{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:07:39Z","timestamp":1786993659995,"version":"build-2736575974"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970237"],"award-info":[{"award-number":["81970237"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600227"],"award-info":[{"award-number":["81600227"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.lfs.2021.119366","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:21:48Z","timestamp":1616026908000},"page":"119366","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":93,"special_numbering":"C","title":["The m6A methyltransferase METTL3 promotes hypoxic pulmonary arterial hypertension"],"prefix":"10.1016","volume":"274","author":[{"given":"Yuhan","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erfei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyu","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengchun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoliang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.lfs.2021.119366_bb0005","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1073\/pnas.71.10.3971","article-title":"Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells","volume":"71","author":"Desrosiers","year":"1974","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6458","key":"10.1016\/j.lfs.2021.119366_bb0010","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1126\/science.aax4468","article-title":"Methyladenosine RNA modification-mediated cellular metabolism rewiring inhibits viral replication","volume":"365","author":"Liu","year":"2019","journal-title":"Science (New York, N.Y.)"},{"issue":"2","key":"10.1016\/j.lfs.2021.119366_bb0015","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nchembio.1432","article-title":"A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation","volume":"10","author":"Liu","year":"2014","journal-title":"Nat. Chem. Biol."},{"issue":"12","key":"10.1016\/j.lfs.2021.119366_bb0020","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nchembio.687","article-title":"N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO","volume":"7","author":"Jia","year":"2011","journal-title":"Nat. Chem. Biol."},{"issue":"1","key":"10.1016\/j.lfs.2021.119366_bb0025","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/nar\/gku1276","article-title":"Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5","volume":"43","author":"Huang","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.lfs.2021.119366_bb0030","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13045-020-00872-8","article-title":"m(6)A-binding proteins: the emerging crucial performers in epigenetics","volume":"13","author":"Zhao","year":"2020","journal-title":"J. Hematol. Oncol."},{"issue":"4","key":"10.1016\/j.lfs.2021.119366_bb0035","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1161\/CIRCULATIONAHA.118.036146","article-title":"The N(6)-methyladenosine mRNA methylase METTL3 controls cardiac homeostasis and hypertrophy","volume":"139","author":"Dorn","year":"2019","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.lfs.2021.119366_bb0040","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1080\/15548627.2019.1586246","article-title":"METTL3 and ALKBH5 oppositely regulate m(6)A modification of TFEB mRNA, which dictates the fate of hypoxia\/reoxygenation-treated cardiomyocytes","volume":"15","author":"Song","year":"2019","journal-title":"Autophagy"},{"issue":"24","key":"10.1016\/j.lfs.2021.119366_bb0045","doi-asserted-by":"crossref","first-page":"797","DOI":"10.21037\/atm.2019.12.65","article-title":"Increased m6A methylation level is associated with the progression of human abdominal aortic aneurysm","volume":"7","author":"He","year":"2019","journal-title":"Ann Transl Med"},{"issue":"3","key":"10.1016\/j.lfs.2021.119366_bb0050","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S2213-2600(15)00517-2","article-title":"Hypoxic pulmonary hypertension in chronic lung diseases: novel vasoconstrictor pathways","volume":"4","author":"Rowan","year":"2016","journal-title":"Lancet Respir. Med."},{"issue":"10","key":"10.1016\/j.lfs.2021.119366_bb0055","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1056\/NEJMoa1203830","article-title":"Pulmonary arterial enlargement and acute exacerbations of COPD","volume":"367","author":"Wells","year":"2012","journal-title":"NEJM"},{"issue":"3","key":"10.1016\/j.lfs.2021.119366_bb0060","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1164\/rccm.201901-0148LE","article-title":"New definition of pulmonary hypertension in patients with heart failure with preserved ejection fraction","volume":"200","author":"Nishihara","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.lfs.2021.119366_bb0065","doi-asserted-by":"crossref","unstructured":"Morrell NW, Adnot S, Archer SL, Dupuis J, Jones PL, MacLean MR, McMurtry IF, Stenmark KR, Thistlethwaite PA, Weissmann N, Yuan JXJ, Weir EK (2009) Cellular and molecular basis of pulmonary arterial hypertension. J. Am. Coll. Cardiol. 