{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:53:29Z","timestamp":1767855209489,"version":"3.49.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","award":["20160101020JC"],"award-info":[{"award-number":["20160101020JC"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","award":["20180101301JC"],"award-info":[{"award-number":["20180101301JC"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005227","name":"Jilin Department of Health","doi-asserted-by":"publisher","award":["2011S009"],"award-info":[{"award-number":["2011S009"]}],"id":[{"id":"10.13039\/501100005227","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.lfs.2020.118283","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T21:21:45Z","timestamp":1597353705000},"page":"118283","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Upregulated neuregulin-1 protects against optic nerve injury by regulating the RhoA\/cofilin\/F-actin axis"],"prefix":"10.1016","volume":"264","author":[{"given":"Qian","family":"Hao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingling","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihua","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.lfs.2020.118283_bb0005","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13024-017-0214-8","article-title":"Together JUN and DDIT3 (CHOP) control retinal ganglion cell death after axonal injury","volume":"12","author":"Syc-Mazurek","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.lfs.2020.118283_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.01.002","article-title":"BAX to basics: how the BCL2 gene family controls the death of retinal ganglion cells","volume":"57","author":"Maes","year":"2017","journal-title":"Prog. Retin. Eye Res."},{"issue":"2","key":"10.1016\/j.lfs.2020.118283_bb0015","doi-asserted-by":"crossref","first-page":"E209","DOI":"10.1073\/pnas.1616811114","article-title":"Mobile zinc increases rapidly in the retina after optic nerve injury and regulates ganglion cell survival and optic nerve regeneration","volume":"114","author":"Li","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.lfs.2020.118283_bb0020","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1084\/jem.20160412","article-title":"Optic nerve astrocyte reactivity protects function in experimental glaucoma and other nerve injuries","volume":"214","author":"Sun","year":"2017","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.lfs.2020.118283_bb0025","doi-asserted-by":"crossref","first-page":"e2847","DOI":"10.1038\/cddis.2017.212","article-title":"Damage-induced neuronal endopeptidase (DINE) enhances axonal regeneration potential of retinal ganglion cells after optic nerve injury","volume":"8","author":"Kaneko","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.lfs.2020.118283_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2019.101643","article-title":"Neuregulin-1\/ErbB network: an emerging modulator of nervous system injury and repair","volume":"180","author":"Kataria","year":"2019","journal-title":"Prog. Neurobiol."},{"issue":"1","key":"10.1016\/j.lfs.2020.118283_bb0035","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0896-6273(00)00087-8","article-title":"Evidence that axon-derived neuregulin promotes oligodendrocyte survival in the developing rat optic nerve","volume":"28","author":"Fernandez","year":"2000","journal-title":"Neuron"},{"issue":"7","key":"10.1016\/j.lfs.2020.118283_bb0040","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1093\/cvr\/cvy059","article-title":"Neuregulin-1 attenuates stress-induced vascular senescence","volume":"114","author":"Shakeri","year":"2018","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.lfs.2020.118283_bb0045","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1161\/CIRCRESAHA.115.306532","article-title":"RhoA\/Rho-kinase in the cardiovascular system","volume":"118","author":"Shimokawa","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2020.118283_bb0050","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.biomaterials.2017.01.003","article-title":"RhoA knockdown by cationic amphiphilic copolymer\/siRhoA polyplexes enhances axonal regeneration in rat spinal cord injury model","volume":"121","author":"Gwak","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.lfs.2020.118283_bb0055","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.pharmthera.2017.02.031","article-title":"Peptide regulation of cofilin activity in the CNS: a novel therapeutic approach for treatment of multiple neurological disorders","volume":"175","author":"Shaw","year":"2017","journal-title":"Pharmacol. Ther."},{"issue":"24","key":"10.1016\/j.lfs.2020.118283_bb0060","doi-asserted-by":"crossref","first-page":"4716","DOI":"10.1242\/dev.113308","article-title":"The NAV2 homolog Sickie regulates F-actin-mediated axonal growth in Drosophila mushroom body neurons via the non-canonical Rac-Cofilin pathway","volume":"141","author":"Abe","year":"2014","journal-title":"Development"},{"issue":"6","key":"10.1016\/j.lfs.2020.118283_bb0065","doi-asserted-by":"crossref","first-page":"C839","DOI":"10.1152\/ajpcell.00324.2017","article-title":"Downregulation of microRNA-149 in retinal ganglion cells suppresses apoptosis through activation of the PI3K\/Akt signaling pathway in mice with glaucoma","volume":"315","author":"Nie","year":"2018","journal-title":"Am J Physiol Cell Physiol"},{"issue":"7","key":"10.1016\/j.lfs.2020.118283_bb0070","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.7150\/ijbs.31904","article-title":"miR-155-5p promotes dorsal root ganglion neuron axonal growth in an inhibitory microenvironment via the cAMP\/PKA pathway","volume":"15","author":"Wang","year":"2019","journal-title":"Int. J. Biol. Sci."},{"issue":"6","key":"10.1016\/j.lfs.2020.118283_bb0075","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1097\/ICU.0000000000000417","article-title":"Advances in experimental optic nerve regeneration","volume":"28","author":"Chun","year":"2017","journal-title":"Curr. Opin. Ophthalmol."