{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:45:07Z","timestamp":1790675107892,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:00:00Z","timestamp":1612483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.lfs.2021.119151","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T12:36:04Z","timestamp":1612269364000},"page":"119151","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Identification of key genes and immune profile in limited cutaneous systemic sclerosis-associated pulmonary arterial hypertension by bioinformatics analysis"],"prefix":"10.1016","volume":"271","author":[{"given":"Tiange","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiting","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaofeng","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10103","key":"10.1016\/j.lfs.2021.119151_bb0005","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/S0140-6736(17)30933-9","article-title":"Systemic sclerosis","volume":"390","author":"Denton","year":"2017","journal-title":"Lancet."},{"issue":"11","key":"10.1016\/j.lfs.2021.119151_bb0010","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1002\/art.38098","article-title":"2013 classification criteria for systemic sclerosis: an American College of Rheumatology\/European League against Rheumatism collaborative initiative","volume":"65","author":"van den Hoogen","year":"2013","journal-title":"Arthritis Rheum."},{"issue":"6","key":"10.1016\/j.lfs.2021.119151_bb0015","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1093\/rheumatology\/ker269","article-title":"Trends in mortality in patients with systemic sclerosis over 40 years: a systematic review and meta-analysis of cohort studies","volume":"51","author":"Elhai","year":"2012","journal-title":"Rheumatology (Oxford)"},{"issue":"2","key":"10.1016\/j.lfs.2021.119151_bb0020","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.berh.2018.08.005","article-title":"Update on the epidemiology, risk factors, and disease outcomes of systemic sclerosis","volume":"32","author":"Ingegnoli","year":"2018","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.lfs.2021.119151_bb0025","doi-asserted-by":"crossref","unstructured":"Condliffe R, Howard LS. Connective tissue disease-associated pulmonary arterial hypertension. F1000Prime Rep. 2015;7:06.","DOI":"10.12703\/P7-06"},{"issue":"6","key":"10.1016\/j.lfs.2021.119151_bb0030","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1378\/chest.10-0260","article-title":"Characterization of connective tissue disease-associated pulmonary arterial hypertension from REVEAL: identifying systemic sclerosis as a unique phenotype","volume":"138","author":"Chung","year":"2010","journal-title":"Chest."},{"issue":"9","key":"10.1016\/j.lfs.2021.119151_bb0035","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1002\/art.38029","article-title":"Survival and prognostic factors in systemic sclerosis-associated pulmonary hypertension: a systematic review and meta-analysis","volume":"65","author":"Lefevre","year":"2013","journal-title":"Arthritis Rheum."},{"issue":"12","key":"10.1016\/j.lfs.2021.119151_bb0040","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1164\/rccm.200909-1331PP","article-title":"Systemic sclerosis-associated pulmonary arterial hypertension","volume":"181","author":"Le Pavec","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"9630","key":"10.1016\/j.lfs.2021.119151_bb0045","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1016\/S0140-6736(08)60919-8","article-title":"Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trial","volume":"371","author":"Galie","year":"2008","journal-title":"Lancet."},{"issue":"7","key":"10.1016\/j.lfs.2021.119151_bb0050","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1080\/1744666X.2019.1614915","article-title":"Pathophysiology of systemic sclerosis: current understanding and new insights","volume":"15","author":"Cutolo","year":"2019","journal-title":"Expert. Rev. Clin. Immunol."},{"issue":"12","key":"10.1016\/j.lfs.2021.119151_bb0055","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1093\/abbs\/gmx095","article-title":"Immune cells and autoantibodies in pulmonary arterial hypertension","volume":"49","author":"Li","year":"2017","journal-title":"Acta Biochim. Biophys. Sin. Shanghai"},{"issue":"6","key":"10.1016\/j.lfs.2021.119151_bb0060","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1002\/art.38390","article-title":"Prediction of pulmonary complications and long-term survival in systemic sclerosis","volume":"66","author":"Nihtyanova","year":"2014","journal-title":"Arthritis Rheumatol."},{"issue":"11","key":"10.1016\/j.lfs.2021.119151_bb0065","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1002\/1529-0131(200011)43:11<2550::AID-ANR24>3.0.CO;2-H","article-title":"Endothelial cell apoptosis in systemic sclerosis is induced by antibody-dependent cell-mediated cytotoxicity via CD95","volume":"43","author":"Sgonc","year":"2000","journal-title":"Arthritis Rheum."},{"issue":"6","key":"10.1016\/j.lfs.2021.119151_bb0070","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.humpath.2006.11.022","article-title":"Fibrous remodeling of the pulmonary venous system in pulmonary arterial hypertension associated with connective tissue diseases","volume":"38","author":"Dorfmuller","year":"2007","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.lfs.2021.119151_bb0075","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2147\/OARRR.S228234","article-title":"Pulmonary arterial hypertension in systemic sclerosis: challenges in diagnosis","volume":"11","author":"Saygin","year":"2019","journal-title":"screening and treatment. Open Access Rheumatol."