{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T21:32:51Z","timestamp":1767648771530,"version":"3.43.0"},"reference-count":96,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["3\/2\/3\/12\/2019\/NCDIII"],"award-info":[{"award-number":["3\/2\/3\/12\/2019\/NCDIII"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.lfs.2020.118676","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T12:55:13Z","timestamp":1603889713000},"page":"118676","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Is highly expressed ACE 2 in pregnant women \u201ca curse\u201d in times of COVID-19 pandemic?"],"prefix":"10.1016","volume":"264","author":[{"given":"Ankit","family":"Dhaundiyal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puja","family":"Kumari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Snehal Sainath","family":"Jawalekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaurav","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sourav","family":"Kalra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umashanker","family":"Navik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2020.118676_bb0005","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1139\/y02-021","article-title":"ACEH\/ACE2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors","volume":"80","author":"Turner","year":"2002","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.lfs.2020.118676_bb0010","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1007\/s00018-004-4240-7","article-title":"Angiotensin-converting enzyme-2: a molecular and cellular perspective","volume":"61","author":"Warner","year":"2004","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.lfs.2020.118676_bb0015","doi-asserted-by":"crossref","first-page":"14838","DOI":"10.1074\/jbc.M200581200","article-title":"Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase","volume":"277","author":"Vickers","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2020.118676_bb0020","doi-asserted-by":"crossref","first-page":"F970","DOI":"10.1152\/ajprenal.00403.2013","article-title":"Of diabetic mice and ACE2: a new biomarker of renal disease?","volume":"305","author":"Chappell","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.lfs.2020.118676_bb0025","doi-asserted-by":"crossref","first-page":"8258","DOI":"10.1073\/pnas.1432869100","article-title":"Angiotensin-(1\u20137) is an endogenous ligand for the G protein-coupled receptor mas","volume":"100","author":"Santos","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2020.118676_bb0030","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.bcp.2014.11.013","article-title":"Tissue specific up regulation of ACE2 in rabbit model of atherosclerosis by atorvastatin: role of epigenetic histone modifications","volume":"93","author":"Tikoo","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.lfs.2020.118676_bb0035","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/nature00786","article-title":"Angiotensin-converting enzyme 2 is an essential regulator of heart function","volume":"417","author":"Crackower","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2020.118676_bb0040","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1161\/01.HYP.0000185148.27901.fe","article-title":"Angiotensin-converting enzyme 2 (ACE2) and ACE activities display tissue-specific sensitivity to undernutrition-programmed hypertension in the adult rat","volume":"46","author":"Riviere","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.lfs.2020.118676_bb0045","doi-asserted-by":"crossref","first-page":"481","DOI":"10.21037\/atm.2020.03.61","article-title":"A profiling analysis on the receptor ACE2 expression reveals the potential risk of different type of cancers vulnerable to SARS-CoV-2 infection","volume":"8","author":"Dai","year":"2020","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.lfs.2020.118676_bb0050","first-page":"1","article-title":"Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection","author":"Zou","year":"2020","journal-title":"Front Med."},{"key":"10.1016\/j.lfs.2020.118676_bb0055","doi-asserted-by":"crossref","first-page":"R1953","DOI":"10.1152\/ajpregu.90592.2008","article-title":"ACE2 expression and activity are enhanced during pregnancy","volume":"295","author":"Levy","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol."