{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T01:02:59Z","timestamp":1788310979505,"version":"build-2803163510"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.lfs.2021.119377","type":"journal-article","created":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T16:26:06Z","timestamp":1616257566000},"page":"119377","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Magnetic-core-based silibinin nanopolymeric carriers for the treatment of renal cell cancer"],"prefix":"10.1016","volume":"275","author":[{"given":"Anjali","family":"Takke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravin","family":"Shende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2021.119377_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers12020521","article-title":"The labyrinth of renal cell carcinoma","volume":"12","author":"Manini","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.lfs.2021.119377_bb0010","article-title":"Nanotechnology enters the renal cancer drug delivery arena: a review","volume":"4","author":"Sharon","year":"2018","journal-title":"Nov Approaches Drug Des Dev"},{"key":"10.1016\/j.lfs.2021.119377_bb0015","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jconrel.2016.01.002","article-title":"Ligand-targeted theranostic nanomedicines against cancer","volume":"240","author":"Yao","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.lfs.2021.119377_bb0020","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.phymed.2018.11.017","article-title":"Development of curcumin-loaded gemini surfactant nanoparticles: synthesis, characterization and evaluation of anticancer activity against human breast cancer cell lines","volume":"57","author":"Karimpour","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.lfs.2021.119377_bb0025","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1002\/jps.23146","article-title":"Molecular nanomedicine towards cancer","volume":"101","author":"Psimadas","year":"2012","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.lfs.2021.119377_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2018.01260","article-title":"PLGA-based nanoparticles in cancer treatment","volume":"9","author":"Rezvantalab","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2021.119377_bb0035","doi-asserted-by":"crossref","first-page":"186","DOI":"10.2174\/1871520611009030186","article-title":"Silibinin\u2014a promising new treatment for cancer","volume":"10","author":"Cheung","year":"2010","journal-title":"Anti Cancer Agents Med. Chem."},{"key":"10.1016\/j.lfs.2021.119377_bb0040","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1055\/s-0032-1328703","article-title":"A rapid and simple chromatographic separation of diastereomers of silibinin and their oxidation to enantiomers in an optically pure form","volume":"79","author":"Fabio","year":"2013","journal-title":"Planta Med."},{"key":"10.1016\/j.lfs.2021.119377_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules24112155","article-title":"Formulation strategies for enhancing the bioavailability of silymarin: the state of the art","volume":"24","author":"Di Costanzo","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.lfs.2021.119377_bb0050","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.3892\/or.2015.4224","article-title":"Silibinin induces apoptosis through inhibition of the mTOR-GLI1-BCL2 pathway in renal cell carcinoma","volume":"34","author":"Ma","year":"2015","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.lfs.2021.119377_bb0055","first-page":"1545","article-title":"Silibinin reverses epithelial-to-mesenchymal transition in metastatic prostate cancer cells by targeting transcription factors","volume":"23","author":"Wu","year":"2010","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.lfs.2021.119377_bb0060","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1158\/1535-7163.MCT-10-0577","article-title":"Chemopreventive and chemotherapeutic effects of intravesical silibinin against bladder cancer by acting on mitochondria","volume":"10","author":"Zeng","year":"2011","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.lfs.2021.119377_bb0065","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1136\/gutjnl-2016-312019","article-title":"Highly bioavailable silibinin nanoparticles inhibit HCV infection","volume":"66","author":"Liu","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.lfs.2021.119377_bb0070","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s12668-018-0512-9","article-title":"Antihepatotoxic activity of liposomal silibinin","volume":"8","author":"Lutsenko","year":"2018","journal-title":"Bionanoscience"},{"key":"10.1016\/j.lfs.2021.119377_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.nano.2019.102057","article-title":"Nanotherapeutic silibinin: an insight of phytomedicine in healthcare reformation","volume":"21","author":"Takke","year":"2019","journal-title":"Nanomedicine Nanotechnology, Biol Med"},{"key":"10.1016\/j.lfs.2021.119377_bb0080","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s12668-018-0556-x","article-title":"Cytotoxic and antitumor activity of liposomal silibinin","volume":"8","author":"Feldman","year":"2018","journal-title":"Bionanoscience"},{"key":"10.1016\/j.lfs.2021.119377_bb0085","first-page":"1233","article-title":"Effects of silibinin-loaded thermosensitive liposome-microbubble complex on inhibiting rabbit liver VX2 tumors in sub-hyperthermia fields","volume":"15","author":"Han","year":"2018","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.lfs.2021.119377_bb0090","first-page":"135","article-title":"In vitro co-delivery evaluation of novel pegylated nano-liposomal herbal drugs of silibinin and glycyrrhizic acid (nano-phytosome) to hepatocellular carcinoma cells","volume":"18","author":"Ochi","year":"2016","journal-title":"Cell J."