{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:47:04Z","timestamp":1788479224273,"version":"build-2803163510"},"reference-count":120,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.lfs.2020.118395","type":"journal-article","created":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T06:26:51Z","timestamp":1599373611000},"page":"118395","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"special_numbering":"C","title":["Hispidulin: A promising flavonoid with diverse anti-cancer properties"],"prefix":"10.1016","volume":"259","author":[{"given":"Kaili","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengchao","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peizhi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7637","key":"10.1016\/j.lfs.2020.118395_bb0005","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nature21349","article-title":"Elements of cancer immunity and the cancer-immune set point","volume":"541","author":"Chen","year":"2017","journal-title":"Nature"},{"issue":"6280","key":"10.1016\/j.lfs.2020.118395_bb0010","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1126\/science.aaf1490","article-title":"Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade","volume":"351","author":"McGranahan","year":"2016","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.lfs.2020.118395_bb0015","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21551","article-title":"Cancer statistics, 2019","volume":"69","author":"Siegel","year":"2019","journal-title":"CA Cancer J. Clin."},{"issue":"11","key":"10.1016\/j.lfs.2020.118395_bb0020","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/ni1102-991","article-title":"Cancer immunoediting: from immunosurveillance to tumor escape","volume":"3","author":"Dunn","year":"2002","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.lfs.2020.118395_bb0025","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.cell.2017.01.017","article-title":"Primary, adaptive, and acquired resistance to cancer immunotherapy","volume":"168","author":"Sharma","year":"2017","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.lfs.2020.118395_bb0030","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nrclinonc.2015.152","article-title":"Cancer-treatment-induced neurotoxicity\u2014focus on newer treatments","volume":"13","author":"Stone","year":"2016","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"3","key":"10.1016\/j.lfs.2020.118395_bb0035","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41571-018-0142-8","article-title":"Cancer immunoediting and resistance to T cell-based immunotherapy","volume":"16","author":"O\u2019Donnell","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"8","key":"10.1016\/j.lfs.2020.118395_bb0040","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1158\/1940-6207.CAPR-17-0419","article-title":"A review of promising natural chemopreventive agents for head and neck cancer","volume":"11","author":"Crooker","year":"2018","journal-title":"Cancer Prev. Res. (Phila.)"},{"key":"10.1016\/j.lfs.2020.118395_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jnutbio.2016.11.007","article-title":"Plant flavonoids in cancer chemoprevention: role in genome stability","volume":"45","author":"George","year":"2017","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.lfs.2020.118395_bb0050","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3332\/ecancer.2015.557","article-title":"Lifestyle, nutrition and breast cancer: facts and presumptions for consideration","volume":"9","author":"Ferrini","year":"2015","journal-title":"Ecancermedicalscience"},{"issue":"3","key":"10.1016\/j.lfs.2020.118395_bb0055","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.7314\/APJCP.2013.14.3.1565","article-title":"Cruciferous vegetables: dietary phytochemicals for cancer prevention","volume":"14","author":"Abdull Razis","year":"2013","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"3","key":"10.1016\/j.lfs.2020.118395_bb0060","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.phrs.2007.01.009","article-title":"Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis","volume":"55","author":"Higdon","year":"2007","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.lfs.2020.118395_bb0065","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/17425255.2017.1251903","article-title":"Pharmacokinetic properties and drug interactions of apigenin, a natural flavone","volume":"13","author":"Tang","year":"2017","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"issue":"9","key":"10.1016\/j.lfs.2020.118395_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/nu8090581","article-title":"The anti-cancer effect of polyphenols against breast cancer and cancer stem cells: molecular mechanisms","volume":"8","author":"Abdal Dayem","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2020.118395_bb0075","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12979-016-0069-9","article-title":"Nutrition, aging and cancer: lessons from dietary intervention studies","volume":"13","author":"Carruba","year":"2016","journal-title":"Immun. Ageing"},{"issue":"3","key":"10.1016\/j.lfs.2020.118395_bb0080","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.soncn.2016.06.001","article-title":"Natural products for cancer prevention: clinical update 2016","volume":"32","author":"Sanders","year":"2016","journal-title":"Semin. Oncol. Nurs."