{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:29:57Z","timestamp":1793039397179,"version":"4.5.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.lfs.2021.119370","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:22:08Z","timestamp":1616026928000},"page":"119370","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Mechanistic insights into the protective effects of chlorogenic acid against indomethacin-induced gastric ulcer in rats: Modulation of the cross talk between autophagy and apoptosis signaling"],"prefix":"10.1016","volume":"275","author":[{"given":"Maha A.E.","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa","family":"Mohanad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amany A.E.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basma E.","family":"Aboulhoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally A.","family":"El-Awdan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.lfs.2021.119370_bb0005","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.apsb.2014.05.001","article-title":"Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats","volume":"4","author":"Boligon","year":"2014","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.lfs.2021.119370_bb0010","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/546560","article-title":"Black tea and theaflavins assist healing of indomethacin-induced gastric ulceration in mice by antioxidative action","volume":"2011","author":"Adhikary","year":"2011","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"2","key":"10.1016\/j.lfs.2021.119370_bb0015","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/head.12769","article-title":"The pharmacology of indomethacin","volume":"56","author":"Lucas","year":"2016","journal-title":"Headache"},{"issue":"4","key":"10.1016\/j.lfs.2021.119370_bb0020","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s10753-009-9176-5","article-title":"Different mechanisms in formation and prevention of indomethacin-induced gastric ulcers","volume":"33","author":"Suleyman","year":"2010","journal-title":"Inflammation"},{"issue":"18","key":"10.1016\/j.lfs.2021.119370_bb0025","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.3748\/wjg.v18.i18.2147","article-title":"Pathogenesis of NSAID-induced gastric damage: importance of cyclooxygenase inhibition and gastric hypermotility","volume":"18","author":"Takeuchi","year":"2012","journal-title":"World J. Gastroenterol."},{"issue":"6","key":"10.1016\/j.lfs.2021.119370_bb0030","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/iep.12370","article-title":"Indomethacin can induce cell death in rat gastric parietal cells through alteration of some apoptosis- and autophagy-associated molecules","volume":"101","author":"Gebril","year":"2020","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.lfs.2021.119370_bb0035","series-title":"Phenolic contents of Gleditsia triacanthos leaves and evaluation of its analgesic, anti-inflammatory, hepatoprotective and antimicrobial activities","author":"Mohamed","year":"2013"},{"issue":"3","key":"10.1016\/j.lfs.2021.119370_bb0040","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3109\/08923973.2015.1021357","article-title":"Attenuating effects of coenzyme Q10 and amlodipine in ulcerative colitis model in rats","volume":"37","author":"El Morsy","year":"2015","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.lfs.2021.119370_bb0045","doi-asserted-by":"crossref","unstructured":"Athaydes BR, Alves GM, Assis A, et al. Avocado seeds (Persea americana Mill.) prevents indomethacin-induced gastric ulcer in mice. Food research international (Ottawa, Ont). May 2019;119:751\u2013760. doi:https:\/\/doi.org\/10.1016\/j.foodres.2018.10.057.","DOI":"10.1016\/j.foodres.2018.10.057"},{"key":"10.1016\/j.lfs.2021.119370_bb0050","doi-asserted-by":"crossref","first-page":"109181","DOI":"10.1016\/j.cbi.2020.109181","article-title":"Carvedilol attenuates l-arginine induced acute pancreatitis in rats through modulation of oxidative stress and inflammatory mediators","volume":"327","author":"El Morsy","year":"2020","journal-title":"Chem. Biol. Interact."