{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T14:04:47Z","timestamp":1778335487824,"version":"3.51.4"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.lfs.2020.118307","type":"journal-article","created":{"date-parts":[[2020,8,22]],"date-time":"2020-08-22T05:35:46Z","timestamp":1598074546000},"page":"118307","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Febuxostat mitigates concanavalin A-induced acute liver injury via modulation of MCP-1, IL-1\u03b2, TNF-\u03b1, neutrophil infiltration, and apoptosis in mice"],"prefix":"10.1016","volume":"260","author":[{"given":"Mohammed M.","family":"Maresh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rania R.","family":"Abdelaziz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek M.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.lfs.2020.118307_bb0005","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1053\/j.gastro.2008.03.002","article-title":"Cellular and molecular mechanisms of liver injury","volume":"134","author":"Malhi","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2020.118307_bb0010","first-page":"282","article-title":"The management of fulminant hepatic failure","volume":"3","author":"Trey","year":"1970","journal-title":"Prog. Liver Dis."},{"key":"10.1016\/j.lfs.2020.118307_bb0015","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jcrc.2017.01.003","article-title":"Acute liver failure: an up-to-date approach","volume":"39","author":"Cardoso","year":"2017","journal-title":"J. Crit. Care"},{"issue":"2","key":"10.1016\/j.lfs.2020.118307_bb0020","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1189\/jlb.0210112","article-title":"The bone marrow\u00a0: a site of neutrophil clearance","volume":"88","author":"Rankin","year":"2010","journal-title":"J. Leukoc. Biol."},{"issue":"8","key":"10.1016\/j.lfs.2020.118307_bb0025","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.it.2010.05.006","article-title":"Neutrophil kinetics in health and disease","volume":"31","author":"Summers","year":"2010","journal-title":"Trends Immunol."},{"issue":"10","key":"10.1016\/j.lfs.2020.118307_bb0030","doi-asserted-by":"crossref","first-page":"6933","DOI":"10.4049\/jimmunol.179.10.6933","article-title":"Inflammasome-mediated production of IL-1 is required for neutrophil recruitment against Staphylococcus aureus in vivo","volume":"179","author":"Miller","year":"2007","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.lfs.2020.118307_bb0035","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1189\/jlb.69.5.698","article-title":"Phenotypic and functional change of cytokine-activated neutrophils: inflammatory neutrophils are heterogeneous and enhance adaptive immune responses","volume":"69","author":"Yamashiro","year":"2001","journal-title":"J. Leukocyte Biol."},{"issue":"6","key":"10.1016\/j.lfs.2020.118307_bb0040","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/S0168-8278(96)80301-1","article-title":"A novel mechanism of murine hepatocyte death inducible by concanavalin A","volume":"25","author":"Leist","year":"1996","journal-title":"J. Hepatol."},{"issue":"special issue","key":"10.1016\/j.lfs.2020.118307_bb0045","first-page":"S262","article-title":"Hepatic congestion is the main pathological sign in concanavalin A-induced acute hepatitis in Bama mini-swine","author":"Quan","year":"2018","journal-title":"Biomed. Res."},{"issue":"4","key":"10.1016\/j.lfs.2020.118307_bb0050","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1159\/000373971","article-title":"Emodin protects against concanavalin a-induced hepatitis in mice through inhibiting activation of the p 38 MAPK-NF-\u03baB signaling pathway","volume":"35","author":"Xue","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"issue":"2","key":"10.1016\/j.lfs.2020.118307_bb0055","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.imlet.2008.10.001","article-title":"Tetrandrine protects mice from concanavalin A-induced hepatitis through inhibiting NF-\u03baB activation","volume":"121","author":"Feng","year":"2008","journal-title":"Immunol. Lett."},{"issue":"5","key":"10.1016\/j.lfs.2020.118307_bb0060","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2146\/ajhp100394","article-title":"Febuxostat for treatment of chronic gout","volume":"68","author":"Gray","year":"2011","journal-title":"Am. J. Heal. Pharm."