{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:13:22Z","timestamp":1791987202709,"version":"4.4.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672669"],"award-info":[{"award-number":["81672669"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972538"],"award-info":[{"award-number":["81972538"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.lfs.2020.118748","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T03:02:23Z","timestamp":1605150143000},"page":"118748","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Nerve growth factor protects salivary glands from irradiation-induced damage"],"prefix":"10.1016","volume":"265","author":[{"given":"Shen-sui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-zhou","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-hang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-chen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long-jiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2018","key":"10.1016\/j.lfs.2020.118748_bb0005","first-page":"3","article-title":"Global cancer statistics","volume":"0","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.lfs.2020.118748_bb0010","first-page":"1061","article-title":"A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impact","volume":"18","author":"Jensen","year":"2010","journal-title":"Support Care Cancer"},{"issue":"Supp11","key":"10.1016\/j.lfs.2020.118748_bb0015","first-page":"E 1481","article-title":"Prospective randomized controled trial to compare 3 dimensional conformal radiotherapy to intensity modulated radiotherapy in head and neck squamous cell carcinoma: long-term results","volume":"38","author":"Ghosh-Laskar","year":"2016","journal-title":"Head Neck"},{"issue":"9","key":"10.1016\/j.lfs.2020.118748_bb0020","first-page":"1","article-title":"Modified technique of submandibular gland transfer followed by intensity modulated radiotherapy to reduce xerostomia in head and neck cancer patients","volume":"429","author":"Chang","year":"2020","journal-title":"Head Neck"},{"issue":"20","key":"10.1016\/j.lfs.2020.118748_bb0025","doi-asserted-by":"crossref","first-page":"5694","DOI":"10.1073\/pnas.1601992113","article-title":"Aquaporin gene therapy corrects Sj\u00f6gren\u2019s syndrome phenotype in mice","volume":"11320","author":"Lai","year":"2016","journal-title":"PANS"},{"issue":"pt19","key":"10.1016\/j.lfs.2020.118748_bb0030","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.1242\/jcs.00786","article-title":"Novel functions and signaling pathways for GDNF","volume":"116","author":"Sariola","year":"2003","journal-title":"J. Cell Sci."},{"issue":"5","key":"10.1016\/j.lfs.2020.118748_bb0035","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrn812","article-title":"The GDNF family: signaling, biological functions and therapeutic value","volume":"3","author":"Airaksinen","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"issue":"8","key":"10.1016\/j.lfs.2020.118748_bb0040","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1172\/JCI74096","article-title":"Neurotrophic factor GDNF promotes survival of salivary stem cells","volume":"124","author":"Xiao","year":"2014","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.lfs.2020.118748_bb0045","first-page":"127","article-title":"Effects of radiation on the expression of nerve growth factor in rat sub-mandibular gland","volume":"13","author":"Yu","year":"2010","journal-title":"Chin. J. Dent. Res."},{"key":"10.1016\/j.lfs.2020.118748_bb0050","doi-asserted-by":"crossref","first-page":"7859","DOI":"10.1073\/pnas.90.16.7859","article-title":"Expression of nerve growth factor receptors leads to altered binding affinity and responsiveness","volume":"90","author":"Benedetti","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2020.118748_bb0055","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1038\/s41598-017-01455-3","article-title":"Nerve growth factor signaling in pathology and regeneration of human teeth","volume":"7","author":"Mitsiadis","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2020.118748_bb0060","doi-asserted-by":"crossref","first-page":"e1202","DOI":"10.1038\/cddis.2014.173","article-title":"Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner","volume":"5","author":"Mnich","year":"2014","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.lfs.2020.118748_bb0065","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/(SICI)1097-0029(19990515\/01)45:4\/5<210::AID-JEMT4>3.0.CO;2-F","article-title":"Trks: signal transduction and intracellular pathways","volume":"45","author":"Klesse","year":"1999","journal-title":"Microsc. Res. Techn."},{"issue":"10","key":"10.1016\/j.lfs.2020.118748_bb0070","first-page":"2212","article-title":"Nerve growth factor stimulates clonal growth of human lung cancer cell lines and a human glioblastoma cell line expressing high-affinity nerve growth factor binding sites involving tyrosine kinase signaling","volume":"55","author":"Oelmann","year":"1995","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.lfs.2020.118748_bb0075","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/sj.cdd.4400377","article-title":"Neurotrophins: the biological para-dox of survival factors eliciting apoptosis","volume":"5","author":"Casaccia-Bonnefil","year":"1998","journal-title":"Cell Death Differ."},{"issue":"12","key":"10.1016\/j.lfs.2020.118748_bb0080","first-page":"4828","article-title":"Nerve growth factor signaling through p75 induces apoptosis in Schwann cells via a Bcl-2-independent pathway","volume":"9","author":"Merja","year":"1991","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.lfs.2020.118748_bb0085","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.ijrobp.2004.12.051","article-title":"On the mechanism of salivary gland radio-sensitivity","volume":"62","author":"Konings","year":"2005","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"23","key":"10.1016\/j.lfs.2020.118748_bb0090","doi-asserted-by":"crossref","first-page":"7265","DOI":"10.1158\/1078-0432.CCR-11-0179","article-title":"A novel aldehyde dehydrogenase-3 activator leads to adult salivary stem cell enrichment in vivo","volume":"17","author":"Banh","year":"2011","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.lfs.2020.118748_bb0095","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/sj.mt.6300331","article-title":"AAV8, 9, Rh10, Rh43 vector gene transfer in the rat brain: effects of serotype, promoter and purification method","volume":"16","author":"Klein","year":"2008","journal-title":"Mol. Ther."