54 (1 Suppl):S20-S31. doi:https:\/\/doi.org\/10.1016\/j.jacc.2009.04.018.","DOI":"10.1016\/j.jacc.2009.04.018"},{"key":"10.1016\/j.lfs.2021.119366_bb0070","doi-asserted-by":"crossref","unstructured":"Osaki M, Oshimura M, Ito H (2004) PI3K-Akt pathway: its functions and alterations in human cancer. Apoptosis: An International Journal on Programmed Cell Death 9 (6):667\u2013676.","DOI":"10.1023\/B:APPT.0000045801.15585.dd"},{"key":"10.1016\/j.lfs.2021.119366_bb0075","doi-asserted-by":"crossref","unstructured":"Xing X-Q, Li B, Xu S-L, Zhang C-F, Liu J, Deng Y-S, Yang J (2019) 5-Aza-2\u2032-deoxycytidine, a DNA methylation inhibitor, attenuates hypoxic pulmonary hypertension via demethylation of the PTEN promoter. Eur. J. Pharmacol. 855:227\u2013234. doi:https:\/\/doi.org\/10.1016\/j.ejphar.2019.05.021.","DOI":"10.1016\/j.ejphar.2019.05.021"},{"issue":"3","key":"10.1016\/j.lfs.2021.119366_bb0080","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000188","article-title":"Selective inactivation of PTEN in smooth muscle cells synergizes with hypoxia to induce severe pulmonary hypertension","volume":"2","author":"Horita","year":"2013","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.lfs.2021.119366_bb0085","doi-asserted-by":"crossref","unstructured":"Thenappan T, Ormiston ML, Ryan JJ, Archer SL (2018) Pulmonary arterial hypertension: pathogenesis and clinical management. Br. Med. J. 360:j5492. doi:https:\/\/doi.org\/10.1136\/bmj.j5492.","DOI":"10.1136\/bmj.j5492"},{"key":"10.1016\/j.lfs.2021.119366_bb0090","doi-asserted-by":"crossref","unstructured":"Wang X, Zhao BS, Roundtree IA, Lu Z, Han D, Ma H, Weng X, Chen K, Shi H, He C (2015) N(6)-methyladenosine modulates messenger RNA translation efficiency. Cell 161 (6):1388\u20131399. doi:https:\/\/doi.org\/10.1016\/j.cell.2015.05.014.","DOI":"10.1016\/j.cell.2015.05.014"},{"key":"10.1016\/j.lfs.2021.119366_bb0095","unstructured":"Yan G, Hu S, Wang Q, Wang D, Wang J, Qiao Y, Tang C, Ma G, Gu Y (2014) Effects of early digoxin treatment on hypoxia-induced pulmonary artery hypertension. Zhong Hua Yi Xue Za Zhi 94 (2):139\u2013143."},{"issue":"3","key":"10.1016\/j.lfs.2021.119366_bb0100","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1016\/j.bbrc.2017.11.185","article-title":"Down-regulation of lncRNA MEG3 promotes hypoxia-induced human pulmonary artery smooth muscle cell proliferation and migration via repressing PTEN by sponging miR-21","volume":"495","author":"Zhu","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.lfs.2021.119366_bb0105","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41556-018-0045-z","article-title":"Recognition of RNA N-methyladenosine by IGF2BP proteins enhances mRNA stability and translation","volume":"20","author":"Huang","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.lfs.2021.119366_bb0110","doi-asserted-by":"crossref","unstructured":"Liu T, Yang S, Sui J, Xu S-Y, Cheng Y-P, Shen B, Zhang Y, Zhang X-M, Yin L-H, Pu Y-P, Liang G-Y (2020) Dysregulated N6-methyladenosine methylation writer METTL3 contributes to the proliferation and migration of gastric cancer. J. Cell. Physiol. 235 (1):548\u2013562. doi:https:\/\/doi.org\/10.1002\/jcp.28994.","DOI":"10.1002\/jcp.28994"},{"key":"10.1016\/j.lfs.2021.119366_bb0115","doi-asserted-by":"crossref","unstructured":"Zhu S, Wang JZ, Chen, He YT, Meng N, Chen M, Lu RX, Chen XH, Zhang XL, Yan GR (2020) An oncopeptide regulates m(6)A recognition by the m(6)A reader IGF2BP1 and tumorigenesis. Nat. Commun. 11 (1):1685. doi:https:\/\/doi.org\/10.1038\/s41467-020-15403-9.","DOI":"10.1038\/s41467-020-15403-9"},{"issue":"10","key":"10.1016\/j.lfs.2021.119366_bb0120","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1093\/nar\/gkw104","article-title":"SRAMP: prediction of mammalian N6-methyladenosine (m6A) sites based on sequence-derived features","volume":"44","author":"Zhou","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.lfs.2021.119366_bb0125","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.cell.2008.04.013","article-title":"Tenets of PTEN tumor suppression","volume":"133","author":"Salmena","year":"2008","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.lfs.2021.119366_bb0130","doi-asserted-by":"crossref","first-page":"14636","DOI":"10.1002\/jcb.28725","article-title":"Promotion of PTEN on apoptosis