},{"key":"10.1016\/j.lfs.2020.118676_bb0060","doi-asserted-by":"crossref","first-page":"e0230295","DOI":"10.1371\/journal.pone.0230295","article-title":"The SARS-CoV-2 receptor ACE2 expression of maternal-fetal interface and fetal organs by single-cell transcriptome study","volume":"15","author":"Li","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2020.118676_bb0065","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1161\/HYPERTENSIONAHA.111.179358","article-title":"Angiotensin-converting enzyme 2 deficiency is associated with impaired gestational weight gain and fetal growth restriction","volume":"58","author":"Bharadwaj","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.lfs.2020.118676_bb0070","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1159\/000494449","article-title":"Fetal but not maternal angiotensin converting enzyme (ACE)-2 gene Rs2074192 polymorphism is associated with increased risk of being a small for gestational age (SGA) newborn","volume":"43","author":"He","year":"2018","journal-title":"Kidney Blood Press Res"},{"key":"10.1016\/j.lfs.2020.118676_bb0075","doi-asserted-by":"crossref","first-page":"110259","DOI":"10.1016\/j.mehy.2020.110259","article-title":"Potential of electric stimulation for the management of COVID-19","volume":"144","author":"Allawadhi","year":"2020","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.lfs.2020.118676_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-2438-7_1","article-title":"Coronaviruses: an overview of their replication and pathogenesis","volume":"1282","author":"Fehr","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.lfs.2020.118676_bb0085","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/nm1267","article-title":"A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury","volume":"11","author":"Kuba","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.lfs.2020.118676_bb0090","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A pneumonia outbreak associated with a new coronavirus of probable bat origin","volume":"579","author":"Zhou","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2020.118676_bb0095","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1016\/S2213-2600(20)30116-8","article-title":"Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?","volume":"8","author":"Fang","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.lfs.2020.118676_bb0100","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41569-020-0368-x","article-title":"Interaction between RAAS inhibitors and ACE2 in the context of COVID-19","volume":"17","author":"Mourad","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.lfs.2020.118676_bb0105","article-title":"Multi-organ failure in COVID-19 patients: a possible mechanistic approach","author":"Navik","year":"2020","journal-title":"Authorea Preprints"},{"key":"10.1016\/j.lfs.2020.118676_bb0110","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.devcel.2019.03.001","article-title":"The pediatric cell atlas: defining the growth phase of human development at single-cell resolution","volume":"49","author":"Taylor","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.lfs.2020.118676_bb0115","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1385\/ENDO:18:3:239","article-title":"Angiotensin-(1-7) in normal and preeclamptic pregnancy","volume":"18","author":"Merrill","year":"2002","journal-title":"Endocrine."},{"key":"10.1016\/j.lfs.2020.118676_bb0120","doi-asserted-by":"crossref","first-page":"F614","DOI":"10.1152\/ajprenal.00410.2003","article-title":"Role of the renin-angiotensin system in the pathogenesis of preeclampsia","volume":"288","author":"Shah","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.lfs.2020.118676_bb0125","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1007\/s00044-012-0348-8","article-title":"Modeling of antitubercular activity of biphenyl analogs of 2-nitroimidazo [2, 1-b][1,3] oxazine to rationalize their activity profile","volume":"22","author":"Kalra","year":"2013","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.lfs.2020.118676_bb0130","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.2337\/db12-0792","article-title":"Angiotensin 1-7 as means to prevent the metabolic syndrome: lessons from the fructose-fed rat model","volume":"62","author":"Marcus","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.lfs.2020.118676_bb0135","doi-asserted-by":"crossref","first-page":"R151","DOI":"10.1152\/ajpregu.00514.2007","article-title":"ACE2 and ANG-(1-7) in the rat uterus during early and late gestation","volume":"294","author":"Neves","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.lfs.2020.118676_bb0140","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1161\/HYPERTENSIONAHA.116.07088","article-title":"Angiotensin 1-7 is a negative modulator of aldosterone secretion in vitro and in vivo","volume":"68","author":"Shefer","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.lfs.2020.118676_bb0145","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/pr.2011.7","article-title":"Ontogeny of angiotensin-converting enzyme 2","volume":"71","author":"Song","year":"2012","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.lfs.2020.118676_bb0150","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1161\/01.HYP.0000205833.89478.5b","article-title":"Deletion of angiotensin-converting enzyme 2 accelerates pressure overload-induced cardiac dysfunction by increasing local angiotensin