},{"issue":"9","key":"10.1016\/j.lfs.2020.118748_bb0100","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/gt.2015.36","article-title":"Ultrasound-assisted nonviral gene transfer of AQP1 to the irradiated minipig parotid gland restores fluid secretion","volume":"22","author":"Wang","year":"2015","journal-title":"Gene Ther."},{"key":"10.1016\/j.lfs.2020.118748_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2020.104712","article-title":"The stress hormone norepinephrine promotes tumor progression through \u03b22-adrenoreceptors in oral cancer","volume":"113","author":"Zhang","year":"2020","journal-title":"Arch. Oral Biol."},{"issue":"5","key":"10.1016\/j.lfs.2020.118748_bb0110","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1267\/ahc.12017","article-title":"Role of stress-related brain-derived neurotrophic factor (BDNF) in the rat submandibular gland","volume":"45","author":"Tsukinoki","year":"2012","journal-title":"Acta Histochem. Cytochem."},{"issue":"3","key":"10.1016\/j.lfs.2020.118748_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004663","article-title":"Suppression of radiation-induced salivary gland dysfunction by IGF-1","volume":"4","author":"Limesand","year":"2009","journal-title":"PLoS One"},{"issue":"14","key":"10.1016\/j.lfs.2020.118748_bb0120","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.1158\/1078-0432.CCR-09-0819","article-title":"Prevention of radiation-induced oral mucositis after adenoviral vector-mediated transfer of the keratinocyte growth factor cDNA to mouse submandibular glands","volume":"15","author":"Zheng","year":"2009","journal-title":"Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.lfs.2020.118748_bb0125","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/odi.12217","article-title":"Toward gene therapy for growth hormone deficiency via salivary gland expression of growth hormone","volume":"21","author":"Racz","year":"2015","journal-title":"Oral Dis."},{"key":"10.1016\/j.lfs.2020.118748_bb0130","doi-asserted-by":"crossref","first-page":"e1202","DOI":"10.1038\/cddis.2014.173","article-title":"Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner","volume":"5","author":"Mnich","year":"2014","journal-title":"Cell Death Dis."},{"issue":"9","key":"10.1016\/j.lfs.2020.118748_bb0135","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/gt.2015.55","article-title":"Persistence of hAQP1 expression in human salivary gland cells following AdhAQP1 transduction is associated with a lack of methylation of hCMV promoter","volume":"22","author":"Zheng","year":"2015","journal-title":"Gene Ther."},{"issue":"3","key":"10.1016\/j.lfs.2020.118748_bb0140","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/gt.2010.142","article-title":"Adenoviral delivery of tousled kinase for the protection of salivary glands against ionizing radiation damage","volume":"18","author":"Palaniyandi","year":"2011","journal-title":"Gene Ther."},{"issue":"6","key":"10.1016\/j.lfs.2020.118748_bb0145","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1089\/hum.2012.235","article-title":"Recombinant AAV9-TLK1B administration ameliorates fractionated radiation-induced xerostomia","volume":"24","author":"Timiri Shanmugam","year":"2013","journal-title":"Hum. Gene Ther."},{"issue":"8","key":"10.1016\/j.lfs.2020.118748_bb0150","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.bbamem.2006.01.022","article-title":"Distribution and roles of aquaporins in salivary glands","volume":"1758","author":"Delpote","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.lfs.2020.118748_bb0155","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1038\/ncomms2526","article-title":"Loss of TRPM2 function protects against IR-induced salivary gland dysfunction","volume":"4","author":"Liu","year":"2014","journal-title":"Nat. Commun."},{"issue":"15","key":"10.1016\/j.lfs.2020.118748_bb0160","doi-asserted-by":"crossref","first-page":"20271","DOI":"10.18632\/oncotarget.7941","article-title":"Prevention of IR-induced salivary hypofunction by rapamycin in swine parotid glands","volume":"7","author":"Zhu","year":"2016","journal-title":"Oncotarget"},{"issue":"9","key":"10.1016\/j.lfs.2020.118748_bb0165","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/gt.2015.55","article-title":"Persistence of hAQP1 expression in human salivary gland cells following AdhAQP1 transduction is associated with a lack of methylation of hCMV promoter","volume":"22","author":"Zheng","year":"2015","journal-title":"Gene Ther."},{"issue":"2","key":"10.1016\/j.lfs.2020.118748_bb0170","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00005-015-0376-4","article-title":"Neurotrophic factors and their potential applications in tissue regeneration","volume":"64","author":"Xiao","year":"2016","journal-title":"Arch. Immunol. Ther. Exp."},{"issue":"1","key":"10.1016\/j.lfs.2020.118748_bb0175","first-page":"105","article-title":"Nerve growth factor exerts differential effects on the growth of human pancreatic cancer cells","volume":"7","author":"Zhu","year":"2001","journal-title":"Clin. Cancer Res."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520315010?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520315010?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:42:26Z","timestamp":1758400946000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320520315010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":35,"alternative-id":["S0024320520315010"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118748","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nerve growth factor protects salivary glands from irradiation-induced damage","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118748","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"118748"}}