},{"key":"10.1016\/j.lfs.2020.118395_bb0085","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.3389\/fphar.2018.01253","article-title":"Natural product interventions for chemotherapy and radiotherapy-induced side effects","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.lfs.2020.118395_bb0090","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/nyas.13387","article-title":"Natural products to prevent drug resistance in cancer chemotherapy: a review","volume":"1401","author":"Yuan","year":"2017","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"1","key":"10.1016\/j.lfs.2020.118395_bb0095","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1038\/s41467-019-11622-x","article-title":"Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort","volume":"10","author":"Bondonno","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2020.118395_bb0100","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3389\/fphar.2017.00109","article-title":"New insights toward colorectal cancer chemotherapy using natural bioactive compounds","volume":"8","author":"Redondo-Blanco","year":"2017","journal-title":"Front. Pharmacol."},{"issue":"16","key":"10.1016\/j.lfs.2020.118395_bb0105","doi-asserted-by":"crossref","first-page":"122","DOI":"10.4103\/0973-7847.134247","article-title":"Cytotoxicity of dietary flavonoids on different human cancer types","volume":"8","author":"Sak","year":"2014","journal-title":"Pharmacogn. Rev."},{"issue":"4","key":"10.1016\/j.lfs.2020.118395_bb0110","doi-asserted-by":"crossref","first-page":"216","DOI":"10.15430\/JCP.2016.21.4.216","article-title":"Role of apigenin in cancer prevention via the induction of apoptosis and autophagy","volume":"21","author":"Sung","year":"2016","journal-title":"Journal of cancer prevention"},{"issue":"37","key":"10.1016\/j.lfs.2020.118395_bb0115","doi-asserted-by":"crossref","first-page":"6786","DOI":"10.2174\/0929867325666181112091700","article-title":"Isoliquiritigenin (ISL) and its formulations: potential antitumor agents","volume":"26","author":"Zhao","year":"2019","journal-title":"Curr. Med. Chem."},{"issue":"2","key":"10.1016\/j.lfs.2020.118395_bb0120","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s11357-017-9970-1","article-title":"Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells","volume":"39","author":"Perrott","year":"2017","journal-title":"GeroScience"},{"issue":"6","key":"10.1016\/j.lfs.2020.118395_bb0125","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1007\/s00280-011-1641-9","article-title":"Quercetin enhances 5-fluorouracil-induced apoptosis in MSI colorectal cancer cells through p53 modulation","volume":"68","author":"Xavier","year":"2011","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"7","key":"10.1016\/j.lfs.2020.118395_bb0130","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s00775-015-1298-7","article-title":"Oxidovanadium(IV) complexes with chrysin and silibinin: anticancer activity and mechanisms of action in a human colon adenocarcinoma model","volume":"20","author":"Le\u00f3n","year":"2015","journal-title":"Journal of biological inorganic chemistry: JBIC: a publication of the Society of Biological Inorganic Chemistry"},{"issue":"11","key":"10.1016\/j.lfs.2020.118395_bb0135","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1021\/np990260y","article-title":"Cytotoxic sesquiterpenoids from Ratibida columnifera","volume":"62","author":"Cui","year":"1999","journal-title":"J. Nat. Prod."},{"issue":"4","key":"10.1016\/j.lfs.2020.118395_bb0140","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0031-9422(01)00066-8","article-title":"Two flavonoids and other compounds from the aerial parts of Centaurea bracteata from Italy","volume":"57","author":"Flamini","year":"2001","journal-title":"Phytochemistry"},{"issue":"6","key":"10.1016\/j.lfs.2020.118395_bb0145","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1021\/np50108a017","article-title":"Cytotoxic constituents of Baccharis gaudichaudiana","volume":"57","author":"Fullas","year":"1994","journal-title":"J. Nat. Prod."},{"issue":"2","key":"10.1016\/j.lfs.2020.118395_bb0150","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1055\/s-2003-37712","article-title":"Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor","volume":"69","author":"Kavvadias","year":"2003","journal-title":"Planta Med."