},{"issue":"11","key":"10.1016\/j.lfs.2020.118283_bb0080","doi-asserted-by":"crossref","first-page":"8567","DOI":"10.1002\/jcp.26501","article-title":"Effects of bone marrow mesenchymal stem cells transfected with Ang-1 gene on hyperoxia-induced optic nerve injury in neonatal mice","volume":"233","author":"Liu","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"6","key":"10.1016\/j.lfs.2020.118283_bb0085","doi-asserted-by":"crossref","first-page":"861","DOI":"10.2174\/1570159X14666161227150250","article-title":"Exploring optic nerve axon regeneration","volume":"15","author":"Li","year":"2017","journal-title":"Curr. Neuropharmacol."},{"issue":"1\u20132","key":"10.1016\/j.lfs.2020.118283_bb0090","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jns.2015.07.023","article-title":"Neuregulin-1 protects against acute optic nerve injury in rat model","volume":"357","author":"Yang","year":"2015","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.lfs.2020.118283_bb0095","doi-asserted-by":"crossref","unstructured":"F.R. Fricker, A. Antunes-Martins, J. Galino, et al. Axonal neuregulin 1 is a rate limiting but not essential factor for nerve remyelination. Brain. 136 (Pt 7) (2013) 2279\u20132297.","DOI":"10.1093\/brain\/awt148"},{"issue":"2","key":"10.1016\/j.lfs.2020.118283_bb0100","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/jcp.20591","article-title":"Neuregulin regulates the formation of radial glial scaffold in hippocampal dentate gyrus of postnatal rats","volume":"207","author":"Zheng","year":"2006","journal-title":"J. Cell. Physiol."},{"issue":"24","key":"10.1016\/j.lfs.2020.118283_bb0105","first-page":"3597","article-title":"Neuregulin-1 preconditioning protects the heart against ischemia\/reperfusion injury through a PI3K\/Akt-dependent mechanism","volume":"123","author":"Fang","year":"2010","journal-title":"Chin. Med. J."},{"issue":"5","key":"10.1016\/j.lfs.2020.118283_bb0110","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.3892\/etm.2013.1273","article-title":"Gene transfer of human neuregulin-1 attenuates ventricular remodeling in diabetic cardiomyopathy rats","volume":"6","author":"Li","year":"2013","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.lfs.2020.118283_bb0115","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.brainres.2013.07.053","article-title":"RhoA activity and post-ischemic inflammation in an experimental model of adult rodent anterior ischemic optic neuropathy","volume":"1534","author":"Fard","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.lfs.2020.118283_bb0120","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.neuroscience.2016.12.027","article-title":"AAV-mediated transfer of RhoA shRNA and CNTF promotes retinal ganglion cell survival and axon regeneration","volume":"343","author":"Cen","year":"2017","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.lfs.2020.118283_bb0125","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.neuropharm.2012.06.037","article-title":"Erythropoietin promotes axonal regeneration after optic nerve crush in vivo by inhibition of RhoA\/ROCK signaling pathway","volume":"63","author":"Tan","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.lfs.2020.118283_bb0130","first-page":"712","article-title":"TGF-beta-induced IOP elevations are mediated by RhoA in the early but not the late fibrotic phase of open angle glaucoma","volume":"24","author":"Hill","year":"2018","journal-title":"Mol. Vis."},{"issue":"26","key":"10.1016\/j.lfs.2020.118283_bb0135","doi-asserted-by":"crossref","first-page":"21836","DOI":"10.1074\/jbc.M112.346114","article-title":"Novel mechanism for negatively regulating Rho-kinase (ROCK) signaling through Coronin1B protein in neuregulin 1 (NRG-1)-induced tumor cell motility","volume":"287","author":"Rana","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.lfs.2020.118283_bb0140","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s12276-018-0156-4","article-title":"CLOCK and BMAL1 stabilize and activate RHOA to promote F-actin formation in cancer cells","volume":"50","author":"Ma","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.lfs.2020.118283_bb0145","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.virol.2018.08.015","article-title":"The V protein of human parainfluenza virus type 2 promotes RhoA-induced filamentous actin formation","volume":"524","author":"Ohta","year":"2018","journal-title":"Virology"},{"issue":"6","key":"10.1016\/j.lfs.2020.118283_bb0150","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1167\/iovs.18-26077","article-title":"Actin dynamics, regulated by RhoA-LIMK-Cofilin signaling, mediates rod photoreceptor axonal retraction after retinal injury","volume":"60","author":"Wang","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"9","key":"10.1016\/j.lfs.2020.118283_bb0155","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1007\/s11064-016-1958-1","article-title":"Simvastatin attenuates neuropathic pain by inhibiting the RhoA\/LIMK\/Cofilin pathway","volume":"41","author":"Qiu","year":"2016","journal-title":"Neurochem. Res."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520310353?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520310353?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T23:07:01Z","timestamp":1762211221000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320520310353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":31,"alternative-id":["S0024320520310353"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118283","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Upregulated neuregulin-1 protects against optic nerve injury by regulating the RhoA\/cofilin\/F-actin axis","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118283","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"118283"}}