},{"key":"10.1016\/j.lfs.2020.118307_bb0065","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ejphar.2014.11.013","article-title":"The xanthine oxidase inhibitor Febuxostat reduces tissue uric acid content and inhibits injury-induced inflammation in the liver and lung","volume":"746","author":"Kataoka","year":"2015","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.lfs.2020.118307_bb0070","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.freeradbiomed.2011.04.004","article-title":"Febuxostat inhibition of endothelial-bound XO: implications for targeting vascular ROS production","volume":"51","author":"Malik","year":"2011","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.lfs.2020.118307_bb0075","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2020.118307_bb0080","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1177\/0023677215572841","article-title":"The concanavalin A model of acute hepatitis in mice","volume":"49","author":"Heymann","year":"2015","journal-title":"Lab. Anim."},{"issue":"1","key":"10.1016\/j.lfs.2020.118307_bb0085","first-page":"200","article-title":"Original article: effect of Febuxostat in rat liver","volume":"3","author":"Misba","year":"2013","journal-title":"Indian Journal of Basic and Applied Medical Research"},{"key":"10.1016\/j.lfs.2020.118307_bb0090","doi-asserted-by":"crossref","unstructured":"Hu et al. Salidroside attenuates concanavalin-induced hepatitis via modulating cytokines secretion and lymphocytes migration in mice. Mediat. Inflamm. Volume 2014 ID, 314081, 11 pages.","DOI":"10.1155\/2014\/314081"},{"key":"10.1016\/j.lfs.2020.118307_bb0095","doi-asserted-by":"crossref","first-page":"4082","DOI":"10.4049\/jimmunol.160.8.4082","article-title":"Roles for TNF-a and Fas ligand in concanavalin A-induced hepatitis","volume":"160","author":"Ksontini","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.lfs.2020.118307_bb0100","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0160-5402(90)90061-O","article-title":"Improved method for quantification of tissue PMN accumulation measured by myeloperoxidase activity","volume":"23","author":"Schierwagen","year":"1990","journal-title":"J. Pharmacol. Methods"},{"key":"10.1016\/j.lfs.2020.118307_bb0105","series-title":"First International Symposium on Pulse Cytophotometry","first-page":"50","author":"Tribukait","year":"1975"},{"issue":"4","key":"10.1016\/j.lfs.2020.118307_bb0110","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1177\/002215540205000401","article-title":"Improved detection of apoptic cells in archival paraffin sections: immunohistochemistry using antibodies to cleaved capsase 3","volume":"50","author":"Gown","year":"2002","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.lfs.2020.118307_bb0115","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1096\/fasebj.10.2.8641555","article-title":"Regulation of signal transduction during liver regeneration","volume":"10","author":"Diehl","year":"1996","journal-title":"FASEB"},{"key":"10.1016\/j.lfs.2020.118307_bb0120","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.pathophys.2011.02.003","article-title":"Montelukast, a leukotriene receptor antagonist abrogates lipopolysaccharide-induced toxicity and oxidative stress in rat liver","volume":"18","author":"Mohamadin","year":"2011","journal-title":"Pathophysiology"},{"key":"10.1016\/j.lfs.2020.118307_bb0125","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/506390","article-title":"The protective effect of resveratrol on concanavalin-A-induced acute hepatic injury in mice","volume":"2015","author":"Zhou","year":"2015","journal-title":"Gastroenterol. Res. Pract."},{"key":"10.1016\/j.lfs.2020.118307_bb0130","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0016-5085(65)80141-X","article-title":"Serum xantine oxidase: a sensitive test of acute liver injury","volume":"48","author":"Shammaa","year":"1965","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.lfs.2020.118307_bb0135","first-page":"417","article-title":"Protection against acetaminophen-induced liver injury by allopurinol is dependant on aldehyde oxidase-mediated liver preconditioning","volume":"274","author":"Williams","year":"2014"},{"issue":"3","key":"10.1016\/j.lfs.2020.118307_bb0140","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1182\/blood-2007-10-117184","article-title":"The endogenous danger signal, crystalline uric acid, signals for enhanced antibody immunity","volume":"111","author":"Behrens","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.lfs.2020.118307_bb0145","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/BOR.0b013e3283257b96","article-title":"The role of hyperuricemia in vascular disorders","volume":"21","author":"Edwards","year":"2009","journal-title":"Curr. Opin. Rheumatol."