through PI3K\/Akt signal in vascular smooth muscle cells of mice model of coronary heart disease","volume":"120","author":"Wang","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.lfs.2021.119366_bb0135","doi-asserted-by":"crossref","unstructured":"Barnes H, Brown Z, Burns A, Williams T (2019) Phosphodiesterase 5 inhibitors for pulmonary hypertension. Cochrane Database Syst. Rev. 1 (1):CD012621. doi:https:\/\/doi.org\/10.1002\/14651858.CD012621.pub2.","DOI":"10.1002\/14651858.CD012621.pub2"},{"key":"10.1016\/j.lfs.2021.119366_bb0140","doi-asserted-by":"crossref","unstructured":"Seeger W, Adir Y, Barber\u00e0 JA, Champion H, Coghlan JG, Cottin V, De Marco T, Gali\u00e8 N, Ghio S, Gibbs S, Martinez FJ, Semigran MJ, Simonneau G, Wells AU, Vachi\u00e9ry J-L (2013) Pulmonary hypertension in chronic lung diseases. J. Am. Coll. Cardiol. 62 (25 Suppl):D109-D116. doi:https:\/\/doi.org\/10.1016\/j.jacc.2013.10.036.","DOI":"10.1016\/j.jacc.2013.10.036"},{"issue":"3","key":"10.1016\/j.lfs.2021.119366_bb0145","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/cvr\/cvy250","article-title":"Long noncoding RNA Hoxaas3 contributes to hypoxia-induced pulmonary artery smooth muscle cell proliferation","volume":"115","author":"Zhang","year":"2019","journal-title":"Cardiovasc. Res."},{"issue":"5","key":"10.1016\/j.lfs.2021.119366_bb0150","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1093\/cvr\/cvx030","article-title":"The rise of epitranscriptomic era: implications for cardiovascular disease","volume":"113","author":"Stellos","year":"2017","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.lfs.2021.119366_bb0155","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-020-01172-y","article-title":"The emerging roles of N6-methyladenosine (m6A) deregulation in liver carcinogenesis","volume":"19","author":"Chen","year":"2020","journal-title":"Mol. Cancer"},{"issue":"11","key":"10.1016\/j.lfs.2021.119366_bb0160","doi-asserted-by":"crossref","first-page":"6251","DOI":"10.1093\/nar\/gkaa347","article-title":"Dynamic landscape and evolution of m6A methylation in human","volume":"48","author":"Zhang","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.lfs.2021.119366_bb0165","doi-asserted-by":"crossref","unstructured":"Liu N, Pan T (2015) RNA epigenetics. Translational Research: The Journal of Laboratory and Clinical Medicine 165 (1):28\u201335. doi:https:\/\/doi.org\/10.1016\/j.trsl.2014.04.003.","DOI":"10.1016\/j.trsl.2014.04.003"},{"issue":"1","key":"10.1016\/j.lfs.2021.119366_bb0170","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-019-1065-4","article-title":"METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer","volume":"18","author":"Yue","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.lfs.2021.119366_bb0175","doi-asserted-by":"crossref","unstructured":"Weng H, Huang H, Wu H, Qin X, Zhao BS, Dong L, Shi H, Skibbe J, Shen C, Hu C, Sheng Y, Wang Y, Wunderlich M, Zhang B, Dore LC, Su R, Deng X, Ferchen K, Li C, Sun M, Lu Z, Jiang X, Marcucci G, Mulloy JC, Yang J, Qian Z, Wei M, He C, Chen J (2018) METTL14 inhibits hematopoietic stem\/progenitor differentiation and promotes leukemogenesis via mRNA m(6)A modification. Cell Stem Cell 22 (2):191\u2013205 e199. doi:https:\/\/doi.org\/10.1016\/j.stem.2017.11.016.","DOI":"10.1016\/j.stem.2017.11.016"},{"issue":"2","key":"10.1016\/j.lfs.2021.119366_bb0180","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.molcel.2016.05.041","article-title":"Structural basis for cooperative function of Mettl3 and Mettl14 methyltransferases","volume":"63","author":"Wang","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.lfs.2021.119366_bb0185","first-page":"405","article-title":"Epigenetic regulation of m(6)A modifications in human cancer","volume":"19","author":"Zhao","year":"2020","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.lfs.2021.119366_bb0190","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-019-1065-4","article-title":"METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer","volume":"18","author":"Yue","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.lfs.2021.119366_bb0195","doi-asserted-by":"crossref","unstructured":"Lin S, Choe J, Du P, Triboulet R, Gregory RI (2016) The m(6)A methyltransferase METTL3 promotes translation in human cancer cells. Mol. Cell 62 (3):335\u2013345. doi:https:\/\/doi.org\/10.1016\/j.molcel.2016.03.021.","DOI":"10.1016\/j.molcel.2016.03.021"},{"issue":"7724","key":"10.1016\/j.lfs.2021.119366_bb0200","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41586-018-0538-8","article-title":"mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis","volume":"561","author":"Choe","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2021.119366_bb0205","doi-asserted-by":"crossref","unstructured":"Lin J, Zhu Q, Huang J, Cai R, Kuang Y (2020) Hypoxia promotes vascular smooth muscle cell (VSMC) differentiation of adipose-derived stem cell (ADSC) by regulating Mettl3 and paracrine factors. Stem Cells Int. 2020:2830565. doi:https:\/\/doi.org\/10.1155\/2020\/2830565.","DOI":"10.1155\/2020\/2830565"},{"key":"10.1016\/j.lfs.2021.119366_bb0210","unstructured":"Liu S, Zhuo L, Wang J, Zhang Q, Li Q, Li G, Yan L, Jin T, Pan T, Sui X, Lv Q, Xie T (2020) METTL3 plays multiple functions in biological processes. Am. J. Cancer Res. 10 (6):1631\u20131646."