},{"issue":"3","key":"10.1016\/j.lfs.2021.119370_bb0055","article-title":"Gastroprotective and cicatrizing activity of the Ziziphus joazeiro Mart. leaf hydroalcoholic extract","volume":"71","author":"Brito","year":"2020","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.lfs.2021.119370_bb0060","doi-asserted-by":"crossref","unstructured":"de Oliveira DR, Quintans-Junior LJ, de Albuquerque TR, et al. Gastroprotective activity of hydroalcoholic extract of the Stryphnodendron rotundifolium Mart. In mice: mechanism actions assay. Letters in Drug Design & Discovery. 2018;15(3):316\u2013324.","DOI":"10.2174\/1570180814666170213154951"},{"issue":"3","key":"10.1016\/j.lfs.2021.119370_bb0065","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2174\/1570180814666170213160114","article-title":"Antimicrobial, gastroprotective and healing effect of the hydroalcoholic extract of Astronium fraxinifolium","volume":"15","author":"Brito Pereira Bezerra Martins","year":"2018","journal-title":"Letters in Drug Design & Discovery"},{"issue":"3","key":"10.1016\/j.lfs.2021.119370_bb0070","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1089\/jmf.2018.4262","article-title":"Bioactivity of fermented green coffee bean extract containing high chlorogenic acid and surfactin","volume":"22","author":"Kim","year":"2019","journal-title":"J. Med. Food"},{"issue":"1","key":"10.1016\/j.lfs.2021.119370_bb0075","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.foodres.2012.02.023","article-title":"Extraction of coffee antioxidants: impact of brewing time and method","volume":"48","author":"Ludwig","year":"2012","journal-title":"Food Res. Int."},{"issue":"7","key":"10.1016\/j.lfs.2021.119370_bb0080","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1007\/s00394-017-1379-1","article-title":"The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature","volume":"56","author":"Tajik","year":"2017","journal-title":"Eur. J. Nutr."},{"issue":"1","key":"10.1016\/j.lfs.2021.119370_bb0085","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00210-012-0807-2","article-title":"Antiulcerogenic activity of chlorogenic acid in different models of gastric ulcer","volume":"386","author":"Shimoyama","year":"2013","journal-title":"Naunyn Schmiedeberg\u2019s Arch. Pharmacol."},{"issue":"23","key":"10.1016\/j.lfs.2021.119370_bb0090","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202000452","article-title":"Chlorogenic acid suppresses miR-155 and ameliorates ulcerative colitis through the NF-\u03baB\/NLRP3 inflammasome pathway","volume":"64","author":"Zeng","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.lfs.2021.119370_bb0095","doi-asserted-by":"crossref","unstructured":"Ock CY, Park JM, Han YM, et al. Genetic ablation or pharmacologic inhibition of autophagy mitigated NSAID-associated gastric damages. Journal of molecular medicine (Berlin, Germany). Apr 2017;95(4):405\u2013416. doi:https:\/\/doi.org\/10.1007\/s00109-016-1491-3.","DOI":"10.1007\/s00109-016-1491-3"},{"key":"10.1016\/j.lfs.2021.119370_bb0100","doi-asserted-by":"crossref","unstructured":"Gao L, Li X, Meng S, Ma T, Wan L, Xu S. Chlorogenic acid alleviates A\u03b2(25-35)-induced autophagy and cognitive impairment via the mTOR\/TFEB signaling pathway. Drug Des Devel Ther. 2020;14:1705\u20131716. doi:https:\/\/doi.org\/10.2147\/DDDT.S235969.","DOI":"10.2147\/DDDT.S235969"},{"key":"10.1016\/j.lfs.2021.119370_bb0105","doi-asserted-by":"crossref","unstructured":"Yan H, Gao YQ, Zhang Y, Wang H, Liu GS, Lei JY. Chlorogenic acid alleviates autophagy and insulin resistance by suppressing JNK pathway in a rat model of nonalcoholic fatty liver disease. J. Biosci.. Jun 2018;43(2):287\u2013294.","DOI":"10.1007\/s12038-018-9746-5"},{"key":"10.1016\/j.lfs.2021.119370_bb0110","doi-asserted-by":"crossref","unstructured":"Bhandarkar NS, Brown L, Panchal SK. Chlorogenic acid attenuates high-carbohydrate, high-fat diet-induced cardiovascular, liver, and metabolic changes in rats. Nutrition research (New York, NY). Feb 2019;62:78\u201388. doi:https:\/\/doi.org\/10.1016\/j.nutres.2018.11.002.","DOI":"10.1016\/j.nutres.2018.11.002"},{"key":"10.1016\/j.lfs.2021.119370_bb0115","doi-asserted-by":"crossref","unstructured":"Vukeli\u0107 I, Detel D, Pu\u010dar LB, Poto\u010dnjak I, Buljevi\u0107 S, Domitrovi\u0107 R. Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis. Food Chem. Toxicol.. Nov 2018;121:140\u2013150. doi:https:\/\/doi.org\/10.1016\/j.fct.2018.08.061.","DOI":"10.1016\/j.fct.2018.08.061"},{"key":"10.1016\/j.lfs.2021.119370_bb0120","doi-asserted-by":"crossref","unstructured":"Tamaddonfard E, Erfanparast A, Farshid AA, et al. Safranal, a constituent of saffron, exerts gastro-protective effects against indomethacin-induced gastric ulcer. Life Sci.. May 1 2019;224:88\u201394. doi:https:\/\/doi.org\/10.1016\/j.lfs.2019.03.054.","DOI":"10.1016\/j.lfs.2019.03.054"},{"key":"10.1016\/j.lfs.2021.119370_bb0125","doi-asserted-by":"crossref","unstructured":"Dawud F, Mabrouk M, Mohammed A, Umar I. Effect of vitamins C & E on aspirin induced gastric mucosal damage and oxidative stress. 2014.","DOI":"10.19026\/crjbs.6.5495"},{"key":"10.1016\/j.lfs.2021.119370_bb0130","doi-asserted-by":"crossref","unstructured":"Shahin NN, Abdelkader NF, Safar MM. A novel role of irbesartan in gastroprotection against indomethacin-induced gastric injury in rats: targeting DDAH\/ADMA and EGFR\/ERK signaling. Sci. Rep.. Mar 9 2018;8(1):4280. doi:https:\/\/doi.org\/10.1038\/s41598-018-22727-6.","DOI":"10.1038\/s41598-018-22727-6"},{"issue":"3","key":"10.1016\/j.lfs.2021.119370_bb0135","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1080\/01913123.2020.1772429","article-title":"Ultra-structural study of the indomethacin-induced apoptosis and autophagy in rat gastric parietal cells","volume":"44","author":"Gebril","year":"2020","journal-title":"Ultrastruct. Pathol."},{"key":"10.1016\/j.lfs.2021.119370_bb0140","doi-asserted-by":"crossref","unstructured":"Feng FB, Qiu HY. Effects of Artesunate on chondrocyte proliferation, apoptosis and autophagy through the PI3K\/AKT\/mTOR signaling pathway in rat models with rheumatoid arthritis. Biomedicine & Pharmacotherapy. Jun 2018;102:1209\u20131220. doi:https:\/\/doi.org\/10.1016\/j.biopha.2018.03.142.","DOI":"10.1016\/j.biopha.2018.03.142"},{"issue":"6","key":"10.1016\/j.lfs.2021.119370_bb0145","first-page":"5424","article-title":"Ghrelin regulates sepsis-induced rat acute gastric injury","volume":"19","author":"Li","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.lfs.2021.119370_bb0150","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.yexmp.2018.12.006","article-title":"Prognostic significance of circulating tumor cells (CTCs) in Egyptian non-metastatic colorectal cancer patients: a comparative study for four different techniques of detection (Flowcytometry, CellSearch, Quantitative Real-time PCR and Cytomorphology)","volume":"106","author":"Bahnassy","year":"2019","journal-title":"Exp. Mol. Pathol."},{"issue":"12","key":"10.1016\/j.lfs.2021.119370_bb0155","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1016\/j.bbamcr.2013.06.001","article-title":"Crosstalk between apoptosis, necrosis and autophagy","volume":"1833","author":"Nikoletopoulou","year":"2013","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"},{"issue":"3","key":"10.1016\/j.lfs.2021.119370_bb0160","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","article-title":"Methods in mammalian autophagy research","volume":"140","author":"Mizushima","year":"2010","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.lfs.2021.119370_bb0165","doi-asserted-by":"crossref","first-page":"400","DOI":"10.4014\/jmb.1012.12019","article-title":"Curative effect of selenium against indomethacin-induced gastric ulcers in rats","volume":"21","author":"Kim","year":"2011","journal-title":"J. Microbiol. Biotechnol."