{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:18:32Z","timestamp":1785449912125,"version":"3.56.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013335","name":"National Key Basic Research Program For Youth","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013335","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.lfs.2020.118606","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T01:44:05Z","timestamp":1603071845000},"page":"118606","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Disrupted eNOS activity and expression account for vasodilator dysfunction in different stage of sepsis"],"prefix":"10.1016","volume":"264","author":[{"given":"Shupeng","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiangzhong","family":"Pi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiudan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzheng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanying","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suxin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2020.118606_bb0005","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ebiom.2019.03.034","article-title":"Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in Sepsis","volume":"42","author":"Heun","year":"2019","journal-title":"EBioMedicine."},{"key":"10.1016\/j.lfs.2020.118606_bb0010","first-page":"1118","article-title":"Arteriolar endothelium-dependent vasodilation occurs during endotoxin shock","volume":"264","author":"Baker","year":"1993","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.lfs.2020.118606_bb0015","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1152\/jappl.1996.80.1.271","article-title":"Inducible nitric oxide synthase and vascular reactivity in rat thoracic aorta: effect of aminoguanidine","volume":"80","author":"Scott","year":"1996","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.lfs.2020.118606_bb0020","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/SHK.0b013e3182903f0d","article-title":"Biomarkers of endothelial cell activation in early sepsis","volume":"39","author":"Skibsted","year":"2013","journal-title":"Shock"},{"key":"10.1016\/j.lfs.2020.118606_bb0025","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13613-019-0577-9","article-title":"Recruiting the microcirculation in septic shock","volume":"9","author":"Legrand","year":"2019","journal-title":"Ann. Intensive Care"},{"key":"10.1016\/j.lfs.2020.118606_bb0030","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1056\/NEJMoa1401602","article-title":"A randomized trial of protocol-based care for early septic shock","volume":"370","author":"ProCESS Investigators","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2020.118606_bb0035","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1089\/sur.2017.278","article-title":"Sepsis 2018: definitions and guideline changes","volume":"19","author":"Napolitano","year":"2018","journal-title":"Surg. Infect."},{"key":"10.1016\/j.lfs.2020.118606_bb0040","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/ijcp.12382","article-title":"Anti-TNF-alpha therapy for patients with sepsis: a systematic meta-analysis","volume":"68","author":"Lv","year":"2014","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.lfs.2020.118606_bb0045","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1600-0463.2010.02705.x","article-title":"Multiplex cytokine profiling in patients with sepsis","volume":"119","author":"Mera","year":"2011","journal-title":"APMIS"},{"key":"10.1016\/j.lfs.2020.118606_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172446","article-title":"Protective effect of minocycline on LPS-induced mitochondrial dysfunction and decreased seizure threshold through nitric oxide pathway","volume":"858","author":"Haj-Mirzaian","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2020.118606_bb0055","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00011-013-0683-3","article-title":"Determination of the safety and efficacy of therapeutic neutralization of tumor necrosis factor-alpha (TNF-alpha) using AZD9773, an anti-TNF-alpha immune Fab, in murine CLP sepsis","volume":"63","author":"Newham","year":"2014","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.lfs.2020.118606_bb0060","doi-asserted-by":"crossref","first-page":"494","DOI":"10.4103\/0377-4929.68290","article-title":"Serum tumor necrosis factor alpha and C-reactive protein in pediatric patients with sepsis and its correlation with microbiologic findings","volume":"53","author":"Surinder","year":"2010","journal-title":"Indian J. Pathol. Microbiol."},{"key":"10.1016\/j.lfs.2020.118606_bb0065","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0140-6736(87)91728-4","article-title":"Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease","volume":"329","author":"Waage","year":"1987","journal-title":"Lancet"},{"key":"10.1016\/j.lfs.2020.118606_bb0070","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.etp.2010.11.011","article-title":"Protective effect of Ulinastatin against murine models of sepsis: inhibition of TNF-\u03b1 and IL-6 and augmentation of IL-10 and IL-13","volume":"64","author":"Cao","year":"2012","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.lfs.2020.118606_bb0075","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1001\/jama.1993.03500140081040","article-title":"Anticytokine strategies in the treatment of the systemic inflammatory response syndrome","volume":"269","author":"Dinarello","year":"1993","journal-title":"JAMA"},{"key":"10.1016\/j.lfs.2020.118606_bb0080","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1055\/s-2007-995821","article-title":"Derangements of coagulation and fibrinolysis in critically ill patients with sepsis and septic shock","volume":"24","author":"Vervloet","year":"1998","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.lfs.2020.118606_bb0085","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1056\/NEJM198905043201802","article-title":"Promotion