{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T20:18:29Z","timestamp":1793650709188,"version":"4.5.1"},"reference-count":91,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.lfs.2021.119386","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T12:15:36Z","timestamp":1616588136000},"page":"119386","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Hyperhomocysteinemia alters cytokine gene expression, cytochrome c oxidase activity and oxidative stress in striatum and cerebellum of rodents"],"prefix":"10.1016","volume":"277","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7328-6092","authenticated-orcid":false,"given":"Tiago Marcon","family":"dos Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2827-8349","authenticated-orcid":false,"given":"Osmar Vieira","family":"Ramires J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin\u00edcius Santos","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7318-0204","authenticated-orcid":false,"given":"Robson","family":"Coutinho-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6712-6885","authenticated-orcid":false,"given":"Luiz Eduardo Baggio","family":"Savio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8769-1147","authenticated-orcid":false,"given":"Angela T.S.","family":"Wyse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2021.119386_bb0005","first-page":"15","article-title":"Hyperhomocysteinemia as a risk factor for the neuronal system disorders","volume":"65","author":"Petras","year":"2014","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.lfs.2021.119386_bb0010","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/bcpt.12424","article-title":"Hyperhomocysteinemia: impact on neurodegenerative diseases","volume":"117","author":"Sharma","year":"2015","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.lfs.2021.119386_bb0015","doi-asserted-by":"crossref","DOI":"10.23937\/iacvd-2017\/1710008","article-title":"Hyperhomocysteinemia: how does it affect the development of cardiovascular disease?","volume":"2","author":"Lopes Cardoso","year":"2018","journal-title":"Int. Arch. Cardiovasc. Dis."},{"key":"10.1016\/j.lfs.2021.119386_bb0020","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1600-079X.2007.00465.x","article-title":"Melatonin inhibits oxidative stress and apoptosis in fetal brains of hyperhomocysteinemic rat dams","volume":"43","author":"Baydas","year":"2007","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.lfs.2021.119386_bb0025","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2217\/nmt-2015-0008","article-title":"The relationship between hyperhomocysteinemia and neurodegeneration","volume":"6","author":"Bonetti","year":"2016","journal-title":"Neurodegener. Dis. Manag."},{"key":"10.1016\/j.lfs.2021.119386_bb0030","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1212\/01.wnl.0000297193.53986.6f","article-title":"Elevated plasma homocysteine levels in patients with amyotrophic lateral sclerosis","volume":"70","author":"Zoccolella","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.lfs.2021.119386_bb0035","doi-asserted-by":"crossref","unstructured":"S. Veeranki, L.J. Winchester, S.C. Tyagi, Hyperhomocysteinemia associated skeletal muscle weakness involves mitochondrial dysfunction and epigenetic modifications, BBA - Mol. Basis Dis. 1852 (2015) 732\u2013741. doi:https:\/\/doi.org\/10.1016\/j.bbadis.2015.01.008.","DOI":"10.1016\/j.bbadis.2015.01.008"},{"key":"10.1016\/j.lfs.2021.119386_bb0040","first-page":"1","article-title":"Adolescence\/adult onset MTHFR deficiency may manifest as isolated and treatable distinct neuro-psychiatric syndromes","author":"Gales","year":"2018","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.lfs.2021.119386_bb0045","series-title":"Hyperhonocysteinaemia and Neurological Disorders","first-page":"281","volume":"10","author":"Ansari","year":"2014"},{"key":"10.1016\/j.lfs.2021.119386_bb0050","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/mds.22511","article-title":"Hyperhomocysteinemia in levodopa-treated patients with Parkinson\u2019s disease dementia","volume":"24","author":"Zoccolella","year":"2009","journal-title":"Mov. Disord."},{"key":"10.1016\/j.lfs.2021.119386_bb0055","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ymgme.2014.10.006","article-title":"Homocysteine and DNA methylation: a review of animal and human literature","volume":"113","author":"Mandaviya","year":"2014","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.lfs.2021.119386_bb0060","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s12640-017-9847-1","article-title":"Chronic mild hyperhomocysteinemia alters inflammatory and oxidative\/nitrative status and causes protein\/DNA damage, as well as ultrastructural changes in cerebral cortex: is acetylsalicylic acid neuroprotective?","volume":"33","author":"de S. Moreira","year":"2018","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.lfs.2021.119386_bb0065","doi-asserted-by":"crossref","DOI":"10.1007\/s10571-019-00674-8","article-title":"Chronic mild hyperhomocysteinemia impairs energy metabolism, promotes DNA damage and induces a Nrf2 response to oxidative stress in rats brain","author":"dos Santos","year":"2019","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.lfs.2021.119386_bb0070","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.ijdevneu.2011.06.004","article-title":"Development of an animal model for chronic mild hyperhomocysteinemia and its response to oxidative