{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T11:43:25Z","timestamp":1792928605876,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602945"],"award-info":[{"award-number":["81602945"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673283"],"award-info":[{"award-number":["81673283"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2019-I2M-5-074"],"award-info":[{"award-number":["2019-I2M-5-074"]}]},{"name":"Program for the Ministry of Education \u201cPeptide Drugs\u201d Innovation Team","award":["IRT_15R27"],"award-info":[{"award-number":["IRT_15R27"]}]},{"DOI":"10.13039\/501100007764","name":"Lanzhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["2019-4-4"],"award-info":[{"award-number":["2019-4-4"]}],"id":[{"id":"10.13039\/501100007764","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["lzujbky-2019-kb11"],"award-info":[{"award-number":["lzujbky-2019-kb11"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["lzujbky-2017-139"],"award-info":[{"award-number":["lzujbky-2017-139"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.lfs.2020.118465","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T04:04:53Z","timestamp":1600401893000},"page":"118465","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Peptide DR8 suppresses epithelial-to-mesenchymal transition via the TGF-\u03b2\/MAPK signaling pathway in renal fibrosis"],"prefix":"10.1016","volume":"261","author":[{"given":"Bochuan","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenle","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Bu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqiu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangzhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2020.118465_bb0005","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1016\/S0140-6736(18)31891-9","article-title":"Global, regional, and national age-sex-specific mortality and life expectancy, 1950\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.lfs.2020.118465_bb0010","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"Global, regional, and national burden of chronic kidney disease, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"395","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.lfs.2020.118465_bb0015","series-title":"Chronic Kidney Disease in the United States, 2019","author":"Centers for Disease Control and Prevention","year":"2019"},{"key":"10.1016\/j.lfs.2020.118465_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-49012-4","article-title":"A new, easily generated mouse model of diabetic kidney fibrosis","volume":"9","author":"He","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2020.118465_bb0025","first-page":"72","article-title":"Kidney disease models: tools to identify mechanisms and potential therapeutic targets","volume":"39","author":"Bao","year":"2018","journal-title":"Zool. Res."},{"key":"10.1016\/j.lfs.2020.118465_bb0030","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cell.2016.06.028","article-title":"Emt: 2016","volume":"166","author":"Nieto","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2020.118465_bb0035","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/nm.3901","article-title":"Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease","volume":"21","author":"Grande","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.lfs.2020.118465_bb0040","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial-mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.lfs.2020.118465_bb0045","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1042\/BJ20100323","article-title":"Mechanisms and functions of p38 MAPK signalling","volume":"429","author":"Cuadrado","year":"2010","journal-title":"Biochem. J."},{"key":"10.1016\/j.lfs.2020.118465_bb0050","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1126\/science.1072682","article-title":"Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases","volume":"298","author":"Johnson","year":"2002","journal-title":"Science."},{"key":"10.1016\/j.lfs.2020.118465_bb0055","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000320172","article-title":"Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin axis in transforming growth factor-\u03b2-induced epithelial-mesenchymal transition","volume":"193","author":"Lamouille","year":"2011","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.lfs.2020.118465_bb0060","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41580-018-0080-4","article-title":"New insights into the mechanisms of epithelial\u2013mesenchymal transition and implications for cancer","volume":"20","author":"Dongre","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.lfs.2020.118465_bb0065","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1021\/acs.jafc.6b04731","article-title":"Transepithelial transport of YWDHNNPQIR and its metabolic fate with cytoprotection against oxidative stress in human intestinal Caco-2 cells","volume":"65","author":"Xu","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.lfs.2020.118465_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2019.114703","article-title":"Protective effect of peptide DR8 on bleomycin-induced pulmonary fibrosis by regulating the TGF-\u03b2\/MAPK signaling pathway and oxidative stress","volume":"382","author":"Wang","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.lfs.2020.118465_bb0075","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.lfs.2019.04.037","article-title":"RAP-8 ameliorates liver fibrosis by modulating cell cycle and oxidative stress","volume":"229","author":"Xu","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2020.118465_bb0080","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3390\/biom9040141","article-title":"Unilateral ureteral obstruction as a model to investigate fibrosis-attenuating treatments","volume":"9","author":"Mart\u00ednez-Klimova","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.lfs.2020.118465_bb0085","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/labinvest.2014.50","article-title":"Dipeptidyl peptidase IV inhibitor protects against renal interstitial fibrosis in a mouse model of ureteral obstruction","volume":"94","author":"Min","year":"2014","journal-title":"Lab. Investig."},{"key":"10.1016\/j.lfs.2020.118465_bb0090","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13287-017-0760-6","article-title":"Human umbilical cord mesenchymal stem cell conditioned medium attenuates renal fibrosis by reducing inflammation and epithelial-to-mesenchymal transition via the TLR4\/NF-\u03baB signaling pathway in vivo and in vitro","volume":"9","author":"Liu","year":"2018","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.lfs.2020.118465_bb0095","first-page":"384","article-title":"Effect of individualized low-protein diet intervention on renal function of patients with chronic kidney disease","volume":"37","author":"Zhang","year":"2015","journal-title":"Acta Acad. Med. Sin."