{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:07:04Z","timestamp":1785928024440,"version":"3.56.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,23]],"date-time":"2021-10-23T00:00:00Z","timestamp":1634947200000},"content-version":"vor","delay-in-days":326,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","award":["427\/2015"],"award-info":[{"award-number":["427\/2015"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["2015\/20082-7"],"award-info":[{"award-number":["2015\/20082-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.lfs.2020.118583","type":"journal-article","created":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T05:16:59Z","timestamp":1602307019000},"page":"118583","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Paternal exercise protects against liver steatosis in the male offspring of mice submitted to high fat diet"],"prefix":"10.1016","volume":"263","author":[{"given":"Rog\u00e9rio Oliveira","family":"Batista","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Budu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tha\u00eds","family":"Alves-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Midori","family":"Arakaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Fernandes S.","family":"Gregnani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talita G.","family":"Rodrigues H\u00fangaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Burgos-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick","family":"Wasinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria Pereira","family":"Lanzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels Olsen Saraiva","family":"Camara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lila Missae","family":"Oyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronaldo Carvalho","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.lfs.2020.118583_bb0005","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s12576-017-0559-3","article-title":"Physical exercise reduces pyruvate carboxylase (PCB) and contributes to hyperglycemia reduction in obese mice","volume":"68","author":"Munoz","year":"2018","journal-title":"J. Physiol. Sci."},{"issue":"2","key":"10.1016\/j.lfs.2020.118583_bb0010","doi-asserted-by":"crossref","first-page":"E243","DOI":"10.1152\/ajpendo.00445.2016","article-title":"High-intensity interval training and calorie restriction promote remodeling of glucose and lipid metabolism in diet-induced obesity","volume":"313","author":"Davis","year":"2017","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"1S1","key":"10.1016\/j.lfs.2020.118583_bb0015","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.orcp.2017.01.004","article-title":"Aerobic endurance training improves nonalcoholic fatty liver disease (NAFLD) features via miR-33 dependent autophagy induction in high fat diet fed mice","volume":"12","author":"Ghareghani","year":"2018","journal-title":"Obes. Res. Clin. Pract."},{"issue":"1","key":"10.1016\/j.lfs.2020.118583_bb0020","doi-asserted-by":"crossref","first-page":"6120","DOI":"10.1038\/s41598-017-05040-6","article-title":"Metabolomic characteristics of cholesterol-induced non-obese nonalcoholic fatty liver disease in mice","volume":"7","author":"Tu","year":"2017","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.lfs.2020.118583_bb0025","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nrendo.2017.42","article-title":"Endocrine-disrupting chemicals and fatty liver disease","volume":"13","author":"Foulds","year":"2017","journal-title":"Nat Rev Endocrinol"},{"issue":"11","key":"10.1016\/j.lfs.2020.118583_bb0030","doi-asserted-by":"crossref","first-page":"21833","DOI":"10.3390\/ijms141121833","article-title":"Rodent models of nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis","volume":"14","author":"Imajo","year":"2013","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.lfs.2020.118583_bb0035","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/nrendo.2017.80","article-title":"Regulation of hepatic glucose metabolism in health and disease","volume":"13","author":"Petersen","year":"2017","journal-title":"Nat Rev Endocrinol"},{"issue":"4","key":"10.1016\/j.lfs.2020.118583_bb0040","doi-asserted-by":"crossref","first-page":"339","DOI":"10.5717\/jenb.2014.18.4.339","article-title":"Effect of aerobic exercise training on non-alcoholic fatty liver disease induced by a high fat diet in C57BL\/6 mice","volume":"18","author":"Cho","year":"2014","journal-title":"J Exerc Nutrition Biochem"},{"issue":"1","key":"10.1016\/j.lfs.2020.118583_bb0045","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12944-016-0398-x","article-title":"The effects of detraining and training on adipose tissue lipid droplet in obese mice after chronic high-fat diet","volume":"16","author":"Bae","year":"2017","journal-title":"Lipids Health Dis."},{"issue":"11","key":"10.1016\/j.lfs.2020.118583_bb0050","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/ijo.2012.12","article-title":"PGC-1alpha and exercise in the control of body weight","volume":"36","author":"Summermatter","year":"2012","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.lfs.2020.118583_bb0055","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12986-015-0052-z","article-title":"Exercise during pregnancy protects adult mouse offspring from diet-induced obesity","volume":"12","author":"Wasinski","year":"2015","journal-title":"Nutr. Metab. (Lond.)"