{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:19:37Z","timestamp":1791361177666,"version":"4.3.1"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.lfs.2020.118731","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T21:18:44Z","timestamp":1604611124000},"page":"118731","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Liraglutide mends cognitive impairment by averting Notch signaling pathway overexpression in a rat model of polycystic ovary syndrome"],"prefix":"10.1016","volume":"265","author":[{"given":"Muhammed A.","family":"Saad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad A.","family":"Eltarzy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania M.","family":"Abdel Salam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha A.E.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"e25","key":"10.1016\/j.lfs.2020.118731_bb0005","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.fertnstert.2011.09.024","article-title":"Consensus on women\u2019s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE\/ASRM-Sponsored 3rd PCOS Consensus Workshop Group","volume":"97","author":"Fauser","year":"2012","journal-title":"Fertil Steril [Internet]"},{"key":"10.1016\/j.lfs.2020.118731_bb0010","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/humrep\/dep399","article-title":"The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria","volume":"25","author":"March","year":"2010","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.lfs.2020.118731_bb0015","first-page":"1626","article-title":"Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: a multicenter, double blind, placebo-controlled trial","volume":"86","author":"Azziz","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2020.118731_bb0020","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.1210\/jc.2003-030617","article-title":"Early endocrine, metabolic, and sonographic characteristics of polycystic ovary syndrome (PCOS): comparison between nonobese and obese adolescents","volume":"88","author":"Silfen","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2020.118731_bb0025","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1093\/molehr\/gat065","article-title":"Involvement of androgens in ovarian health and disease","volume":"19","author":"Lebbe","year":"2013","journal-title":"Mol. Hum. Reprod."},{"issue":"3","key":"10.1016\/j.lfs.2020.118731_bb0030","doi-asserted-by":"crossref","first-page":"201.e1","DOI":"10.1016\/j.ajog.2010.03.008","article-title":"The diagnosis of polycystic ovary syndrome in adolescents","volume":"203","author":"Carmina","year":"2010","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.lfs.2020.118731_bb0035","first-page":"942","article-title":"Beta-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome","volume":"81","author":"Dunaif","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2020.118731_bb0040","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1093\/humrep\/den211","article-title":"Obesity, body composition and metabolic disturbances in polycystic ovary syndrome","volume":"23","author":"Svendsen","year":"2008","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.lfs.2020.118731_bb0045","doi-asserted-by":"crossref","first-page":"E1047","DOI":"10.1152\/ajpendo.00361.2004","article-title":"Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling","volume":"288","author":"Corbould","year":"2005","journal-title":"Am J Physiol Endocrinol Metab [Internet]"},{"key":"10.1016\/j.lfs.2020.118731_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yfrne.2017.05.002","article-title":"Polycystic ovary syndrome: understanding the role of the brain","volume":"46","author":"Moore","year":"2017","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.lfs.2020.118731_bb0055","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1210\/jc.2015-2318","article-title":"White matter microstructure and cognitive function in young women with polycystic ovary syndrome","volume":"101","author":"Rees","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2020.118731_bb0060","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.yhbeh.2007.02.002","article-title":"Effects of the pharmacologic manipulation of testosterone on cognitive functioning in women with polycystic ovary syndrome: a randomized, placebo-controlled treatment study","volume":"51","author":"Schattmann","year":"2007","journal-title":"Horm. Behav."},{"issue":"e1","key":"10.1016\/j.lfs.2020.118731_bb0065","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.fertnstert.2016.01.034","article-title":"Does polycystic ovary syndrome affect cognition? A functional magnetic resonance imaging study exploring working memory","volume":"105","author":"Soleman","year":"2016","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.lfs.2020.118731_bb0070","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.psyneuen.2007.06.010","article-title":"Cognitive functioning in polycystic ovary syndrome","volume":"32","author":"Barnard","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.lfs.2020.118731_bb0075","first-page":"587","article-title":"Testosterone levels and cognitive functioning in women with polycystic ovary syndrome and in healthy young women. Horm Behav [Internet]. 