II","volume":"47","author":"Yamamoto","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.lfs.2020.118676_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcv.2020.104372","article-title":"SARS-CoV-2: is it the newest spark in the TORCH?","volume":"127","author":"Muldoon","year":"2020","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.lfs.2020.118676_bb0160","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1046\/j.1471-0528.2003.03008.x","article-title":"Severe acute respiratory syndrome and pregnancy","volume":"110","author":"Wong","year":"2003","journal-title":"BJOG"},{"key":"10.1016\/j.lfs.2020.118676_bb0165","doi-asserted-by":"crossref","unstructured":"Zambrano LI, Fuentes-Barahona IC, Bejarano-Torres DA, Bustillo C, Gonzales G, Vallecillo-Chinchilla G, et al. A pregnant woman with COVID-19 in Central America. Travel Med. Infect. Dis.. 2020;101639:101639.","DOI":"10.1016\/j.tmaid.2020.101639"},{"key":"10.1016\/j.lfs.2020.118676_bb0170","doi-asserted-by":"crossref","first-page":"510","DOI":"10.2174\/1389557518666181018163448","article-title":"A review on quinoline derived scaffolds as anti-hiv agents","volume":"19","author":"Chokkar","year":"2019","journal-title":"Mini Reviews in Medicinal Chemistry"},{"key":"10.1016\/j.lfs.2020.118676_bb0175","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.antiviral.2014.06.013","article-title":"Accessory proteins of SARS-CoV and other coronaviruses","volume":"109","author":"Liu","year":"2014","journal-title":"Antivir. Res."},{"key":"10.1016\/j.lfs.2020.118676_bb0180","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0065-3527(06)66005-3","article-title":"The molecular biology of coronaviruses","volume":"66","author":"Masters","year":"2006","journal-title":"Adv. Virus Res."},{"key":"10.1016\/j.lfs.2020.118676_bb0185","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.febslet.2004.09.009","article-title":"Efficient assembly and release of SARS coronavirus-like particles by a heterologous expression system","volume":"576","author":"Mortola","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.lfs.2020.118676_bb0190","doi-asserted-by":"crossref","first-page":"12686","DOI":"10.18632\/oncotarget.8475","article-title":"MERS-CoV virus-like particles produced in insect cells induce specific humoural and cellular imminity in rhesus macaques","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.lfs.2020.118676_bb0195","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0065-3527(05)64006-7","article-title":"Molecular interactions in the assembly of coronaviruses","volume":"64","author":"de Haan","year":"2005","journal-title":"Adv. Virus Res."},{"key":"10.1016\/j.lfs.2020.118676_bb0200","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jsb.2010.11.021","article-title":"A structural analysis of M protein in coronavirus assembly and morphology","volume":"174","author":"Neuman","year":"2011","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.lfs.2020.118676_bb0205","first-page":"281","article-title":"Replication of coronavirus MHV-A59 in sac-cells: determination of the first site of budding of progeny virions","volume":"33","author":"Tooze","year":"1984","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.lfs.2020.118676_bb0210","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1006\/viro.2000.0757","article-title":"Coronavirus spike proteins in viral entry and pathogenesis","volume":"279","author":"Gallagher","year":"2001","journal-title":"Virology"},{"key":"10.1016\/j.lfs.2020.118676_bb0215","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.ejmech.2017.08.071","article-title":"Structural insights of cyclin dependent kinases: implications in design of selective inhibitors","volume":"142","author":"Kalra","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.lfs.2020.118676_bb0220","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.antiviral.2013.09.028","article-title":"Proteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research","volume":"100","author":"Simmons","year":"2013","journal-title":"Antivir. Res."},{"key":"10.1016\/j.lfs.2020.118676_bb0225","doi-asserted-by":"crossref","first-page":"5871","DOI":"10.1073\/pnas.0809524106","article-title":"Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites","volume":"106","author":"Belouzard","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2020.118676_bb0230","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1073\/pnas.0306446101","article-title":"Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry","volume":"101","author":"Simmons","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2020.118676_bb0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007236","article-title":"Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2","volume":"14","author":"Song","year":"2018","journal-title":"PLoS Path"},{"key":"10.1016\/j.lfs.2020.118676_bb0240","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1080\/07391102.2017.1332688","article-title":"In