},{"issue":"4","key":"10.1016\/j.lfs.2021.119151_bb0080","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/rheumatology\/40.4.453","article-title":"Pulmonary hypertension in systemic sclerosis: risk factors for progression and consequences for survival","volume":"40","author":"MacGregor","year":"2001","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.lfs.2021.119151_bb0085","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinformatics."},{"issue":"7","key":"10.1016\/j.lfs.2021.119151_bb0090","doi-asserted-by":"crossref","first-page":"1902880","DOI":"10.1002\/advs.201902880","article-title":"ImmuCellAI: a unique method for comprehensive T-cell subsets abundance prediction and its application in cancer immunotherapy","volume":"7","author":"Miao","year":"2020","journal-title":"Adv Sci (Weinh)."},{"issue":"5","key":"10.1016\/j.lfs.2021.119151_bb0095","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS."},{"issue":"8","key":"10.1016\/j.lfs.2021.119151_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012106","article-title":"Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury","volume":"5","author":"Pendergrass","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2021.119151_bb0105","doi-asserted-by":"crossref","first-page":"816","DOI":"10.3389\/fgene.2020.00816","article-title":"Identification and validation of key genes associated with systemic sclerosis-related pulmonary hypertension","volume":"11","author":"Zheng","year":"2020","journal-title":"Front. Genet."},{"key":"10.1016\/j.lfs.2021.119151_bb0110","doi-asserted-by":"crossref","unstructured":"Marsh LM, Jandl K, Grunig G, et al. The inflammatory cell landscape in the lungs of patients with idiopathic pulmonary arterial hypertension. Eur Respir J. 2018;51(1).","DOI":"10.1183\/13993003.01214-2017"},{"issue":"6","key":"10.1016\/j.lfs.2021.119151_bb0115","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1165\/rcmb.2007-0368OC","article-title":"Human herpesvirus-8 infection of primary pulmonary microvascular endothelial cells","volume":"39","author":"Bull","year":"2008","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.lfs.2021.119151_bb0120","unstructured":"Yong WC, Upala S, Sanguankeo A. Helicobacter pylori infection in systemic sclerosis: a systematic review and meta-analysis of observational studies. Clin Exp Rheumatol. 2018;36 Suppl 113(4):168\u201374."},{"issue":"6","key":"10.1016\/j.lfs.2021.119151_bb0125","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1097\/00002281-200211000-00011","article-title":"The role of infectious agents in the pathogenesis of systemic sclerosis","volume":"14","author":"Hamamdzic","year":"2002","journal-title":"Curr. Opin. Rheumatol."},{"issue":"6","key":"10.1016\/j.lfs.2021.119151_bb0130","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1183\/09031936.05.00045705","article-title":"Autoimmunity and pulmonary hypertension: a perspective","volume":"26","author":"Nicolls","year":"2005","journal-title":"Eur. Respir. J."},{"issue":"5","key":"10.1016\/j.lfs.2021.119151_bb0135","first-page":"497","article-title":"Anti-endothelial cell antibodies in connective tissue diseases associated with pulmonary arterial hypertension","volume":"6","author":"Liu","year":"2014","journal-title":"J Thorac Dis."},{"issue":"6","key":"10.1016\/j.lfs.2021.119151_bb0140","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1097\/01.bor.0000179945.73518.28","article-title":"B lymphocytes and systemic sclerosis","volume":"17","author":"Fujimoto","year":"2005","journal-title":"Curr. Opin. Rheumatol."},{"issue":"2","key":"10.1016\/j.lfs.2021.119151_bb0145","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1183\/13993003.01523-2015","article-title":"CD133+ cells in pulmonary arterial hypertension","volume":"48","author":"Foris","year":"2016","journal-title":"Eur. Respir. J."},{"issue":"2","key":"10.1016\/j.lfs.2021.119151_bb0150","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1440-1843.2006.00821.x","article-title":"Increased plasma monocyte chemoattractant protein-1 level in idiopathic pulmonary arterial hypertension","volume":"11","author":"Itoh","year":"2006","journal-title":"Respirology."},{"issue":"2","key":"10.1016\/j.lfs.2021.119151_bb0155","doi-asserted-by":"crossref","first-page":"L292","DOI":"10.1152\/ajplung.00120.2016","article-title":"Leukotriene B4 mediates macrophage influx and pulmonary hypertension in bleomycin-induced chronic neonatal lung injury","volume":"311","author":"Ee","year":"2016","journal-title":"Am J Physiol Lung Cell Mol Physiol."},{"issue":"8","key":"10.1016\/j.lfs.2021.119151_bb0160","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1164\/rccm.201008-1303OC","article-title":"A central role for CD68(+) macrophages in hepatopulmonary syndrome. Reversal by macrophage depletion","volume":"183","author":"Thenappan","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"8","key":"10.1016\/j.lfs.2021.119151_bb0165","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1111\/resp.12152","article-title":"Professional killer cell deficiencies and decreased survival in pulmonary arterial hypertension","volume":"18","author":"Edwards","year":"2013","journal-title":"Respirology."},{"issue":"5","key":"10.1016\/j.lfs.2021.119151_bb0170","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1165\/rcmb.2009-0152OC","article-title":"Innate immunity in the therapeutic actions of endothelial progenitor cells in pulmonary hypertension","volume":"43","author":"Ormiston","year":"2010","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"6","key":"10.1016\/j.lfs.2021.119151_bb0175","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/ni.2035","article-title":"T cell exhaustion","volume":"12","author":"Wherry","year":"2011","journal-title":"Nat. Immunol."