},{"issue":"8","key":"10.1016\/j.lfs.2020.118395_bb0155","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1021\/acs.jnatprod.5b00324","article-title":"Total synthesis of hispidulin and the structural basis for its inhibition of proto-oncogene kinase Pim-1","volume":"78","author":"Chao","year":"2015","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.lfs.2020.118395_bb0160","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.biopha.2018.04.014","article-title":"Hispidulin inhibits hepatocellular carcinoma growth and metastasis through AMPK and ERK signaling mediated activation of PPARgamma","volume":"103","author":"Han","year":"2018","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"issue":"3","key":"10.1016\/j.lfs.2020.118395_bb0165","first-page":"1047","article-title":"Hispidulin prevents hypoxia-induced epithelial-mesenchymal transition in human colon carcinoma cells","volume":"5","author":"Xie","year":"2015","journal-title":"Am. J. Cancer Res."},{"issue":"1","key":"10.1016\/j.lfs.2020.118395_bb0170","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s12013-013-9762-x","article-title":"Hispidulin induces apoptosis through mitochondrial dysfunction and inhibition of P13k\/Akt signalling pathway in HepG2 cancer cells","volume":"69","author":"Gao","year":"2014","journal-title":"Cell Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.lfs.2020.118395_bb0175","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.taap.2012.09.022","article-title":"Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K\/Akt signaling pathway in HepG2 cancer cells","volume":"265","author":"Yuan","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.lfs.2020.118395_bb0180","first-page":"1","article-title":"Chemomodulatory effects of Alysicarpus vaginalis extract via mitochondria-dependent apoptosis and necroptosis in breast cancer","author":"Sakle","year":"2019","journal-title":"Nutr. Cancer"},{"issue":"14","key":"10.1016\/j.lfs.2020.118395_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20143415","article-title":"N-Methylparoxetine blocked autophagic flux and induced apoptosis by activating ROS-MAPK pathway in non-small cell lung cancer cells","volume":"20","author":"Wang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.lfs.2020.118395_bb0190","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cbi.2010.07.016","article-title":"Importance of the core structure of flavones in promoting inhibition of the mitochondrial respiratory chain","volume":"188","author":"Valdameri","year":"2010","journal-title":"Chem. Biol. Interact."},{"issue":"12","key":"10.1016\/j.lfs.2020.118395_bb0195","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1080\/13561820500177659","article-title":"Hispidulin: antioxidant properties and effect on mitochondrial energy metabolism","volume":"39","author":"Dabaghi-Barbosa","year":"2005","journal-title":"Free Radic. Res."},{"issue":"1\u20132","key":"10.1016\/j.lfs.2020.118395_bb0200","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s11010-015-2518-8","article-title":"Dual properties of hispidulin: antiproliferative effects on HepG2 cancer cells and selective inhibition of ABCG2 transport activity","volume":"409","author":"Scoparo","year":"2015","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.lfs.2020.118395_bb0205","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/B978-0-12-407704-1.00005-1","article-title":"Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration","volume":"301","author":"Bravo","year":"2013","journal-title":"Int. Rev. Cell Mol. Biol."},{"issue":"1","key":"10.1016\/j.lfs.2020.118395_bb0210","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000484622","article-title":"Endoplasmic reticulum stress promotes autophagy and apoptosis and reduces chemotherapy resistance in mutant p53 lung cancer cells","volume":"44","author":"Gan","year":"2017","journal-title":"Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry, and pharmacology"},{"issue":"3","key":"10.1016\/j.lfs.2020.118395_bb0215","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ceca.2011.04.001","article-title":"A dual role for Ca(2+) in autophagy regulation","volume":"50","author":"Decuypere","year":"2011","journal-title":"Cell Calcium"},{"issue":"50","key":"10.1016\/j.lfs.2020.118395_bb0220","doi-asserted-by":"crossref","first-page":"6419","DOI":"10.1038\/onc.2008.309","article-title":"The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family","volume":"27","author":"Heath-Engel","year":"2008","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.lfs.2020.118395_bb0225","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41401-018-0159-7","article-title":"Hispidulin induces ER stress-mediated apoptosis in human hepatocellular carcinoma cells in vitro and in vivo by activating AMPK signaling pathway","volume":"40","author":"Han","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"issue":"1","key":"10.1016\/j.lfs.2020.118395_bb0230","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bcp.2014.07.018","article-title":"Natural product agonists of peroxisome proliferator-activated receptor gamma (PPAR\u03b3): a review","volume":"92","author":"Wang","year":"2014","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.lfs.2020.118395_bb0235","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.3892\/ijo.2015.2829","article-title":"Genistein exerts growth inhibition on human osteosarcoma MG-63 cells via PPAR\u03b3 pathway","volume":"46","author":"Song","year":"2015","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.lfs.2020.118395_bb0240","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/8972570","article-title":"PPAR\u03b3 as a novel therapeutic target in lung cancer","volume":"2016","author":"Reddy","year":"2016","journal-title":"PPAR Res."