{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:44:19Z","timestamp":1785552259697,"version":"3.56.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Guangxi Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.lfs.2021.119332","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T16:30:17Z","timestamp":1615307417000},"page":"119332","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Talin1 regulates endometrial adhesive capacity through the Ras signaling pathway"],"prefix":"10.1016","volume":"274","author":[{"given":"Saiqiong","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengbin","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2021.119332_bb0005","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.rbmo.2013.08.011","article-title":"Recurrent implantation failure: definition and management","volume":"28","author":"Coughlan","year":"2014","journal-title":"Reprod. BioMed. Online"},{"issue":"5","key":"10.1016\/j.lfs.2021.119332_bb0010","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40738-019-0059-7","article-title":"15 years of transcriptomic analysis on endometrial receptivity: what have we learnt?","volume":"5","author":"Messaoudi","year":"2019","journal-title":"Fertil. Res. Pract."},{"key":"10.1016\/j.lfs.2021.119332_bb0015","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/GCO.0000000000000173","article-title":"Understanding and improving endometrial receptivity","volume":"27","author":"Miravet-Valenciano","year":"2015","journal-title":"Curr. Opin. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.lfs.2021.119332_bb0020","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/ijgo.13160","article-title":"Low-dose aspirin improves endometrial receptivity in the midluteal phase in unexplained recurrent pregnancy loss","volume":"150","author":"Wang","year":"2020","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"10.1016\/j.lfs.2021.119332_bb0025","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3389\/fcell.2020.00105","article-title":"Loss of CDYL results in suppression of CTNNB1 and decreased endometrial receptivity","volume":"8","author":"Zhou","year":"2020","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.lfs.2021.119332_bb0030","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1530\/JOE-10-0461","article-title":"Bridging endometrial receptivity and implantation: network of hormones, cytokines, and growth factors","volume":"210","author":"Singh","year":"2011","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.lfs.2021.119332_bb0035","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1210\/er.2003-0020","article-title":"Molecular cues to implantation","author":"Dey","year":"2004","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.lfs.2021.119332_bb0040","series-title":"Pyrrolotriazolopyrimidine Derivatives, Pharmaceutical Compositions Containing Them and Methods of Treating Conditions and Diseases Mediated by the Adenosine A2A Receptor Activity","author":"Moorman","year":"2010"},{"key":"10.1016\/j.lfs.2021.119332_bb0045","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0015-0282(16)57422-6","article-title":"Integrins as markers of uterine receptivity in women with primary unexplained infertility","volume":"63","author":"Lessey","year":"1995","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.lfs.2021.119332_bb0050","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1023\/A:1021254620888","article-title":"Reduced expression of \u03b1v\u03b23 integrin in the endometrium of unexplained infertility patients with recurrent IVF-ET failures: improvement by Danazol treatment","volume":"20","author":"Tei","year":"2003","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.lfs.2021.119332_bb0055","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1095\/biolreprod66.2.297","article-title":"Elevated endometrial androgen receptor expression in women with polycystic ovarian syndrome","volume":"66","author":"Apparao and B. C. K","year":"2002","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.lfs.2021.119332_bb0060","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/S0015-0282(03)00792-1","article-title":"Endometrial integrin expression in women undergoing in vitro fertilization and the association with subsequent treatment outcome","volume":"80","author":"Thomas","year":"2003","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.lfs.2021.119332_bb0065","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.fertnstert.2004.11.008","article-title":"Heparanase improves mouse embryo implantation","volume":"83","author":"Revel","year":"2005","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.lfs.2021.119332_bb0070","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3109\/09513590.2015.1130811","article-title":"Increased expression of Talin1 in the eutopic and ectopic endometria of women with adenomyosis","volume":"32","author":"Jiang","year":"2016","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.lfs.2021.119332_bb0075","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1126\/science.1086652","article-title":"Talin binding to integrin beta tails: a final common step in integrin activation","volume":"302","author":"Tadokoro","year":"2003","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.lfs.2021.119332_bb0080","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1038\/onc.2014.116","article-title":"Talin1 