{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T10:18:22Z","timestamp":1778494702290,"version":"3.51.4"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773435"],"award-info":[{"award-number":["81773435"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Program of Development of Transgenic New Species of China","award":["2016ZX08011006"],"award-info":[{"award-number":["2016ZX08011006"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573158"],"award-info":[{"award-number":["81573158"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.lfs.2020.118514","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T05:43:18Z","timestamp":1601530998000},"page":"118514","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Cholera toxin induces food allergy through Th2 cell differentiation which is unaffected by Jagged2"],"prefix":"10.1016","volume":"263","author":[{"given":"Shanfeng","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songsong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiwen","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huilian","family":"Che","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.lfs.2020.118514_bb0005","doi-asserted-by":"crossref","first-page":"0","DOI":"10.1006\/jmbi.1995.0456","article-title":"The three-dimensional crystal structure of cholera toxin","volume":"251","author":"Zhang","year":"1995","journal-title":"J. Mol. Biol."},{"issue":"3","key":"10.1016\/j.lfs.2020.118514_bb0010","first-page":"21","article-title":"A review on Fagopyrum esculentum: a potential medicinal plant","volume":"7","author":"Al-Snafi","year":"2017","journal-title":"IOSR J. Pharm."},{"key":"10.1016\/j.lfs.2020.118514_bb0015","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.foodchem.2019.01.123","article-title":"Allergenicity reduction of cow\u2019s milk proteins using latex peptidases","volume":"284","author":"Oliveira","year":"2019","journal-title":"Food Chem."},{"key":"10.1016\/j.lfs.2020.118514_bb0020","series-title":"A Mouse Model of Peanut Allergy Induced by Sensitization Through the Gastrointestinal Tract[M]\/\/Type 2 Immunity","first-page":"39","author":"Orgel","year":"2018"},{"issue":"3","key":"10.1016\/j.lfs.2020.118514_bb0025","doi-asserted-by":"crossref","first-page":"239","DOI":"10.4168\/aair.2016.8.3.239","article-title":"Antibody production, anaphylactic signs, and T-cell responses induced by oral sensitization with ovalbumin in BALB\/c and C3H\/HeOuJ mice","volume":"8","author":"Pablos-Tanarro","year":"2016","journal-title":"Allergy, Asthma Immunol. Res."},{"issue":"11","key":"10.1016\/j.lfs.2020.118514_bb0030","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1021\/acs.jafc.8b00402","article-title":"Assessment of the allergenic potential of the main egg white proteins in BALB\/c mice","volume":"66","author":"Pablos-Tanarro","year":"2018","journal-title":"J. Agric. Food Chem."},{"issue":"4","key":"10.1016\/j.lfs.2020.118514_bb0035","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1365-3083.2012.02756.x","article-title":"Cross-allergic reactions to legumes in lupin and fenugreek-sensitized mice","volume":"76","author":"Vinje","year":"2012","journal-title":"Scand. J. Immunol."},{"issue":"5","key":"10.1016\/j.lfs.2020.118514_bb0040","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1080\/09540105.2015.1129600","article-title":"BALB\/c mice can be used to evaluate allergenicity of different food protein extracts","volume":"27","author":"Zhou","year":"2016","journal-title":"Food Agric. Immunol."},{"issue":"3","key":"10.1016\/j.lfs.2020.118514_bb0045","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1084\/jem.184.3.1045","article-title":"Role of the glycocalyx in regulating access of microparticles to apical plasma membranes of intestinal epithelial cells: implications for microbial attachment and oral vaccine targeting","volume":"184","author":"Frey","year":"1996","journal-title":"J. Exp. Med."},{"issue":"10","key":"10.1016\/j.lfs.2020.118514_bb0050","doi-asserted-by":"crossref","first-page":"5533","DOI":"10.1128\/IAI.70.10.5533-5539.2002","article-title":"Cholera toxin and heat-labile enterotoxin activate human monocyte-derived dendritic cells and dominantly inhibit cytokine production through a cyclic AMP-dependent pathway","volume":"70","author":"Bagley","year":"2002","journal-title":"Infect. Immun."},{"issue":"8","key":"10.1016\/j.lfs.2020.118514_bb0055","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1002\/1521-4141(2000)30:8<2394::AID-IMMU2394>3.0.CO;2-Y","article-title":"Cholera toxin induces maturation of human dendritic cells and licences them for Th2 priming","volume":"30","author":"Gagliardi","year":"2000","journal-title":"Eur. J. Immunol."},{"issue":"6\u20137","key":"10.1016\/j.lfs.2020.118514_bb0060","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1078\/1438-4221-00169","article-title":"Effects of the adjuvant cholera toxin on dendritic cells: stimulatory and inhibitory signals that result in the amplification of immune responses","volume":"291","author":"Gagliardi","year":"2001","journal-title":"Inte. J. Med. Microbiol."