexin43 in neuropathic pain induced by spinal cord injury","volume":"51","author":"Wang","year":"2019","journal-title":"Acta Biochim. Biophys. Sin."},{"issue":"5","key":"10.1016\/j.lfs.2020.118198_bb0235","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/WNR.0000000000001209","article-title":"The gap junction inhibitor INI-0602 attenuates mechanical allodynia and depression-like behaviors induced by spared nerve injury in rats","volume":"30","author":"Zhang","year":"2019","journal-title":"Neuroreport"},{"issue":"2","key":"10.1016\/j.lfs.2020.118198_bb0240","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0169-328X(02)00112-2","article-title":"Induction of connexin 37 expression in a rat model of neuropathic pain","volume":"99","author":"Lin","year":"2002","journal-title":"Mol. Brain Res."},{"issue":"1","key":"10.1016\/j.lfs.2020.118198_bb0245","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/ALN.0000000000000942","article-title":"Attenuation of neuropathic pain by inhibiting electrical synapses in the anterior cingulate cortex","volume":"124","author":"Chen","year":"2016","journal-title":"Anesthesiology"},{"key":"10.1016\/j.lfs.2020.118198_bb0250","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.lfs.2016.05.021","article-title":"Lycopene ameliorates neuropathic pain by upregulating spinal astrocytic connexin 43 expression","volume":"155","author":"Zhang","year":"2016","journal-title":"Life Sci."},{"issue":"Pt 1","key":"10.1016\/j.lfs.2020.118198_bb0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2016.10.012","article-title":"The role of spinal interleukin-1\u03b2 and astrocyte connexin 43 in the development of mirror-image pain in an inflammatory pain model","volume":"287","author":"Choi","year":"2017","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.lfs.2020.118198_bb0260","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s12031-017-0957-2","article-title":"Carbon monoxide-releasing molecule-2 inhibits connexin 43-hemichannel activity in spinal cord astrocytes to attenuate neuropathic pain","volume":"63","author":"Wang","year":"2017","journal-title":"Journal of molecular neuroscience\u202f: MN"},{"issue":"2","key":"10.1016\/j.lfs.2020.118198_bb0265","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/glia.23255","article-title":"Downregulation of spinal astrocytic connexin43 leads to upregulation of interleukin-6 and cyclooxygenase-2 and mechanical hypersensitivity in mice","volume":"66","author":"Morioka","year":"2018","journal-title":"Glia"},{"issue":"4","key":"10.1016\/j.lfs.2020.118198_bb0270","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1017\/S1740925X09990093","article-title":"Differential expression of connexins in trigeminal ganglion neurons and satellite glial cells in response to chronic or acute joint inflammation","volume":"4","author":"Garrett","year":"2008","journal-title":"Neuron Glia Biol."},{"key":"10.1016\/j.lfs.2020.118198_bb0275","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neulet.2017.06.035","article-title":"Gap junctions, pannexins and pain","volume":"695","author":"Spray","year":"2019","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.lfs.2020.118198_bb0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.20567","article-title":"Glial and neuronal connexin expression patterns in the rat spinal cord during development and following injury","volume":"489","author":"Lee","year":"2005","journal-title":"J. Comp. Neurol."},{"issue":"5","key":"10.1016\/j.lfs.2020.118198_bb0285","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/glia.23554","article-title":"Gap junction mediated signaling between satellite glia and neurons in trigeminal ganglia","volume":"67","author":"Spray","year":"2019","journal-title":"Glia"},{"issue":"4","key":"10.1016\/j.lfs.2020.118198_bb0290","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/jcmm.12499","article-title":"Interaction between connexin 43 and nitric oxide synthase in mice heart mitochondria","volume":"19","author":"Kirca","year":"2015","journal-title":"J. Cell. Mol. Med."},{"issue":"3","key":"10.1016\/j.lfs.2020.118198_bb0295","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00395-017-0618-1","article-title":"Mitochondrial Cx43 hemichannels contribute to mitochondrial calcium entry and cell death in the heart","volume":"112","author":"Gadicherla","year":"2017","journal-title":"Basic Res. Cardiol."},{"issue":"Pt A","key":"10.1016\/j.lfs.2020.118198_bb0300","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.pnpbp.2017.10.002","article-title":"Astroglial correlates of neuropsychiatric disease: from astrocytopathy to astrogliosis","volume":"87","author":"Kim","year":"2018","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"6","key":"10.1016\/j.lfs.2020.118198_bb0305","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1152\/jn.90722.2008","article-title":"Evidence for a role of connexin 43 in trigeminal pain using RNA interference in vivo","volume":"100","author":"Ohara","year":"2008","journal-title":"J. Neurophysiol."