and subsequent inhibition of plasminogen activation after administration of intravenous endotoxin to normal subjects","volume":"320","author":"Suffredini","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2020.118606_bb0090","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.niox.2019.04.011","article-title":"Targeting nitric oxide as a key modulator of sepsis, arthritis and pain","volume":"89","author":"Spiller","year":"2019","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.lfs.2020.118606_bb0095","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1007\/s00018-015-2021-0","article-title":"Endothelial nitric oxide synthase in the microcirculation","volume":"72","author":"Shu","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.lfs.2020.118606_bb0100","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/bj3570593","article-title":"Nitric oxide synthases: structure, function and inhibition","volume":"357","author":"Alderton","year":"2001","journal-title":"Biochem. J."},{"key":"10.1016\/j.lfs.2020.118606_bb0105","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1540\/jsmr.43.117","article-title":"Vascular biology in sepsis: pathophysiological and therapeutic significance of vascular dysfunction","volume":"43","author":"Matsuda","year":"2007","journal-title":"J. Smooth Muscle Res."},{"key":"10.1016\/j.lfs.2020.118606_bb0110","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1373\/jalm.2018.026377","article-title":"Inducible nitric oxide synthase in circulating microvesicles: discovery, evolution, and evidence as a novel biomarker and the probable causative agent for sepsis","volume":"3","author":"Webber","year":"2019","journal-title":"J. Appl. Lab. Med."},{"key":"10.1016\/j.lfs.2020.118606_bb0115","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/S0022-3565(24)29198-9","article-title":"Post-translational control of endothelial nitric oxide synthase: why isn\u2019t calcium\/calmodulin enough?","volume":"299","author":"Fulton","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2020.118606_bb0120","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.yjmcc.2006.05.023","article-title":"Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation","volume":"42","author":"Mount","year":"2007","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.lfs.2020.118606_bb0125","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1161\/hh1101.092677","article-title":"Phosphorylation of Thr(495) regulates Ca(2+)\/calmodulin-dependent endothelial nitric oxide synthase activity","volume":"88","author":"Fleming","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2020.118606_bb0130","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1161\/CIRCRESAHA.108.187567","article-title":"AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633","volume":"104","author":"Chen","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2020.118606_bb0135","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1161\/01.RES.73.1.205","article-title":"Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life","volume":"73","author":"Yoshizumi","year":"1993","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2020.118606_bb0140","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1161\/CIRCRESAHA.108.173963","article-title":"Tumor necrosis factor-alpha downregulates endothelial nitric oxide synthase mRNA stability via translation elongation factor 1-alpha 1","volume":"103","author":"Yan","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2020.118606_bb0145","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.freeradbiomed.2017.01.010","article-title":"Aspirin prevents TNF-\u03b1-induced endothelial cell dysfunction by regulating the NF-\u03baB-dependent miR-155\/eNOS pathway: role of a miR-155\/eNOS axis in preeclampsia","volume":"104","author":"Kim","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.lfs.2020.118606_bb0150","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nprot.2008.214","article-title":"Immunodesign of experimental sepsis by cecal ligation and puncture","volume":"4","author":"Rittirsch","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.lfs.2020.118606_bb0155","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1373\/clinchem.2004.037531","article-title":"Genetic predisposition of the interleukin-6 response to inflammation: implications for a variety of major diseases?","volume":"50","author":"Bennermo","year":"2004","journal-title":"Clin. Chem."},{"issue":"7","key":"10.1016\/j.lfs.2020.118606_bb0160","doi-asserted-by":"crossref","first-page":"e99823","DOI":"10.1371\/journal.pone.0099823","article-title":"PKC-dependent phosphorylation of eNOS at T495 regulates eNOS coupling and endothelial barrier function in response to G+ \u2212toxins","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.lfs.2020.118606_bb0165","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/cvr\/cvm100","article-title":"Disruption of phospholipase Cgamma1 signalling attenuates cardiac tumor necrosis factor-alpha expression and improves myocardial function during endotoxemia","volume":"78","author":"Tianqing","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2020.118606_bb0170","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1097\/00005344-199424050-00014","article-title":"Alterations of ex vivo vascular reactivity in intraperitoneal sepsis","volume":"24","author":"Chen","year":"1994","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.lfs.2020.118606_bb0175","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/FJC.0b013e3181bfafd6","article-title":"Atorvastatin restores the impaired vascular endothelium-dependent relaxations mediated by nitric oxide and endothelium-derived hyperpolarizing factors but not hypotension in sepsis","volume":"54","author":"Subramani","year":"2009","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.lfs.2020.118606_bb0180","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nprot.2008.214","article-title":"Immunodesign