},{"issue":"1","key":"10.1016\/j.lfs.2021.119370_bb0170","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1038\/s41598-018-21455-1","article-title":"Indomethacin disrupts autophagic flux by inducing lysosomal dysfunction in gastric cancer cells and increases their sensitivity to cytotoxic drugs","volume":"8","author":"Vallecillo-Hern\u00e1ndez","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2021.119370_bb0175","doi-asserted-by":"crossref","unstructured":"Fu X, Tan T, Liu P. Regulation of autophagy by non-steroidal anti-inflammatory drugs in cancer. Cancer Manag. Res.. 2020;12:4595\u20134604. doi:https:\/\/doi.org\/10.2147\/CMAR.S253345.","DOI":"10.2147\/CMAR.S253345"},{"issue":"5","key":"10.1016\/j.lfs.2021.119370_bb0180","doi-asserted-by":"crossref","first-page":"420","DOI":"10.4062\/biomolther.2014.066","article-title":"Protective effects of chlorogenic acid against experimental reflux esophagitis in rats","volume":"22","author":"Kang","year":"2014","journal-title":"Biomol. Ther."},{"key":"10.1016\/j.lfs.2021.119370_bb0185","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6769789","article-title":"Chlorogenic acid attenuates dextran sodium sulfate-induced ulcerative colitis in mice through MAPK\/ERK\/JNK pathway","volume":"2019","author":"Gao","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.lfs.2021.119370_bb0190","doi-asserted-by":"crossref","unstructured":"Lee YC, Cheng CW, Lee HJ, Chu HC. Apple polyphenol suppresses indomethacin-induced gastric damage in experimental animals by lowering oxidative stress status and modulating the MAPK signaling pathway. J Med Food. Nov 2017;20(11):1113\u20131120. doi:https:\/\/doi.org\/10.1089\/jmf.2017.3951.","DOI":"10.1089\/jmf.2017.3951"},{"issue":"10","key":"10.1016\/j.lfs.2021.119370_bb0195","doi-asserted-by":"crossref","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","article-title":"ROS function in redox signaling and oxidative stress","volume":"24","author":"Schieber","year":"2014","journal-title":"Curr. Biol."},{"issue":"1","key":"10.1016\/j.lfs.2021.119370_bb0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10495-007-0154-9","article-title":"Apoptosis and autophagy: regulatory connections between two supposedly different processes","volume":"13","author":"Thorburn","year":"2008","journal-title":"Apoptosis"},{"key":"10.1016\/j.lfs.2021.119370_bb0205","doi-asserted-by":"crossref","unstructured":"Bhardwaj A, Sethi G, Vadhan-Raj S, et al. Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. Blood. Mar 15 2007;109(6):2293\u2013302. doi:https:\/\/doi.org\/10.1182\/blood-2006-02-003988.","DOI":"10.1182\/blood-2006-02-003988"},{"issue":"8","key":"10.1016\/j.lfs.2021.119370_bb0210","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1177\/0960327120909882","article-title":"Protective effects of lycopene on hippocampal neurotoxicity and memory impairment induced by bisphenol A in rats","volume":"39","author":"El Morsy","year":"2020","journal-title":"Human & experimental toxicology"},{"key":"10.1016\/j.lfs.2021.119370_bb0215","doi-asserted-by":"crossref","unstructured":"Wang X, Liu J, Xie Z, et al. Chlorogenic acid inhibits proliferation and induces apoptosis in A498 human kidney cancer cells via inactivating PI3K\/Akt\/mTOR signalling pathway. J. Pharm. Pharmacol.. Jul 2019;71(7):1100\u20131109. doi:https:\/\/doi.org\/10.1111\/jphp.13095.","DOI":"10.1111\/jphp.13095"},{"key":"10.1016\/j.lfs.2021.119370_bb0220","doi-asserted-by":"crossref","DOI":"10.1186\/s40360-019-0336-4","article-title":"Chlorogenic acid protects PC12 cells against corticosterone-induced neurotoxicity related to inhibition of autophagy and apoptosis","volume":"20","author":"Shi","year":"2019","journal-title":"BMC Pharmacology & Toxicology"},{"key":"10.1016\/j.lfs.2021.119370_bb0225","doi-asserted-by":"crossref","first-page":"110672","DOI":"10.1016\/j.fct.2019.110672","article-title":"Phenolic compounds from coffee by-products modulate adipogenesis-related inflammation, mitochondrial dysfunction, and insulin resistance in adipocytes, via insulin\/PI3K\/AKT signaling pathways","volume":"132","author":"Rebollo-Hernanz","year":"2019","journal-title":"Food Chem. Toxicol."