{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T08:51:27Z","timestamp":1749113487771,"version":"3.37.3"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Research Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangdong Province","award":["81570751","2016A030311050","2013B021800098044"],"award-info":[{"award-number":["81570751","2016A030311050","2013B021800098044"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.lfs.2020.118373","type":"journal-article","created":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T10:25:26Z","timestamp":1599387926000},"page":"118373","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Asymmetrical dimethylarginine induces dysfunction of insulin signal transduction via endoplasmic reticulum stress in the liver of diabetic rats"],"prefix":"10.1016","volume":"260","author":[{"given":"Ni","family":"Qiu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Mei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Lian","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Ke","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.lfs.2020.118373_bb0005","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrendo.2017.151","article-title":"Global aetiology and epidemiology of type 2 diabetes mellitus and its complications","volume":"14","author":"Zheng","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"issue":"4","key":"10.1016\/j.lfs.2020.118373_bb0010","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.cmet.2017.03.004","article-title":"Imbalanced insulin actions in obesity and type 2 diabetes: key mouse models of insulin signaling pathway","volume":"25","author":"Kubota","year":"2017","journal-title":"Cell Metab."},{"issue":"7503","key":"10.1016\/j.lfs.2020.118373_bb0015","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nature13478","article-title":"The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes","volume":"510","author":"Perry","year":"2014","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.lfs.2020.118373_bb0020","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S2213-8587(13)70143-8","article-title":"Towards metabolic biomarkers of insulin resistance and type 2 diabetes: progress from the metabolome","volume":"2","author":"Roberts","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"8","key":"10.1016\/j.lfs.2020.118373_bb0025","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/s41589-019-0326-2","article-title":"Pharmacological targeting of the unfolded protein response for disease intervention","volume":"15","author":"Hetz","year":"2019","journal-title":"Nat. Chem. Biol."},{"issue":"9","key":"10.1016\/j.lfs.2020.118373_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8091385","article-title":"Relationship between oxidative stress, ER stress, and inflammation in type 2 diabetes: the battle continues","volume":"8","author":"Burgos-Mor\u00f3n","year":"2019","journal-title":"J. Clin. Med."},{"issue":"3","key":"10.1016\/j.lfs.2020.118373_bb0035","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s12020-010-9429-y","article-title":"Inhibition of obesity-induced hepatic ER stress by early insulin therapy in obese diabetic rats","volume":"39","author":"Sun","year":"2011","journal-title":"Endocrine"},{"issue":"4","key":"10.1016\/j.lfs.2020.118373_bb0040","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1074\/jbc.M111.316760","article-title":"Dissociation of inositol-requiring enzyme (IRE1\u03b1)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice","volume":"287","author":"Jurczak","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.lfs.2020.118373_bb0045","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s10753-017-0687-1","article-title":"Elevated levels of ADMA are associated with lower DDAH2 and higher PRMT1 in LPS-induced endometritis rats","volume":"41","author":"Xiao","year":"2018","journal-title":"Inflammation"},{"issue":"9","key":"10.1016\/j.lfs.2020.118373_bb0050","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1093\/eurheartj\/ehp061","article-title":"Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis","volume":"30","author":"Antoniades","year":"2009","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.lfs.2020.118373_bb0055","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1038\/s41598-018-20549-0","article-title":"Asymmetric dimethylarginine (ADMA) is identified as a potential biomarker of insulin resistance in skeletal muscle","volume":"8","author":"Lee","year":"2018","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.lfs.2020.118373_bb0060","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.lfs.2004.10.062","article-title":"Effect of diabetic duration on serum concentrations of endogenous inhibitor of nitric oxide synthase in patients and rats with diabetes","volume":"77","author":"Xiong","year":"2005","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.lfs.2020.118373_bb0065","article-title":"Involvement of increased endogenous asymmetric dimethylarginine in the hepatic endoplasmic reticulum stress of type 2 diabetic rats","volume":"9","author":"Leng","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.lfs.2020.118373_bb0070","doi-asserted-by":"crossref","first-page":"E869","DOI":"10.1152\/ajpendo.91011.2008","article-title":"Asymmetrical dimethylarginine triggers lipolysis and inflammatory response via induction of endoplasmic reticulum stress in cultured adipocytes","volume":"296","author":"Zhou","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2020.118373_bb0075","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.fct.2013.10.014","article-title":"The ER stress-mediated decrease in DDAH1 expression is involved in formaldehyde-induced apoptosis in lung epithelial cells","volume":"62","author":"Lim","year":"2013","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.lfs.2020.118373_bb0080","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3390\/ijms15010484","article-title":"The inhibitory effect of quercetin on asymmetric dimethylarginine-induced apoptosis is mediated by the endoplasmic reticulum stress pathway in glomerular endothelial cells","volume":"15","author":"Guo","year":"2014","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.lfs.2020.118373_bb0085","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.1074\/jbc.M606742200","article-title":"p38 