{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T09:21:41Z","timestamp":1769246501981,"version":"3.49.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.lfs.2020.118882","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T16:56:09Z","timestamp":1607619369000},"page":"118882","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Cilostazol mitigates mesenteric ischemia\/reperfusion-induced lung lesion: Contribution of PPAR-\u03b3, NF-\u03baB, and STAT3 crosstalk"],"prefix":"10.1016","volume":"266","author":[{"given":"Abdallah M.","family":"Gendy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed M.","family":"Amin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa K.","family":"Al-Mokaddem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed F.","family":"Abd Ellah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.lfs.2020.118882_bb0005","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1023\/B:DDAS.0000042232.98927.91","article-title":"Ischemia-reperfusion injury of the intestine and protective strategies against injury","volume":"49","author":"Mallick","year":"2004","journal-title":"Dig. Dis. Sci."},{"issue":"4","key":"10.1016\/j.lfs.2020.118882_bb0010","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1590\/S0102-86502005000400013","article-title":"Pathophysiology of mesenteric ischemia\/reperfusion: a review","volume":"20","author":"Cerqueira","year":"2005","journal-title":"Acta Cir. Bras."},{"key":"10.1016\/j.lfs.2020.118882_bb0015","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ejphar.2017.05.021","article-title":"Mangiferin protects against intestinal ischemia\/reperfusion-induced liver injury: involvement of PPAR-gamma, GSK-3beta and Wnt\/beta-catenin pathway","volume":"809","author":"El-Sayyad","year":"2017","journal-title":"Eur. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.lfs.2020.118882_bb0020","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1016\/j.bbamcr.2013.06.001","article-title":"Crosstalk between apoptosis, necrosis and autophagy","volume":"1833","author":"Nikoletopoulou","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.lfs.2020.118882_bb0025","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1179\/135100002125000983","article-title":"Suppression of intestinal ischemia-reperfusion injury by a specific peroxisome proliferator-activated receptor-gamma ligand, pioglitazone, in rats","volume":"7","author":"Naito","year":"2002","journal-title":"Redox Rep."},{"issue":"6","key":"10.1016\/j.lfs.2020.118882_bb0030","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.vph.2004.10.004","article-title":"Peroxisome proliferator-activated receptors gamma ligands and ischemia and reperfusion injury","volume":"41","author":"Cuzzocrea","year":"2004","journal-title":"Vasc. Pharmacol."},{"issue":"2","key":"10.1016\/j.lfs.2020.118882_bb0035","doi-asserted-by":"crossref","first-page":"242","DOI":"10.4161\/cc.4.2.1471","article-title":"Nuclear receptors as negative modulators of STAT3 in multiple myeloma","volume":"4","author":"Wang","year":"2005","journal-title":"Cell Cycle"},{"issue":"2","key":"10.1016\/j.lfs.2020.118882_bb0040","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1124\/pr.119.018440","article-title":"Targeting Janus kinases and signal transducer and activator of transcription 3 to treat inflammation, fibrosis, and cancer: rationale, progress, and caution","volume":"72","author":"Bharadwaj","year":"2020","journal-title":"Pharmacol. Rev."},{"issue":"1","key":"10.1016\/j.lfs.2020.118882_bb0045","first-page":"75","article-title":"Cilostazol hepatoprotective effect against ischemia\/reperfusion: involvement of GSK-3 [Beta], Cyclin D1 and WNT\/[Beta]-Catenin pathway","volume":"4","author":"Gendy","year":"2014","journal-title":"J. Pharmacol. Res."},{"issue":"5","key":"10.1016\/j.lfs.2020.118882_bb0050","doi-asserted-by":"crossref","first-page":"e95313","DOI":"10.1371\/journal.pone.0095313","article-title":"Cilostazol renoprotective effect: modulation of PPAR-gamma, NGAL, KIM-1 and IL-18 underlies its novel effect in a model of ischemia-reperfusion","volume":"9","author":"Ragab","year":"2014","journal-title":"PLoS One"},{"issue":"1\u20132","key":"10.1016\/j.lfs.2020.118882_bb0055","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.mce.2013.07.011","article-title":"Cilostazol improves the response to ischemia in diabetic mice by a mechanism dependent on PPARgamma","volume":"381","author":"Biscetti","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.lfs.2020.118882_bb0060","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.fct.2016.12.018","article-title":"Cilostazol and enzymatically modified isoquercitrin attenuate experimental colitis and colon cancer in mice by inhibiting cell proliferation and inflammation","volume":"100","author":"Kangawa","year":"2017","journal-title":"Food Chem. Toxicol."},{"issue":"5","key":"10.1016\/j.lfs.2020.118882_bb0065","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/01.shk.0000228800.56223.db","article-title":"Comparison of the protective effects of type III phosphodiesterase (PDE3) inhibitor (cilostazol) and acetylsalicylic acid on intestinal microcirculation after ischemia reperfusion injury in mice","volume":"26","author":"Iba","year":"2006","journal-title":"Shock"},{"issue":"1","key":"10.1016\/j.lfs.2020.118882_bb0070","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4103\/0976-500X.92513","article-title":"Non-occlusive mesenteric ischemia and the role of cilostazol in its management","volume":"3","author":"Murthy","year":"2012","journal-title":"J. Pharmacol. Pharmacother."