2007\/03\/02","volume":"51","author":"Schattmann","year":"2007","journal-title":"United States"},{"key":"10.1016\/j.lfs.2020.118731_bb0080","doi-asserted-by":"crossref","first-page":"a011213","DOI":"10.1101\/cshperspect.a011213","article-title":"Notch signaling","volume":"4","author":"Kopan","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.lfs.2020.118731_bb0085","first-page":"770","article-title":"Notch signaling: cell fate control and signal integration in development. Science [Internet]","volume":"284","author":"Artavanis-Tsakonas","year":"1999","journal-title":"United States"},{"key":"10.1016\/j.lfs.2020.118731_bb0090","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nrg3272","article-title":"The Notch signalling system: recent insights into the complexity of a conserved pathway","volume":"13","author":"Guruharsha","year":"2012","journal-title":"Nat Rev Genet [Internet]"},{"key":"10.1016\/j.lfs.2020.118731_bb0095","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1097\/00005072-199808000-00003","article-title":"Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease","volume":"57","author":"Berezovska","year":"1998","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.lfs.2020.118731_bb0100","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1097\/00001756-200110290-00035","article-title":"Requirement of Notch in adulthood for neurological function and longevity","volume":"12","author":"Presente","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.lfs.2020.118731_bb0105","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nrm2009","article-title":"Notch signalling: a simple pathway becomes complex","volume":"7","author":"Bray","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.lfs.2020.118731_bb0110","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.arr.2013.03.004","article-title":"Notch signaling in the brain: in good and bad times","volume":"12","author":"Alberi","year":"2013","journal-title":"Ageing Res Rev [Internet]"},{"key":"10.1016\/j.lfs.2020.118731_bb0115","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.pneurobio.2006.06.004","article-title":"Molecular and systems mechanisms of memory consolidation and storage","volume":"79","author":"Wang","year":"2006","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.lfs.2020.118731_bb0120","doi-asserted-by":"crossref","first-page":"9458","DOI":"10.1073\/pnas.0308126101","article-title":"Involvement of Notch signaling in hippocampal synaptic plasticity","volume":"101","author":"Wang","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2020.118731_bb0125","doi-asserted-by":"crossref","first-page":"4458","DOI":"10.4049\/jimmunol.167.8.4458","article-title":"Notch-1 regulates NF-kappaB activity in hemopoietic progenitor cells","volume":"167","author":"Cheng","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.lfs.2020.118731_bb0130","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1073\/pnas.96.6.3263","article-title":"Evidence for a physical interaction between presenilin and Notch","volume":"96","author":"Ray","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2020.118731_bb0135","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nature01506","article-title":"The role of presenilin cofactors in the gamma-secretase complex","volume":"422","author":"Takasugi","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2020.118731_bb0140","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1146\/annurev.neuro.26.041002.131334","article-title":"Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration","volume":"26","author":"Selkoe","year":"2003","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.lfs.2020.118731_bb0145","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/44973","article-title":"Alzheimer\u2019s disease. A firm base for drug development","volume":"402","author":"De Strooper","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2020.118731_bb0150","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1101\/gad.836900","article-title":"A common enzyme connects notch signaling and Alzheimer\u2019s disease","volume":"14","author":"Kopan","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.lfs.2020.118731_bb0155","doi-asserted-by":"crossref","first-page":"10794","DOI":"10.1523\/JNEUROSCI.1348-08.2008","article-title":"Notch1 signaling in pyramidal neurons regulates synaptic connectivity and experience-dependent modifications of acuity in the visual cortex","volume":"28","author":"Dahlhaus","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2020.118731_bb0160","first-page":"1451","article-title":"Activation of the Notch pathway in Down syndrome: cross-talk of Notch and APP","volume":"19","author":"Fischer","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.lfs.2020.118731_bb0165","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.bbamcr.2011.09.014","article-title":"Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: implications for cellular A\u03b2 metabolism","volume":"1823","author":"Leal","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.lfs.2020.118731_bb0170","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13048-017-0308-5","article-title":"The role of Notch signalling in ovarian angiogenesis","volume":"10","author":"Xie","year":"2017","journal-title":"J Ovarian Res"},{"key":"10.1016\/j.lfs.2020.118731_bb0175","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1128\/MCB.25.4.1425-1436.2005","article-title":"Hey1, a mediator