{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:23:00Z","timestamp":1785817380476,"version":"3.56.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["HE 5825\/6-1"],"award-info":[{"award-number":["HE 5825\/6-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["201608210185"],"award-info":[{"award-number":["201608210185"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["201706370083"],"award-info":[{"award-number":["201706370083"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.lfs.2020.118468","type":"journal-article","created":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T10:57:12Z","timestamp":1600513032000},"page":"118468","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Rac1 silencing, NSC23766 and EHT1864 reduce growth and actin organization of bladder smooth muscle cells"],"prefix":"10.1016","volume":"261","author":[{"given":"Ruixiao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfeng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingsheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Ciotkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Rutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian G.","family":"Stief","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hennenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.lfs.2020.118468_bb0005","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1152\/physrev.2001.81.1.153","article-title":"Small GTP-binding proteins","volume":"81","author":"Takai","year":"2001","journal-title":"Physiol. Rev."},{"issue":"Pt 8","key":"10.1016\/j.lfs.2020.118468_bb0010","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1242\/jcs.01118","article-title":"Rho-family GTPases: it\u2019s not only Rac and Rho (and I like it)","volume":"117","author":"Wennerberg","year":"2004","journal-title":"J. Cell Sci."},{"issue":"13","key":"10.1016\/j.lfs.2020.118468_bb0015","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.2174\/1389450115666141027110156","article-title":"Rac-1 as a new therapeutic target in cerebro- and cardio-vascular diseases","volume":"15","author":"Carrizzo","year":"2014","journal-title":"Curr. Drug Targets"},{"issue":"5","key":"10.1016\/j.lfs.2020.118468_bb0020","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1113\/jphysiol.2013.262998","article-title":"The small GTPase Rac1 is required for smooth muscle contraction","volume":"592","author":"Rahman","year":"2014","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.lfs.2020.118468_bb0025","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1152\/physrev.00038.2003","article-title":"Urinary bladder contraction and relaxation: physiology and pathophysiology","volume":"84","author":"Andersson","year":"2004","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.lfs.2020.118468_bb0030","first-page":"1","article-title":"Overview on the lower urinary tract","volume":"202","author":"Chapple","year":"2011","journal-title":"Handb. Exp. Pharmacol."},{"issue":"2","key":"10.1016\/j.lfs.2020.118468_bb0035","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.semnephrol.2005.09.009","article-title":"Diabetic uropathy","volume":"26","author":"Daneshgari","year":"2006","journal-title":"Semin. Nephrol."},{"issue":"11","key":"10.1016\/j.lfs.2020.118468_bb0040","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1111\/bph.13099","article-title":"Inhibition of prostate smooth muscle contraction and prostate stromal cell growth by the inhibitors of Rac, NSC23766 and EHT1864","volume":"172","author":"Wang","year":"2015","journal-title":"Br. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.lfs.2020.118468_bb0045","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1002\/pros.23780","article-title":"New strategies for inhibition of non-adrenergic prostate smooth muscle contraction by pharmacologic intervention","volume":"79","author":"Yu","year":"2019","journal-title":"Prostate"},{"key":"10.1016\/j.lfs.2020.118468_bb0050","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3389\/fphar.2020.00409","article-title":"Inhibition of Female and Male Human Detrusor Smooth Muscle Contraction by the Rac Inhibitors EHT1864 and NSC23766","volume":"11","author":"Li","year":"2020","journal-title":"Front. Pharmacol"},{"issue":"6","key":"10.1016\/j.lfs.2020.118468_bb0055","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/bcpt.12346","article-title":"The role of Rac1 on carbachol-induced contractile activity in detrusor smooth muscle from streptozotocin-induced diabetic rats","volume":"116","author":"Evcim","year":"2015","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"9","key":"10.1016\/j.lfs.2020.118468_bb0060","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1111\/j.1442-2042.2012.03043.x","article-title":"Effect of cyclic hydrodynamic pressure-induced proliferation of human bladder smooth muscle through Ras-related C3 botulinum toxin substrate 1, mitogen-activated protein kinase kinase 1\/2 and extracellular regulated protein kinases 1\/2","volume":"19","author":"Wu","year":"2012","journal-title":"Int. J. Urol."