},{"issue":"2","key":"10.1016\/j.lfs.2020.118307_bb0150","doi-asserted-by":"crossref","DOI":"10.1002\/hep.23717","article-title":"Association between serum uric acid level and chronic liver disease in the United States","volume":"52","author":"Afzali","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2020.118307_bb0155","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/978-3-642-00663-0_7","article-title":"Role of reactive metabolites in drug-induced hepatotoxicity","author":"Srivastava","year":"2010","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.lfs.2020.118307_bb0160","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cyto.2014.09.004","article-title":"Betulinic acid attenuates lung injury by modulation of inflammatory cytokine response in experimentally-induced polymicrobial sepsis in mice","volume":"71","author":"Lingaraju","year":"2015","journal-title":"Cytokine"},{"key":"10.1016\/j.lfs.2020.118307_bb0165","article-title":"Hepatoprotective effect of San-Cao granule on Con A-induced liver injury in mice and mechanisms of action exploration","author":"Yang","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2020.118307_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105884","article-title":"Febuxostat attenuates ulcerative colitis by the inhibition of NF-\u03baB, proinflammatory cytokines, and oxidative stress in mice","volume":"76","author":"Amirshahrokhi","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.lfs.2020.118307_bb0175","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/0092-8674(83)90037-5","article-title":"Molecular cloning of gene sequences regulated by platelet-derived growth factor","volume":"33","author":"Cochran","year":"1983","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.lfs.2020.118307_bb0180","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1089\/jir.2008.0027","article-title":"Monocyte chemoattractant protein-1 (MCP-1): an overview","volume":"29","author":"Deshmane","year":"2009","journal-title":"J. Interf. Cytokine Res."},{"issue":"10","key":"10.1016\/j.lfs.2020.118307_bb0185","doi-asserted-by":"crossref","first-page":"5252","DOI":"10.4049\/jimmunol.170.10.5252","article-title":"C-C chemokine ligand 2\/monocyte chemoattractant protein-1 directly inhibits NKT cell IL-4 production and is hepatoprotective in T cell-mediated hepatitis in the mouse","volume":"170","author":"Ajuebor","year":"2003","journal-title":"J. Immunol."},{"issue":"9","key":"10.1016\/j.lfs.2020.118307_bb0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0075527","article-title":"Febuxostat, an inhibitor of xanthine oxidase, suppresses lipopolysaccharide-induced MCP-1 production via MAPK Phosphatase-1-mediated inactivation of JNK","volume":"8","author":"Nomura","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.lfs.2020.118307_bb0195","first-page":"215","article-title":"Interleukin-4: a multifunctional cytokine","volume":"22","author":"Zamorano","year":"2003","journal-title":"Inmunolog\u00eda"},{"issue":"6","key":"10.1016\/j.lfs.2020.118307_bb0200","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/PL00000207","article-title":"Reduced hepatic ischemia\/reperfusion injury by IL-4: potential anti-inflammatory role of STAT6A","volume":"49","author":"Kato","year":"2000","journal-title":"Inflamm. Res."},{"issue":"1","key":"10.1016\/j.lfs.2020.118307_bb0205","first-page":"812","article-title":"Effects of febuxostat on serum cytokines IL-1, IL-4, IL-6, IL-8, TNF-\u03b1 and COX-2","volume":"17","author":"Hao","year":"2019","journal-title":"Exp. Ther. Med."},{"issue":"1","key":"10.1016\/j.lfs.2020.118307_bb0210","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0378-1119(87)90398-2","article-title":"Human interleukin-1 beta gene","volume":"52","author":"Bensi","year":"1987","journal-title":"Gene"},{"key":"10.1016\/j.lfs.2020.118307_bb0215","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.berh.2006.06.004","article-title":"Is IL-1 a good therapeutic target in the treatment of arthritis?","volume":"20","author":"Burger","year":"2006","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.lfs.2020.118307_bb0220","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.jhep.2007.06.017","article-title":"Granulocyte colony-stimulating factor impairs liver regeneration in mice through the upregulation of interleukin-1beta","volume":"47","author":"Ogiso","year":"2007","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2020.118307_bb0225","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1053\/gast.1996.v110.pm8964413","article-title":"Regulation of monocyte chemoattractant protein 1 by cytokines and oxygen free radicals in rat hepatic fat-storing cells","volume":"110","author":"Xu","year":"1996","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.lfs.2020.118307_bb0230","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.intimp.2006.11.014","article-title":"Concanavalin a induced expression of toll-like receptors in murine peritoneal macrophages in vitro","volume":"7","author":"Sodhi","year":"2007","journal-title":"Int. Immunopharmacol."