},{"issue":"8","key":"10.1016\/j.lfs.2020.118395_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17081226","article-title":"Peroxisome proliferator-activated receptor \u03b3 expression is inversely associated with macroscopic vascular invasion in human hepatocellular carcinoma","volume":"17","author":"Hsu","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2020.118395_bb0250","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.biopha.2016.06.047","article-title":"Rosiglitazone elevates sensitization of drug-resistant oral epidermoid carcinoma cells to vincristine by G2\/M-phase arrest, independent of PPAR-\u03b3 pathway","volume":"83","author":"Wang","year":"2016","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"issue":"12","key":"10.1016\/j.lfs.2020.118395_bb0255","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1002\/mc.22231","article-title":"Pioglitazone, a PPAR\u03b3 agonist, inhibits growth and invasion of human hepatocellular carcinoma via blockade of the rage signaling","volume":"54","author":"Yang","year":"2015","journal-title":"Mol. Carcinog."},{"issue":"4","key":"10.1016\/j.lfs.2020.118395_bb0260","doi-asserted-by":"crossref","first-page":"3638","DOI":"10.1002\/jcp.26225","article-title":"Pioglitazone inhibits cancer cell growth through STAT3 inhibition and enhanced AIF expression via a PPAR\u03b3-independent pathway","volume":"233","author":"Tsubaki","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"10","key":"10.1016\/j.lfs.2020.118395_bb0265","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1158\/1940-6207.CAPR-19-0006","article-title":"A randomized phase II trial of pioglitazone for lung cancer chemoprevention in high-risk current and former smokers","volume":"12","author":"Keith","year":"2019","journal-title":"Cancer Prev. Res. (Phila.)"},{"issue":"3","key":"10.1016\/j.lfs.2020.118395_bb0270","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s10495-006-4003-z","article-title":"Pioglitazone, a synthetic ligand for PPARgamma, induces apoptosis in RB-deficient human colorectal cancer cells","volume":"11","author":"Lee","year":"2006","journal-title":"Apoptosis\u202f: an international journal on programmed cell death"},{"key":"10.1016\/j.lfs.2020.118395_bb0275","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.biomaterials.2016.05.001","article-title":"Redox nanoparticle increases the chemotherapeutic efficiency of pioglitazone and suppresses its toxic side effects","volume":"99","author":"Thangavel","year":"2016","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.lfs.2020.118395_bb0280","doi-asserted-by":"crossref","first-page":"G447","DOI":"10.1152\/ajpgi.00209.2004","article-title":"Activation of PPAR{gamma} by curcumin inhibits Moser cell growth and mediates suppression of gene expression of cyclin D1 and EGFR","volume":"288","author":"Chen","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"9","key":"10.1016\/j.lfs.2020.118395_bb0285","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1097\/CAD.0000000000000125","article-title":"Luteolin potentiates the sensitivity of colorectal cancer cell lines to oxaliplatin through the PPAR\u03b3\/OCTN2 pathway","volume":"25","author":"Qu","year":"2014","journal-title":"Anti-Cancer Drugs"},{"issue":"21","key":"10.1016\/j.lfs.2020.118395_bb0290","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.1021\/acs.jafc.6b00766","article-title":"Chrysin, abundant in Morinda citrifolia fruit water-EtOAc extracts, combined with apigenin synergistically induced apoptosis and inhibited migration in human breast and liver cancer cells","volume":"64","author":"Huang","year":"2016","journal-title":"J. Agric. Food Chem."},{"issue":"5","key":"10.1016\/j.lfs.2020.118395_bb0295","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1111\/jcmm.15028","article-title":"Therapeutic potential of PPAR\u03b3 natural agonists in liver diseases","volume":"24","author":"Wu","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.lfs.2020.118395_bb0300","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.biopha.2018.04.014","article-title":"Hispidulin inhibits hepatocellular carcinoma growth and metastasis through AMPK and ERK signaling mediated activation of PPAR\u03b3","volume":"103","author":"Han","year":"2018","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"key":"10.1016\/j.lfs.2020.118395_bb0305","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.jpba.2016.03.050","article-title":"UHPLC-MS-based metabolomics analysis on mice bearing neoplasm (H22) for hispidulin","volume":"125","author":"Li","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"2","key":"10.1016\/j.lfs.2020.118395_bb0310","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s12013-014-0260-6","article-title":"Hispidulin potentiates the antitumor effect of sunitinib against human renal cell carcinoma in laboratory models","volume":"71","author":"Gao","year":"2015","journal-title":"Cell Biochem. Biophys."