{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:08:27Z","timestamp":1786993707102,"version":"build-2736575974"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603520"],"award-info":[{"award-number":["81603520"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030313658"],"award-info":[{"award-number":["2017A030313658"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.lfs.2020.118686","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T12:21:38Z","timestamp":1603887698000},"page":"118686","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["ATF4 promotes renal tubulointerstitial fibrosis by suppressing autophagy in diabetic nephropathy"],"prefix":"10.1016","volume":"264","author":[{"given":"Qiuer","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wencong","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liguo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2020.118686_bb0005","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.disamonth.2015.07.002","article-title":"Diabetes and chronic kidney disease","volume":"61","author":"Kowalski","year":"2015","journal-title":"Dis. Mon."},{"key":"10.1016\/j.lfs.2020.118686_bb0010","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1172\/JCI72267","article-title":"Cellular and molecular mechanisms in kidney fibrosis","volume":"124","author":"Duffield","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2020.118686_bb0015","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s007950200011","article-title":"Transformation of interstitial fibroblasts and tubulointerstitial fibrosis in diabetic nephropathy","volume":"35","author":"Ina","year":"2002","journal-title":"Med Electron Microsc"},{"key":"10.1016\/j.lfs.2020.118686_bb0020","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/ncb0910-823","article-title":"Autophagy in mammalian development and differentiation","volume":"12","author":"Mizushima","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.lfs.2020.118686_bb0025","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"Mizushima","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2020.118686_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.172989","article-title":"4-Octyl itaconate protects against renal fibrosis via inhibiting TGF-\u03b2\/Smad pathway, autophagy and reducing generation of reactive oxygen species","volume":"873","author":"Tian","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2020.118686_bb0035","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.bbrc.2018.11.090","article-title":"Autophagy in FOXD1 stroma-derived cells regulates renal fibrosis through TGF-\u03b2 and NLRP3 inflammasome pathway","volume":"508","author":"Nam","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2020.118686_bb0040","first-page":"5472","article-title":"ANGPTL2 regulates autophagy through the MEK\/ERK\/Nrf-1 pathway and affects the progression of renal fibrosis in diabetic nephropathy","volume":"11","author":"Huang","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.lfs.2020.118686_bb0045","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/nrneph.2017.129","article-title":"Endoplasmic reticulum stress, the unfolded protein response and autophagy in kidney diseases","volume":"13","author":"Cybulsky","year":"2017","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.lfs.2020.118686_bb0050","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/978-981-15-0602-4_8","article-title":"Endoplasmic reticulum stress and autophagy","volume":"1206","author":"Qi","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.lfs.2020.118686_bb0055","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1038\/s41467-020-15624-y","article-title":"The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates","volume":"11","author":"Park","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2020.118686_bb0060","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1007\/s12035-014-8970-8","article-title":"ATF4: a novel potential therapeutic target for Alzheimer\u2019s disease","volume":"52","author":"Wei","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.lfs.2020.118686_bb0065","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.tem.2017.07.003","article-title":"Surviving stress: modulation of ATF4-mediated stress responses in normal and malignant cells","volume":"28","author":"Wortel","year":"2017","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2020.118686_bb0070","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1159\/000496047","article-title":"Intermittent-hypoxia-induced autophagy activation through the ER-stress-related PERK\/eIF2\u03b1\/ATF4 pathway is a protective response to pancreatic \u03b2-cell apoptosis","volume":"51","author":"Song","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.lfs.2020.118686_bb0075","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1080\/15548627.2016.1156823","article-title":"Activation of the EIF2AK4-EIF2A\/eIF2\u03b1-ATF4 pathway triggers autophagy response to Crohn disease-associated adherent-invasive Escherichia coli infection","volume":"12","author":"Bretin","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.lfs.2020.118686_bb0080","doi-asserted-by":"crossref","first-page":"553","DOI":"10.7150\/ijbs.40643","article-title":"The role of Akt2 in the protective effect of fenofibrate against diabetic nephropathy","volume":"16","author":"Cheng","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.lfs.2020.118686_bb0085","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.lfs.2019.01.044","article-title":"Telmisartan attenuates diabetic nephropathy progression by inhibiting the dimerization of angiotensin type-1 receptor and adiponectin receptor-1","volume":"221","author":"Zha","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2020.118686_bb0090","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0006-291X(02)00693-9","article-title":"Differential expression of type IV collagen isoforms in rat glomerular endothelial and mesangial cells","volume":"295","author":"Zeisberg","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.lfs.2020.118686_bb0095","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1755-1536-7-4","article-title":"The extracellular matrix in the kidney: a source of novel non-invasive biomarkers of kidney fibrosis?","volume":"7","author":"Genovese","year":"2014","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1016\/j.lfs.2020.118686_bb0100","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1093\/ndt\/gfl691","article-title":"PDGF-D inhibition by CR002 ameliorates tubulointerstitial fibrosis following