},{"issue":"5","key":"10.1016\/j.lfs.2020.118468_bb0065","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/jth.12861","article-title":"Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets","volume":"13","author":"Dutting","year":"2015","journal-title":"J. Thromb. Haemost."},{"issue":"1","key":"10.1016\/j.lfs.2020.118468_bb0070","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1124\/jpet.113.207266","article-title":"NSC23766, a widely used inhibitor of Rac1 activation, additionally acts as a competitive antagonist at muscarinic acetylcholine receptors","volume":"347","author":"Levay","year":"2013","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"3","key":"10.1016\/j.lfs.2020.118468_bb0075","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9","article-title":"The Ki-67 protein: from the known and the unknown","volume":"182","author":"Scholzen","year":"2000","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.lfs.2020.118468_bb0080","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s10875-012-9836-3","article-title":"Eosinophils induce airway smooth muscle cell proliferation","volume":"33","author":"Halwani","year":"2013","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.lfs.2020.118468_bb0085","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.atherosclerosis.2019.07.010","article-title":"RhoGDI stability is regulated by SUMOylation and ubiquitination via the AT1 receptor and participates in Ang II-induced smooth muscle proliferation and vascular remodeling","volume":"288","author":"Dai","year":"2019","journal-title":"Atherosclerosis"},{"issue":"32","key":"10.1016\/j.lfs.2020.118468_bb0090","doi-asserted-by":"crossref","first-page":"12231","DOI":"10.1074\/jbc.RA119.007958","article-title":"A NAV2729-sensitive mechanism promotes adrenergic smooth muscle contraction and growth of stromal cells in the human prostate","volume":"294","author":"Yu","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2020.118468_bb0095","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/S0076-6879(06)06043-5","article-title":"Rational design and applications of a Rac GTPase-specific small molecule inhibitor","volume":"406","author":"Akbar","year":"2006","journal-title":"Methods Enzymol."},{"issue":"20","key":"10.1016\/j.lfs.2020.118468_bb0100","doi-asserted-by":"crossref","first-page":"7618","DOI":"10.1073\/pnas.0307512101","article-title":"Rational design and characterization of a Rac GTPase-specific small molecule inhibitor","volume":"101","author":"Gao","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"49","key":"10.1016\/j.lfs.2020.118468_bb0105","doi-asserted-by":"crossref","first-page":"35666","DOI":"10.1074\/jbc.M703571200","article-title":"Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases","volume":"282","author":"Shutes","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.lfs.2020.118468_bb0110","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/sj.bjp.0706780","article-title":"Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladder","volume":"148","author":"Abrams","year":"2006","journal-title":"Br. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.lfs.2020.118468_bb0115","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1517\/14656566.9.10.1787","article-title":"Fesoterodine: a novel muscarinic receptor antagonist for the treatment of overactive bladder syndrome","volume":"9","author":"Michel","year":"2008","journal-title":"Expert. Opin. Pharmacother."},{"issue":"45","key":"10.1016\/j.lfs.2020.118468_bb0120","doi-asserted-by":"crossref","first-page":"37516","DOI":"10.1074\/jbc.M507913200","article-title":"RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo","volume":"280","author":"Desire","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.lfs.2020.118468_bb0125","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1124\/mol.119.118927","article-title":"New author guidelines for displaying data and reporting data analysis and statistical methods in experimental biology","volume":"97","author":"Michel","year":"2020","journal-title":"Mol. Pharmacol."},{"issue":"1","key":"10.1016\/j.lfs.2020.118468_bb0130","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.atherosclerosis.2007.02.003","article-title":"Epidermal growth factor stimulates Rac1 and p21-activated kinase in vascular smooth muscle cells","volume":"196","author":"Beier","year":"2008","journal-title":"Atherosclerosis"},{"issue":"2","key":"10.1016\/j.lfs.2020.118468_bb0135","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1093\/cvr\/cvn188","article-title":"Rho GTPase, Rac1, regulates Skp2 levels, vascular smooth muscle cell proliferation, and intima formation in vitro and in vivo","volume":"80","author":"Bond","year":"2008","journal-title":"Cardiovasc. Res."