{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T18:34:53Z","timestamp":1772735693350,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800948"],"award-info":[{"award-number":["81800948"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970901"],"award-info":[{"award-number":["81970901"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.lfs.2021.119073","type":"journal-article","created":{"date-parts":[[2021,1,17]],"date-time":"2021-01-17T23:54:44Z","timestamp":1610927684000},"page":"119073","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Thrombin inhibitor argatroban modulates bone marrow stromal cells behaviors and promotes osteogenesis through canonical Wnt signaling"],"prefix":"10.1016","volume":"269","author":[{"given":"Jian","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueqi","family":"Gan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuoli","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"20","key":"10.1016\/j.lfs.2021.119073_bb0005","doi-asserted-by":"crossref","first-page":"5281","DOI":"10.1182\/blood-2011-01-315069","article-title":"Bone and the hematopoietic niche: a tale of two stem cells","volume":"117","author":"Bianco","year":"2011","journal-title":"Blood"},{"issue":"7308","key":"10.1016\/j.lfs.2021.119073_bb0010","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nature09262","article-title":"Mesenchymal and haematopoietic stem cells form a unique bone marrow niche","volume":"466","author":"Mendez-Ferrer","year":"2010","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.lfs.2021.119073_bb0015","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/SAP.0b013e318157a185","article-title":"Role of platelet-rich plasma in acceleration of bone fracture healing","volume":"61","author":"Simman","year":"2008","journal-title":"Ann. Plast. Surg."},{"issue":"3","key":"10.1016\/j.lfs.2021.119073_bb0020","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1538-7836.2006.01788.x","article-title":"Thrombin and PAR-1 stimulate differentiation of bone marrow-derived endothelial progenitor cells","volume":"4","author":"Tarzami","year":"2006","journal-title":"J. Thromb. Haemost."},{"issue":"6","key":"10.1016\/j.lfs.2021.119073_bb0025","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.thromres.2013.09.037","article-title":"The study of the thrombin generation mechanism and the effect of low molecular weight heparin as thromboprophylaxis in patients undergoing total knee and hip replacement","volume":"132","author":"Gionis","year":"2013","journal-title":"Thromb. Res."},{"issue":"1","key":"10.1016\/j.lfs.2021.119073_bb0030","first-page":"5","article-title":"Efficacy and safety of dabigatran in prevention of venous throbmoembolism in patients undergoing major orthopedic surgeries: a review","volume":"5","author":"Narayanan Varsha","year":"2019","journal-title":"Int. J. Res. Orthopaedics"},{"issue":"6","key":"10.1016\/j.lfs.2021.119073_bb0035","first-page":"e704","article-title":"Efficacy of plasma rich in growth factor used for dry socket management: a systematic review","volume":"24","author":"Xu","year":"2019","journal-title":"Med. Oral Patol. Oral Cir. Bucal."},{"issue":"15","key":"10.1016\/j.lfs.2021.119073_bb0040","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1182\/blood-2012-08-447458","article-title":"A novel role for factor VIII and thrombin\/PAR1 in regulating hematopoiesis and its interplay with the bone structure","volume":"122","author":"Aronovich","year":"2013","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.lfs.2021.119073_bb0045","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0031-6997(24)01493-5","article-title":"Proteinase-activated receptors","volume":"53","author":"Macfarlane","year":"2001","journal-title":"Pharmacol. Rev."},{"issue":"1","key":"10.1016\/j.lfs.2021.119073_bb0050","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1023\/A:1002869310180","article-title":"Thrombin as a regulator of inflammation and reparative processes in tissues","volume":"66","author":"Strukova","year":"2001","journal-title":"Biochemistry-Moscow"},{"issue":"3","key":"10.1016\/j.lfs.2021.119073_bb0055","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/BF01122457","article-title":"Thrombin, a stimulator of bone resorption","volume":"3","author":"Gustafson","year":"1983","journal-title":"Biosci. Rep."},{"issue":"8","key":"10.1016\/j.lfs.2021.119073_bb0060","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1359\/jbmr.1999.14.8.1320","article-title":"Modulation of osteoblast-like cell behavior by activation of protease-activated receptor-1","volume":"14","author":"Abraham","year":"1999","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.lfs.2021.119073_bb0065","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.biocel.2004.04.026","article-title":"Studies on the receptors mediating responses of osteoblasts to thrombin","volume":"37","author":"Song","year":"2005","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"4","key":"10.1016\/j.lfs.2021.119073_bb0070","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1358\/dot.2006.42.4.953588","article-title":"Argatroban: a direct thrombin inhibitor with reliable and predictable anticoagulant actions","volume":"42","author":"Escolar","year":"2006","journal-title":"Drugs Today (Barc)"},{"issue":"3","key":"10.1016\/j.lfs.2021.119073_bb0075","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/STROKEAHA.113.004488","article-title":"Direct thrombin inhibitor Argatroban reduces stroke damage in 2 different models","volume":"45","author":"Lyden","year":"2014","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.lfs.2021.119073_bb0080","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1161\/CIRCULATIONAHA.112.091918","article-title":"Suppression of arterial thrombosis without affecting hemostatic parameters with a cell-penetrating PAR1 Pepducin","volume":"126","author":"Zhang","year":"2012","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.lfs.2021.119073_bb0085","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s12282-012-0334-5","article-title":"The thrombin inhibitor, argatroban, inhibits breast cancer metastasis to bone","volume":"20","author":"Asanuma","year":"2013","journal-title":"Breast Cancer"},{"issue":"6","key":"10.1016\/j.lfs.2021.119073_bb0090","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/joim.12368","article-title":"The WNT system: background and its role in bone","volume":"277","author":"Lerner","year":"2015","journal-title":"J. Intern. Med."