},{"issue":"4","key":"10.1016\/j.lfs.2020.118198_bb0310","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2334\/josnusd.17-0452","article-title":"Connexin 43 expression in satellite glial cells contributes to ectopic tooth-pulp pain","volume":"60","author":"Komiya","year":"2018","journal-title":"J. Oral Sci."},{"key":"10.1016\/j.lfs.2020.118198_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2019.134301","article-title":"Connexin 43 contributes to temporomandibular joint inflammation induced-hypernociception via sodium channel 1.7 in trigeminal ganglion","volume":"707","author":"Jin","year":"2019","journal-title":"Neurosci. Lett."},{"issue":"1\u20132","key":"10.1016\/j.lfs.2020.118198_bb0320","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.pain.2004.04.007","article-title":"The effects of axotomy on neurons and satellite glial cells in mouse trigeminal ganglion","volume":"110","author":"Cherkas","year":"2004","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.lfs.2020.118198_bb0325","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1017\/S1740925X10000098","article-title":"Can satellite glial cells be therapeutic targets for pain control?","volume":"6","author":"Jasmin","year":"2010","journal-title":"Neuron Glia Biol."},{"issue":"7","key":"10.1016\/j.lfs.2020.118198_bb0330","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1097\/00001756-200005150-00028","article-title":"Expression of connexin36 mRNA in adult rodent brain","volume":"11","author":"Parenti","year":"2000","journal-title":"Neuroreport"},{"issue":"22","key":"10.1016\/j.lfs.2020.118198_bb0335","doi-asserted-by":"crossref","first-page":"9848","DOI":"10.1523\/JNEUROSCI.19-22-09848.1999","article-title":"Functional properties of channels formed by the neuronal gap junction protein connexin36","volume":"19","author":"Srinivas","year":"1999","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.lfs.2020.118198_bb0340","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.neuron.2010.06.028","article-title":"Rapid desynchronization of an electrically coupled interneuron network with sparse excitatory synaptic input","volume":"67","author":"Vervaeke","year":"2010","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.lfs.2020.118198_bb0345","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1523\/JNEUROSCI.3872-11.2012","article-title":"Neuronal gap junction coupling is regulated by glutamate and plays critical role in cell death during neuronal injury","volume":"32","author":"Wang","year":"2012","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.lfs.2020.118198_bb0350","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neulet.2012.06.065","article-title":"Neuronal gap junctions play a role in the secondary neuronal death following controlled cortical impact","volume":"524","author":"Belousov","year":"2012","journal-title":"Neurosci. Lett."},{"issue":"4","key":"10.1016\/j.lfs.2020.118198_bb0355","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.tins.2012.11.001","article-title":"Neuronal gap junctions: making and breaking connections during development and injury","volume":"36","author":"Belousov","year":"2013","journal-title":"Trends Neurosci."},{"issue":"18","key":"10.1016\/j.lfs.2020.118198_bb0360","doi-asserted-by":"crossref","first-page":"10260","DOI":"10.1073\/pnas.160037097","article-title":"Connexin expression in electrically coupled postnatal rat brain neurons","volume":"97","author":"Venance","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.lfs.2020.118198_bb0365","article-title":"Microarray-based screening system identifies temperature-controlled activity of Connexin 26 that is distorted by mutations","volume":"9","author":"Wang","year":"2019","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.lfs.2020.118198_bb0370","doi-asserted-by":"crossref","DOI":"10.1098\/rsos.191128","article-title":"Cx26 keratitis ichthyosis deafness syndrome mutations trigger alternative splicing of Cx26 to prevent expression and cause toxicity in vitro","volume":"6","author":"Cook","year":"2019","journal-title":"R. Soc. Open Sci."},{"issue":"4","key":"10.1016\/j.lfs.2020.118198_bb0375","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.neures.2006.04.017","article-title":"The lumbar spinal cord glial cells actively modulate subcutaneous formalin induced hyperalgesia in the rat","volume":"55","author":"Qin","year":"2006","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.lfs.2020.118198_bb0380","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neuropharm.2016.08.027","article-title":"Astrocyte sigma-1 receptors modulate connexin 43 expression leading to the induction of below-level mechanical allodynia in spinal cord injured mice","volume":"111","author":"Choi","year":"2016","journal-title":"Neuropharmacology"},{"issue":"Pt 1","key":"10.1016\/j.lfs.2020.118198_bb0385","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2016.10.012","article-title":"The role of spinal interleukin-1beta and astrocyte connexin 43 in the development of mirror-image pain in an inflammatory pain model","volume":"287","author":"Choi","year":"2017","journal-title":"Exp. Neurol."