of experimental sepsis by cecal ligation and puncture","volume":"4","author":"Rittirsch","year":"2009","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.lfs.2020.118606_bb0185","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.niox.2012.04.005","article-title":"Augmented nitric oxide production and up-regulation of endothelial nitric oxide synthase during cecal ligation and perforation","volume":"27","author":"Ara\u00fajo","year":"2012","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.lfs.2020.118606_bb0190","doi-asserted-by":"crossref","first-page":"F1045","DOI":"10.1152\/ajprenal.00148.2011","article-title":"Erythropoietin prevents sepsis-related acute kidney injury in rats by inhibiting NF-\u03baB and upregulating endothelial nitric oxide synthase","volume":"302","author":"Souza","year":"2012","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.lfs.2020.118606_bb0195","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1164\/rccm.2011144","article-title":"Functional inhibition of constitutive nitric oxide synthase in a rat model of sepsis","volume":"165","author":"Scott","year":"2002","journal-title":"Am. J. Resp. Crit. Care Med."},{"key":"10.1016\/j.lfs.2020.118606_bb0200","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0898-6568(03)00054-8","article-title":"Lipopolysaccharide signal transduction in oral keratinocytes\u2014involvement of CD59 but not CD14","volume":"15","author":"Yamamoto","year":"2003","journal-title":"Cell. Signal."},{"key":"10.1016\/j.lfs.2020.118606_bb0205","first-page":"100","article-title":"Serum tumor necrosis factor levels in patients with infectious disease and septic shock","volume":"116","author":"Offner","year":"1990","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.lfs.2020.118606_bb0210","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1097\/CCM.0b013e3182982add","article-title":"Antitumor necrosis factor therapy is associated with improved survival in clinical sepsis trials: a meta-analysis","volume":"41","author":"Ping","year":"2013","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.lfs.2020.118606_bb0215","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1001\/jama.1995.03520360048038","article-title":"Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial","volume":"273","author":"Abraham","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.lfs.2020.118606_bb0220","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1001\/jama.1997.03540430043031","article-title":"p55 tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock. A randomized controlled multicenter trial. Ro 45-2081 Study Group","volume":"277","author":"Abraham","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.lfs.2020.118606_bb0225","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0140-6736(05)60602-2","article-title":"Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock","volume":"351","author":"Abraham","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.lfs.2020.118606_bb0230","first-page":"1608","article-title":"Tumor necrosis factor receptor: Fc fusion protein in septic shock","volume":"335","author":"Whiteley","year":"1996","journal-title":"New Eng. J. Med."},{"key":"10.1016\/j.lfs.2020.118606_bb0235","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1097\/CCM.0000000000000064","article-title":"Tumor necrosis factor inhibition in severe sepsis: a promise not fulfilled","volume":"42","author":"Tom","year":"2014","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.lfs.2020.118606_bb0240","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1097\/01.CCM.0000145229.59014.6C","article-title":"Monoclonal anti-TNF: a Randomized Controlled Sepsis Study Investigators. Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab\u2019)2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels","volume":"32","author":"Panacek","year":"2004","journal-title":"Crit. Care Med."},{"issue":"1","key":"10.1016\/j.lfs.2020.118606_bb0245","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.kint.2016.07.032","article-title":"Renal perfusion in sepsis: from macro- to microcirculation","volume":"91","author":"Post","year":"2017","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.lfs.2020.118606_bb0250","doi-asserted-by":"crossref","DOI":"10.1111\/micc.12483","article-title":"Sepsis-induced acute kidney injury: a disease of the microcirculation","volume":"26","author":"Ma","year":"2019","journal-title":"Microcirculation"},{"issue":"2","key":"10.1016\/j.lfs.2020.118606_bb0255","first-page":"131","article-title":"Recent advances in pathophysiology and biomarkers of sepsis-induced acute kidney injury","volume":"72","author":"Umbro","year":"2016","journal-title":"J. Inf. Secur."},{"issue":"3","key":"10.1016\/j.lfs.2020.118606_bb0260","doi-asserted-by":"crossref","first-page":"F583","DOI":"10.1152\/ajprenal.00270.2001","article-title":"Protective effect of renal denervation on normotensive endotoxemia-induced acute renal failure in mice","volume":"283","author":"Wang","year":"2002","journal-title":"Am. J. Physiol. Renal. Physiol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002432052031359X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002432052031359X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T23:15:08Z","timestamp":1762211708000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002432052031359X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":52,"alternative-id":["S002432052031359X"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118606","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disrupted eNOS activity and expression account for vasodilator dysfunction in different stage of sepsis","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118606","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"118606"}}