},{"issue":"12","key":"10.1016\/j.lfs.2020.118395_bb0315","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11121960","article-title":"Hispidulin enhances TRAIL-mediated apoptosis via CaMKK\u03b2\/AMPK\/USP51 axis-mediated Bim stabilization","volume":"11","author":"Woo","year":"2019","journal-title":"Cancers"},{"issue":"7","key":"10.1016\/j.lfs.2020.118395_bb0320","first-page":"1501","article-title":"Hispidulin suppresses tumor growth and metastasis in renal cell carcinoma by modulating ceramide-sphingosine 1-phosphate rheostat","volume":"7","author":"Gao","year":"2017","journal-title":"Am. J. Cancer Res."},{"issue":"12","key":"10.1016\/j.lfs.2020.118395_bb0325","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1038\/aps.2017.154","article-title":"Hispidulin mediates apoptosis in human renal cell carcinoma by inducing ceramide accumulation","volume":"38","author":"Gao","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.lfs.2020.118395_bb0330","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.pharmthera.2018.10.011","article-title":"The sphingosine kinase-1\/sphingosine-1-phosphate axis in cancer: potential target for anticancer therapy","volume":"195","author":"Zheng","year":"2019","journal-title":"Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.lfs.2020.118395_bb0335","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s12272-019-01114-3","article-title":"Acid ceramidase, an emerging target for anti-cancer and anti-angiogenesis","volume":"42","author":"Cho","year":"2019","journal-title":"Arch. Pharm. Res."},{"issue":"10","key":"10.1016\/j.lfs.2020.118395_bb0340","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1158\/1535-7163.MCT-16-0167","article-title":"FTY720 (fingolimod) inhibits HIF1 and HIF2 signaling, promotes vascular remodeling, and chemosensitizes in renal cell carcinoma animal model","volume":"15","author":"Gstalder","year":"2016","journal-title":"Mol. Cancer Ther."},{"issue":"12","key":"10.1016\/j.lfs.2020.118395_bb0345","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2018.1502130","article-title":"Sphingosine kinase 1 overexpression contributes to sunitinib resistance in clear cell renal cell carcinoma","volume":"7","author":"Xu","year":"2018","journal-title":"Oncoimmunology"},{"issue":"2","key":"10.1016\/j.lfs.2020.118395_bb0350","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.bbrc.2017.03.084","article-title":"Modulation of the sphingolipid rheostat is involved in paclitaxel resistance of the human prostate cancer cell line PC3-PR","volume":"486","author":"Aoyama","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.lfs.2020.118395_bb0355","first-page":"261","article-title":"Vaticanol C, a phytoalexin, induces apoptosis of leukemia and cancer cells by modulating expression of multiple sphingolipid metabolic enzymes","volume":"82","author":"Inoue","year":"2020","journal-title":"Nagoya J. Med. Sci."},{"issue":"10207","key":"10.1016\/j.lfs.2020.118395_bb0360","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/S0140-6736(19)32319-0","article-title":"Colorectal cancer","volume":"394","author":"Dekker","year":"2019","journal-title":"Lancet (London, England)"},{"issue":"3","key":"10.1016\/j.lfs.2020.118395_bb0365","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.tcb.2018.12.001","article-title":"EMT transition states during tumor progression and metastasis","volume":"29","author":"Pastushenko","year":"2019","journal-title":"Trends Cell Biol."},{"issue":"36","key":"10.1016\/j.lfs.2020.118395_bb0370","doi-asserted-by":"crossref","first-page":"39262","DOI":"10.18632\/oncotarget.5741","article-title":"NF-\u03baB contributes to MMP1 expression in breast cancer spheroids causing paracrine PAR1 activation and disintegrations in the lymph endothelial barrier in vitro","volume":"6","author":"Nguyen","year":"2015","journal-title":"Oncotarget"},{"issue":"9","key":"10.1016\/j.lfs.2020.118395_bb0375","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/sj.bjc.6605656","article-title":"Multifactorial anticancer effects of digalloyl-resveratrol encompass apoptosis, cell-cycle arrest, and inhibition of lymphendothelial gap formation in