},{"key":"10.1016\/j.lfs.2021.119377_bb0095","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1080\/21691401.2017.1326928","article-title":"Effect of silibinin-loaded nano-niosomal coated with trimethyl chitosan on miRNAs expression in 2D and 3D models of T47D breast cancer cell line","volume":"46","author":"Yazdi Rouholamini","year":"2018","journal-title":"Artif Cells, Nanomedicine, Biotechnol"},{"key":"10.1016\/j.lfs.2021.119377_bb0100","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201602225","article-title":"Graphene quantum dots-capped magnetic mesoporous silica nanoparticles as a multifunctional platform for controlled drug delivery, magnetic hyperthermia, and photothermal therapy","volume":"13","author":"Yao","year":"2017","journal-title":"Small"},{"key":"10.1016\/j.lfs.2021.119377_bb0105","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1080\/21691401.2017.1362415","article-title":"Comparative study of superparamagnetic iron oxide\/doxorubicin co-loaded poly (lactic-co-glycolic acid) nanospheres prepared by different emulsion solvent evaporation methods","volume":"46","author":"Mosafer","year":"2018","journal-title":"Artif Cells, Nanomedicine Biotechnol"},{"key":"10.1016\/j.lfs.2021.119377_bb0110","first-page":"49","article-title":"Applications of nanotechnology in pharmaceuticals","volume":"37","author":"Doke","year":"2016","journal-title":"Int J Pharm Sci Rev Res"},{"key":"10.1016\/j.lfs.2021.119377_bb0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2018.00745","article-title":"Potential applications of nanotechnology in urological cancer","volume":"9","author":"He","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2021.119377_bb0120","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1515\/ntrev-2013-0011","article-title":"Magnetic nanoparticles for cancer therapy","volume":"2","author":"D\u00fcrr","year":"2013","journal-title":"Nanotechnol. Rev."},{"key":"10.1016\/j.lfs.2021.119377_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/adhm.201901058","article-title":"Magnetic nanoparticles in cancer therapy and diagnosis","volume":"9","author":"Farzin","year":"2020","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.lfs.2021.119377_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fbioe.2020.00048","article-title":"the design of poly(lactide-co-glycolide) nanocarriers for medical applications","volume":"8","author":"Essa","year":"2020","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.lfs.2021.119377_bb0135","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ijpharm.2011.05.049","article-title":"The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems - a review","volume":"415","author":"Fredenberg","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.lfs.2021.119377_bb0140","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1002\/jps.24318","article-title":"Comparison of sorafenib-loaded poly (lactic\/glycolic) acid and dppc liposome nanoparticles in the in vitro treatment of renal cell carcinoma","volume":"104","author":"Liu","year":"2015","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.lfs.2021.119377_bb0145","doi-asserted-by":"crossref","first-page":"364","DOI":"10.2174\/1567201816666181227114109","article-title":"Design of experiments (DoE) approach to optimize the sustained release microparticles of gefitinib","volume":"16","author":"Soni","year":"2018","journal-title":"Curr Drug Deliv"},{"key":"10.1016\/j.lfs.2021.119377_bb0150","first-page":"1","article-title":"Enzyme bioconjugated PAMAM dendrimers for estimation of glucose in saliva","volume":"0","author":"Shende","year":"2020","journal-title":"Int. J. Polym. Mater. Polym. Biomater."},{"key":"10.1016\/j.lfs.2021.119377_bb0155","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1080\/21691401.2016.1276922","article-title":"Silibinin-loaded magnetic nanoparticles inhibit hTERT gene expression and proliferation of lung cancer cells","volume":"45","author":"Amirsaadat","year":"2017","journal-title":"Artif. Cells, Nanomedicine Biotechnol."