},{"issue":"3","key":"10.1016\/j.lfs.2020.118882_bb0075","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1007\/s10620-012-2391-1","article-title":"Febuxostat improves the local and remote organ changes induced by intestinal ischemia\/reperfusion in rats","volume":"58","author":"Shafik","year":"2013","journal-title":"Dig. Dis. Sci."},{"issue":"7","key":"10.1016\/j.lfs.2020.118882_bb0080","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00210-017-1370-7","article-title":"The potential curative effect of rebamipide in hepatic ischemia\/reperfusion injury","volume":"390","author":"Gendy","year":"2017","journal-title":"Naunyn Schmiedeberg\u2019s Arch. Pharmacol."},{"issue":"3","key":"10.1016\/j.lfs.2020.118882_bb0085","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/1523-1747.ep12506462","article-title":"Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker","volume":"78","author":"Bradley","year":"1982","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.lfs.2020.118882_bb0090","series-title":"Theory and Practice of Histology Techniques","first-page":"p83","author":"Bancroft","year":"2008"},{"issue":"4","key":"10.1016\/j.lfs.2020.118882_bb0095","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1001\/archsurg.1970.01340280030009","article-title":"Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal","volume":"101","author":"Chiu","year":"1970","journal-title":"Arch. Surg."},{"issue":"8","key":"10.1016\/j.lfs.2020.118882_bb0100","doi-asserted-by":"crossref","first-page":"13678","DOI":"10.18632\/oncotarget.14624","article-title":"Down-regulation of toll-like receptor 4 alleviates intestinal ischemia reperfusion injury and acute lung injury in mice","volume":"8","author":"Zhu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.lfs.2020.118882_bb0105","doi-asserted-by":"crossref","unstructured":"Hamdan D, El-Shiekh R, El-Sayed M, Khalil HM, Mousa M, Al-Gendy AA, et al. (2020). Phytochemical characterization and anti-inflammatory potential of Egyptian Murcott Mandarin cultivar waste (stem, leaves and peel). Food & Function.","DOI":"10.1039\/D0FO01796E"},{"issue":"12","key":"10.1016\/j.lfs.2020.118882_bb0110","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1007\/s00210-019-01699-y","article-title":"Gastroprotective effect of cilostazol against ethanol- and pylorus ligation-induced gastric lesions in rats","volume":"392","author":"Moawad","year":"2019","journal-title":"Naunyn Schmiedeberg\u2019s Arch. Pharmacol."},{"issue":"9","key":"10.1016\/j.lfs.2020.118882_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0203837","article-title":"Cilostazol disrupts TLR-4, Akt\/GSK-3beta\/CREB, and IL-6\/JAK-2\/STAT-3\/SOCS-3 crosstalk in a rat model of Huntington\u2019s disease","volume":"13","author":"El-Abhar","year":"2018","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.lfs.2020.118882_bb0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0168286","article-title":"Concurrent treatment with taxifolin and cilostazol on the lowering of beta-amyloid accumulation and neurotoxicity via the suppression of P-JAK2\/P-STAT3\/NF-kappaB\/BACE1 signaling pathways","volume":"11","author":"Park","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.lfs.2020.118882_bb0125","doi-asserted-by":"crossref","first-page":"862","DOI":"10.3349\/ymj.2015.56.3.862","article-title":"Jak1\/Stat3 is an upstream signaling of NF-kappaB activation in Helicobacter pylori-induced IL-8 production in gastric epithelial AGS cells","volume":"56","author":"Cha","year":"2015","journal-title":"Yonsei Med. J."},{"issue":"3","key":"10.1016\/j.lfs.2020.118882_bb0130","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s13238-013-2084-3","article-title":"NF-kappaB and STAT3 signaling pathways collaboratively link inflammation to cancer","volume":"4","author":"Fan","year":"2013","journal-title":"Protein Cell"},{"key":"10.1016\/j.lfs.2020.118882_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.172974","article-title":"Gabapentin attenuates intestinal inflammation: role of PPAR-gamma receptor","volume":"873","author":"de Brito","year":"2020","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.lfs.2020.118882_bb0140","doi-asserted-by":"crossref","first-page":"G616","DOI":"10.1152\/ajpgi.00248.2005","article-title":"Differential induction of PPAR-gamma by luminal glutamine and iNOS by luminal arginine in the rodent postischemic small bowel","volume":"290","author":"Sato","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"5","key":"10.1016\/j.lfs.2020.118882_bb0145","doi-asserted-by":"crossref","first-page":"503","DOI":"10.5551\/jat.3392","article-title":"Anti-inflammatory role of cilostazol in vascular smooth muscle cells in vitro and in vivo","volume":"17","author":"Aoki","year":"2010","journal-title":"J. Atheroscler. Thromb."},{"key":"10.1016\/j.lfs.2020.118882_bb0150","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ejphar.2018.01.021","article-title":"Cilostazol attenuates indices of liver damage induced by thioacetamide in albino rats through regulating inflammatory cytokines and apoptotic biomarkers","volume":"822","author":"El Awdan","year":"2018","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.lfs.2020.118882_bb0155","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/cr.2010.178","article-title":"Crosstalk of reactive oxygen species and NF-kappaB signaling","volume":"21","author":"Morgan","year":"2011","journal-title":"Cell Res."