damage","volume":"29","author":"Scherer","year":"2011","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.lfs.2021.119386_bb0075","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of Nrf2 in oxidative stress and toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.lfs.2021.119386_bb0080","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1523\/JNEUROSCI.4464-06.2007","article-title":"Deficiency in Na+,K+-ATPase alpha isoform genes alters spatial learning, motor activity, and anxiety in mice","volume":"27","author":"Moseley","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2021.119386_bb0085","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.biopha.2003.11.004","article-title":"Neurodegenerative diseases and oxidative stress","volume":"58","author":"Emerit","year":"2004","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.lfs.2021.119386_bb0090","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1523\/JNEUROSCI.23-01-00043.2003","article-title":"Global loss of Na,K-ATPase and its nitric oxide-mediated regulation in a transgenic mouse model of amyotrophic lateral sclerosis","volume":"23","author":"Ellis","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2021.119386_bb0095","doi-asserted-by":"crossref","unstructured":"M. Quick, D. Zhang, X.A. Perez, T. Bordia, Role for the nicotinic cholinergic system in movement disorders; therapeutic implications, Pharmacol. Ther. 144 (2014) 50\u201359. doi:https:\/\/doi.org\/10.1016\/j.pharmthera.2014.05.004.","DOI":"10.1016\/j.pharmthera.2014.05.004"},{"key":"10.1016\/j.lfs.2021.119386_bb0100","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.nbd.2014.01.014","article-title":"Selective disruption of acetylcholine synthesis in subsets of motor neurons: a new model of late-onset motor neuron disease","volume":"65","author":"Lecomte","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.lfs.2021.119386_bb0105","doi-asserted-by":"crossref","unstructured":"R. Chinthu, T.R. Anju, C.S. Paulose, Cholinergic receptor alterations in the cerebral cortex of spinal cord injured rat, Biochem. Biophys. Reports. 10 (2017) 46\u201351. doi:https:\/\/doi.org\/10.1016\/j.bbrep.2017.02.003.","DOI":"10.1016\/j.bbrep.2017.02.003"},{"key":"10.1016\/j.lfs.2021.119386_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnmol.2016.00160","article-title":"Neuromuscular junction impairment in amyotrophic lateral sclerosis: reassessing the role of acetylcholinesterase","volume":"9","author":"Campanari","year":"2016","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.lfs.2021.119386_bb0115","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3389\/fnbeh.2017.00207","article-title":"Microglial over-activation by social defeat stress contributes to anxiety- and depressive-like behaviors","volume":"11","author":"Stein","year":"2017","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.lfs.2021.119386_bb0120","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s12035-014-8660-6","article-title":"Mild hyperhomocysteinemia increases brain acetylcholinesterase and proinflammatory cytokine levels in different tissues","volume":"50","author":"Scherer","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.lfs.2021.119386_bb0125","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1007\/s12035-017-0463-0","article-title":"Homocysteine induces glial reactivity in adult rat astrocyte cultures","volume":"55","author":"Longoni","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.lfs.2021.119386_bb0130","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.freeradbiomed.2013.07.003","article-title":"Free radical biology and medicine oxidative stress and vascular inflammation in aging","volume":"65","author":"El Assar","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.lfs.2021.119386_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20205002","article-title":"TGF-\u03b2 signaling in cellular senescence and aging-related pathology","volume":"20","author":"Tominaga","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2021.119386_bb0140","doi-asserted-by":"crossref","first-page":"6920","DOI":"10.1523\/JNEUROSCI.20-18-06920.2000","article-title":"Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity","volume":"20","author":"Kruman","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2021.119386_bb0145","doi-asserted-by":"crossref","first-page":"146592","DOI":"10.1016\/j.brainres.2019.146592","article-title":"Chronic mild hyperhomocysteinemia induces anxiety-like symptoms, aversive memory deficits and hippocampus atrophy in adult rats: new insights into physiopathological mechanisms","volume":"1728","author":"Wyse","year":"2020","journal-title":"Brain Res."},{"key":"10.1016\/j.lfs.2021.119386_bb0150","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.neucli.2015.09.004","article-title":"Sensory modulation of movement, posture and locomotion","volume":"45","author":"Saradjian","year":"2015","journal-title":"Neurophysiol. Clin."