},{"key":"10.1016\/j.lfs.2021.119377_bb0160","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.3109\/13880209.2010.489228","article-title":"Toxicological studies on aqueous extract of Gmelina arborea in rodents","volume":"48","author":"Kulkarni","year":"2010","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.lfs.2021.119377_bb0165","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1002\/jps.24416","article-title":"Acute and repeated dose toxicity studies of different \u03b2-cyclodextrin-based nanosponge formulations","volume":"104","author":"Shende","year":"2015","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.lfs.2021.119377_bb0170","first-page":"1","article-title":"Acute toxicity of intravenously administered titanium dioxide nanoparticles in mice","volume":"8","author":"Xu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2021.119377_bb0175","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jddst.2017.08.010","article-title":"Characterization and cytotoxicity of PLGA nanoparticles loaded with formononetin cyclodextrin complex","volume":"41","author":"Guo","year":"2017","journal-title":"J Drug Deliv Sci Technol"},{"key":"10.1016\/j.lfs.2021.119377_bb0180","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3389\/fchem.2019.00642","article-title":"Surface study of Fe3O4 nanoparticles functionalized with biocompatible adsorbed molecules","volume":"7","author":"Lesiak","year":"2019","journal-title":"Front Chem"},{"key":"10.1016\/j.lfs.2021.119377_bb0185","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jmmm.2013.04.062","article-title":"Synthesis and characterization of Fe3O4 nanoparticles coated with fucan polysaccharides","volume":"343","author":"Silva","year":"2013","journal-title":"J. Magn. Magn. Mater."},{"key":"10.1016\/j.lfs.2021.119377_bb0190","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.2147\/DDDT.S133806","article-title":"Fabrication, characterization and in vitro evaluation of silibinin nanoparticles: an attempt to enhance its oral bioavailability","volume":"11","author":"Sahibzada","year":"2017","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.lfs.2021.119377_bb0195","first-page":"1","article-title":"Characterization and in vitro sustained release of silibinin from pH responsive carbon nanotube-based drug delivery system","volume":"2014","author":"Tan","year":"2014","journal-title":"J. Nanomater."},{"key":"10.1016\/j.lfs.2021.119377_bb0200","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.3389\/fmicb.2018.02567","article-title":"Low temperature synthesis of superparamagnetic iron oxide (Fe3O4) nanoparticles and their ROS mediated inhibition of biofilm formed by food-associated bacteria","volume":"9","author":"Arshad","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.lfs.2021.119377_bb0205","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1166\/jbn.2014.1735","article-title":"Silymarin encapsulated poly(D,L-lactic-co-glycolic acid) nanoparticles: a prospective candidate for prostate cancer therapy","volume":"10","author":"Snima","year":"2014","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.lfs.2021.119377_bb0210","doi-asserted-by":"crossref","first-page":"815","DOI":"10.3109\/02652048.2014.940011","article-title":"Synthesis and in vitro study of cisplatin-loaded Fe3O4 nanoparticles modified with PLGA-PEG6000 copolymers in treatment of lung cancer","volume":"31","author":"Nejati-Koshki","year":"2014","journal-title":"J. Microencapsul."},{"key":"10.1016\/j.lfs.2021.119377_bb0215","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jcis.2010.05.022","article-title":"Fabrication of curcumin encapsulated PLGA nanoparticles for improved therapeutic effects in metastatic cancer cells","volume":"351","author":"Yallapu","year":"2010","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.lfs.2021.119377_bb0220","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jddst.2016.01.007","article-title":"Factorial design formulation optimization and in vitro characterization of curcumin-loaded PLGA nanoparticles for colon delivery","volume":"32","author":"Akl","year":"2016","journal-title":"J Drug Deliv Sci Technol"},{"key":"10.1016\/j.lfs.2021.119377_bb0225","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1007\/s11095-017-2146-y","article-title":"Preparation of drug-loaded PLGA-PEG nanoparticles by membrane-assisted nanoprecipitation","volume":"34","author":"Albisa","year":"2017","journal-title":"Pharm. Res."},{"key":"10.1016\/j.lfs.2021.119377_bb0230","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.cep.2011.06.008","article-title":"Optimization of protein encapsulation in PLGA nanoparticles","volume":"50","author":"Feczk\u00f3","year":"2011","journal-title":"Chem. Eng. Process. Process Intensif."},{"key":"10.1016\/j.lfs.2021.119377_bb0235","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s12668-019-00713-0","article-title":"Formulation and optimization of ansamycin-loaded polymeric nanoparticles using response surface methodology for bacterial meningitis","volume":"10","author":"Nair","year":"2020","journal-title":"Bionanoscience"},{"key":"10.1016\/j.lfs.2021.119377_bb0240","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1080\/03639040802498849","article-title":"Formulation and comparative characterization of chitosan, gelatin, and chitosan-gelatin-coated liposomes of CPT-11HCl","volume":"35","author":"Shende","year":"2009","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.lfs.2021.119377_bb0245","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/aps.2017.45","article-title":"Enhanced intracellular delivery and controlled drug release of magnetic PLGA nanoparticles modified with transferrin","volume":"38","author":"Cui","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.lfs.2021.119377_bb0250","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1016\/j.jmmm.2010.01.005","article-title":"Raman spectroscopy investigation of magnetite nanoparticles in ferrofluids","volume":"322","author":"Slavov","year":"2010","journal-title":"J. Magn. Magn. Mater."