},{"key":"10.1016\/j.lfs.2020.118465_bb0100","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1080\/10715762.2016.1181757","article-title":"Apocynin attenuates renal fibrosis via inhibition of NOXs-ROS-ERK-myofibroblast accumulation in UUO rats","volume":"50","author":"Cheng","year":"2016","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.lfs.2020.118465_bb0105","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jphs.2016.12.005","article-title":"\u03b2-Aminoisobutyric acid ameliorates the renal fibrosis in mouse obstructed kidneys via inhibition of renal fibroblast activation and fibrosis","volume":"133","author":"Wang","year":"2017","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.lfs.2020.118465_bb0110","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1007\/s00210-018-1544-y","article-title":"Empagliflozin, SGLT2 inhibitor, attenuates renal fibrosis in rats exposed to unilateral ureteric obstruction: potential role of klotho expression, Naunyn. Schmiedebergs","volume":"391","author":"Abbas","year":"2018","journal-title":"Arch. Pharmacol."},{"key":"10.1016\/j.lfs.2020.118465_bb0115","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.pharep.2017.03.002","article-title":"Thymoquinone ameliorates renal damage in unilateral ureteral obstruction in rats","volume":"69","author":"Hosseinian","year":"2017","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.lfs.2020.118465_bb0120","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1365-2613.2011.00764.x","article-title":"Fibroblasts and myofibroblasts in renal fibrosis","volume":"92","author":"Meran","year":"2011","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.lfs.2020.118465_bb0125","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s00018-015-2110-0","article-title":"The myofibroblast, a key cell in normal and pathological tissue repair","volume":"73","author":"Darby","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.lfs.2020.118465_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0202409","article-title":"Deubiquitinase inhibitor PR-619 reduces Smad4 expression and suppresses renal fibrosis in mice with unilateral ureteral obstruction","volume":"13","author":"Soji","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2020.118465_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.intimp.2017.11.043","article-title":"Telbivudine attenuates UUO-induced renal fibrosis via TGF-\u03b2\/Smad and NF-\u03baB signaling","volume":"55","author":"Chen","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.lfs.2020.118465_bb0140","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","article-title":"Epithelial-mesenchymal transitions in development and disease","volume":"139","author":"Thiery","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2020.118465_bb0145","doi-asserted-by":"crossref","first-page":"e915","DOI":"10.1038\/cddis.2013.442","article-title":"An EMT spectrum defines an anoikis-resistant and spheroidogenic intermediate mesenchymal state that is sensitive to e-cadherin restoration by a src-kinase inhibitor, saracatinib (AZD0530)","volume":"4","author":"Huang","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.lfs.2020.118465_bb0150","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-\u03b2: the master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.lfs.2020.118465_bb0155","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.matbio.2015.05.005","article-title":"Latent TGF-\u03b2-binding proteins","volume":"47","author":"Robertson","year":"2015","journal-title":"Matrix Biol."},{"key":"10.1016\/j.lfs.2020.118465_bb0160","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1242\/jcs.00229","article-title":"Making sense of latent TGF\u03b2 activation","volume":"116","author":"Annes","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.lfs.2020.118465_bb0165","doi-asserted-by":"crossref","first-page":"F159","DOI":"10.1152\/ajprenal.00546.2013","article-title":"RhoA\/Rho kinase mediates TGF-\u03b2 1-induced kidney myofibroblast activation through Poldip2\/Nox4-derived reactive oxygen species","volume":"307","author":"Manickam","year":"2014","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.lfs.2020.118465_bb0170","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1097\/TP.0000000000001608","article-title":"Kidney fibrosis: origins and interventions","volume":"101","author":"Vanhove","year":"2017","journal-title":"Transplantation"},{"key":"10.1016\/j.lfs.2020.118465_bb0175","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/ki.2014.287","article-title":"Origin of myofibroblasts and cellular events triggering fibrosis","volume":"87","author":"Mack","year":"2015","journal-title":"Kidney Int."},{"key":"10.1016\/j.lfs.2020.118465_bb0180","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1017\/S1462399411001967","article-title":"Myofibroblast differentiation and survival in fibrotic disease","volume":"13","author":"Kis","year":"2011","journal-title":"Expert Rev. Mol. Med."},{"key":"10.1016\/j.lfs.2020.118465_bb0185","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nature02006","article-title":"Smad-dependent and Smad-independent pathways in TGF-\u03b2 family signalling","volume":"425","author":"Derynck","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2020.118465_bb0190","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1038\/sj.emboj.7601818","article-title":"TGF-\u03b2 activates Erk MAP kinase signalling through direct phosphorylation of ShcA","volume":"26","author":"Lee","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.lfs.2020.118465_bb0195","doi-asserted-by":"crossref","first-page":"F495","DOI":"10.1152\/ajprenal.2001.280.3.F495","article-title":"Stimulation of pro-\u03b11(I) collagen by TGF-\u03b21 in mesangial cells: role of the p38 MAPK pathway","volume":"280","author":"Chin","year":"2001","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.lfs.2020.118465_bb0200","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1681\/ASN.2006060604","article-title":"A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis","volume":"18","author":"Ma","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.lfs.2020.118465_bb0205","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1681\/ASN.2018020209","article-title":"The MEK inhibitor trametinib ameliorates kidney fibrosis by suppressing ERK1\/2 and mTORC1 signaling","volume":"30","author":"Andrikopoulos","year":"2019","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.lfs.2020.118465_bb0210","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1126\/science.aam7928","article-title":"Inflammation and metabolism in tissue repair and regeneration","volume":"356","author":"Eming","year":"2017","journal-title":"Science"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520312182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520312182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:39:05Z","timestamp":1758400745000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320520312182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":42,"alternative-id":["S0024320520312182"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118465","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Peptide DR8 suppresses epithelial-to-mesenchymal transition via the TGF-\u03b2\/MAPK signaling pathway in renal fibrosis","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118465","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"118465"}}