silico binding mechanism prediction of benzimidazole based corticotropin releasing factor-1 receptor antagonists by quantitative structure activity relationship, molecular docking and pharmacokinetic parameters calculation","volume":"36","author":"Kumar","year":"2018","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.lfs.2020.118676_bb0245","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1126\/science.1116480","article-title":"Structure of SARS coronavirus spike receptor-binding domain complexed with receptor","volume":"309","author":"Li","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.lfs.2020.118676_bb0250","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.virusres.2014.11.021","article-title":"Host cell proteases: critical determinants of coronavirus tropism and pathogenesis","volume":"202","author":"Millet","year":"2015","journal-title":"Virus Res."},{"key":"10.1016\/j.lfs.2020.118676_bb0255","doi-asserted-by":"crossref","first-page":"11876","DOI":"10.1073\/pnas.0505577102","article-title":"Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry","volume":"102","author":"Simmons","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2020.118676_bb0260","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.2174\/1568026619666190208164801","article-title":"Quinoline-based protein\u2013protein interaction inhibitors of LEDGF\/p75 and HIV Integrase: an in Silico study","volume":"18","author":"Chhokar","year":"2018","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.lfs.2020.118676_bb0265","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1126\/science.abb2507","article-title":"Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation","volume":"367","author":"Wrapp","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.lfs.2020.118676_bb0270","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/01.RES.87.5.e1","article-title":"A novel angiotensin-converting enzyme\u2013related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9","volume":"87","author":"Donoghue","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2020.118676_bb0275","doi-asserted-by":"crossref","first-page":"17132","DOI":"10.1074\/jbc.M006723200","article-title":"Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys","volume":"276","author":"Zhang","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2020.118676_bb0280","doi-asserted-by":"crossref","first-page":"H137","DOI":"10.1152\/ajpheart.00618.2015","article-title":"Biochemical evaluation of the renin-angiotensin system: the good, bad, and absolute?","volume":"310","author":"Chappell","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.lfs.2020.118676_bb0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/path.2162","article-title":"The emerging role of ACE2 in physiology and disease","volume":"212","author":"Hamming","year":"2007","journal-title":"J. Pathol."},{"key":"10.1016\/j.lfs.2020.118676_bb0290","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.canep.2010.11.003","article-title":"Population attributable risk of invasive postmenopausal breast cancer and breast cancer subtypes for modifiable and non-modifiable risk factors","volume":"35","author":"Barnes","year":"2011","journal-title":"Cancer Epidemol"},{"key":"10.1016\/j.lfs.2020.118676_bb0295","doi-asserted-by":"crossref","first-page":"100982","DOI":"10.1016\/j.nantod.2020.100982","article-title":"Nanoceria as a possible agent for the management of COVID-19","volume":"35","author":"Allawadhi","year":"2020","journal-title":"Nano Today"},{"key":"10.1016\/j.lfs.2020.118676_bb0300","doi-asserted-by":"crossref","first-page":"7760","DOI":"10.1021\/acsnano.0c04006","article-title":"Nanotechnology for COVID-19: therapeutics and vaccine research","volume":"14","author":"Chauhan","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.lfs.2020.118676_bb0305","first-page":"1","article-title":"Computational investigation of potential inhibitors of novel coronavirus 2019 through structure-based virtual screening, molecular dynamics and density functional theory studies","author":"Mishra","year":"2020","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.lfs.2020.118676_bb0310","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.pharmthera.2013.08.005","article-title":"Mechanisms of aspirin resistance","volume":"141","author":"Floyd","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.lfs.2020.118676_bb0315","doi-asserted-by":"crossref","first-page":"108142","DOI":"10.1016\/j.diabres.2020.108142","article-title":"COVID-19 and diabetes: knowledge in progress","volume":"162","author":"Hussain","year":"2020","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.lfs.2020.118676_bb0320","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/jmv.25722","article-title":"Understanding of COVID-19 based on current