},{"key":"10.1016\/j.lfs.2021.119377_bb0255","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jcis.2010.05.010","article-title":"Amino-functionalized Fe3O4@SiO2 core-shell magnetic nanomaterial as a novel adsorbent for aqueous heavy metals removal","volume":"349","author":"Wang","year":"2010","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.lfs.2021.119377_bb0260","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s11595-018-1814-z","article-title":"Preparation of magnetic fluorescent dual-drug nanocomposites for codelivery of kaempferol and paclitaxel","volume":"33","author":"Zhang","year":"2018","journal-title":"J Wuhan Univ Technol Mater Sci Ed"},{"key":"10.1016\/j.lfs.2021.119377_bb0265","first-page":"672","article-title":"Synchronous microencapsulation of multiple components in silymarin into PLGA nanoparticles by an emulsification\/solvent evaporation method","volume":"21","author":"Xie","year":"2016","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.lfs.2021.119377_bb0270","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s12034-012-0313-7","article-title":"PLGA 50:50 nanoparticles of paclitaxel: development, in vitro anti-tumor activity in BT-549 cells and in vivo evaluation","volume":"35","author":"Averineni","year":"2012","journal-title":"Bull. Mater. Sci."},{"key":"10.1016\/j.lfs.2021.119377_bb0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/polym10080895","article-title":"Dual drug delivery of sorafenib and doxorubicin from PLGA and PEG-PLGA polymeric nanoparticles","volume":"10","author":"Babos","year":"2018","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.lfs.2021.119377_bb0280","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jconrel.2012.01.043","article-title":"PLGA-based nanoparticles: an overview of biomedical applications","volume":"161","author":"Danhier","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.lfs.2021.119377_bb0285","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jmmm.2019.04.058","article-title":"Engineered polymeric iron oxide nanoparticles as potential drug carrier for targeted delivery of docetaxel to breast cancer cells","volume":"485","author":"Panda","year":"2019","journal-title":"J. Magn. Magn. Mater."},{"key":"10.1016\/j.lfs.2021.119377_bb0290","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1080\/21691401.2017.1373655","article-title":"Anticancer activity of metal nanoparticles and their peptide conjugates against human colon adenorectal carcinoma cells","volume":"46","author":"Bai Aswathanarayan","year":"2018","journal-title":"Artif Cells, Nanomedicine Biotechnol"},{"key":"10.1016\/j.lfs.2021.119377_bb0295","doi-asserted-by":"crossref","first-page":"10527","DOI":"10.1039\/D0TB01983F","article-title":"In vitro exploration of the synergistic effect of alternating magnetic field mediated thermo-chemotherapy with doxorubicin loaded dual pH- and thermo-responsive magnetic nanocomposite carriers","volume":"8","author":"Wang","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.lfs.2021.119377_bb0300","doi-asserted-by":"crossref","first-page":"6","DOI":"10.22159\/ijap.2018.v10s1.02","article-title":"Acute toxicity of chitosan nanoparticles containing mahkota dewa (Phaleria Macrocarpa) leaf extract and anti-inflammatory effects in a dextran sodium sulfate-induced mouse model of ulcerative colitis","volume":"10","author":"Estuningtyas","year":"2018","journal-title":"Int J Appl Pharm"},{"key":"10.1016\/j.lfs.2021.119377_bb0305","first-page":"207","article-title":"Silibinin Inhibits the Hepatocellular Carcinoma in NDEA-Induced Rodent Carcinogenesis Model: An Evaluation through Biochemical and Bio-Structural Parameters","volume":"07","author":"Kumar","year":"2015","journal-title":"J Cancer Sci Ther"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521003623?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521003623?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T15:19:52Z","timestamp":1758986392000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320521003623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":61,"alternative-id":["S0024320521003623"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119377","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Magnetic-core-based silibinin nanopolymeric carriers for the treatment of renal cell cancer","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119377","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"119377"}}