mitogen-activated protein kinase plays an inhibitory role in hepatic lipogenesis","volume":"282","author":"Xiong","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.lfs.2020.118373_bb0090","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/nyas.13435","article-title":"Insulin regulation of gluconeogenesis","volume":"1411","author":"Hatting","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"2","key":"10.1016\/j.lfs.2020.118373_bb0095","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.cmet.2007.11.013","article-title":"Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis","volume":"7","author":"Biddinger","year":"2008","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.lfs.2020.118373_bb0100","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1210\/jc.2011-3172","article-title":"Features of hepatic and skeletal muscle insulin resistance unique to type 1 diabetes","volume":"97","author":"Bergman","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"7","key":"10.1016\/j.lfs.2020.118373_bb0105","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1007\/s00125-013-2904-2","article-title":"Insulin resistance in type 1 diabetes: what is \u2018double diabetes\u2019 and what are the risks?","volume":"56","author":"Cleland","year":"2013","journal-title":"Diabetologia"},{"issue":"2","key":"10.1016\/j.lfs.2020.118373_bb0110","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/00005344-200308000-00006","article-title":"Elevated levels of the serum endogenous inhibitor of nitric oxide synthase and metabolic control in rats with streptozotocin-induced diabetes","volume":"42","author":"Xiong","year":"2003","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"3\u20134","key":"10.1016\/j.lfs.2020.118373_bb0115","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1159\/000327960","article-title":"Contribution of endogenous inhibitor of nitric oxide synthase to hepatic mitochondrial dysfunction in streptozotocin-induced diabetic rats","volume":"27","author":"Chen","year":"2011","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.lfs.2020.118373_bb0120","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12933-014-0156-1","article-title":"Asymmetric dimethylarginine and long-term adverse cardiovascular events in patients with type 2 diabetes: relation with the glycemic control","volume":"13","author":"Hsu","year":"2014","journal-title":"Cardiovasc. Diabetol."},{"issue":"4","key":"10.1016\/j.lfs.2020.118373_bb0125","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ando.2010.02.026","article-title":"ADMA is a correlate of insulin resistance in early-stage diabetes independent of hs-CRP and body adiposity","volume":"71","author":"Nakhjavani","year":"2010","journal-title":"Ann. Endocrinol. (Paris)"},{"issue":"7","key":"10.1016\/j.lfs.2020.118373_bb0130","doi-asserted-by":"crossref","first-page":"10640","DOI":"10.1002\/jcp.27743","article-title":"A correlational study between serum asymmetric dimethylarginine level and impaired glucose tolerance patients associated with obesity","volume":"234","author":"Huang","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"6","key":"10.1016\/j.lfs.2020.118373_bb0135","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3390\/cells7060063","article-title":"Endoplasmic reticulum stress in metabolic disorders","volume":"7","author":"Ghemrawi","year":"2018","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.lfs.2020.118373_bb0140","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1074\/jbc.M411860200","article-title":"Involvement of endoplasmic reticulum stress in insulin resistance and diabetes","volume":"280","author":"Nakatani","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.lfs.2020.118373_bb0145","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/bph.12124","article-title":"Inhibitory cross-talk between the AMPK and ERK pathways mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle","volume":"169","author":"Hwang","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2020.118373_bb0150","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.2147\/DMSO.S218336","article-title":"Endoplasmic reticulum stress may be involved in insulin resistance and lipid metabolism disorders of the white adipose tissues induced by high-fat diet containing industrial trans-fatty acids","volume":"12","author":"Zhu","year":"2019","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"10.1016\/j.lfs.2020.118373_bb0155","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/S1097-2765(01)00264-7","article-title":"Diabetes mellitus and exocrine pancreatic dysfunction in PERK\u2212\/\u2212 mice reveals a role for translational control in secretory cell survival","volume":"7","author":"Harding","year":"2001","journal-title":"Mol. Cell"},{"issue":"5453","key":"10.1016\/j.lfs.2020.118373_bb0160","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1126\/science.287.5453.664","article-title":"Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1","volume":"287","author":"Urano","year":"2000","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.lfs.2020.118373_bb0165","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.tem.2012.06.003","article-title":"New insights into ER stress-induced insulin resistance","volume":"23","author":"Flamment","year":"2012","journal-title":"Trends Endocrinol. Metab."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520311267?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520311267?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T10:25:33Z","timestamp":1717237533000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320520311267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":33,"alternative-id":["S0024320520311267"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118373","relation":{},"ISSN":["0024-3205"],"issn-type":[{"type":"print","value":"0024-3205"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Asymmetrical dimethylarginine induces dysfunction of insulin signal transduction via endoplasmic reticulum stress in the liver of diabetic rats","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118373","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118373"}}