},{"issue":"8","key":"10.1016\/j.lfs.2021.119366_bb0215","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nrcardio.2011.87","article-title":"Mechanisms of disease: pulmonary arterial hypertension","volume":"8","author":"Schermuly","year":"2011","journal-title":"Nat. Rev. Cardiol."},{"issue":"14","key":"10.1016\/j.lfs.2021.119366_bb0220","doi-asserted-by":"crossref","first-page":"E2047","DOI":"10.1073\/pnas.1602883113","article-title":"Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m(6)A-demethylation of NANOG mRNA","volume":"113","author":"Zhang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.lfs.2021.119366_bb0225","doi-asserted-by":"crossref","first-page":"8482","DOI":"10.1111\/jcmm.14738","article-title":"Thymoquinone suppresses platelet-derived growth factor-BB-induced vascular smooth muscle cell proliferation, migration and neointimal formation","volume":"23","author":"Zhu","year":"2019","journal-title":"J. Cell. Mol. Med."},{"issue":"2","key":"10.1016\/j.lfs.2021.119366_bb0230","doi-asserted-by":"crossref","first-page":"L208","DOI":"10.1152\/ajplung.00242.2014","article-title":"Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension","volume":"308","author":"Tang","year":"2015","journal-title":"American Journal of Physiology Lung Cellular and Molecular Physiology"},{"key":"10.1016\/j.lfs.2021.119366_bb0235","doi-asserted-by":"crossref","unstructured":"Kim G-W, Imam H, Khan M, Mir SA, Kim S-J, Yoon SK, Hur W, Siddiqui A (2020) HBV-induced increased N6 methyladenosine modification of PTEN RNA affects innate immunity and contributes to HCC. Hepatology (Baltimore, Md). doi:https:\/\/doi.org\/10.1002\/hep.31313.","DOI":"10.1002\/hep.31313"},{"issue":"4","key":"10.1016\/j.lfs.2021.119366_bb0240","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.bbrc.2019.11.016","article-title":"LncRNA LINC00470 promotes the degradation of PTEN mRNA to facilitate malignant behavior in gastric cancer cells","volume":"521","author":"Yan","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.lfs.2021.119366_bb0245","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nrg3724","article-title":"Gene expression regulation mediated through reversible m6A RNA methylation","volume":"15","author":"Fu","year":"2014","journal-title":"Nat. Rev. Genet."},{"issue":"4","key":"10.1016\/j.lfs.2021.119366_bb0250","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000664","article-title":"YTHDF2 promotes mitotic entry and is regulated by cell cycle mediators","volume":"18","author":"Fei","year":"2020","journal-title":"PLoS Biol."},{"issue":"1","key":"10.1016\/j.lfs.2021.119366_bb0255","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-020-01158-w","article-title":"RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner","volume":"19","author":"Guo","year":"2020","journal-title":"Mol. Cancer"},{"issue":"5","key":"10.1016\/j.lfs.2021.119366_bb0260","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00418-020-01847-z","article-title":"MiR-145 alleviates Hcy-induced VSMC proliferation, migration, and phenotypic switch through repression of the PI3K\/Akt\/mTOR pathway","volume":"153","author":"Zhang","year":"2020","journal-title":"Histochem. Cell Biol."}],"updated-by":[{"DOI":"10.1016\/j.lfs.2023.121937","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000}}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521003519?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521003519?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:47:46Z","timestamp":1758401266000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320521003519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":52,"alternative-id":["S0024320521003519"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119366","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The m6A methyltransferase METTL3 promotes hypoxic pulmonary arterial hypertension","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119366","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"119366"}}