experimental glomerulonephritis","volume":"22","author":"Boor","year":"2007","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.lfs.2020.118686_bb0105","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1681\/ASN.2011010055","article-title":"Suppression of microRNA-29 expression by TGF-\u03b21 promotes collagen expression and renal fibrosis","volume":"23","author":"Wang","year":"2012","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.lfs.2020.118686_bb0110","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1182\/blood.V99.3.736","article-title":"Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice","volume":"99","author":"Masuoka","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.lfs.2020.118686_bb0115","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1242\/dev.043281","article-title":"Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription","volume":"136","author":"Wang","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.lfs.2020.118686_bb0120","first-page":"10","article-title":"Autophagy function and regulation in kidney disease","author":"Kaushal","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.lfs.2020.118686_bb0125","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1080\/0886022X.2018.1489287","article-title":"The protective effects of rapamycin on cell autophagy in the renal tissues of rats with diabetic nephropathy via mTOR-S6K1-LC3II signaling pathway","volume":"40","author":"Liu","year":"2018","journal-title":"Ren. Fail."},{"key":"10.1016\/j.lfs.2020.118686_bb0130","first-page":"7","article-title":"Mesenchymal stem cell-derived exosomes ameliorated diabetic nephropathy by autophagy induction through the mTOR signaling pathway","author":"Ebrahim","year":"2018","journal-title":"Cells"},{"key":"10.1016\/j.lfs.2020.118686_bb0135","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1080\/15548627.2016.1190071","article-title":"Atg5-mediated autophagy deficiency in proximal tubules promotes cell cycle G2\/M arrest and renal fibrosis","volume":"12","author":"Li","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.lfs.2020.118686_bb0140","first-page":"3560238","article-title":"Podocyte autophagy: a potential therapeutic target to prevent the progression of diabetic nephropathy","author":"Liu","year":"2017","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.lfs.2020.118686_bb0145","first-page":"4728645","article-title":"MicroRNA-22 promotes renal tubulointerstitial fibrosis by targeting PTEN and suppressing autophagy in diabetic nephropathy","author":"Zhang","year":"2018","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.lfs.2020.118686_bb0150","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.bbrc.2018.02.187","article-title":"Notch1 regulates PTEN expression to exacerbate renal tubulointerstitial fibrosis in diabetic nephropathy by inhibiting autophagy via interactions with Hes1","volume":"497","author":"Liu","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2020.118686_bb0155","doi-asserted-by":"crossref","DOI":"10.1007\/s10571-020-00814-5","article-title":"FAM134B attenuates seizure-induced apoptosis and endoplasmic reticulum stress in hippocampal neurons by promoting autophagy","author":"Xie","year":"2020","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.lfs.2020.118686_bb0160","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1080\/15384101.2020.1718851","article-title":"Endoplasmic reticulum stress potentiates the autophagy of alveolar macrophage to attenuate acute lung injury and airway inflammation","volume":"19","author":"Qian","year":"2020","journal-title":"Cell Cycle"},{"key":"10.1016\/j.lfs.2020.118686_bb0165","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1080\/15548627.2015.1091141","article-title":"ER stress: autophagy induction, inhibition and selection","volume":"11","author":"Rashid","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.lfs.2020.118686_bb0170","doi-asserted-by":"crossref","first-page":"715","DOI":"10.3390\/jcm4040715","article-title":"Endoplasmic reticulum stress in the diabetic kidney, the good, the bad and the ugly","volume":"4","author":"Cunard","year":"2015","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.lfs.2020.118686_bb0175","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/aps.2017.30","article-title":"Chrysin ameliorates podocyte injury and slit diaphragm protein loss via inhibition of the PERK-eIF2\u03b1-ATF-CHOP pathway in diabetic mice","volume":"38","author":"Kang","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.lfs.2020.118686_bb0180","doi-asserted-by":"crossref","first-page":"F1054","DOI":"10.1152\/ajprenal.00021.2011","article-title":"The endoplasmic reticulum stress response and diabetic kidney disease","volume":"300","author":"Cunard","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.lfs.2020.118686_bb0185","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11892-017-0842-y","article-title":"The role of endoplasmic reticulum stress in diabetic nephropathy","volume":"17","author":"Fan","year":"2017","journal-title":"Curr Diab Rep"},{"key":"10.1016\/j.lfs.2020.118686_bb0190","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1007\/s00125-012-2594-1","article-title":"Activating transcription factor 4 mediates hyperglycaemia-induced endothelial inflammation and retinal vascular leakage through activation of STAT3 in a mouse model of type 1 diabetes","volume":"55","author":"Chen","year":"2012","journal-title":"Diabetologia"},{"key":"10.1016\/j.lfs.2020.118686_bb0195","doi-asserted-by":"crossref","first-page":"368","DOI":"10.18632\/oncotarget.26569","article-title":"ATF4 contributes to autophagy and survival in sunitinib treated brain tumor initiating cells (BTICs)","volume":"10","author":"Moeckel","year":"2019","journal-title":"Oncotarget"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520314399?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520314399?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T23:09:47Z","timestamp":1762211387000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320520314399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":39,"alternative-id":["S0024320520314399"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118686","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-32316\/v1","asserted-by":"object"}]},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ATF4 promotes renal tubulointerstitial fibrosis by suppressing autophagy in diabetic nephropathy","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118686","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118686"}}