},{"issue":"4","key":"10.1016\/j.lfs.2020.118583_bb0060","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/ijo.2013.150","article-title":"Exercise in obese female rats has beneficial effects on maternal and male and female offspring metabolism","volume":"39","author":"Vega","year":"2015","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.lfs.2020.118583_bb0065","doi-asserted-by":"crossref","DOI":"10.1038\/srep44650","article-title":"Exercise rescues obese mothers\u2019 insulin sensitivity, placental hypoxia and male offspring insulin sensitivity","volume":"7","author":"Fernandez-Twinn","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.lfs.2020.118583_bb0070","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jhep.2015.08.022","article-title":"Gestational exercise protects adult male offspring from high-fat diet-induced hepatic steatosis","volume":"64","author":"Sheldon","year":"2016","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.lfs.2020.118583_bb0075","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.2337\/db13-1614","article-title":"Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1alpha gene and age-dependent metabolic dysfunction in the offspring","volume":"63","author":"Laker","year":"2014","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.lfs.2020.118583_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120980","article-title":"Effects of maternal diet and exercise during pregnancy on glucose metabolism in skeletal muscle and fat of weanling rats","volume":"10","author":"Raipuria","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.lfs.2020.118583_bb0085","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.cmet.2016.01.014","article-title":"Paternal psychological stress reprograms hepatic gluconeogenesis in offspring","volume":"23","author":"Wu","year":"2016","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.lfs.2020.118583_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/nu9020122","article-title":"An exercise-only intervention in obese fathers restores glucose and insulin regulation in conjunction with the rescue of pancreatic islet cell morphology and microRNA expression in male offspring","volume":"9","author":"McPherson","year":"2017","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.lfs.2020.118583_bb0095","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.cmet.2017.02.016","article-title":"Epigenetic mechanisms of transmission of metabolic disease across generations","volume":"25","author":"Sales","year":"2017","journal-title":"Cell Metab."},{"issue":"3\u20134","key":"10.1016\/j.lfs.2020.118583_bb0100","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1159\/000365026","article-title":"Paternal obesity, interventions, and mechanistic pathways to impaired health in offspring","volume":"64","author":"McPherson","year":"2014","journal-title":"Ann Nutr Metab"},{"issue":"6198","key":"10.1016\/j.lfs.2020.118583_bb0105","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1126\/science.1254400","article-title":"Parenting from before conception","volume":"345","author":"Lane","year":"2014","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.lfs.2020.118583_bb0110","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2019-000890","article-title":"Maternal and paternal exercise regulate offspring metabolic health and beta cell phenotype","volume":"8","author":"Zheng","year":"2020","journal-title":"BMJ Open Diabetes Res. Care"},{"issue":"2","key":"10.1016\/j.lfs.2020.118583_bb0115","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1096\/fj.15-274274","article-title":"Paternal long-term exercise programs offspring for low energy expenditure and increased risk for obesity in mice","volume":"30","author":"Murashov","year":"2016","journal-title":"FASEB J."},{"issue":"9","key":"10.1016\/j.lfs.2020.118583_bb0120","doi-asserted-by":"crossref","first-page":"E805","DOI":"10.1152\/ajpendo.00013.2015","article-title":"Preconception diet or exercise intervention in obese fathers normalizes sperm microRNA profile and metabolic syndrome in female offspring","volume":"308","author":"McPherson","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"12","key":"10.1016\/j.lfs.2020.118583_bb0125","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1590\/S0100-879X2003001200018","article-title":"Duration-controlled swimming exercise training induces cardiac hypertrophy in mice","volume":"36","author":"Evangelista","year":"2003","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"4","key":"10.1016\/j.lfs.2020.118583_bb0130","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1096\/fj.13-244046","article-title":"Paternal high-fat diet consumption induces common changes in the transcriptomes of retroperitoneal adipose and pancreatic islet tissues in female rat offspring","volume":"28","author":"Ng","year":"2014","journal-title":"FASEB J."},{"issue":"5","key":"10.1016\/j.lfs.2020.118583_bb0135","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1073\/pnas.1321195111","article-title":"Paternally induced transgenerational inheritance of susceptibility to diabetes in mammals","volume":"111","author":"Wei","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.lfs.2020.118583_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/nu8090521","article-title":"Paternal high fat diet in rats leads to renal accumulation of lipid and tubular changes in adult offspring","volume":"8","author":"Chowdhury","year":"2016","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.lfs.2020.118583_bb0145","doi-asserted-by":"crossref","first-page":"E117","DOI":"10.1152\/ajpendo.00262.2016","article-title":"Effects of paternal obesity on growth and adiposity of male rat offspring","volume":"312","author":"Lecomte","year":"2017","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.lfs.2020.118583_bb0150","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1530\/JOE-17-0082","article-title":"Paternal hyperglycemia in rats exacerbates the development of obesity in offspring","volume":"234","author":"Shi","year":"2017","journal-title":"J. Endocrinol."