{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:09:33Z","timestamp":1793322573946,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.lfs.2021.119071","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T21:30:15Z","timestamp":1611783015000},"page":"119071","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["miR-125b promotes the NF-\u03baB-mediated inflammatory response in NAFLD via directly targeting TNFAIP3"],"prefix":"10.1016","volume":"270","author":[{"given":"Qian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazhen","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2021.119071_bb0005","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.3390\/nu9101065","article-title":"Isocaloric dietary changes and non-alcoholic fatty liver disease in high cardiometabolic risk individuals","volume":"9","author":"Giuseppe Della Pepa","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2021.119071_bb0010","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3389\/fmed.2019.00202","article-title":"Cardiovascular risk in fatty liver disease: the liver-heart axis\u2014Literature review","volume":"6","author":"Abdulrahman Ismaiel","year":"2019","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.lfs.2021.119071_bb0015","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.metabol.2016.01.001","article-title":"Non-alcoholic fatty liver disease and diabete","volume":"65","author":"Jonathan","year":"2016","journal-title":"Metabolism."},{"key":"10.1016\/j.lfs.2021.119071_bb0020","doi-asserted-by":"crossref","first-page":"4104","DOI":"10.3748\/wjg.v24.i36.4104","article-title":"Role of microRNAs in alcohol-induced liver disorders and non-alcoholic fatty liver disease","volume":"24","author":"Jorge-Luis Torres","year":"2018","journal-title":"World J Gastroenterol."},{"key":"10.1016\/j.lfs.2021.119071_bb0025","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/ijms18010021","article-title":"Long non-coding RNA profiling in a non-alcoholic fatty liver disease rodent model: new insight into pathogenesis","volume":"18","author":"Yi Chen","year":"2017","journal-title":"Int J Mol Sci."},{"key":"10.1016\/j.lfs.2021.119071_bb0030","first-page":"2669","article-title":"Analysis of non-alcoholic fatty liver disease microRNA expression spectra in rat liver tissues","volume":"18","author":"Nie","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.lfs.2021.119071_bb0035","doi-asserted-by":"crossref","first-page":"101140","DOI":"10.1016\/j.redox.2019.101140","article-title":"miR-125b suppresses oral oncogenicity by targeting the anti-oxidative gene PRXL2A","volume":"22","author":"Yi-Fen Chen","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.lfs.2021.119071_bb0040","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/nm.4424","article-title":"lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt\/\u03b2-catenin signaling","volume":"23","author":"Yuanyuan Lu","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.lfs.2021.119071_bb0045","article-title":"miR-125b-5p functions as a tumor suppressor gene partially by regulating HMGA2 in esophageal squamous cell carcinoma","volume":"12","author":"Li-Li Mei","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2021.119071_bb0050","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/jvh.12522","article-title":"The expression of miR-125b-5p is increased in the serum of patients with chronic hepatitis B infection and inhibits the detection of hepatitis B virus surface antigen","volume":"23","author":"Shimosegawa","year":"2016","journal-title":"J. Viral Hepat."},{"key":"10.1016\/j.lfs.2021.119071_bb0055","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1002\/hep.22569","article-title":"Nonalcoholic steatohepatitis is associated with altered hepatic microrna expression","volume":"48","author":"Onpan Cheung","year":"2008","journal-title":"Hepatology."},{"key":"10.1016\/j.lfs.2021.119071_bb0060","first-page":"3019794","article-title":"Curcumin and \u03b1\/\u03b2-adrenergic antagonists cotreatment reverse liver cirrhosis in hamsters: participation of Nrf-2 and NF-\u03baB","volume":"2019","author":"Jos\u00e9 Roberto Mac\u00edas-P\u00e9rez","year":"2019","journal-title":"J Immunol Res"},{"key":"10.1016\/j.lfs.2021.119071_bb0065","article-title":"Hepatitis B e antigen inhibits NF-\u03baB activity by interrupting K63-linked ubiquitination of NEMO","volume":"93","author":"Yuan Wang","year":"2019","journal-title":"J Virol."},{"key":"10.1016\/j.lfs.2021.119071_bb0070","article-title":"The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population","volume":"62","author":"Kenichi Shimane","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.lfs.2021.119071_bb0075","doi-asserted-by":"crossref","first-page":"38914","DOI":"10.18632\/oncotarget.17153","article-title":"Elevated serum A20 is associated with severity of chronic hepatitis B and A20 inhibits NF-\u03baB-mediated inflammatory response","volume":"8","author":"Hanchen Xu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.lfs.2021.119071_bb0080","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nm.4453","article-title":"The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis","volume":"24","author":"Zhang","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.lfs.2021.119071_bb0085","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1159\/000366394","article-title":"Aberrant hepatic microRNA expression in nonalcoholic fatty liver disease","volume":"34","author":"Feng","year":"2014","journal-title":"Cell Physiol Biochem."},{"key":"10.1016\/j.lfs.2021.119071_bb0090","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1136\/gutjnl-2015-310822","article-title":"Stress-activated miR-21\/miR-21* in hepatocytes promotes lipid and glucose metabolic disorders associated with high-fat diet consumption","volume":"65","author":"Nicolas Calo","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.lfs.2021.119071_bb0095","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.jhep.2018.08.008","article-title":"miRNAs in patients with non-alcoholic fatty liver disease: a systematic review and meta-analysis","volume":"69","author":"Chang-Hai Liu","year":"2018","journal-title":"J Hepatol."