of notch signaling, is an androgen receptor corepressor","volume":"25","author":"Belandia","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.lfs.2020.118731_bb0180","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1124\/jpet.103.063222","article-title":"Brain uptake of the glucagon-like peptide-1 antagonist exendin(9-39) after intranasal administration","volume":"309","author":"Banks","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2020.118731_bb0185","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/jnc.12469","article-title":"Neuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to methylglyoxal stress","volume":"128","author":"Sharma","year":"2014","journal-title":"J Neurochem [Internet]"},{"issue":"2","key":"10.1016\/j.lfs.2020.118731_bb0190","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.arcmed.2003.10.005","article-title":"Letrozole-induced polycystic ovaries in the rat: a new model for cystic ovarian disease","volume":"35","author":"Kafali","year":"2004","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.lfs.2020.118731_bb0195","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s12020-019-01891-3","article-title":"Liraglutide modulates adipokine expression during adipogenesis, ameliorating obesity, and polycystic ovary syndrome in mice","volume":"64","author":"Singh","year":"2019","journal-title":"Endocrine [Internet]"},{"key":"10.1016\/j.lfs.2020.118731_bb0200","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3233\/JAD-130584","article-title":"The neuroprotection of liraglutide on alzheimer-like learning and memory impairment by modulating the hyperphosphorylation of tau and neurofilament proteins and insulin signaling pathways in mice","volume":"37","author":"Xiong","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.lfs.2020.118731_bb0205","article-title":"Effects of electro-acupuncture on ovarian P450arom, P450c17\u03b1 and mRNA expression induced by letrozole in PCOS rats. PLoS One","volume":"8","author":"Sun","year":"2013","journal-title":"Public Libr. Sci."},{"key":"10.1016\/j.lfs.2020.118731_bb0210","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","article-title":"Developments of a water-maze procedure for studying spatial learning in the rat","volume":"11","author":"Morris","year":"1984","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.lfs.2020.118731_bb0215","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejphar.2016.02.003","article-title":"Neurobehavioral effects of liraglutide and sitagliptin in experimental models","volume":"774","author":"Kamble","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2020.118731_bb0220","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0166-4328(88)90157-X","article-title":"A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data","volume":"31","author":"Ennaceur","year":"1988","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.lfs.2020.118731_bb0225","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/sj.npp.1301256","article-title":"The allosteric potentiation of nicotinic acetylcholine receptors by galantamine ameliorates the cognitive dysfunction in beta amyloid 25-35 I.c.v.-injected mice: involvement of dopaminergic systems","volume":"32","author":"Wang","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.lfs.2020.118731_bb0230","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0031-9384(02)00639-X","article-title":"Behavioral characterization of the Tg2576 transgenic model of Alzheimer\u2019s disease through 19 months","volume":"75","author":"King","year":"2002","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.lfs.2020.118731_bb0235","article-title":"Theory and Practice of Histological Techniques","author":"Banchroft","year":"1996"},{"key":"10.1016\/j.lfs.2020.118731_bb0240","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1590\/S1519-69842002000400008","article-title":"Determination of the estrous cycle phases of rats: some helpful considerations","volume":"62","author":"Marcondes","year":"2002","journal-title":"Brazilian J Biol. SciELO Brasil"},{"key":"10.1016\/j.lfs.2020.118731_bb0245","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1214\/aoms\/1177728732","article-title":"Power under normality of several nonparametric tests","volume":"25","author":"Dixon","year":"1954","journal-title":"Ann. Math. Stat."},{"key":"10.1016\/j.lfs.2020.118731_bb0250","series-title":"The Design of Experiments: Statistical Principles for Practical Applications","author":"Mead","year":"1988"},{"key":"10.1016\/j.lfs.2020.118731_bb0255","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.neuroscience.2014.02.022","article-title":"Lixisenatide rescues spatial memory and synaptic plasticity from amyloid \u03b2 protein-induced impairments in rats","volume":"277","author":"Cai","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.lfs.2020.118731_bb0260","doi-asserted-by":"crossref","first-page":"6587","DOI":"10.1523\/JNEUROSCI.0529-11.2011","article-title":"The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer\u2019s disease","volume":"31","author":"McClean","year":"2011","journal-title":"J Neurosci. Soc Neuroscience"},{"key":"10.1016\/j.lfs.2020.118731_bb0265","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.devcel.2009.03.010","article-title":"Notch signaling: the core pathway and its posttranslational