},{"issue":"13","key":"10.1016\/j.lfs.2020.118198_bb0390","doi-asserted-by":"crossref","first-page":"R473","DOI":"10.1016\/S0960-9822(00)00576-5","article-title":"A ubiquitous family of putative gap junction molecules","volume":"10","author":"Panchin","year":"2000","journal-title":"Current biology\u202f: CB"},{"issue":"1","key":"10.1016\/j.lfs.2020.118198_bb0395","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bbamem.2012.01.017","article-title":"The biochemistry and function of pannexin channels","volume":"1828","author":"Penuela","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"23","key":"10.1016\/j.lfs.2020.118198_bb0400","doi-asserted-by":"crossref","first-page":"14647","DOI":"10.1074\/jbc.M115.650218","article-title":"Pannexin-1 up-regulation in the dorsal root ganglion contributes to neuropathic pain development","volume":"290","author":"Zhang","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"24","key":"10.1016\/j.lfs.2020.118198_bb0405","doi-asserted-by":"crossref","first-page":"6257","DOI":"10.1113\/jphysiol.2012.240911","article-title":"Physiological mechanisms for the modulation of pannexin 1 channel activity","volume":"590","author":"Sandilos","year":"2012","journal-title":"J. Physiol."},{"issue":"7317","key":"10.1016\/j.lfs.2020.118198_bb0410","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/nature09413","article-title":"Pannexin 1 channels mediate \u2018find-me\u2019 signal release and membrane permeability during apoptosis","volume":"467","author":"Chekeni","year":"2010","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.lfs.2020.118198_bb0415","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/abbs\/gmv028","article-title":"Pannexin-1 channels and their emerging functions in cardiovascular diseases","volume":"47","author":"Li","year":"2015","journal-title":"Acta Biochim. Biophys. Sin."},{"issue":"1","key":"10.1016\/j.lfs.2020.118198_bb0420","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bbamcr.2016.10.006","article-title":"Pannexin1 as mediator of inflammation and cell death","volume":"1864","author":"Crespo Yanguas","year":"2017","journal-title":"Biochimica et biophysica acta. Molecular cell research"},{"issue":"1\u20133","key":"10.1016\/j.lfs.2020.118198_bb0425","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.febslet.2004.07.009","article-title":"Pannexin membrane channels are mechanosensitive conduits for ATP","volume":"572","author":"Bao","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.lfs.2020.118198_bb0430","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3389\/fphar.2013.00061","article-title":"Promises and pitfalls of a Pannexin1 transgenic mouse line","volume":"4","author":"Hanstein","year":"2013","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2020.118198_bb0435","doi-asserted-by":"crossref","DOI":"10.1038\/srep38266","article-title":"Glial pannexin1 contributes to tactile hypersensitivity in a mouse model of orofacial pain","volume":"6","author":"Hanstein","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2020.118198_bb0440","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3389\/fncel.2014.00306","article-title":"The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes","volume":"8","author":"Abudara","year":"2014","journal-title":"Front. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.lfs.2020.118198_bb0445","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/00002508-200201000-00002","article-title":"Pathophysiology of trigeminal neuralgia: the ignition hypothesis","volume":"18","author":"Devor","year":"2002","journal-title":"Clin. J. Pain"},{"issue":"Suppl. 1","key":"10.1016\/j.lfs.2020.118198_bb0450","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12860-016-0092-x","article-title":"Connexinopathies: a structural and functional glimpse","volume":"17","author":"Garcia","year":"2016","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.lfs.2020.118198_bb0455","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3389\/fncel.2015.00267","article-title":"Diseases associated with leaky hemichannels","volume":"9","author":"Retamal","year":"2015","journal-title":"Front. Cell. Neurosci."},{"issue":"1\u20133","key":"10.1016\/j.lfs.2020.118198_bb0460","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ejphar.2010.06.008","article-title":"Involvement of temporomandibular joint P2X3 and P2X2\/3 receptors in carrageenan-induced inflammatory hyperalgesia in rats","volume":"645","author":"Teixeira","year":"2010","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.lfs.2020.118198_bb0465","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1017\/S1740925X09990408","article-title":"Bidirectional calcium signaling between satellite glial cells and neurons in cultured mouse trigeminal ganglia","volume":"6","author":"Suadicani","year":"2010","journal-title":"Neuron Glia Biol."},{"issue":"13","key":"10.1016\/j.lfs.2020.118198_bb0470","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1038\/sj.onc.1205187","article-title":"Gap junction intercellular communication propagates cell death in cancerous cells","volume":"21","author":"Krutovskikh","year":"2002","journal-title":"Oncogene"},{"issue":"32","key":"10.1016\/j.lfs.2020.118198_bb0475","doi-asserted-by":"crossref","first-page":"3830","DOI":"10.2174\/0929867324666170710110630","article-title":"Tackling chronic pain and inflammation through the purinergic system","volume":"25","author":"Magni","year":"2018","journal-title":"Curr. Med. Chem."