},{"issue":"7","key":"10.1016\/j.lfs.2020.118514_bb0065","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.4049\/jimmunol.180.7.4441","article-title":"Gastrointestinal dendritic cells promote Th2 skewing via OX40L","volume":"180","author":"Bl\u00e1zquez","year":"2008","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.lfs.2020.118514_bb0070","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jaci.2008.04.036","article-title":"Disruption of T-cell immunoglobulin and mucin domain molecule (TIM)\u20131\/TIM4 interaction as a therapeutic strategy in a dendritic cell\u2013induced peanut allergy model","volume":"122","author":"Feng","year":"2008","journal-title":"J. Allergy Clin. Immunol."},{"issue":"4","key":"10.1016\/j.lfs.2020.118514_bb0075","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0092-8674(04)00451-9","article-title":"Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells","volume":"117","author":"Amsen","year":"2004","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.lfs.2020.118514_bb0080","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1084\/jem.20062648","article-title":"Notch\u2013RBP-J signaling controls the homeostasis of CD8\u2212 dendritic cells in the spleen","volume":"204","author":"Caton","year":"2007","journal-title":"J. Exp. Med."},{"issue":"8","key":"10.1016\/j.lfs.2020.118514_bb0085","doi-asserted-by":"crossref","first-page":"4458","DOI":"10.4049\/jimmunol.167.8.4458","article-title":"Notch-1 regulates NF-\u03baB activity in hemopoietic progenitor cells","volume":"167","author":"Cheng","year":"2001","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.lfs.2020.118514_bb0090","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.1182\/blood-2003-04-1034","article-title":"Notch signaling is necessary but not sufficient for differentiation of dendritic cells","volume":"102","author":"Cheng","year":"2003","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.lfs.2020.118514_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-4598-9-90","article-title":"The transcription factor RBP-J-mediated signaling is essential for dendritic cells to evoke efficient anti-tumor immune responses in mice","volume":"9","author":"Feng","year":"2010","journal-title":"Mol. Cancer"},{"issue":"5","key":"10.1016\/j.lfs.2020.118514_bb0100","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.immuni.2011.08.013","article-title":"Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine","volume":"35","author":"Lewis","year":"2011","journal-title":"Immunity"},{"issue":"23","key":"10.1016\/j.lfs.2020.118514_bb0105","doi-asserted-by":"crossref","first-page":"15993","DOI":"10.1074\/jbc.M901144200","article-title":"Lipopolysaccharide-induced maturation of bone marrow-derived dendritic cells is regulated by notch signaling through the up-regulation of CXCR4","volume":"284","author":"Wang","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.lfs.2020.118514_bb0110","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.anai.2016.10.024","article-title":"Inhibition effect of blunting Notch signaling on food allergy through improving TH1\/TH2 balance in mice","volume":"118","author":"Jiang","year":"2017","journal-title":"Ann. Allergy Asthma Immunol."},{"issue":"2","key":"10.1016\/j.lfs.2020.118514_bb0115","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0091-6749(99)70492-6","article-title":"A murine model of IgE-mediated cow\u2019s milk hypersensitivity","volume":"103","author":"Li","year":"1999","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5","key":"10.1016\/j.lfs.2020.118514_bb0120","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1084\/jem.175.5.1157","article-title":"Identification of proliferating dendritic cell precursors in mouse blood","volume":"175","author":"Inaba","year":"1992","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.lfs.2020.118514_bb0125","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.4049\/jimmunol.172.4.2549","article-title":"Contribution of antigen-primed CD8+ T cells to the development of airway hyperresponsiveness and inflammation is associated with IL-13","volume":"172","author":"Miyahara","year":"2004","journal-title":"J. Immunol."},{"issue":"22","key":"10.1016\/j.lfs.2020.118514_bb0130","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1016\/S0264-410X(99)00135-8","article-title":"Mutants of cholera toxin as an effective and safe adjuvant for nasal influenza vaccine","volume":"17","author":"Hagiwara","year":"1999","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.lfs.2020.118514_bb0135","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1007\/s00284-010-9739-6","article-title":"Increased immunogenicity to LipL32 of Leptospira interrogans when expressed as a fusion protein with the cholera toxin B subunit","volume":"62","author":"Habarta","year":"2011","journal-title":"Curr. Microbiol."},{"issue":"10","key":"10.1016\/j.lfs.2020.118514_bb0140","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/0264-410X(94)90033-7","article-title":"Helper Th1 and Th2 cell responses following mucosal or systemic immunization with cholera toxin","volume":"12","author":"Xu-Amano","year":"1994","journal-title":"Vaccine"},{"issue":"12","key":"10.1016\/j.lfs.2020.118514_bb0145","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1002\/1097-0142(20001215)89:12<2637::AID-CNCR17>3.0.CO;2-B","article-title":"COX-2 is expressed in human pulmonary, colonic, and mammary tumors","volume":"89","author":"Soslow","year":"2000","journal-title":"Cancer"},{"issue":"12","key":"10.1016\/j.lfs.2020.118514_bb0150","doi-asserted-by":"crossref","first-page":"7098","DOI":"10.4049\/jimmunol.1003636","article-title":"Chronic helminth infection promotes immune regulation in vivo through dominance of CD11cloCD103\u2212 dendritic cells","volume":"186","author":"Smith","year":"2011","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.lfs.2020.118514_bb0155","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1084\/jem.20101563","article-title":"Inflammatory dendritic cells\u2014not basophils\u2014are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen","volume":"207","author":"Hammad","year":"2010","journal-title":"J. Exp. Med."