},{"issue":"3","key":"10.1016\/j.lfs.2020.118882_bb0160","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.coph.2006.01.008","article-title":"Peroxisome proliferator-activated receptors and acute lung injury","volume":"6","author":"Cuzzocrea","year":"2006","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.lfs.2020.118882_bb0165","doi-asserted-by":"crossref","first-page":"508","DOI":"10.3389\/fimmu.2014.00508","article-title":"Neutrophil-derived cytokines: facts beyond expression","volume":"5","author":"Tecchio","year":"2014","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.lfs.2020.118882_bb0170","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1111\/j.1538-7836.2007.02425.x","article-title":"Neuroprotective effect of cilostazol against retinal ischemic damage via inhibition of leukocyte-endothelial cell interactions","volume":"5","author":"Iwama","year":"2007","journal-title":"J. Thromb. Haemost."},{"issue":"3","key":"10.1016\/j.lfs.2020.118882_bb0175","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1124\/jpet.300.3.787","article-title":"Neuroprotective effect of cilostazol against focal cerebral ischemia via antiapoptotic action in rats","volume":"300","author":"Choi","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"5","key":"10.1016\/j.lfs.2020.118882_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0216301","article-title":"Regression of fibrosis by cilostazol in a rat model of thioacetamide-induced liver fibrosis: up regulation of hepatic cAMP, and modulation of inflammatory, oxidative stress and apoptotic biomarkers","volume":"14","author":"El Awdan","year":"2019","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.lfs.2020.118882_bb0185","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"issue":"7","key":"10.1016\/j.lfs.2020.118882_bb0190","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.3390\/molecules24071410","article-title":"MicroRNA-181c inhibits interleukin-6-mediated beta cell apoptosis by targeting TNF-alpha expression","volume":"24","author":"Oh","year":"2019","journal-title":"Molecules"},{"issue":"2\u20134","key":"10.1016\/j.lfs.2020.118882_bb0195","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0171-2985(11)80543-7","article-title":"TNF-induced activation of NF-kappa B","volume":"193","author":"Schutze","year":"1995","journal-title":"Immunobiology"},{"issue":"3","key":"10.1016\/j.lfs.2020.118882_bb0200","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0014-2999(98)00274-X","article-title":"Nitric oxide and its role in apoptosis","volume":"351","author":"Brune","year":"1998","journal-title":"Eur. J. Pharmacol."},{"issue":"51","key":"10.1016\/j.lfs.2020.118882_bb0205","doi-asserted-by":"crossref","first-page":"37006","DOI":"10.1074\/jbc.M700447200","article-title":"Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis","volume":"282","author":"Fuenzalida","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"25","key":"10.1016\/j.lfs.2020.118882_bb0210","doi-asserted-by":"crossref","first-page":"17082","DOI":"10.1074\/jbc.M809042200","article-title":"Tumor necrosis factor-alpha induces caspase-mediated cleavage of peroxisome proliferator-activated receptor gamma in adipocytes","volume":"284","author":"Guilherme","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.lfs.2020.118882_bb0215","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/SHK.0b013e3182662266","article-title":"Ischemic postconditioning during reperfusion attenuates intestinal injury and mucosal cell apoptosis by inhibiting JAK\/STAT signaling activation","volume":"38","author":"Wen","year":"2012","journal-title":"Shock"},{"issue":"1","key":"10.1016\/j.lfs.2020.118882_bb0220","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1006\/excr.1997.3737","article-title":"Bcl-2 suppresses apoptosis resulting from disruption of the NF-kappa B survival pathway","volume":"237","author":"Herrmann","year":"1997","journal-title":"Exp. Cell Res."},{"issue":"9","key":"10.1016\/j.lfs.2020.118882_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007059","article-title":"Nitric oxide induces cell death by regulating anti-apoptotic BCL-2 family members","volume":"4","author":"Snyder","year":"2009","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.lfs.2020.118882_bb0230","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/SHK.0b013e3181f6aaf1","article-title":"The mucus layer is critical in protecting against ischemia\/reperfusion-mediated gut injury and in the restitution of gut barrier function","volume":"35","author":"Qin","year":"2011","journal-title":"Shock (Augusta, Ga.)"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520316350?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320520316350?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T15:19:42Z","timestamp":1758986382000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320520316350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":46,"alternative-id":["S0024320520316350"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118882","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cilostazol mitigates mesenteric ischemia\/reperfusion-induced lung lesion: Contribution of PPAR-\u03b3, NF-\u03baB, and STAT3 crosstalk","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2020.118882","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"118882"}}