},{"issue":"5","key":"10.1016\/j.lfs.2020.118468_bb0140","doi-asserted-by":"crossref","first-page":"e0155726","DOI":"10.1371\/journal.pone.0155726","article-title":"Smooth muscle-alpha actin inhibits vascular smooth muscle cell proliferation and migration by inhibiting Rac1 activity","volume":"11","author":"Chen","year":"2016","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.lfs.2020.118468_bb0145","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1160\/TH08-07-0473","article-title":"Rac-1 promotes pulmonary artery smooth muscle cell proliferation by upregulation of plasminogen activator inhibitor-1: role of NFkappaB-dependent hypoxia-inducible factor-1alpha transcription","volume":"100","author":"Diebold","year":"2008","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.lfs.2020.118468_bb0150","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.vph.2015.04.013","article-title":"IL-1beta enhances vascular smooth muscle cell proliferation and migration via P2Y2 receptor-mediated RAGE expression and HMGB1 release","volume":"72","author":"Eun","year":"2015","journal-title":"Vasc. Pharmacol."},{"issue":"4","key":"10.1016\/j.lfs.2020.118468_bb0155","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1161\/ATVBAHA.112.300234","article-title":"Kalirin promotes neointimal hyperplasia by activating Rac in smooth muscle cells","volume":"33","author":"Wu","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"23","key":"10.1016\/j.lfs.2020.118468_bb0160","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1111\/bph.13623","article-title":"Smooth muscle contraction and growth of stromal cells in the human prostate are both inhibited by the Src family kinase inhibitors, AZM475271 and PP2","volume":"173","author":"Wang","year":"2016","journal-title":"Br. J. Pharmacol"},{"issue":"3","key":"10.1016\/j.lfs.2020.118468_bb0165","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.jaci.2017.09.049","article-title":"Targeting of Rac1 prevents bronchoconstriction and airway hyperresponsiveness","volume":"142","author":"Andre-Gregoire","year":"2018","journal-title":"J. Allergy Clin. Immunol"},{"issue":"9","key":"10.1016\/j.lfs.2020.118468_bb0170","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1248\/bpb.b19-00404","article-title":"Increased Rac1 activation in the enhanced carbachol-induced bronchial smooth muscle contraction of repeatedly antigen-challenged mice","volume":"42","author":"Kai","year":"2019","journal-title":"Biol. Pharm. Bull."},{"issue":"1","key":"10.1016\/j.lfs.2020.118468_bb0175","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/bcpt.13204","article-title":"Up-regulation of Rac1 in the bronchial smooth muscle of murine experimental asthma","volume":"125","author":"Kai","year":"2019","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"4","key":"10.1016\/j.lfs.2020.118468_bb0180","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1016\/j.bbrc.2018.07.009","article-title":"Pharmacological inhibition of Rac1 exerts a protective role in ischemia\/reperfusion-induced renal fibrosis","volume":"503","author":"Liang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2020.118468_bb0185","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ejphar.2017.10.032","article-title":"Rac1 modulates G-protein-coupled receptor-induced bronchial smooth muscle contraction","volume":"818","author":"Sakai","year":"2018","journal-title":"Eur. J. Pharmacol."},{"issue":"25","key":"10.1016\/j.lfs.2020.118468_bb0190","doi-asserted-by":"crossref","first-page":"6118","DOI":"10.1182\/blood-2011-09-379263","article-title":"Signaling and cytoskeletal requirements in erythroblast enucleation","volume":"119","author":"Konstantinidis","year":"2012","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.lfs.2020.118468_bb0195","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1124\/jpet.106.107375","article-title":"Determining the potency and molecular mechanism of action of insurmountable antagonists","volume":"319","author":"Kenakin","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"7","key":"10.1016\/j.lfs.2020.118468_bb0200","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1002\/nau.22467","article-title":"Prostatic alpha1-adrenoceptors: new concepts of function, regulation, and intracellular signaling","volume":"33","author":"Hennenberg","year":"2014","journal-title":"Neurourol. Urodyn."},{"issue":"17","key":"10.1016\/j.lfs.2020.118468_bb0205","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1111\/bph.15172","article-title":"Regulation of smooth muscle contraction by monomeric non-RhoA GTPases","volume":"177","author":"Li","year":"2020","journal-title":"Br. J. Pharmacol"},{"issue":"6 Pt 1","key":"10.1016\/j.lfs.2020.118468_bb0210","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1097\/01.ju.0000085024.47406.6c","article-title":"Y-27632, a Rho-kinase inhibitor, inhibits proliferation and adrenergic contraction of prostatic smooth muscle cells","volume":"170","author":"Rees","year":"2003","journal-title":"J. Urol."