},{"issue":"2","key":"10.1016\/j.lfs.2020.118198_bb0480","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S1385-299X(02)00188-5","article-title":"Microdialysis in trigeminal ganglia","volume":"10","author":"Neubert","year":"2002","journal-title":"Brain Res Brain Res Protoc"},{"issue":"4","key":"10.1016\/j.lfs.2020.118198_bb0485","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jdsr.2017.01.003","article-title":"Neuropeptides and ATP signaling in the trigeminal ganglion","volume":"53","author":"Goto","year":"2017","journal-title":"The Japanese dental science review"},{"issue":"4","key":"10.1016\/j.lfs.2020.118198_bb0490","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00702-020-02161-7","article-title":"Cross-talk signaling in the trigeminal ganglion: role of neuropeptides and other mediators","volume":"127","author":"Messlinger","year":"2020","journal-title":"Journal of neural transmission (Vienna, Austria : 1996)"},{"issue":"26","key":"10.1016\/j.lfs.2020.118198_bb0495","doi-asserted-by":"crossref","first-page":"15735","DOI":"10.1073\/pnas.95.26.15735","article-title":"Connexins regulate calcium signaling by controlling ATP release","volume":"95","author":"Cotrina","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.lfs.2020.118198_bb0500","doi-asserted-by":"crossref","first-page":"C752","DOI":"10.1152\/ajpcell.00228.2008","article-title":"P2X7 receptor-Pannexin1 complex: pharmacology and signaling","volume":"295","author":"Iglesias","year":"2008","journal-title":"American journal of physiology. Cell physiology"},{"issue":"6","key":"10.1016\/j.lfs.2020.118198_bb0505","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21062034","article-title":"Interaction between calcium chelators and the activity of P2X7 receptors in mouse motor synapses","volume":"21","author":"Miteva","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.lfs.2020.118198_bb0510","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115187","article-title":"Abortive and propagating intracellular calcium waves: analysis from a hybrid model","volume":"10","author":"Guisoni","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.lfs.2020.118198_bb0515","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1152\/physrev.00007.2003","article-title":"Plasma membrane channels formed by connexins: their regulation and functions","volume":"83","author":"Saez","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.lfs.2020.118198_bb0520","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ceca.2018.07.009","article-title":"Calcium release-activated calcium channels and pain","volume":"74","author":"Mei","year":"2018","journal-title":"Cell Calcium"},{"issue":"1","key":"10.1016\/j.lfs.2020.118198_bb0525","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1152\/physrev.00023.2013","article-title":"Calcium-permeable ion channels in pain signaling","volume":"94","author":"Bourinet","year":"2014","journal-title":"Physiol. Rev."},{"issue":"4","key":"10.1016\/j.lfs.2020.118198_bb0530","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3344\/kjp.2015.28.4.231","article-title":"Spinal gap junction channels in neuropathic pain","volume":"28","author":"Jeon","year":"2015","journal-title":"The Korean journal of pain"},{"issue":"1","key":"10.1016\/j.lfs.2020.118198_bb0535","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20060175","article-title":"The gap junction cellular internet: connexin hemichannels enter the signalling limelight","volume":"397","author":"Evans","year":"2006","journal-title":"The Biochemical journal"},{"issue":"7","key":"10.1016\/j.lfs.2020.118198_bb0540","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1177\/0271678X15611912","article-title":"Hemichannel-mediated release of lactate","volume":"36","author":"Karagiannis","year":"2016","journal-title":"Journal of cerebral blood flow and metabolism\u202f: official journal of the International Society of Cerebral Blood Flow and Metabolism"},{"issue":"10","key":"10.1016\/j.lfs.2020.118198_bb0545","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1089\/neu.2000.17.857","article-title":"Neuronal apoptosis after CNS injury: the roles of glutamate and calcium","volume":"17","author":"Zipfel","year":"2000","journal-title":"J. Neurotrauma"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520309504?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520309504?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T23:05:53Z","timestamp":1762211153000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320520309504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":109,"alternative-id":["S0024320520309504"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118198","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of connexins and pannexins in orofacial pain","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118198","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"118198"}}