},{"issue":"19","key":"10.1016\/j.lfs.2020.118307_bb0235","doi-asserted-by":"crossref","first-page":"4680","DOI":"10.3390\/ijms20194680","article-title":"Xanthine oxidase inhibitor Febuxostat exerts an anti-inflammatory action and protects against diabetic nephropathy development in KK-ay obese diabetic mice","volume":"20","author":"Mizuno","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2020.118307_bb0240","doi-asserted-by":"crossref","first-page":"6555","DOI":"10.1038\/ncomms7555","article-title":"Xanthine oxidoreductase regulates macrophage IL1beta secretion upon NLRP3 inflammasome activation","volume":"6","author":"Ives","year":"2015","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.lfs.2020.118307_bb0245","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s40139-015-0093-z","article-title":"TNF\u03b1 in liver fibrosis","volume":"3","author":"Yang","year":"2015","journal-title":"Curr. Pathobiol. Rep."},{"issue":"9","key":"10.1016\/j.lfs.2020.118307_bb0250","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1172\/JCI504","article-title":"Concanavalin A\u2013induced liver injury triggers hepatocyte proliferation","volume":"101","author":"Trautwein","year":"1998","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.lfs.2020.118307_bb0255","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1016\/j.ajpath.2017.05.015","article-title":"Stellate cells orchestrate Concanavalin A-induced acute liver damage","volume":"187","author":"Rani","year":"2017","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.lfs.2020.118307_bb0260","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4049\/jimmunol.172.1.45","article-title":"Essential role for neutrophil recruitment to the liver in concanavalin A-induced hepatitis","volume":"172","author":"Bonder","year":"2004","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.lfs.2020.118307_bb0265","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1038\/s41598-017-01366-3","article-title":"Xanthine oxidase inhibition by febuxostat attenuates stress-induced hyperuricemia, glucose dysmetabolism, and prothrombotic state in mice","volume":"7","author":"Yisireyili","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2020.118307_bb0270","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1159\/000430165","article-title":"Ultra low dose delta 9-tetrahydrocannabinol protects mouse liver from ischemia reperfusion injury","volume":"36","author":"Hochhauser","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"issue":"6","key":"10.1016\/j.lfs.2020.118307_bb0275","first-page":"4599","article-title":"Salidroside mediates apoptosis and autophagy inhibition in concanavalin A-induced liver injury","volume":"15","author":"Feng","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.lfs.2020.118307_bb0280","doi-asserted-by":"crossref","first-page":"962","DOI":"10.2353\/ajpath.2008.080358","article-title":"Differential roles of JNK in ConA\/GalN and ConA induced liver injury in mice","volume":"173","author":"Ni","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.lfs.2020.118307_bb0285","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.bbrc.2006.08.140","article-title":"Synergistic protective effect of ischemic preconditioning and allopurinol on ischemia\/reperfusion injury in rat liver","volume":"349","author":"Lee","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2020.118307_bb0290","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/s12967-015-0578-x","article-title":"Febuxostat pretreatment attenuates myocardial ischemia\/reperfusion injury via mitochondrial apoptosis","volume":"13","author":"Wang","year":"2015","journal-title":"J. Transl. Med."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520310596?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520310596?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T10:23:49Z","timestamp":1717237429000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320520310596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":58,"alternative-id":["S0024320520310596"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118307","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Febuxostat mitigates concanavalin A-induced acute liver injury via modulation of MCP-1, IL-1\u03b2, TNF-\u03b1, neutrophil infiltration, and apoptosis in mice","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118307","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"118307"}}