},{"issue":"6","key":"10.1016\/j.lfs.2020.118468_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/cells8060551","article-title":"RhoGTPase in vascular disease","volume":"8","author":"Strassheim","year":"2019","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.lfs.2020.118468_bb0220","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12894-018-0329-4","article-title":"Progressive bladder remodeling due to bladder outlet obstruction: a systematic review of morphological and molecular evidences in humans","volume":"18","author":"Fusco","year":"2018","journal-title":"BMC Urol."},{"issue":"1","key":"10.1016\/j.lfs.2020.118468_bb0225","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.eururo.2006.07.050","article-title":"The detrusor muscle: an innocent victim of bladder outlet obstruction","volume":"51","author":"Mirone","year":"2007","journal-title":"Eur. Urol."},{"key":"10.1016\/j.lfs.2020.118468_bb0230","doi-asserted-by":"crossref","first-page":"911","DOI":"10.3389\/fphar.2019.00911","article-title":"Urinary bladder weight and function in a rat model of mild hyperglycemia and its treatment with dapagliflozin","volume":"10","author":"Yesilyurt","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.lfs.2020.118468_bb0235","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1172\/JCI2552","article-title":"A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy","volume":"102","author":"Pracyk","year":"1998","journal-title":"J. Clin. Invest."},{"issue":"19","key":"10.1016\/j.lfs.2020.118468_bb0240","doi-asserted-by":"crossref","first-page":"7432","DOI":"10.1073\/pnas.0510444103","article-title":"Requirement of Rac1 in the development of cardiac hypertrophy","volume":"103","author":"Satoh","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.lfs.2020.118468_bb0245","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1042\/BC20080021","article-title":"TGFbeta1 regulates endothelial cell spreading and hypertrophy through a Rac-p38-mediated pathway","volume":"100","author":"Varon","year":"2008","journal-title":"Biol. Cell."},{"issue":"4","key":"10.1016\/j.lfs.2020.118468_bb0250","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.eururo.2017.12.031","article-title":"EAU guidelines on assessment and nonsurgical management of urinary incontinence","volume":"73","author":"Nambiar","year":"2018","journal-title":"Eur. Urol."},{"issue":"1","key":"10.1016\/j.lfs.2020.118468_bb0255","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.eururo.2013.03.004","article-title":"EAU guidelines on the treatment and follow-up of non-neurogenic male lower urinary tract symptoms including benign prostatic obstruction","volume":"64","author":"Oelke","year":"2013","journal-title":"Eur. Urol."},{"key":"10.1016\/j.lfs.2020.118468_bb0260","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/978-3-642-16499-6_16","article-title":"Muscarinic acetylcholine receptors in the urinary tract","volume":"202","author":"Andersson","year":"2011","journal-title":"Handb. Exp. Pharmacol."},{"issue":"9","key":"10.1016\/j.lfs.2020.118468_bb0265","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1111\/j.1464-410X.2008.07782.x","article-title":"Spontaneous contractions of the pig urinary bladder: the effect of ATP-sensitive potassium channels and the role of the mucosa","volume":"102","author":"Akino","year":"2008","journal-title":"BJU Int."},{"issue":"6","key":"10.1016\/j.lfs.2020.118468_bb0270","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1111\/bju.13240","article-title":"On the origin of spontaneous activity in the bladder","volume":"117","author":"Kushida","year":"2016","journal-title":"BJU Int."},{"issue":"5","key":"10.1016\/j.lfs.2020.118468_bb0275","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1742-1241.2010.02626.x","article-title":"Persistence and adherence in the treatment of overactive bladder syndrome with anticholinergic therapy: a systematic review of the literature","volume":"65","author":"Sexton","year":"2011","journal-title":"Int. J. Clin. Pract."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520312212?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520312212?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:44:18Z","timestamp":1777423458000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320520312212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":55,"alternative-id":["S0024320520312212"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118468","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rac1 silencing, NSC23766 and EHT1864 reduce growth and actin organization of bladder smooth muscle cells","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118468","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"118468"}}