{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T21:59:13Z","timestamp":1766181553704,"version":"build-2065373602"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"vor","delay-in-days":323,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005285","name":"FAPEG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005285","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.lfs.2021.119198","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T13:06:06Z","timestamp":1612875966000},"page":"119198","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Testosterone exposure in prenatal life disrupts epithelial nuclear morphology, smooth muscle layer pattern, and FGF10 and Shh expression in prostate"],"prefix":"10.1016","volume":"271","author":[{"given":"Luana Ara\u00fajo","family":"Manso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara Costa Malmann","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna Amaral","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordana Gomes","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara R\u00fabia","family":"Marques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebasti\u00e3o Roberto","family":"Taboga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Cristina Alcantara","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoel Francisco","family":"Biancardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2021.119198_bb0005","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.ecl.2011.05.003","article-title":"The critical role of androgens in prostate development","volume":"40","author":"Wilson","year":"2011","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"10.1016\/j.lfs.2021.119198_bb0010","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1242\/dev.148270","article-title":"Prostate organogenesis: tissue induction, hormonal regulation and cell type specification","volume":"144","author":"Toivanen","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.lfs.2021.119198_bb0015","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1749-6632.2009.04360.x","article-title":"The dual, opposing roles of estrogen in the prostate","volume":"1155","author":"Ellem","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.lfs.2021.119198_bb0020","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/j.1939-4640.2004.tb02796.x","article-title":"Estrogenic regulation of signaling pathways and homeobox genes during rat prostate development","volume":"25","author":"Huang","year":"2004","journal-title":"J. Androl."},{"key":"10.1016\/j.lfs.2021.119198_bb0025","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1432-0436.2008.00278.x","article-title":"Prostate development: a historical perspective","volume":"76","author":"Timms","year":"2008","journal-title":"Differentiation"},{"key":"10.1016\/j.lfs.2021.119198_bb0030","doi-asserted-by":"crossref","first-page":"7180","DOI":"10.1038\/onc.2008.327","article-title":"Androgen-induced programs for epithelial growth and invasion arise in embryogenesis and are reactivated in cancer","volume":"27","author":"Schaeffer","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.lfs.2021.119198_bb0035","doi-asserted-by":"crossref","first-page":"7014","DOI":"10.1073\/pnas.0502544102","article-title":"Estrogenic chemicals in plastic and oral contraceptives disrupt development of the fetal mouse prostate and urethra","volume":"102","author":"Timms","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2021.119198_bb0040","doi-asserted-by":"crossref","unstructured":"D.A.O. Rodr\u00edguez, R.F. de Lima, M.S. Campos, J.R. Costa, M.F. Biancardi, M.R. Marques, S.R. Taboga, F.C.A. Santos, Intrauterine exposure to bisphenol A promotes different effects in both neonatal and adult prostate of male and female gerbils (Meriones unguiculatus), Environ. Toxicol. 31 (2016) 1740\u20131750. doi:https:\/\/doi.org\/10.1002\/tox.22176.","DOI":"10.1002\/tox.22176"},{"key":"10.1016\/j.lfs.2021.119198_bb0045","doi-asserted-by":"crossref","unstructured":"A.P. Perez, M.F. Biancardi, C.R. Caires, L.R. Falleiros J\u00fanior, R.M. G\u00f3es, F.C. Santos, S.R. Taboga, Pubertal exposure to ethinylestradiol promotes different effects on the morphology of the prostate of the male and female gebril during aging, Environ. Toxicol. 32 (2017) 477\u2013489. doi:https:\/\/doi.org\/10.1002\/tox.22252.","DOI":"10.1002\/tox.22252"},{"key":"10.1016\/j.lfs.2021.119198_bb0050","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1258\/ebm.2012.012051","article-title":"Prenatal testosterone exposure as a model for the study of endocrine-disrupting chemicals on the gerbil prostate","volume":"237","author":"Biancardi","year":"2012","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.lfs.2021.119198_bb0055","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1071\/RD13387","article-title":"Prenatal exposure to testosterone masculinises the female gerbil and promotes the development of lesions in the prostate (Skene\u2019s gland)","volume":"27","author":"Biancardi","year":"2015","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.lfs.2021.119198_bb0060","doi-asserted-by":"crossref","unstructured":"M.F. Biancardi, A.P. Perez, C.R. Caires, L.R. Falleiros, R.M. G\u00f3es, P.S. Vilamaior, D.R. Freitas, F.C. Santos, S.R. Taboga, Prenatal and pubertal testosterone exposure imprint permanent modifications in the prostate that predispose to the development of lesions in old Mongolian gerbils, Asian. J. Androl. 