},{"issue":"10","key":"10.1016\/j.lfs.2021.119151_bb0180","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/nri3044","article-title":"NK cell development, homeostasis and function: parallels with CD8(+) T cells","volume":"11","author":"Sun","year":"2011","journal-title":"Nat Rev Immunol."},{"key":"10.1016\/j.lfs.2021.119151_bb0185","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.imlet.2017.11.003","article-title":"Dendritic cells in systemic sclerosis: advances from human and mice studies","volume":"195","author":"Affandi","year":"2018","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.lfs.2021.119151_bb0190","doi-asserted-by":"crossref","unstructured":"Ah Kioon MD, Tripodo C, Fernandez D, et al. Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8. Sci Transl Med. 2018;10(423).","DOI":"10.1126\/scitranslmed.aam8458"},{"key":"10.1016\/j.lfs.2021.119151_bb0195","doi-asserted-by":"crossref","unstructured":"Kafaja S, Valera I, Divekar AA, et al. pDCs in lung and skin fibrosis in a bleomycin-induced model and patients with systemic sclerosis. JCI Insight. 2018;3(9).","DOI":"10.1172\/jci.insight.98380"},{"key":"10.1016\/j.lfs.2021.119151_bb0200","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fimmu.2019.00011","article-title":"Dendritic cell subsets and effector function in idiopathic and connective tissue disease-associated pulmonary arterial hypertension","volume":"10","author":"van Uden","year":"2019","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.lfs.2021.119151_bb0205","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s10875-009-9322-8","article-title":"Impairment of monocyte-derived dendritic cells in idiopathic pulmonary arterial hypertension","volume":"29","author":"Wang","year":"2009","journal-title":"J. Clin. Immunol."},{"issue":"2","key":"10.1016\/j.lfs.2021.119151_bb0210","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.yexmp.2013.06.003","article-title":"Active systemic lupus erythematosus is associated with decreased blood conventional dendritic cells","volume":"95","author":"Khan","year":"2013","journal-title":"Exp. Mol. Pathol."},{"issue":"11","key":"10.1016\/j.lfs.2021.119151_bb0215","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/ni.3298","article-title":"The burgeoning family of unconventional T cells","volume":"16","author":"Godfrey","year":"2015","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.lfs.2021.119151_bb0220","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/sji.12585","article-title":"Mucosal-associated invariant cells are deficient in systemic sclerosis","volume":"86","author":"Mekinian","year":"2017","journal-title":"Scand. J. Immunol."},{"issue":"1","key":"10.1016\/j.lfs.2021.119151_bb0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/imm.12582","article-title":"Mucosal-associated invariant T cells in autoimmunity, immune-mediated diseases and airways disease","volume":"148","author":"Hinks","year":"2016","journal-title":"Immunology."},{"issue":"4","key":"10.1016\/j.lfs.2021.119151_bb0230","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/sj.gene.6364189","article-title":"Association of interferon gamma and interleukin 10 genes with tuberculosis in Hong Kong Chinese","volume":"6","author":"Tso","year":"2005","journal-title":"Genes Immun."},{"issue":"6","key":"10.1016\/j.lfs.2021.119151_bb0235","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.4049\/jimmunol.1500262","article-title":"Defective NK cells in acute myeloid leukemia patients at diagnosis are associated with blast transcriptional signatures of immune evasion","volume":"195","author":"Khaznadar","year":"2015","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.lfs.2021.119151_bb0240","doi-asserted-by":"crossref","first-page":"418","DOI":"10.4049\/jimmunol.1401978","article-title":"Granzyme B-activated p53 interacts with Bcl-2 to promote cytotoxic lymphocyte-mediated apoptosis","volume":"194","author":"Ben Safta","year":"2015","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.lfs.2021.119151_bb0245","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.4049\/jimmunol.169.4.1705","article-title":"TCR\/CD3 down-modulation and zeta degradation are regulated by ZAP-70","volume":"169","author":"Dumont","year":"2002","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.lfs.2021.119151_bb0250","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.clim.2008.11.011","article-title":"Synovial B cells of rheumatoid arthritis express ZAP-70 which increases the survival and correlates with the inflammatory and autoimmune phenotype","volume":"131","author":"Tolusso","year":"2009","journal-title":"Clin. Immunol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521001363?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521001363?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:42:30Z","timestamp":1758400950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320521001363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":50,"alternative-id":["S0024320521001363"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119151","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of key genes and immune profile in limited cutaneous systemic sclerosis-associated pulmonary arterial hypertension by bioinformatics analysis","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119151","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"119151"}}