vitro","volume":"102","author":"Madlener","year":"2010","journal-title":"Br. J. Cancer"},{"issue":"5","key":"10.1016\/j.lfs.2020.118395_bb0380","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1172\/JCI44751","article-title":"Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse","volume":"121","author":"Kerjaschki","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2020.118395_bb0385","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.fct.2017.11.015","article-title":"Intravasation of SW620 colon cancer cell spheroids through the blood endothelial barrier is inhibited by clinical drugs and flavonoids in vitro","volume":"111","author":"Holzner","year":"2018","journal-title":"Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association"},{"issue":"9","key":"10.1016\/j.lfs.2020.118395_bb0390","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.2217\/fon.10.106","article-title":"Why target PIM1 for cancer diagnosis and treatment?","volume":"6","author":"Magnuson","year":"2010","journal-title":"Future oncology (London, England)"},{"key":"10.1016\/j.lfs.2020.118395_bb0395","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.canlet.2018.12.015","article-title":"PIM1 kinase promotes cell proliferation, metastasis and tumor growth of lung adenocarcinoma by potentiating the c-MET signaling pathway","volume":"444","author":"Cao","year":"2019","journal-title":"Cancer Lett."},{"issue":"2","key":"10.1016\/j.lfs.2020.118395_bb0400","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bbamcr.2018.10.017","article-title":"Inhibition of PIM1 blocks the autophagic flux to sensitize glioblastoma cells to ABT-737-induced apoptosis","volume":"1866","author":"Remy","year":"2019","journal-title":"Biochimica et biophysica acta Molecular cell research"},{"issue":"4","key":"10.1016\/j.lfs.2020.118395_bb0405","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1517\/13543784.2012.668527","article-title":"PIM1 kinase as a target for cancer therapy","volume":"21","author":"Merkel","year":"2012","journal-title":"Expert Opin. Investig. Drugs"},{"issue":"5","key":"10.1016\/j.lfs.2020.118395_bb0410","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1111\/cas.13562","article-title":"Pim1 supports human colorectal cancer growth during glucose deprivation by enhancing the Warburg effect","volume":"109","author":"Zhang","year":"2018","journal-title":"Cancer Sci."},{"issue":"5","key":"10.1016\/j.lfs.2020.118395_bb0415","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1111\/cas.13575","article-title":"Hispidulin suppresses cell growth and metastasis by targeting PIM1 through JAK2\/STAT3 signaling in colorectal cancer","volume":"109","author":"Liu","year":"2018","journal-title":"Cancer Sci."},{"issue":"10","key":"10.1016\/j.lfs.2020.118395_bb0420","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076693","article-title":"Expression of pim-1 in tumors, tumor stroma and tumor-adjacent mucosa co-determines the prognosis of colon cancer patients","volume":"8","author":"Peng","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.lfs.2020.118395_bb0425","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0130340","article-title":"Pim kinases promote migration and metastatic growth of prostate cancer xenografts","volume":"10","author":"Santio","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.lfs.2020.118395_bb0430","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1002\/cam4.664","article-title":"Hypoxia-responsive miR-124 and miR-144 reduce hypoxia-induced autophagy and enhance radiosensitivity of prostate cancer cells via suppressing PIM1","volume":"5","author":"Gu","year":"2016","journal-title":"Cancer medicine"},{"issue":"1","key":"10.1016\/j.lfs.2020.118395_bb0435","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0891-5849(90)90045-K","article-title":"Flavonoids as superoxide scavengers and antioxidants","volume":"9","author":"Chen","year":"1990","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.lfs.2020.118395_bb0440","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2008.07.029","article-title":"Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita","volume":"120","author":"Yin","year":"2008","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.lfs.2020.118395_bb0445","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/sj.bjp.0705828","article-title":"The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects","volume":"142","author":"Kavvadias","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2020.118395_bb0450","first-page":"211","article-title":"Mechanism of action of hispidulin, a natural flavone, on human platelets","volume":"280","author":"Bourdillat","year":"1988","journal-title":"Prog. Clin. Biol. Res."},{"issue":"1","key":"10.1016\/j.lfs.2020.118395_bb0455","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s12013-014-9888-5","article-title":"The effects of hispidulin on bupivacaine-induced neurotoxicity: role of AMPK signaling pathway","volume":"70","author":"Niu","year":"2014","journal-title":"Cell Biochem. Biophys."