},{"issue":"9","key":"10.1016\/j.lfs.2020.118583_bb0155","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/s42255-020-00274-7","article-title":"Effects of maternal and paternal exercise on offspring metabolism","volume":"2","author":"Kusuyama","year":"2020","journal-title":"Nat Metab"},{"issue":"8","key":"10.1016\/j.lfs.2020.118583_bb0160","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.2337\/db17-0098","article-title":"Maternal exercise improves glucose tolerance in female offspring","volume":"66","author":"Stanford","year":"2017","journal-title":"Diabetes"},{"issue":"12","key":"10.1016\/j.lfs.2020.118583_bb0165","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.2337\/db18-0667","article-title":"Paternal exercise improves glucose metabolism in adult offspring","volume":"67","author":"Stanford","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.lfs.2020.118583_bb0170","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jnutbio.2018.03.013","article-title":"Paternal exercise protects mouse offspring from high-fat-diet-induced type 2 diabetes risk by increasing skeletal muscle insulin signaling","volume":"57","author":"Krout","year":"2018","journal-title":"J. Nutr. Biochem."},{"issue":"11","key":"10.1016\/j.lfs.2020.118583_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/cells8111464","article-title":"Sex differences in high fat diet-induced metabolic alterations correlate with changes in the modulation of GRK2 levels","volume":"8","author":"Arcones","year":"2019","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.lfs.2020.118583_bb0180","first-page":"6","article-title":"r\u00e9gulateur de l\u2019\u00e9nergie et des fonctions des spermatozo\u00efdes","volume":"32","author":"Nguyen TMDF","year":"2016","journal-title":"M\u00e9decine\/Sciences"},{"key":"10.1016\/j.lfs.2020.118583_bb0185","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fcell.2017.00025","article-title":"Impact of 5\u2032-amp-activated protein kinase on male gonad and spermatozoa functions","volume":"5","author":"Nguyen","year":"2017","journal-title":"Front Cell Dev Biol"},{"issue":"1\u20132","key":"10.1016\/j.lfs.2020.118583_bb0190","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.mce.2010.08.007","article-title":"Adenosine regulates Sertoli cell function by activating AMPK","volume":"330","author":"Galardo","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.lfs.2020.118583_bb0195","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3389\/fnins.2015.00235","article-title":"AMPK: a master energy regulator for gonadal function","volume":"9","author":"Bertoldo","year":"2015","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.lfs.2020.118583_bb0200","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1038\/s41467-018-05721-4","article-title":"Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation","volume":"9","author":"Lee","year":"2018","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.lfs.2020.118583_bb0205","doi-asserted-by":"crossref","first-page":"E730","DOI":"10.1152\/ajpendo.00225.2016","article-title":"Treatment of nonalcoholic fatty liver disease: role of AMPK","volume":"311","author":"Smith","year":"2016","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"10","key":"10.1016\/j.lfs.2020.118583_bb0210","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.2337\/diacare.21.10.1652","article-title":"Birth weight, adult weight, and girth as predictors of the metabolic syndrome in postmenopausal women: the Rancho Bernardo Study","volume":"21","author":"Yarbrough","year":"1998","journal-title":"Diabetes Care"},{"issue":"12","key":"10.1016\/j.lfs.2020.118583_bb0215","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1161\/01.CIR.94.12.3246","article-title":"Birth weight and adult hypertension, diabetes mellitus, and obesity in US men","volume":"94","author":"Curhan","year":"1996","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.lfs.2020.118583_bb0220","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nmeth.1806","article-title":"A guide to analysis of mouse energy metabolism","volume":"9","author":"Tschop","year":"2011","journal-title":"Nat. Methods"},{"issue":"3","key":"10.1016\/j.lfs.2020.118583_bb0225","doi-asserted-by":"crossref","first-page":"554","DOI":"10.2337\/db09-0482","article-title":"AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol","volume":"59","author":"Um","year":"2010","journal-title":"Diabetes"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520313369?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520313369?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:14:43Z","timestamp":1718410483000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320520313369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":45,"alternative-id":["S0024320520313369"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118583","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Paternal exercise protects against liver steatosis in the male offspring of mice submitted to high fat diet","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118583","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118583"}}