},{"issue":"10","key":"10.1016\/j.lfs.2021.119370_bb0230","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.3390\/nu10101366","article-title":"Chlorogenic acid targeting of the AKT PH domain activates AKT\/GSK3\u03b2\/FOXO1 signaling and improves glucose metabolism","volume":"10","author":"Gao","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2021.119370_bb0235","doi-asserted-by":"crossref","unstructured":"Zhao N, Guo Y, Zhang M, Lin L, Zheng Z. Akt-mTOR signaling is involved in Notch-1-mediated glioma cell survival and proliferation. Oncol. Rep.. May 2010;23(5):1443\u20137. doi:https:\/\/doi.org\/10.3892\/or_00000782.","DOI":"10.3892\/or_00000782"},{"issue":"3","key":"10.1016\/j.lfs.2021.119370_bb0240","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.yexmp.2018.09.002","article-title":"MiRNAs as molecular biomarkers in stage II egyptian colorectal cancer patients","volume":"105","author":"Bahnassy","year":"2018","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.lfs.2021.119370_bb0245","doi-asserted-by":"crossref","unstructured":"Ahmed MAE, El Morsy EM, Ahmed AAE. Protective effects of febuxostat against paraquat-induced lung toxicity in rats: impact on RAGE\/PI3K\/Akt pathway and downstream inflammatory cascades. Life Sci.. Mar 15 2019;221:56\u201364. doi:https:\/\/doi.org\/10.1016\/j.lfs.2019.02.007.","DOI":"10.1016\/j.lfs.2019.02.007"},{"issue":"7","key":"10.1016\/j.lfs.2021.119370_bb0250","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.febslet.2010.01.017","article-title":"mTOR regulation of autophagy","volume":"584","author":"Jung","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.lfs.2021.119370_bb0255","doi-asserted-by":"crossref","unstructured":"Xue Z, Guo Y, Zhang S, et al. Beta-asarone attenuates amyloid beta-induced autophagy via Akt\/mTOR pathway in PC12 cells. Eur. J. Pharmacol.. Oct 15 2014;741:195\u2013204. doi:https:\/\/doi.org\/10.1016\/j.ejphar.2014.08.006.","DOI":"10.1016\/j.ejphar.2014.08.006"},{"issue":"4","key":"10.1016\/j.lfs.2021.119370_bb0260","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/cdd.2010.191","article-title":"The Beclin 1 network regulates autophagy and apoptosis","volume":"18","author":"Kang","year":"2011","journal-title":"Cell Death & Differentiation"},{"key":"10.1016\/j.lfs.2021.119370_bb0265","doi-asserted-by":"crossref","unstructured":"Tatti M, Motta M, Di Bartolomeo S, et al. Reduced cathepsins B and D cause impaired autophagic degradation that can be almost completely restored by overexpression of these two proteases in Sap C-deficient fibroblasts. Hum. Mol. Genet.. Dec 1 2012;21(23):5159\u201373. doi:https:\/\/doi.org\/10.1093\/hmg\/dds367.","DOI":"10.1093\/hmg\/dds367"},{"key":"10.1016\/j.lfs.2021.119370_bb0270","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1101\/sqb.2011.76.011023","article-title":"Autophagy in protein and organelle turnover","volume":"76","author":"Mizushima","year":"2011","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/j.lfs.2021.119370_bb0275","doi-asserted-by":"crossref","unstructured":"Kaushik S, Cuervo AM. The coming of age of chaperone-mediated autophagy. Nat. Rev. Mol. Cell Biol.. 2018;19(6):365\u2013381.","DOI":"10.1038\/s41580-018-0001-6"},{"issue":"2","key":"10.1016\/j.lfs.2021.119370_bb0280","doi-asserted-by":"crossref","first-page":"241","DOI":"10.4161\/auto.22557","article-title":"Cathepsin-mediated regulation of autophagy in saposin C deficiency","volume":"9","author":"Tatti","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.lfs.2021.119370_bb0285","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/5296341","article-title":"Autophagy upregulation by the TFEB inducer trehalose protects