},{"issue":"2","key":"10.1016\/j.lfs.2020.118395_bb0460","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s12013-013-9800-8","article-title":"Hispidulin exerts anti-osteoporotic activity in ovariectomized mice via activating AMPK signaling pathway","volume":"69","author":"Zhou","year":"2014","journal-title":"Cell Biochem. Biophys."},{"issue":"17","key":"10.1016\/j.lfs.2020.118395_bb0465","doi-asserted-by":"crossref","first-page":"9511","DOI":"10.1021\/jf1019533","article-title":"Hispidulin potently inhibits human glioblastoma multiforme cells through activation of AMP-activated protein kinase (AMPK)","volume":"58","author":"Lin","year":"2010","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.lfs.2020.118395_bb0470","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s12013-014-0252-6","article-title":"Hispidulin enhances the anti-tumor effects of temozolomide in glioblastoma by activating AMPK","volume":"71","author":"Wang","year":"2015","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.lfs.2020.118395_bb0475","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.blre.2019.04.005","article-title":"Epidemiology of acute myeloid leukemia: recent progress and enduring challenges","volume":"36","author":"Shallis","year":"2019","journal-title":"Blood Rev."},{"issue":"2","key":"10.1016\/j.lfs.2020.118395_bb0480","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1053\/j.seminhematol.2018.08.006","article-title":"Maintenance therapy in acute myeloid leukemia: what is the future?","volume":"56","author":"McMahon","year":"2019","journal-title":"Semin. Hematol."},{"issue":"6","key":"10.1016\/j.lfs.2020.118395_bb0485","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.juro.2015.06.085","article-title":"Emmprin expression predicts response and survival following cisplatin containing chemotherapy for bladder cancer: a validation study","volume":"194","author":"Hemdan","year":"2015","journal-title":"J. Urol."},{"issue":"11","key":"10.1016\/j.lfs.2020.118395_bb0490","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1093\/jjco\/hyq098","article-title":"CD147 and VEGF co-expression predicts prognosis in patients with acute myeloid leukemia","volume":"40","author":"Fu","year":"2010","journal-title":"Jpn. J. Clin. Oncol."},{"issue":"2","key":"10.1016\/j.lfs.2020.118395_bb0495","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s12013-014-0270-4","article-title":"shRNA-mediated EMMPRIN silencing inhibits human leukemic monocyte lymphoma U937 cell proliferation and increases chemosensitivity to adriamycin","volume":"71","author":"Gao","year":"2015","journal-title":"Cell Biochem. Biophys."},{"issue":"2","key":"10.1016\/j.lfs.2020.118395_bb0500","first-page":"1115","article-title":"Hispidulin induces mitochondrial apoptosis in acute myeloid leukemia cells by targeting extracellular matrix metalloproteinase inducer","volume":"8","author":"Gao","year":"2016","journal-title":"Am. J. Transl. Res."},{"issue":"1","key":"10.1016\/j.lfs.2020.118395_bb0505","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1349-7006.2010.01778.x","article-title":"Hispidulin, a small flavonoid molecule, suppresses the angiogenesis and growth of human pancreatic cancer by targeting vascular endothelial growth factor receptor 2-mediated PI3K\/Akt\/mTOR signaling pathway","volume":"102","author":"He","year":"2011","journal-title":"Cancer Sci."},{"key":"10.1016\/j.lfs.2020.118395_bb0510","article-title":"Potential therapeutic role of hispidulin in gastric cancer through induction of apoptosis via NAG-1 signaling","volume":"2013","author":"Yu","year":"2013","journal-title":"Evidence-based complementary and alternative medicine\u202f: eCAM"},{"issue":"1","key":"10.1016\/j.lfs.2020.118395_bb0515","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3892\/etm.2013.1361","article-title":"Variations in NAG-1 expression of human gastric carcinoma and normal gastric tissues","volume":"7","author":"Yang","year":"2014","journal-title":"Experimental and therapeutic medicine"},{"issue":"7","key":"10.1016\/j.lfs.2020.118395_bb0520","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/s41568-018-0005-8","article-title":"Revisiting the role of ABC transporters in multidrug-resistant cancer","volume":"18","author":"Robey","year":"2018","journal-title":"Nat. Rev. Cancer"},{"issue":"2","key":"10.1016\/j.lfs.2020.118395_bb0525","first-page":"296","article-title":"Clinical relationship between MDR1 gene and gallbladder cancer","volume":"3","author":"Wang","year":"2004","journal-title":"Hepatobiliary & pancreatic diseases international\u202f: HBPD INT"},{"issue":"2","key":"10.1016\/j.lfs.2020.118395_bb0530","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.yexcr.2014.11.021","article-title":"Hispidulin inhibits proliferation and enhances chemosensitivity of gallbladder cancer cells by targeting HIF-1\u03b1","volume":"332","author":"Gao","year":"2015","journal-title":"Exp. Cell Res."