},{"issue":"7","key":"10.1016\/j.lfs.2021.119073_bb0095","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1016\/j.biomaterials.2013.11.061","article-title":"Postnatal epithelium and mesenchyme stem\/progenitor cells in bioengineered amelogenesis and dentinogenesis","volume":"35","author":"Jiang","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.lfs.2021.119073_bb0100","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.thromres.2019.12.014","article-title":"Inhibitory effects of dabigatran etexilate, a direct thrombin inhibitor, on osteoclasts and osteoblasts","volume":"186","author":"Rocha","year":"2020","journal-title":"Thromb. Res."},{"issue":"2","key":"10.1016\/j.lfs.2021.119073_bb0105","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.3074","article-title":"WNT signaling in bone homeostasis and disease: from human mutations to treatments","volume":"19","author":"Baron","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.lfs.2021.119073_bb0110","doi-asserted-by":"crossref","first-page":"d741","DOI":"10.1136\/bmj.d741","article-title":"Old drugs, new tricks","volume":"342","author":"Shaughnessy","year":"2011","journal-title":"BMJ"},{"issue":"2","key":"10.1016\/j.lfs.2021.119073_bb0115","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.devcel.2010.07.010","article-title":"Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels","volume":"19","author":"Maes","year":"2010","journal-title":"Dev. Cell"},{"issue":"4","key":"10.1016\/j.lfs.2021.119073_bb0120","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/jre.12439","article-title":"Antibiotic administration alleviates the aggravating effect of orthodontic force on ligature-induced experimental periodontitis bone loss in mice","volume":"52","author":"Shi","year":"2017","journal-title":"J. Periodontal Res."},{"issue":"5","key":"10.1016\/j.lfs.2021.119073_bb0125","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.bone.2008.12.031","article-title":"Thrombin-stimulated growth factor and cytokine expression in osteoblasts is mediated by protease-activated receptor-1 and prostanoids","volume":"44","author":"Pagel","year":"2009","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.lfs.2021.119073_bb0130","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","article-title":"Wnt\/beta-catenin signaling: components, mechanisms, and diseases","volume":"17","author":"MacDonald","year":"2009","journal-title":"Dev. Cell"},{"issue":"39","key":"10.1016\/j.lfs.2021.119073_bb0135","doi-asserted-by":"crossref","first-page":"33132","DOI":"10.1074\/jbc.M500608200","article-title":"Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression","volume":"280","author":"Gaur","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"15","key":"10.1016\/j.lfs.2021.119073_bb0140","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/S0960-894X(01)00351-1","article-title":"A short synthesis of argatroban. A potent selective thrombin inhibitor","volume":"11","author":"Cossy","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"6","key":"10.1016\/j.lfs.2021.119073_bb0145","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1182\/blood.V92.6.2064","article-title":"No effect of clot age or thrombolysis on argatroban\u2019s inhibition of thrombin","volume":"92","author":"Hantgan","year":"1998","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.lfs.2021.119073_bb0150","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/S0003-4975(02)03373-8","article-title":"Therapeutic angiogenesis induced by local autologous bone marrow cell implantation","volume":"73","author":"Hamano","year":"2002","journal-title":"Ann. Thorac. Surg."},{"issue":"5","key":"10.1016\/j.lfs.2021.119073_bb0155","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1054\/ijom.2002.0244","article-title":"Bone growth factors in maxillofacial skeletal reconstruction","volume":"31","author":"Schilephake","year":"2002","journal-title":"Int. J. Oral Maxillofac. Surg."},{"issue":"7","key":"10.1016\/j.lfs.2021.119073_bb0160","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1302\/0301-620X.90B7.20235","article-title":"The effect of the platelet concentration in platelet-rich plasma gel on the regeneration of bone","volume":"90","author":"Kawasumi","year":"2008","journal-title":"J. Bone Joint Surg. (Br.)"},{"issue":"12","key":"10.1016\/j.lfs.2021.119073_bb0165","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/S0024-3205(00)01036-5","article-title":"Adenosine enhances glial glutamate efflux via A2a adenosine receptors","volume":"68","author":"Li","year":"2001","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.lfs.2021.119073_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2014.12.1202","article-title":"A bell-shaped dose-dependent induction of allergen-specific tetramer+CD4 T cells and activated lung ILC2s following Epicutaneous allergen sensitization in HLA-DR4 transgenic mice","volume":"135","author":"Rudulier","year":"2015","journal-title":"J. Allergy Clin. Immunol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521000588?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521000588?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T17:45:19Z","timestamp":1772732719000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320521000588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":34,"alternative-id":["S0024320521000588"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119073","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thrombin inhibitor argatroban modulates bone marrow stromal cells behaviors and promotes osteogenesis through canonical Wnt signaling","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119073","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"119073"}}