evidence","volume":"92","author":"Sun","year":"2020","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.lfs.2020.118676_bb0325","first-page":"e7386","article-title":"Brief review on COVID-19: the 2020 pandemic caused by SARS-CoV-2","volume":"12","author":"Valencia","year":"2020","journal-title":"Cureus"},{"key":"10.1016\/j.lfs.2020.118676_bb0330","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(20)30211-7","article-title":"Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study","volume":"395","author":"Chen","year":"2020","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.lfs.2020.118676_bb0335","first-page":"34","article-title":"Coronavirus COV-19\/SARS-CoV-2 affects women less than men: clinical response to viral infection","author":"Conti","year":"2020","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"10.1016\/j.lfs.2020.118676_bb0340","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1093\/cid\/ciaa329","article-title":"Is there an association between COVID-19 mortality and the renin-angiotensin system-a call for epidemiologic investigations","volume":"71","author":"Hanff","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.lfs.2020.118676_bb0345","doi-asserted-by":"crossref","first-page":"104326","DOI":"10.1016\/j.bioorg.2020.104326","article-title":"A perspective on potential target proteins of COVID-19: comparison with SARS-CoV for designing new small molecules","author":"Kumar","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.lfs.2020.118676_bb0350","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.molonc.2012.02.004","article-title":"Discovery of small molecule cancer drugs: successes, challenges and opportunities","volume":"6","author":"Hoelder","year":"2012","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.lfs.2020.118676_bb0355","doi-asserted-by":"crossref","first-page":"II","DOI":"10.1634\/theoncologist.1-3-120i","article-title":"Cancer drug development: new targets for Cancer treatment","volume":"1","author":"Curt","year":"1996","journal-title":"Oncologist"},{"key":"10.1016\/j.lfs.2020.118676_bb0360","first-page":"5","article-title":"Cancer statistics, 2015","volume":"65","author":"Siegel","year":"2015","journal-title":"CA Cancer J. Clin."},{"year":"2015","series-title":"How are Income and Wealth Linked to Health and Longevity?","author":"Woolf","key":"10.1016\/j.lfs.2020.118676_bb0365"},{"key":"10.1016\/j.lfs.2020.118676_bb0370","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.placenta.2011.09.020","article-title":"The expression and localization of the human placental prorenin\/renin-angiotensin system throughout pregnancy: roles in trophoblast invasion and angiogenesis?","volume":"32","author":"Pringle","year":"2011","journal-title":"Placenta"},{"key":"10.1016\/j.lfs.2020.118676_bb0375","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.placenta.2005.02.015","article-title":"Distribution of angiotensin-(1-7) and ACE2 in human placentas of normal and pathological pregnancies","volume":"27","author":"Vald\u00e9s","year":"2006","journal-title":"Placenta"},{"key":"10.1016\/j.lfs.2020.118676_bb0380","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1590\/S0100-879X2004000800017","article-title":"Enhanced expression of Ang-(1-7) during pregnancy","volume":"37","author":"Brosnihan","year":"2004","journal-title":"Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas"},{"key":"10.1016\/j.lfs.2020.118676_bb0385","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0140-6736(20)30360-3","article-title":"Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records","volume":"395","author":"Chen","year":"2020","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.lfs.2020.118676_bb0390","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1093\/cid\/ciaa200","article-title":"A case of 2019 novel coronavirus in a pregnant woman with preterm delivery","volume":"71","author":"Wang","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.lfs.2020.118676_bb0395","first-page":"1","article-title":"Pregnancy and perinatal outcomes of women with coronavirus disease (COVID-19) pneumonia: a preliminary analysis","author":"Liu","year":"2020","journal-title":"Am. J. Roentgenol."},{"key":"10.1016\/j.lfs.2020.118676_bb0400","doi-asserted-by":"crossref","first-page":"799","DOI":"10.5858\/arpa.2020-0901-SA","article-title":"An analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: maternal coronavirus infections and pregnancy outcomes","volume":"144","author":"Schwartz","year":"2020","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.lfs.2020.118676_bb0405","article-title":"Perinatal transmission of COVID-19 associated SARS-CoV-2: should we worry?","author":"Fan","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.lfs.2020.118676_bb0410","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1093\/cid\/ciaa225","article-title":"A case report of neonatal COVID-19 infection in