},{"issue":"9","key":"10.1016\/j.lfs.2020.118395_bb0535","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrurol.2014.194","article-title":"Landmarks in the diagnosis and treatment of renal cell carcinoma","volume":"11","author":"Bhatt","year":"2014","journal-title":"Nature reviews Urology"},{"issue":"7","key":"10.1016\/j.lfs.2020.118395_bb0540","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1002\/ijc.32256","article-title":"Identification of mutations associated with acquired resistance to sunitinib in renal cell cancer","volume":"145","author":"Elgendy","year":"2019","journal-title":"Int. J. Cancer"},{"issue":"17","key":"10.1016\/j.lfs.2020.118395_bb0545","doi-asserted-by":"crossref","first-page":"5386","DOI":"10.1093\/emboj\/16.17.5386","article-title":"TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL","volume":"16","author":"Walczak","year":"1997","journal-title":"EMBO J."},{"issue":"9","key":"10.1016\/j.lfs.2020.118395_bb0550","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/cdd.2014.81","article-title":"Getting TRAIL back on track for cancer therapy","volume":"21","author":"Lemke","year":"2014","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.lfs.2020.118395_bb0555","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3892\/ijo.2016.3525","article-title":"Overcoming resistance to TRAIL-induced apoptosis in solid tumor cells by simultaneously targeting death receptors, c-FLIP and IAPs","volume":"49","author":"Huang","year":"2016","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.lfs.2020.118395_bb0560","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.critrevonc.2019.08.008","article-title":"The TRAIL to cancer therapy: hindrances and potential solutions","volume":"143","author":"Wong","year":"2019","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"12","key":"10.1016\/j.lfs.2020.118395_bb0565","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11121960","article-title":"Hispidulin enhances TRAIL-mediated apoptosis via CaMKK\/AMPK\/USP51 axis-mediated Bim stabilization","volume":"11","author":"Woo","year":"2019","journal-title":"Cancers"},{"issue":"18","key":"10.1016\/j.lfs.2020.118395_bb0570","doi-asserted-by":"crossref","first-page":"10020","DOI":"10.1021\/jf102304g","article-title":"Hispidulin sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by AMPK activation leading to Mcl-1 block in translation","volume":"58","author":"Yang","year":"2010","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.lfs.2020.118395_bb0575","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/ijc.32123","article-title":"JAK-STAT signalling controls cancer stem cell properties including chemotherapy resistance in myxoid liposarcoma","volume":"145","author":"Dolatabadi","year":"2019","journal-title":"Int. J. Cancer"},{"issue":"12","key":"10.1016\/j.lfs.2020.118395_bb0580","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s11095-019-2694-4","article-title":"Chrysin and docetaxel loaded biodegradable micelle for combination chemotherapy of cancer stem cell","volume":"36","author":"Ghamkhari","year":"2019","journal-title":"Pharm. Res."},{"issue":"10","key":"10.1016\/j.lfs.2020.118395_bb0585","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1002\/ptr.6464","article-title":"Genistein inhibits nasopharyngeal cancer stem cells through sonic hedgehog signaling","volume":"33","author":"Zhang","year":"2019","journal-title":"Phytotherapy research\u202f: PTR"},{"issue":"3","key":"10.1016\/j.lfs.2020.118395_bb0590","doi-asserted-by":"crossref","DOI":"10.3390\/nu11030624","article-title":"Baicalein suppresses stem cell-like characteristics in radio- and chemoresistant MDA-MB-231 human breast cancer cells through up-regulation of IFIT2","volume":"11","author":"Koh","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2020.118395_bb0595","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.biopha.2017.12.097","article-title":"Autophagy induction by hispidulin provides protection against sevoflurane-induced neuronal apoptosis in aged rats","volume":"98","author":"Huang","year":"2018","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"key":"10.1016\/j.lfs.2020.118395_bb0600","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jpba.2016.07.034","article-title":"Pharmacokinetics of homoplantaginin in rats following intravenous, peritoneal injection and oral administration","volume":"129","author":"Cong","year":"2016","journal-title":"J. Pharm. Biomed. Anal."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520311486?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520311486?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T06:27:42Z","timestamp":1717223262000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320520311486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":120,"alternative-id":["S0024320520311486"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118395","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hispidulin: A promising flavonoid with diverse anti-cancer properties","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118395","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"118395"}}