{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:58:50Z","timestamp":1773295130806,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873664"],"award-info":[{"award-number":["81873664"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81660154"],"award-info":[{"award-number":["81660154"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004880","name":"Xinjiang Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004880","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Discipline of the 13th Five-Year Plan (Plateau Discipline) of Xinjiang Uygur Autonomous Region"},{"name":"Karamay Innovation Talent Project","award":["2017RC001A-21"],"award-info":[{"award-number":["2017RC001A-21"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.lfs.2020.118762","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T03:02:48Z","timestamp":1605150168000},"page":"118762","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Ad36 promotes differentiation of hADSCs into brown adipocytes by up-regulating LncRNA ROR"],"prefix":"10.1016","volume":"265","author":[{"given":"Yi","family":"Jiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanyu","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiale","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youzongsheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuerbiye","family":"Nuermaimaiti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqun","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2020.118762_bb0005","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fendo.2018.00002","article-title":"Type 2 diabetes mellitus and cardiovascular disease: genetic and epigenetic links","volume":"9","author":"De Rosa","year":"2018","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.lfs.2020.118762_bb0010","doi-asserted-by":"crossref","first-page":"324","DOI":"10.5830\/CVJA-2017-034","article-title":"Prevalence of obesity and body size perceptions in urban and rural Senegal: new insight on the epidemiological transition in West Africa","volume":"28","author":"Macia","year":"2017","journal-title":"Cardiovasc J Afr"},{"key":"10.1016\/j.lfs.2020.118762_bb0015","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s13679-017-0251-1","article-title":"Viral infections and obesity","volume":"6","author":"Voss","year":"2017","journal-title":"Curr. Obes. Rep."},{"key":"10.1016\/j.lfs.2020.118762_bb0020","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/sj.ijo.0802830","article-title":"Human adenovirus-36 is associated with increased body weight and paradoxical reduction of serum lipids","volume":"29","author":"Atkinson","year":"2005","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.lfs.2020.118762_bb0025","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1038\/ijo.2017.142","article-title":"Insulin-sparing and fungible effects of E4orf1 combined with an adipocyte-targeting sequence in mouse models of type 1 and type 2 diabetes","volume":"41","author":"Yoon","year":"2017","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.lfs.2020.118762_bb0030","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12944-019-1004-9","article-title":"Adenovirus type 36 regulates adipose stem cell differentiation and glucolipid metabolism through the PI3K\/Akt\/FoxO1\/PPAR\u03b3 signaling pathway","volume":"18","author":"Jiao","year":"2019","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.lfs.2020.118762_bb0035","doi-asserted-by":"crossref","first-page":"8888","DOI":"10.1038\/s41598-017-09025-3","article-title":"Extracellular calcium modulates brown adipocyte differentiation and identity","volume":"7","author":"Pramme-Steinwachs","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2020.118762_bb0040","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1056\/NEJMoa0810780","article-title":"Identification and importance of brown adipose tissue in adult humans","volume":"360","author":"Cypess","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2020.118762_bb0045","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/nature08262","article-title":"Initiation of myoblast to brown fat switch by a PRDM16-C\/EBP-beta transcriptional complex","volume":"460","author":"Kajimura","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2020.118762_bb0050","doi-asserted-by":"crossref","first-page":"989","DOI":"10.5551\/jat.RV17011","article-title":"CIDE family-mediated unique lipid droplet morphology in white adipose tissue and brown adipose tissue determines the adipocyte energy metabolism","volume":"24","author":"Nishimoto","year":"2017","journal-title":"J. Atheroscler. Thromb."},{"key":"10.1016\/j.lfs.2020.118762_bb0055","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12554","article-title":"Diurnal and photoperiodic changes in thyrotrophin-stimulating hormone \u03b2 expression and associated regulation of deiodinase enzymes (DIO2, DIO3) in the female juvenile chicken hypothalamus","volume":"29","author":"Dunn","year":"2017","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.lfs.2020.118762_bb0060","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1101\/gad.177857.111","article-title":"FGF21 regulates PGC-1\u03b1 and browning of white adipose tissues in adaptive thermogenesis","volume":"26","author":"Fisher","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.lfs.2020.118762_bb0065","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/ng.710","article-title":"Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells","volume":"42","author":"Loewer","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.lfs.2020.118762_bb0070","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1159\/000373999","article-title":"Downregulation of lncRNA TUG1 affects apoptosis and insulin secretion in mouse pancreatic \u03b2 cells","volume":"35","author":"Yin","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.lfs.2020.118762_bb0075","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/1746-1596-9-83","article-title":"Adenovirus36 infection expresses cellular APMI and Visfatin genes in overweight Uygur individuals","volume":"9","author":"Jiao","year":"2014","journal-title":"Diagn. Pathol."},{"key":"10.1016\/j.lfs.2020.118762_bb0080","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.biochi.2014.11.005","article-title":"Human adenovirus Ad36 and its E4orf1 gene enhance cellular glucose uptake even in the presence of inflammatory cytokines","volume":"124","author":"Na","year":"2016","journal-title":"Biochimie"},{"key":"10.1016\/j.lfs.2020.118762_bb0085","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.3390\/ijms18122578","article-title":"Long non-coding RNAs in metabolic organs and energy homeostasis","volume":"18","author":"Giroud","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2020.118762_bb0090","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.cmet.2015.02.004","article-title":"A liver-enriched long non-coding RNA, lncLSTR, regulates systemic lipid metabolism in mice","volume":"21","author":"Li","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.lfs.2020.118762_bb0095","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1073\/pnas.1222643110","article-title":"Long noncoding RNAs regulate adipogenesis","volume":"110","author":"Sun","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2020.118762_bb0100","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.cmet.2015.04.003","article-title":"De novo reconstruction of adipose tissue transcriptomes reveals long non-coding RNA regulators of brown adipocyte development","volume":"21","author":"Alvarez-Dominguez","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.lfs.2020.118762_bb0105","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1038\/s41467-018-03754-3","article-title":"De novo reconstruction of human adipose transcriptome reveals conserved lncRNAs as regulators of brown adipogenesis","volume":"9","author":"Ding","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2020.118762_bb0110","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.devcel.2013.03.002","article-title":"Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human embryonic stem cell self-renewal","volume":"25","author":"Wang","year":"2013","journal-title":"Dev. Cell"},{"key":"10.1016\/j.lfs.2020.118762_bb0115","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12395","article-title":"Corrigendum: Cidea improves the metabolic profile through expansion of adipose tissue","volume":"7","author":"Abreu-Vieira","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2020.118762_bb0120","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2337\/diabetes.53.3.577","article-title":"Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis","volume":"53","author":"Christoffolete","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.lfs.2020.118762_bb0125","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.cmet.2017.08.003","article-title":"The FGF21-CCL11 axis mediates beiging of white adipose tissues by coupling sympathetic nervous system to type 2 immunity","volume":"26","author":"Huang","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.lfs.2020.118762_bb0130","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nrg.2016.20","article-title":"Endogenous microRNA sponges: evidence and controversy","volume":"17","author":"Thomson","year":"2016","journal-title":"Nat Rev Genet"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520315150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520315150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:45:48Z","timestamp":1758401148000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320520315150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":26,"alternative-id":["S0024320520315150"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118762","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ad36 promotes differentiation of hADSCs into brown adipocytes by up-regulating LncRNA ROR","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118762","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118762"}}