},{"key":"10.1016\/j.lfs.2021.119071_bb0100","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1136\/gutjnl-2014-306996","article-title":"Circulating microRNA signature in non-alcoholic fatty liver disease: from serum non-coding RNAs to liver histology and disease pathogenesis","volume":"64","author":"Carlos","year":"2015","journal-title":"Gut."},{"key":"10.1016\/j.lfs.2021.119071_bb0105","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.3390\/ijerph16173104","article-title":"Cardiovascular risk in non-alcoholic fatty liver disease: mechanisms and therapeutic implications","volume":"16","author":"Claudio Tana","year":"2019","journal-title":"Int J Environ Res Public Health."},{"key":"10.1016\/j.lfs.2021.119071_bb0110","doi-asserted-by":"crossref","first-page":"715","DOI":"10.4254\/wjh.v9.i16.715","article-title":"Non-alcoholic fatty liver disease: an expanded review","volume":"9","author":"Mark Benedict","year":"2017","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.lfs.2021.119071_bb0115","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/cei.12838","article-title":"MicroRNA-26a\u2013interleukin (IL)-6\u2013IL-17 axis regulates the development of non-alcoholic fatty liver disease in a murine model","volume":"187","author":"He","year":"2017","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.lfs.2021.119071_bb0120","doi-asserted-by":"crossref","first-page":"947","DOI":"10.3390\/ijms17060947","article-title":"A guide to non-alcoholic fatty liver disease in childhood and adolescence","volume":"17","author":"Jonathan","year":"2016","journal-title":"Int J Mol Sci."},{"key":"10.1016\/j.lfs.2021.119071_bb0125","article-title":"Association of tumor necrosis factor-alpha polymorphisms and risk of coronary artery disease in patients with non-alcoholic fatty liver disease","volume":"15","author":"Yuting Cheng","year":"2015","journal-title":"Hepat Mon."},{"key":"10.1016\/j.lfs.2021.119071_bb0130","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12933-016-0443-0","article-title":"TNF-\u03b1 induces vascular insulin resistance via positive modulation of PTEN and decreased Akt\/eNOS\/NO signaling in high fat diet-fed mice","volume":"15","author":"da Costa KBN","year":"2016","journal-title":"Cardiovasc Diabetol."},{"key":"10.1016\/j.lfs.2021.119071_bb0135","doi-asserted-by":"crossref","first-page":"872","DOI":"10.3390\/nu11040872","article-title":"Oxidative stress and non-alcoholic fatty liver disease: effects of omega-3 fatty acid supplementation","volume":"11","author":"Jinchunzi Yang","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2021.119071_bb0140","doi-asserted-by":"crossref","first-page":"18070","DOI":"10.3748\/wjg.v20.i48.18070","article-title":"Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease","volume":"20","author":"Sanja Stojsavljevi\u0107","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.lfs.2021.119071_bb0145","article-title":"Interleukin-1\u03b2 regulates fat-liver crosstalk in obesity by auto-paracrine modulation of adipose tissue inflammation and expandability","volume":"8","author":"Ori Nov","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2021.119071_bb0150","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1080\/19382014.2017.1356558","article-title":"Effect of liver histopathology on islet cell engraftment in the model mimicking autologous islet cell transplantation","volume":"9","author":"Chirag","year":"2017","journal-title":"Islets."},{"key":"10.1016\/j.lfs.2021.119071_bb0155","doi-asserted-by":"crossref","first-page":"5877","DOI":"10.3748\/wjg.v21.i19.5877","article-title":"Effect of nuclear factor-\u03baB and angiotensin II receptor type 1 on the pathogenesis of rat non-alcoholic fatty liver disease","volume":"21","author":"Dao-Yu Tan","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.lfs.2021.119071_bb0160","doi-asserted-by":"crossref","first-page":"12956","DOI":"10.3748\/wjg.v20.i36.12956","article-title":"Non-alcoholic fatty liver disease: what the clinician needs to know","volume":"20","author":"Mariana Verdelho Machado","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.lfs.2021.119071_bb0165","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/s41388-018-0472-0","article-title":"The pleiotropic effects of TNF\u03b1 in breast cancer subtypes is regulated by TNFAIP3\/A20","volume":"38","author":"Eunmi Lee","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.lfs.2021.119071_bb0170","doi-asserted-by":"crossref","first-page":"540","DOI":"10.4292\/wjgpt.v7.i4.540","article-title":"A20 inhibits lipopolysaccharide-induced inflammation in enterocytes","volume":"7","author":"Cui-Fang Zheng","year":"2016","journal-title":"World J Gastrointest Pharmacol Ther."},{"key":"10.1016\/j.lfs.2021.119071_bb0175","article-title":"A20 rescues hepatocytes from apoptosis through the NF-\u03baB signaling pathway in rats with acute liver failure","volume":"39","author":"Ke-Zhi Li","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.lfs.2021.119071_bb0180","article-title":"The Edwardsiella piscicida thioredoxin-like protein inhibits ASK1-MAPKs signaling cascades to promote pathogenesis during infection","volume":"15","author":"Dahai Yang","year":"2019","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.lfs.2021.119071_bb0185","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/s12944-016-0370-9","article-title":"Melatonin improves non-alcoholic fatty liver disease via MAPK-JNK\/P38 signaling in high-fat-diet-induced obese mice","volume":"15","author":"Hang Sun","year":"2016","journal-title":"Lipids Health Dis"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521000564?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521000564?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:45:12Z","timestamp":1758401112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320521000564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":37,"alternative-id":["S0024320521000564"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119071","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miR-125b promotes the NF-\u03baB-mediated inflammatory response in NAFLD via directly targeting TNFAIP3","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119071","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"119071"}}