regulation","volume":"16","author":"Fortini","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.lfs.2020.118731_bb0270","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1523\/JNEUROSCI.20-05-01657.2000","article-title":"Neurons regulate extracellular levels of amyloid \u03b2-protein via proteolysis by insulin-degrading enzyme","volume":"20","author":"Vekrellis","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2020.118731_bb0275","doi-asserted-by":"crossref","first-page":"13389","DOI":"10.1074\/jbc.M111571200","article-title":"Insulin-degrading enzyme rapidly removes the \u03b2-amyloid precursor protein intracellular domain (AICD)","volume":"277","author":"Edbauer","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2020.118731_bb0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13195-016-0206-x","article-title":"Protective effect of melatonin on soluble A\u03b21-42-induced memory impairment, astrogliosis, and synaptic dysfunction via the Musashi1\/Notch1\/Hes1 signaling pathway in the rat hippocampus","volume":"8","author":"Zhang","year":"2016","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.lfs.2020.118731_bb0285","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrn3024","article-title":"Not(ch) just development: Notch signalling in the adult brain","volume":"12","author":"Ables","year":"2011","journal-title":"Nat Rev Neurosci. Nature Publishing Group"},{"key":"10.1016\/j.lfs.2020.118731_bb0290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21051725","article-title":"Liraglutide suppresses tau hyperphosphorylation, amyloid beta accumulation through regulating neuronal insulin signaling and BACE-1 activity","volume":"21","author":"Jantrapirom","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2020.118731_bb0295","first-page":"426","article-title":"Comparative evaluation of NOTCH signaling molecules in the endometrium of women with various gynecological diseases during the window of implantation","volume":"22","author":"Amjadi","year":"2019","journal-title":"Iran J Basic Med Sci"},{"key":"10.1016\/j.lfs.2020.118731_bb0300","doi-asserted-by":"crossref","first-page":"8637","DOI":"10.1007\/s12035-018-1002-3","article-title":"Chronic hippocampal expression of Notch intracellular domain induces vascular thickening, reduces glucose availability, and exacerbates spatial memory deficits in a rat model of early Alzheimer","volume":"55","author":"Galeano","year":"2018","journal-title":"Mol Neurobiol. Molecular Neurobiology"},{"key":"10.1016\/j.lfs.2020.118731_bb0305","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/humupd\/dmq001","article-title":"Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis","volume":"16","author":"Moran","year":"2010","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.lfs.2020.118731_bb0310","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.bbr.2009.06.035","article-title":"Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: interaction between type 2 diabetes and Alzheimer\u2019s disease","volume":"205","author":"Abbas","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.lfs.2020.118731_bb0315","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/nm.3259","article-title":"Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability","volume":"19","author":"Pajvani","year":"2013","journal-title":"Nat Med. Nature Publishing Group"},{"key":"10.1016\/j.lfs.2020.118731_bb0320","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/nm.2378","article-title":"Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner","volume":"17","author":"Pajvani","year":"2011","journal-title":"Nat Med. Nature Publishing Group"},{"key":"10.1016\/j.lfs.2020.118731_bb0325","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.brainres.2014.07.037","article-title":"Hes1, a Notch signaling downstream target, regulates adult hippocampal neurogenesis following traumatic brain injury","volume":"1583","author":"Zhang","year":"2014","journal-title":"Brain Res."},{"key":"10.1016\/j.lfs.2020.118731_bb0330","first-page":"4","article-title":"Exenatide promotes cognitive enhancement and positive brain metabolic changes in PS1-KI mice but has no effects in 3xTg-AD animals","volume":"e612","author":"Bomba","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.lfs.2020.118731_bb0335","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3892\/ijmm.2015.2399","article-title":"MicroRNA-375 overexpression influences P19 cell proliferation, apoptosis and differentiation through the Notch signaling pathway","volume":"37","author":"Wang","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.lfs.2020.118731_bb0340","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.3892\/mmr.2016.5641","article-title":"Notch signaling in cerebrovascular diseases (review)","volume":"14","author":"Cai","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.lfs.2020.118731_bb0345","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.brainres.2014.08.054","article-title":"Evidence that neuronal Notch-1 promotes JNK\/c-Jun activation and cell death following ischemic stress","volume":"1586","author":"Cheng","year":"2014","journal-title":"Brain Res."