phosphorylation activates \u03b21 integrins: a novel mechanism to promote prostate cancer bone metastasis","volume":"34","author":"Jin","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.lfs.2021.119332_bb0085","first-page":"3265","article-title":"Talin1, a valuable marker for diagnosis and prognostic assessment of human Hepatocelluar carcinomas","volume":"12","author":"Zhang","year":"2011","journal-title":"Asian Pacific J. Cancer Prev. Apjcp"},{"key":"10.1016\/j.lfs.2021.119332_bb0090","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/01.pai.0000194762.78889.26","article-title":"The cytoskeletal proteins alpha-actinin, ezrin, and talin are de-expressed in endometriosis and endometrioid carcinoma compared with normal uterine epithelium","volume":"15","author":"Slater","year":"2007","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"issue":"Suppl. 1","key":"10.1016\/j.lfs.2021.119332_bb0095","article-title":"PO-12 - the key role of talin-1 in cancer cell extravasation dissected through human vascularized 3D microfluidic model","volume":"140","author":"Gilardi","year":"2016","journal-title":"Thromb. Res."},{"key":"10.1016\/j.lfs.2021.119332_bb0100","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/cas.13247","article-title":"Downregulation of Talin1 promotes hepatocellular carcinoma progression through activation of the ERK1\/2 pathway","volume":"108","author":"Chen","year":"2017","journal-title":"Cancer Sci."},{"key":"10.1016\/j.lfs.2021.119332_bb0105","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1158\/2159-8274.CD-11-0010","article-title":"Ovarian cancer spheroids use myosin-generated force to clear the mesothelium","volume":"1","author":"Iwanicki","year":"2011","journal-title":"Cancer Discov."},{"key":"10.1016\/j.lfs.2021.119332_bb0110","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.fertnstert.2016.09.016","article-title":"HOXA-10 and E-cadherin expression in the endometrium of women with recurrent implantation failure and recurrent miscarriage","volume":"107","author":"Yang","year":"2017","journal-title":"Fertil. Steril."},{"issue":"2","key":"10.1016\/j.lfs.2021.119332_bb0115","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.repbio.2020.02.006","article-title":"Talin1 regulates the endometrial epithelial cell adhesive capacity by interacting with LASP1 and Vitronectin","volume":"20","author":"Li","year":"2020","journal-title":"Reprod. Biol."},{"key":"10.1016\/j.lfs.2021.119332_bb0120","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.lfs.2021.119332_bb0125","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"Bmc Bioinforma."},{"issue":"6","key":"10.1016\/j.lfs.2021.119332_bb0130","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/cbf.3550","article-title":"CDC20 inhibitor Apcin inhibits embryo implantation in vivo and in vitro","volume":"38","author":"Guo","year":"2020","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.lfs.2021.119332_bb0135","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1101\/gad.998402","article-title":"C. elegans EOR-1\/PLZF and EOR-2 positively regulate Ras and Wnt signaling and function redundantly with LIN-25 and the SUR-2 mediator component","volume":"16","author":"Howard","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.lfs.2021.119332_bb0140","series-title":"Syndecan-1 Suppresses Cell Growth and Migration Via Blocking JAK1\/STAT3 and Ras\/Raf\/MEK\/ERK Pathways in Human Colorectal Carcinoma Cells","first-page":"1160","volume":"vol. 19","author":"Wang","year":"2019"},{"key":"10.1016\/j.lfs.2021.119332_bb0145","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/354191","article-title":"RAS\/RAF\/MEK\/ERK and PI3K\/PTEN\/AKT signaling in malignant melanoma progression and therapy","volume":"2012","author":"Yajima","year":"2012","journal-title":"Dermatol. Res. Pract."},{"key":"10.1016\/j.lfs.2021.119332_bb0150","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nrc2109","article-title":"Hyperactive Ras in developmental disorders and cancer","volume":"7","author":"Schubbert","year":"2007","journal-title":"Nat. Rev. Cancer"},{"issue":"Suppl. 1","key":"10.1016\/j.lfs.2021.119332_bb0155","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1600-0897.2011.01048.x","article-title":"Endometrial receptivity and human embryo implantation","volume":"66","author":"Rashid","year":"2011","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.lfs.2021.119332_bb0160","article-title":"Loss of ITGB3 in ovine conceptuses decreases conceptus expression of NOS3 and SPP1: implications for the developing placental vasculature\u2020","volume":"24","author":"Frank","year":"2020","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.lfs.2021.119332_bb0165","doi-asserted-by":"crossref","first-page":"9145","DOI":"10.1002\/jcp.26852","article-title":"Endometrial pinopode biomarkers: Molecules and microRNAs","volume":"233","author":"Rarani","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.lfs.2021.119332_bb0170","first-page":"683","article-title":"Cell adhesion molecules and in vitro fertilization","volume":"28","author":"Simopoulou","year":"2014","journal-title":"In vivo (Athens, Greece)"},{"key":"10.1016\/j.lfs.2021.119332_bb0175","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/humrep\/dey365","article-title":"Rab11a drives adhesion molecules to the surface of endometrial