19 (2017) 160\u2013167. doi:https:\/\/doi.org\/10.4103\/1008-682X.170436.","DOI":"10.4103\/1008-682X.170436"},{"key":"10.1016\/j.lfs.2021.119198_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2020.104473","article-title":"Developmental changes induced by exogenous testosterone during early phases of prostate organogenesis","volume":"115","author":"Ramos","year":"2020","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.lfs.2021.119198_bb0070","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/j.1432-0436.2008.00277.x","article-title":"Molecular signaling pathways that regulate prostate gland development","volume":"76","author":"Prins","year":"2008","journal-title":"Differentiation"},{"key":"10.1016\/j.lfs.2021.119198_bb0075","doi-asserted-by":"crossref","unstructured":"J.L. Winters, P.H. Chapman, D.E. Powell, E.R. Banks, W.R. Allen, D.P. Wood Jr, Female Pseudohermaphroditism due to congenital adrenal hyperplasia complicated by adenocarcinoma of the prostate and clear cell carcinoma of the endometrium, Am. J. Clin. Pathol. 106 (1996)660\u2013664. doi:https:\/\/doi.org\/10.1093\/ajcp\/106.5.660.","DOI":"10.1093\/ajcp\/106.5.660"},{"key":"10.1016\/j.lfs.2021.119198_bb0080","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1080\/02841850500270449","article-title":"Complex genital malformation in a female with congenital adrenal hyperplasia: evaluation with magnetic resonance imaging","volume":"46","author":"Klessen","year":"2005","journal-title":"Acta Radiol."},{"key":"10.1016\/j.lfs.2021.119198_bb0085","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/humupd\/dmi013","article-title":"Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome?","volume":"11","author":"Abbott","year":"2005","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.lfs.2021.119198_bb0090","doi-asserted-by":"crossref","unstructured":"K. Sathishkumar, R. Elkins, V. Chinnathambi, H. Gao, G.D.V. Hankins, C. Yallampalli, Prenatal testosterone-induced fetal growth restriction is associated with down-regulation of rat placental amino acid transport, Reprod. Biol. Endrocrinol. 9 (2011).110. doi:https:\/\/doi.org\/10.1186\/1477-7827-9-110.","DOI":"10.1186\/1477-7827-9-110"},{"key":"10.1016\/j.lfs.2021.119198_bb0095","doi-asserted-by":"crossref","unstructured":"S. Kumar, G.H. Gordon, D.H. Abbott, J.S. Mishra, Androgens in maternal vascular and placental function: implications for preeclampsia pathogenesis, Reproduction 156 (2018) R155-R167. doi:https:\/\/doi.org\/10.1530\/REP-18-0278.","DOI":"10.1530\/REP-18-0278"},{"key":"10.1016\/j.lfs.2021.119198_bb0100","doi-asserted-by":"crossref","unstructured":"C.J. Wolf, A. Hotchkiss, J.S. Ostby, G.A. LeBlanc, L.E. Gray Jr, Effects of prenatal testosterone propionate on the sexual development of male and female rats: a dose-response study. Toxicol. Sci. 65 (2002) 71\u201386. doi:https:\/\/doi.org\/10.1093\/toxsci\/65.1.71.","DOI":"10.1093\/toxsci\/65.1.71"},{"key":"10.1016\/j.lfs.2021.119198_bb0105","doi-asserted-by":"crossref","unstructured":"A.K. Hotchkiss, C.S. Lambright, J.S. Ostby, L. Parks-Saldutti, J.G. Vandenbergh, L.E. Gray Jr, Prenatal testosterone exposure permanently masculinizes anogenital distance, nipple development, and reproductive tract morphology in female Sprague-Dawley rats, Toxicol. Sci. 96 (2007) 335\u2013345. doi:https:\/\/doi.org\/10.1093\/toxsci\/kfm002.","DOI":"10.1093\/toxsci\/kfm002"},{"key":"10.1016\/j.lfs.2021.119198_bb0110","doi-asserted-by":"crossref","unstructured":"C.F. Heyns, P.D. Rimington, T.F. Kurger, V.G. Falck, Benign prostatic hyperplasia and uterine leiomyomas in a female pseudohermaphrodite: a case report, J. Urol. 137 (1987)1245\u20131247. doi:https:\/\/doi.org\/10.1016\/s0022-5347(17)44470-3.","DOI":"10.1016\/S0022-5347(17)44470-3"},{"key":"10.1016\/j.lfs.2021.119198_bb0115","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1158\/0008-5472.CAN-07-6817","article-title":"Conserved gene expression programs integrate mammalian prostate development and tumorigenesis","volume":"69","author":"Pritchard","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2021.119198_bb0120","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0012-1606(03)00250-1","article-title":"FGF-10 plays an essential role in the growth of the fetal prostate","volume":"261","author":"Donjacour","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.lfs.2021.119198_bb0125","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1006\/dbio.1999.9229","article-title":"Prostate development requires sonic hedgehog expressed by the urogenital sinus epithelium","volume":"209","author":"Podlasek","year":"1999","journal-title":"Dev. Biol."