},{"key":"10.1016\/j.lfs.2020.118731_bb0350","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008244","article-title":"Notch2 signaling sensitizes endothelial cells to apoptosis by negatively regulating the key protective molecule survivin","volume":"4","author":"Quillard","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2020.118731_bb0355","doi-asserted-by":"crossref","DOI":"10.1152\/ajprenal.90005.2013","article-title":"Interplay between the Notch and PI3K\/Akt pathways in high glucose-induced podocyte apoptosis","volume":"306","author":"Wang","year":"2014","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.lfs.2020.118731_bb0360","first-page":"321","article-title":"Ramirez MJ. c-Jun N-terminal kinase (JNK) signaling as a therapeutic target for Alzheimer\u2019s disease [Internet]","author":"Yarza","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2020.118731_bb0365","first-page":"1","article-title":"The neuroprotection of liraglutide against ischaemia-induced apoptosis through the activation of the PI3K\/AKT and MAPK pathways","volume":"6","author":"Zhu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2020.118731_bb0370","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/cen.12951","article-title":"Serum levels of TSP-1, NF-\u03baB and TGF-\u03b21 in polycystic ovarian syndrome (PCOS) patients in northern China suggest PCOS is associated with chronic inflammation","volume":"83","author":"Liu","year":"2015","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.lfs.2020.118731_bb0375","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1210\/jc.2005-2327","article-title":"Increased activation of nuclear factor \u03baB triggers inflammation and insulin resistance in polycystic ovary syndrome","volume":"91","author":"Gonz\u00e1lez","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2020.118731_bb0380","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.3892\/mmr.2016.4948","article-title":"Role of neuroinflammation in neurodegenerative diseases (review)","volume":"13","author":"Chen","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.lfs.2020.118731_bb0385","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1161\/STROKEAHA.111.614834","article-title":"Notch activation enhances the microglia-mediated inflammatory response associated with focal cerebral ischemia","volume":"42","author":"Wei","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.lfs.2020.118731_bb0390","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s10557-013-6463-z","article-title":"Glucagon-like peptide-1 receptor agonist liraglutide inhibits endothelin-1 in endothelial cell by repressing nuclear factor-kappa B activation","volume":"27","author":"Dai","year":"2013","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.lfs.2020.118731_bb0395","first-page":"1","article-title":"GnRH dysregulation in polycystic ovarian syndrome (PCOS) is a manifestation of an altered neurotransmitter profile","volume":"16","author":"Chaudhari","year":"2018","journal-title":"Reprod Biol Endocrinol. Reproductive Biology and Endocrinology"},{"key":"10.1016\/j.lfs.2020.118731_bb0400","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1159\/000101510","article-title":"Galantamine for Alzheimer\u2019s disease and mild cognitive impairment","volume":"28","author":"Cusi","year":"2007","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.lfs.2020.118731_bb0405","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.pt.2019.07.001","article-title":"Toxoplasma gondii","volume":"35","author":"Lourido","year":"2019","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.lfs.2020.118731_bb0410","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1093\/humrep\/det335","article-title":"Visual-spatial cognition in women with polycystic ovarian syndrome: the role of androgens","volume":"28","author":"Barry","year":"2013","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.lfs.2020.118731_bb0415","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1210\/jc.2008-0115","article-title":"Comparison of single and combined treatment with exenatide and metformin on menstrual cyclicity in overweight women with polycystic ovary syndrome","volume":"93","author":"Elkind-Hirsch","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2020.118731_bb0420","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.3892\/etm.2016.3081","article-title":"Metformin as an initial adjunct to low-dose liraglutide enhances the weight-decreasing potential of liraglutide in obese polycystic ovary syndrome: randomized control study","volume":"11","author":"Jensterle","year":"2016","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.lfs.2020.118731_bb0425","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","author":"group TREP consensus workshop","year":"2004","journal-title":"Hum. Reprod."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520314843?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520314843?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:44:20Z","timestamp":1758401060000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320520314843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":85,"alternative-id":["S0024320520314843"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118731","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liraglutide mends cognitive impairment by averting Notch signaling pathway overexpression in a rat model of polycystic ovary syndrome","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118731","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"118731"}}