against oxidative damage and cell death associated with NRF2 inhibition in human RPE cells","volume":"2020","author":"Abokyi","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.lfs.2021.119370_bb0290","doi-asserted-by":"crossref","unstructured":"Bj\u00f8rk\u00f8y G, Lamark T, Brech A, et al. p62\/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J. Cell Biol.. 2005;171(4):603\u2013614. doi:https:\/\/doi.org\/10.1083\/jcb.200507002.","DOI":"10.1083\/jcb.200507002"},{"issue":"11","key":"10.1016\/j.lfs.2021.119370_bb0295","doi-asserted-by":"crossref","DOI":"10.1002\/bies.202000122","article-title":"Monitoring autophagy flux and activity: principles and applications","volume":"42","author":"Ueno","year":"2020","journal-title":"BioEssays"},{"key":"10.1016\/j.lfs.2021.119370_bb0300","doi-asserted-by":"crossref","unstructured":"Moscat J, Diaz-Meco MT. p62 at the crossroads of autophagy, apoptosis, and cancer. Cell. Jun 12 2009;137(6):1001\u20134. doi:https:\/\/doi.org\/10.1016\/j.cell.2009.05.023.","DOI":"10.1016\/j.cell.2009.05.023"},{"issue":"1\u20132","key":"10.1016\/j.lfs.2021.119370_bb0305","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.brainres.2004.03.029","article-title":"Transcriptional activation of p62\/A170\/ZIP during the formation of the aggregates: possible mechanisms and the role in Lewy body formation in Parkinson\u2019s disease","volume":"1012","author":"Nakaso","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.lfs.2021.119370_bb0310","doi-asserted-by":"crossref","unstructured":"Williams A, Jahreiss L, Sarkar S, et al. Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications. Curr. Top. Dev. Biol.. 2006;76:89\u2013101.","DOI":"10.1016\/S0070-2153(06)76003-3"},{"issue":"4","key":"10.1016\/j.lfs.2021.119370_bb0315","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/nrd2272","article-title":"Potential therapeutic applications of autophagy","volume":"6","author":"Rubinsztein","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"issue":"7","key":"10.1016\/j.lfs.2021.119370_bb0320","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nn.2575","article-title":"Autophagy gone awry in neurodegenerative diseases","volume":"13","author":"Wong","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.lfs.2021.119370_bb0325","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/6757368","article-title":"PICK1 deficiency induces autophagy dysfunction via lysosomal impairment and amplifies sepsis-induced acute lung injury","volume":"2018","author":"Mo","year":"2018","journal-title":"Mediat. Inflamm."},{"issue":"3","key":"10.1016\/j.lfs.2021.119370_bb0330","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1681\/ASN.2011070690","article-title":"Inhibition of MTOR disrupts autophagic flux in podocytes","volume":"23","author":"Cin\u00e0","year":"2012","journal-title":"J. Am. Soc. Nephrol."},{"issue":"19","key":"10.1016\/j.lfs.2021.119370_bb0335","doi-asserted-by":"crossref","first-page":"7826","DOI":"10.1073\/pnas.1013800108","article-title":"Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation","volume":"108","author":"Rong","year":"2011","journal-title":"Proc. Natl. Acad. Sci."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521003556?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521003556?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T15:20:33Z","timestamp":1758986433000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320521003556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":67,"alternative-id":["S0024320521003556"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119370","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanistic insights into the protective effects of chlorogenic acid against indomethacin-induced gastric ulcer in rats: Modulation of the cross talk between autophagy and apoptosis signaling","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119370","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"119370"}}