},{"issue":"7","key":"10.1016\/j.lfs.2021.119198_bb0130","doi-asserted-by":"crossref","first-page":"4867","DOI":"10.1242\/dev.124.23.4867","article-title":"Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung","volume":"124","author":"Bellusci","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.lfs.2021.119198_bb0135","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ydbio.2004.11.020","article-title":"The role of Fgf10 signaling in branching morphogenesis and gene expression of the rat prostate gland: lobe-specific suppression by neonatal estrogens","volume":"278","author":"Huang","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.lfs.2021.119198_bb0140","doi-asserted-by":"crossref","unstructured":"A.A. Thomson, , B.G. Timms, L. Barton, G.R. Cunha, O.C. Grace, The role of smooth muscle in regulating prostatic induction, Development 129 (2002) 1905\u20131912.","DOI":"10.1242\/dev.129.8.1905"},{"key":"10.1016\/j.lfs.2021.119198_bb0145","doi-asserted-by":"crossref","unstructured":"F.C.A. Santos, R.P. Leite, A.M.G. Cust\u00f3dio, K.P. Carvalho, L.H. Monteiro-Leal, A.B. Santos, R.M. G\u00f3es, H.F. Carvalho, S.R. Taboga, Testosterone stimulates growth and secretory activity of the adult female prostate of the gerbil (Meriones unguiculatus), Biol. Reprod. 75 (2006) 370\u2013379. doi:https:\/\/doi.org\/10.1095\/biolreprod.106.051789.","DOI":"10.1095\/biolreprod.106.051789"},{"key":"10.1016\/j.lfs.2021.119198_bb0150","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.lfs.2013.02.005","article-title":"Progesterone restores the female prostate activity in ovariectomized gerbil and may act as competitor of testosterone in intraprostatic environment","volume":"92","author":"Shinohara","year":"2013","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2021.119198_bb0155","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1002\/cbin.10759","article-title":"Female prostate: historical, developmental, and morphological perspectives","volume":"41","author":"Biancardi","year":"2017","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.lfs.2021.119198_bb0160","first-page":"383","article-title":"Histological observation on the female prostate in Mongolian gerbils (Meriones unguiculatus)","volume":"41","author":"Inomata","year":"1992","journal-title":"Jikken Dobutsu"},{"key":"10.1016\/j.lfs.2021.119198_bb0165","doi-asserted-by":"crossref","unstructured":"B.D.A. Sanches, M.F. Biancardi, F.C.A. Santos, R.M. G\u00f3es, P.S.L. Vilamaior, S.R. Taboga, Budding process during the organogenesis of the ventral prostatic lobe in Mongolina gerbil, Microsc. Res. Tech. 77 (2014) 458\u201366. doi:https:\/\/doi.org\/10.1002\/jemt.22370.","DOI":"10.1002\/jemt.22370"},{"key":"10.1016\/j.lfs.2021.119198_bb0170","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.lfs.2021.119198_bb0175","first-page":"15","article-title":"Nuclear phenotypes and morphometry of human secretory prostate cells: a comparative study of benign and malignant lesions in Brazilian patients","volume":"3","author":"Taboga","year":"2003","journal-title":"Caryologia"},{"key":"10.1016\/j.lfs.2021.119198_bb0180","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/aja.2011.148","article-title":"Nuclear morphometry, nucleomics and prostate cancer progression","volume":"14","author":"Veltri","year":"2012","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.lfs.2021.119198_bb0185","doi-asserted-by":"crossref","unstructured":"A.A. Thomson, G.R. Cunha, Prostatic growth and development are regulated by FGF10, Development 126 (1999) 3693\u2013701.","DOI":"10.1242\/dev.126.16.3693"},{"key":"10.1016\/j.lfs.2021.119198_bb0190","doi-asserted-by":"crossref","unstructured":"W. Lu, Y. Luo, M. Kan, W.L. McKeehan, Fibroblast growth factor-10: a second candidate stromal to epithelial cell andromedin in prostate, J. Biol. Chem. 274 (1999) 12827\u201312834. doi:https:\/\/doi.org\/10.1074\/jbc.274.18.12827.","DOI":"10.1074\/jbc.274.18.12827"},{"key":"10.1016\/j.lfs.2021.119198_bb0195","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1742-7843.2007.00166.x","article-title":"Perinatal exposure to oestradiol and bisphenol A alters the prostate epigenome and increases susceptibility to carcinogenesis","volume":"102","author":"Prins","year":"2008","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.lfs.2021.119198_bb0200","doi-asserted-by":"crossref","first-page":"12542","DOI":"10.1073\/pnas.0901647106","article-title":"De novo synthesis of estrogen in pregnant uterus is critical for stromal decidualization and angiogenesis","volume":"106","author":"Das","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2021.119198_bb0205","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.steroids.2011.10.013","article-title":"Tissue physiology and pathology of aromatase","volume":"77","author":"Stocco","year":"2012","journal-title":"Steroids"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521001831?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521001831?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:47:19Z","timestamp":1758401239000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320521001831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":41,"alternative-id":["S0024320521001831"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119198","relation":{},"ISSN":["0024-3205"],"issn-type":[{"type":"print","value":"0024-3205"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Testosterone exposure in prenatal life disrupts epithelial nuclear morphology, smooth muscle layer pattern, and FGF10 and Shh expression in prostate","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119198","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"119198"}}