epithelial cells","volume":"34","author":"Kakar-Bhanot","year":"2019","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.lfs.2021.119332_bb0180","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1080\/09513590.2020.1727433","article-title":"Assessment of endometrial receptivity during implantation window in women with unexplained infertility","volume":"36","author":"Wang","year":"2020","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.lfs.2021.119332_bb0185","first-page":"5408","article-title":"Talin1 knockdown prohibits the proliferation and migration of colorectal cancer cells via the EMT signaling pathway","volume":"18","author":"Ji","year":"2019","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.lfs.2021.119332_bb0190","doi-asserted-by":"crossref","first-page":"13003","DOI":"10.18632\/oncotarget.14674","article-title":"Talin-1 interaction network promotes hepatocellular carcinoma progression","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"issue":"70","key":"10.1016\/j.lfs.2021.119332_bb0195","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1158\/0008-5472.CAN-09-2833","article-title":"Talin1 promotes tumor invasion and metastasis via focal adhesion signaling and anoikis resistance","volume":"1","author":"Sakamoto","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2021.119332_bb0200","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/1097-0177(2000)9999:9999<::AID-DVDY1079>3.0.CO;2-Y","article-title":"Disruption of the talin gene arrests mouse development at the gastrulation stage","volume":"219","author":"Monkley","year":"2000","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.lfs.2021.119332_bb0205","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1128\/MCB.01403-10","article-title":"Talin1 regulates integrin turnover to promote embryonic epithelial morphogenesis","volume":"31","author":"Liu","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.lfs.2021.119332_bb0210","doi-asserted-by":"crossref","first-page":"885","DOI":"10.2217\/fon.10.71","article-title":"Salirasib in the treatment of pancreatic cancer","volume":"6","author":"Bustinza-Linares","year":"2010","journal-title":"Future Oncol."},{"key":"10.1016\/j.lfs.2021.119332_bb0215","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1161\/CIRCRESAHA.110.230888","article-title":"The Ras activator RasGRP3 mediates diabetes-induced embryonic defects and affects endothelial cell migration","volume":"108","author":"Randhawa","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2021.119332_bb0220","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.modgep.2005.12.007","article-title":"Expression analysis of the Epha1 receptor tyrosine kinase and its high-affinity ligands Efna1 and Efna3 during early mouse development","volume":"6","author":"Duffy","year":"2006","journal-title":"Gene Expr. Patterns"},{"key":"10.1016\/j.lfs.2021.119332_bb0225","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.placenta.2008.12.015","article-title":"LAT-1 expression in pre- and post-implantation embryos and placenta","volume":"30","author":"Chrostowski","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.lfs.2021.119332_bb0230","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1093\/humrep\/der027","article-title":"Human chorionic gonadotrophin regulates FGF2 and other cytokines produced by human endometrial epithelial cells, providing a mechanism for enhancing endometrial receptivity","volume":"26","author":"Paiva","year":"2011","journal-title":"Hum. Reprod."},{"issue":"4","key":"10.1016\/j.lfs.2021.119332_bb0235","doi-asserted-by":"crossref","first-page":"474","DOI":"10.3109\/0284186X.2015.1073350","article-title":"Prognostic significance of PLA2G4C gene polymorphism in patients with stage II colorectal cancer","volume":"55","author":"Renate","year":"2016","journal-title":"Acta Oncol."},{"key":"10.1016\/j.lfs.2021.119332_bb0240","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/1476-4598-9-256","article-title":"Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition","volume":"9","author":"Charette","year":"2010","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.lfs.2021.119332_bb0245","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1210\/en.2017-00103","article-title":"Tissue-specific ablation of the LIF receptor in the murine uterine epithelium results in implantation failure","volume":"158","author":"Cheng","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.lfs.2021.119332_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/7201562","article-title":"IGHG1 regulates prostate Cancer growth via the MEK\/ERK\/c-Myc pathway","volume":"2019","author":"Chu","year":"2019","journal-title":"Biomed. Res. Int."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521003179?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521003179?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:45:30Z","timestamp":1758401130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320521003179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":50,"alternative-id":["S0024320521003179"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119332","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Talin1 regulates endometrial adhesive capacity through the Ras signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119332","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"119332"}}