},{"issue":"5","key":"10.1016\/j.lfs.2020.118514_bb0160","doi-asserted-by":"crossref","first-page":"G1074","DOI":"10.1152\/ajpgi.1999.276.5.G1074","article-title":"I. Mucosal dendritic cells: their specialized role in initiating T cell responses","volume":"276","author":"Iwasaki","year":"1999","journal-title":"Am. J. Physiol.-Gastrointest. Liver Physiol."},{"issue":"8","key":"10.1016\/j.lfs.2020.118514_bb0165","doi-asserted-by":"crossref","first-page":"4090","DOI":"10.4049\/jimmunol.160.8.4090","article-title":"Dendritic cells are required for the development of chronic eosinophilic airway inflammation in response to inhaled antigen in sensitized mice","volume":"160","author":"Lambrecht","year":"1998","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.lfs.2020.118514_bb0170","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1164\/rccm.201101-0019OC","article-title":"Persistent activation of dendritic cells after resolution of allergic airway inflammation breaks tolerance to inhaled allergens in mice","volume":"184","author":"van Rijt","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"12","key":"10.1016\/j.lfs.2020.118514_bb0175","doi-asserted-by":"crossref","first-page":"7931","DOI":"10.4049\/jimmunol.180.12.7931","article-title":"Th2 differentiation is unaffected by Jagged2 expression on dendritic cells","volume":"180","author":"Krawczyk","year":"2008","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.lfs.2020.118514_bb0180","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/eji.200737335","article-title":"Dendritic cell expression of the Notch ligand jagged2 is not essential for Th2 response induction in vivo","volume":"38","author":"Worsley","year":"2008","journal-title":"Eur. J. Immunol."},{"issue":"12","key":"10.1016\/j.lfs.2020.118514_bb0185","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/nri954","article-title":"The lineage decisions of helper T cells","volume":"2","author":"Murphy","year":"2002","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.lfs.2020.118514_bb0190","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.immuni.2007.04.018","article-title":"Notch directly regulates Gata3 expression during T helper 2 cell differentiation","volume":"27","author":"Fang","year":"2007","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.lfs.2020.118514_bb0195","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1365-2222.2007.02876.x","article-title":"The immune system in healthy adults and patients with atopic dermatitis seems to be affected differently by a probiotic intervention","volume":"38","author":"Friedrich","year":"2008","journal-title":"Clin. Exp. Allergy"},{"issue":"8","key":"10.1016\/j.lfs.2020.118514_bb0200","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1111\/j.1399-3038.2008.00731.x","article-title":"Is caesarean delivery associated with sensitization to food allergens and IgE-mediated food allergy: a systematic review","volume":"19","author":"Koplin","year":"2008","journal-title":"Pediatr. Allergy Immunol."},{"issue":"5","key":"10.1016\/j.lfs.2020.118514_bb0205","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nri2515","article-title":"The gut microbiota shapes intestinal immune responses during health and disease","volume":"9","author":"Round","year":"2009","journal-title":"Nat. Rev. Immunol."},{"issue":"10","key":"10.1016\/j.lfs.2020.118514_bb0210","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nri2850","article-title":"The immune system and the gut microbiota: friends or foes?","volume":"10","author":"Cerf-Bensussan","year":"2010","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.lfs.2020.118514_bb0215","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/ni0111-5","article-title":"Diet, gut microbiota and immune responses","volume":"12","author":"Maslowski","year":"2010","journal-title":"Nat. Immunol."},{"issue":"6","key":"10.1016\/j.lfs.2020.118514_bb0220","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nri.2016.42","article-title":"Gut microbiota, metabolites and host immunity","volume":"16","author":"Rooks","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.lfs.2020.118514_bb0225","series-title":"[D] Research of the Role and Mechanism of Notch Signaling in Food Allergy","author":"Songsong","year":"2018"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520312674?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520312674?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:13:06Z","timestamp":1718410386000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320520312674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":45,"alternative-id":["S0024320520312674"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118514","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cholera toxin induces food allergy through Th2 cell differentiation which is unaffected by Jagged2","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118514","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"118514"}}