{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:48:18Z","timestamp":1793332098209,"version":"4.5.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.lfs.2020.118469","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T04:04:45Z","timestamp":1600401885000},"page":"118469","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Assessment of effective imidazole derivatives against SARS-CoV-2 main protease through computational approach"],"prefix":"10.1016","volume":"262","author":[{"given":"Assia","family":"Belhassan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"En-nahli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanane","family":"Zaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahar","family":"Lakhlifi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Bouachrine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2020.118469_bb0005","doi-asserted-by":"crossref","first-page":"138436","DOI":"10.1016\/j.scitotenv.2020.138436","article-title":"Correlation between weather and Covid-19 pandemic in Jakarta, Indonesia","author":"Tosepu","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"5","key":"10.1016\/j.lfs.2020.118469_bb0010","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.apsb.2020.02.008","article-title":"Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods","volume":"10","author":"Wu","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.lfs.2020.118469_bb0015","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.dsx.2020.03.011","article-title":"Chloroquine and hydroxychloroquine in the treatment of COVID-19 with or without diabetes: a systematic search and a narrative review with a special reference to India and other developing countries","volume":"14","author":"Singh","year":"2020","journal-title":"Diabetes Metab. Syndr. Clin. Res. Rev."},{"key":"10.1016\/j.lfs.2020.118469_bb0020","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ijid.2020.03.076","article-title":"Spatial epidemic dynamics of the COVID-19 outbreak in China","volume":"94","author":"Kang","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.lfs.2020.118469_bb0025","doi-asserted-by":"crossref","first-page":"105955","DOI":"10.1016\/j.ijantimicag.2020.105955","article-title":"The epidemiology, diagnosis and treatment of COVID-19","author":"Zhai","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.lfs.2020.118469_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117477","article-title":"Anti-HCV, nucleotide inhibitors, repurposing against COVID-19","volume":"248","author":"Elfiky","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2020.118469_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2020.103670","article-title":"Computers and viral diseases. Preliminary bioinformatics studies on the design of a synthetic vaccine and a preventative peptidomimetic antagonist against the SARS-CoV-2 (2019-nCoV, COVID-19) coronavirus","volume":"119","author":"Robson","year":"2020","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.lfs.2020.118469_bb0040","series-title":"Fragment Molecular Orbital Based Interaction Analyses on COVID-19 Main Protease - Inhibitor N3 Complex (PDB ID:6LU7)","author":"Hatada","year":"2020"},{"key":"10.1016\/j.lfs.2020.118469_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104904","article-title":"The possible mechanisms of action of 4-aminoquinolines (chloroquine\/hydroxychloroquine) against Sars-Cov-2 infection (COVID-19): a role for iron homeostasis?","volume":"158","author":"Quiros Roldan","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"4","key":"10.1016\/j.lfs.2020.118469_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2020.105945","article-title":"Aminoquinolines against coronavirus disease 2019 (COVID-19): chloroquine or hydroxychloroquine","volume":"55","author":"Sahraei","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.lfs.2020.118469_bb0055","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ajo.2019.04.025","article-title":"The diagnostic utility of multifocal electroretinography in detecting chloroquine and hydroxychloroquine retinal toxicity","volume":"206","author":"Tsang","year":"2019","journal-title":"Am J. Ophthalmol."},{"key":"10.1016\/j.lfs.2020.118469_bb0060","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.toxrep.2019.10.006","article-title":"Diagnostic pitfalls and laboratory test interference after hydroxychloroquine intoxication: a case report","volume":"6","author":"Radke","year":"2019","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.lfs.2020.118469_bb0065","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/s41565-020-0674-9","article-title":"Insights from nanomedicine into chloroquine efficacy against COVID-19","volume":"15","author":"Hu","year":"2020","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.lfs.2020.118469_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2020.128595","article-title":"Inhibitory activity of hydroxychloroquine on COVID-19 main protease: an insight from MD-simulation studies","volume":"1219","author":"Baildya","year":"2020","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.lfs.2020.118469_bb0075","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.ophtha.2016.01.058","article-title":"Recommendations on screening for chloroquine and hydroxychloroquine retinopathy (2016 revision)","volume":"123","author":"Marmor","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.lfs.2020.118469_bb0085","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.2174\/1570179416666191007092548","article-title":"Contemporary progress in the synthetic strategies of imidazole and its biological activities","volume":"16","author":"Soni","year":"2019","journal-title":"Curr. Org. Synth."},{"issue":"1","key":"10.1016\/j.lfs.2020.118469_bb0090","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.chest.2020.03.032","article-title":"Comparison of hospitalized patients with acute respiratory distress syndrome caused by COVID-19 and H1N1","volume":"158","author":"Tang","year":"2020","journal-title":"Chest"},{"key":"10.1016\/j.lfs.2020.118469_bb0095","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.bioorg.2018.06.012","article-title":"Design, synthesis and antiplasmodial activity of novel imidazole derivatives based on 7-chloro-4-aminoquinoline","volume":"80","author":"Kondaparla","year":"2018","journal-title":"Bioorg. Chem."},{"issue":"5","key":"10.1016\/j.lfs.2020.118469_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2020.105960","article-title":"Structural and molecular modeling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection","volume":"55","author":"Fantini","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"1","key":"10.1016\/j.lfs.2020.118469_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2020.105949","article-title":"Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial","volume":"56","author":"Gautret","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.lfs.2020.118469_bb0110","unstructured":"Tripos Inc., St. Louis, MO, USA. SYBYL-X 2.0."},{"key":"10.1016\/j.lfs.2020.118469_bb0115","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1002\/jcc.540100804","article-title":"Validation of the general purpose Tripos 5.2 force field","volume":"10","author":"Clark","year":"1989","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.lfs.2020.118469_bb0120","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1021\/je60033a020","article-title":"A brief review and table of semiempirical parameters used in the Hueckel molecular orbital method","volume":"12","author":"Purcell","year":"1967","journal-title":"J. Chem. Eng. Data"},{"key":"10.1016\/j.lfs.2020.118469_bb0130","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.lfs.2020.118469_bb0135","series-title":"Release 2017 Dassault Syst\u00e8mes, San Diego","author":"Dassault Syst\u00e8mes BIOVIA Discovery Studio Modeling Environment","year":"2016"},{"key":"10.1016\/j.lfs.2020.118469_bb0140","doi-asserted-by":"crossref","first-page":"301","DOI":"10.6026\/97320630016301","article-title":"Repurposing of known anti-virals as potential inhibitors for SARS-CoV-2 main protease using molecular docking analysis","volume":"16","author":"Hakmi","year":"2020","journal-title":"Bioinformation"},{"key":"10.1016\/j.lfs.2020.118469_bb0145","first-page":"1","article-title":"Moroccan medicinal plants as inhibitors of COVID-19: computational investigations","author":"Aanouz","year":"2020","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.lfs.2020.118469_bb0150","first-page":"1","article-title":"Structure of M pro from SARS-CoV-2 and discovery of its inhibitors","author":"Jin","year":"2020","journal-title":"Nature"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520312224?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520312224?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:35:17Z","timestamp":1758400517000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320520312224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":28,"alternative-id":["S0024320520312224"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118469","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessment of effective imidazole derivatives against SARS-CoV-2 main protease through computational approach","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118469","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"118469"}}