China","volume":"71","author":"Wang","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.lfs.2020.118676_bb0415","doi-asserted-by":"crossref","first-page":"51","DOI":"10.21037\/tp.2020.02.06","article-title":"Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia","volume":"9","author":"Zhu","year":"2020","journal-title":"Transl Pediatr"},{"key":"10.1016\/j.lfs.2020.118676_bb0420","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/j.1471-0528.2004.00199.x","article-title":"A case-controlled study comparing clinical course and outcomes of pregnant and non-pregnant women with severe acute respiratory syndrome","volume":"111","author":"Lam","year":"2004","journal-title":"BJOG"},{"key":"10.1016\/j.lfs.2020.118676_bb0425","first-page":"1848","article-title":"Antibodies in infants born to mothers with COVID-19 pneumonia","volume":"323","author":"Zeng","year":"2020","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.lfs.2020.118676_bb0430","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S1473-3099(20)30176-6","article-title":"Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-Centre, descriptive study","volume":"20","author":"Yu","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.lfs.2020.118676_bb0435","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1001\/jamapediatrics.2020.0878","article-title":"Neonatal early-onset infection with SARS-CoV-2 in 33 neonates born to mothers with COVID-19 in Wuhan, China","volume":"174","author":"Zeng","year":"2020","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.lfs.2020.118676_bb0440","first-page":"1846","article-title":"Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn","volume":"323","author":"Dong","year":"2020","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.lfs.2020.118676_bb0445","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1056\/NEJMra1213566","article-title":"Pregnancy and infection","volume":"370","author":"Kourtis","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2020.118676_bb0450","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1530\/REP-10-0360","article-title":"A balancing act: mechanisms by which the fetus avoids rejection by the maternal immune system","volume":"141","author":"Warning","year":"2011","journal-title":"Reproduction (Cambridge, England)"},{"key":"10.1016\/j.lfs.2020.118676_bb0455","doi-asserted-by":"crossref","DOI":"10.1093\/cid\/ciaa352","article-title":"Maternal and neonatal outcomes of pregnant women with coronavirus disease 2019 (COVID-19) pneumonia: a case-control study","author":"Li","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.lfs.2020.118676_bb0460","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fped.2020.00104","article-title":"Infants born to mothers with a new coronavirus (COVID-19)","volume":"8","author":"Chen","year":"2020","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.lfs.2020.118676_bb0465","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.ajog.2020.03.021","article-title":"Coronavirus disease 2019 (COVID-19) pandemic and pregnancy","volume":"222","author":"Dashraath","year":"2020","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.lfs.2020.118676_bb0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102951","article-title":"SARS-CoV2 vertical transmission with adverse effects on the newborn revealed through integrated immunohistochemical, electron microscopy and molecular analyses of placenta","volume":"59","author":"Facchetti","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.lfs.2020.118676_bb0475","article-title":"Confirming vertical fetal infection with COVID-19: neonatal and pathology criteria for early onset and transplacental transmission of SARS-CoV-2 from infected pregnant mothers","author":"Schwartz","year":"2020","journal-title":"Archives of pathology & laboratory medicine"},{"key":"10.1016\/j.lfs.2020.118676_bb0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102983","article-title":"Characterizing COVID-19 maternal-fetal transmission and placental infection using comprehensive molecular pathology","volume":"60","author":"Schwartz","year":"2020","journal-title":"EBioMedicine"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520314296?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520314296?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T07:32:19Z","timestamp":1754465539000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320520314296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":96,"alternative-id":["S0024320520314296"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118676","relation":{},"ISSN":["0024-3205"],"issn-type":[{"type":"print","value":"0024-3205"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is highly expressed ACE 2 in pregnant women \u201ca curse\u201d in times of COVID-19 pandemic?","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118676","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"118676"}}