},{"key":"10.1016\/j.lfs.2021.119386_bb0155","doi-asserted-by":"crossref","unstructured":"I.Q. Whishaw, B. Kolb, The Behavior of the Laboratory Rat: A Handbook With Tests, Oxford University Press, 2005.","DOI":"10.1093\/acprof:oso\/9780195162851.001.0001"},{"key":"10.1016\/j.lfs.2021.119386_bb0160","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.tins.2016.11.006","article-title":"Secondary motor cortex: where \u2018sensory\u2019 meets \u2018motor\u2019 in the rodent frontal cortex","volume":"40","author":"Barthas","year":"2017","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.lfs.2021.119386_bb0165","doi-asserted-by":"crossref","first-page":"7","DOI":"10.31887\/DCNS.2016.18.1\/shaber","article-title":"Corticostriatal circuitry","volume":"18","author":"Haber","year":"2016","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.lfs.2021.119386_bb0170","doi-asserted-by":"crossref","unstructured":"J.A. Taylor, R.B. Ivry, Cerebellar and prefrontal cortex contributions to adaptation, strategies, and reinforcement learning, Prog. Brain Res. 210 (2014) 217\u2013253. doi:https:\/\/doi.org\/10.1016\/B978-0-444-63356-9.00009-1.","DOI":"10.1016\/B978-0-444-63356-9.00009-1"},{"key":"10.1016\/j.lfs.2021.119386_bb0175","article-title":"Review on cross talk between neurotransmitters and neuroinflammation in striatum and cerebellum in the mediation of motor behaviour","volume":"2019","author":"Wahab","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.lfs.2021.119386_bb0180","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4329\/wjr.v9.i10.371","article-title":"Cerebellum and neurodegenerative diseases: beyond conventional magnetic resonance imaging","volume":"9","author":"Mormina","year":"2017","journal-title":"World J. Radiol."},{"key":"10.1016\/j.lfs.2021.119386_bb0185","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/mp.2012.54","article-title":"Striatal morphology as a biomarker in neurodegenerative disease","volume":"18","author":"Looi","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.lfs.2021.119386_bb0190","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1136\/jnnp-2017-315607","article-title":"Cerebellar atrophy in neurodegeneration - a meta-analysis","volume":"88","author":"Gellersen","year":"2017","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.lfs.2021.119386_bb0195","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000151753","article-title":"Evaluation of long-lasting sensorimotor consequences following neonatal hypoxic-ischemic brain injury in rats: the neuroprotective role of MgSO 4","volume":"95","author":"Pazaiti","year":"2008","journal-title":"Neonatology"},{"key":"10.1016\/j.lfs.2021.119386_bb0200","doi-asserted-by":"crossref","unstructured":"G.A. Metz, M.E. Schwab, Behavioral characterization in a comprehensive mouse test battery reveals motor and sensory impairments in growth-associated protein-43 null mutant mice, 129 (2004) 563\u2013574. doi:https:\/\/doi.org\/10.1016\/j.neuroscience.2004.07.053.","DOI":"10.1016\/j.neuroscience.2004.07.053"},{"key":"10.1016\/j.lfs.2021.119386_bb0205","doi-asserted-by":"crossref","DOI":"10.1002\/0471142301.ns0812s15","article-title":"Motor coordination and balance in rodents","author":"Carter","year":"2001","journal-title":"Curr. Protoc. Neurosci."},{"key":"10.1016\/j.lfs.2021.119386_bb0210","unstructured":"P. Curzon, M. Zhang, R.J. Radek, G.B. Fox, The behavioral assessment of sensorimotor processes in the mouse: acoustic startle, sensory gating, locomotor activity, rotarod, and beam walking., in: J.J. Buccafusco (Ed.), Methods Behav. Anal. Neurosci., 2nd editio, Boca Raton (FL): CRC Press\/Taylor & Francis, Boca Raton (FL), 2009."},{"key":"10.1016\/j.lfs.2021.119386_bb0215","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.bbr.2010.02.015","article-title":"Lateralized and sex-dependent behavioral and morphological effects of unilateral neonatal cerebral hypoxia-ischemia in the rat","volume":"210","author":"Arteni","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.lfs.2021.119386_bb0220","unstructured":"K.R. Bailey, J.N. Crawley, Anxiety-related behaviors in mice., in: J.J. Buccafusco (Ed.), Methods Behav. Anal. Neurosci., 2nd editio, Boca Raton (FL): CRC Press\/Taylor & Francis, Boca Raton (FL), 2009."},{"key":"10.1016\/j.lfs.2021.119386_bb0225","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1203\/00006450-199711000-00021","article-title":"Sensorimotor function and neuropathology five to six weeks after hypoxia-ischemia in seven-day-old rats","volume":"42","author":"Bona","year":"1997","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.lfs.2021.119386_bb0230","doi-asserted-by":"crossref","first-page":"434","DOI":"10.2478\/v10042-010-0047-6","article-title":"The effects of docosahexaenoic acid on glial derived neurotrophic factor and neurturin in bilateral rat model of parkinson\u2019s disease","volume":"48","author":"Tanriover","year":"2010","journal-title":"Folia Histochem. Cytobiol."},{"key":"10.1016\/j.lfs.2021.119386_bb0235","doi-asserted-by":"crossref","first-page":"911","DOI":"10.12965\/jer.1836508.254","article-title":"Treadmill exercise and wheel exercise improve motor function by suppressing apoptotic neuronal cell death in brain inflammation rats","volume":"14","author":"Song","year":"2018","journal-title":"J. Exerc. Rehabil."},{"key":"10.1016\/j.lfs.2021.119386_bb0240","doi-asserted-by":"crossref","unstructured":"C.P. Lebel, H. Ischiropoulos, S.C. Bondys, Evaluation of the probe 2\u2032,7\u2032-dichiorofluorescin as an indicator of reactive oxygen species formation and oxidative stress, Chem. Res. Toxicol. 1992,. 5 (1992) 227\u2013231.","DOI":"10.1021\/tx00026a012"},{"key":"10.1016\/j.lfs.2021.119386_bb0245","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.lfs.2021.119386_bb0250","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.lfs.2021.119386_bb0255","doi-asserted-by":"crossref","unstructured":"M.Y. Aksenov, W.R. Markesbery, Changes in thiol content and expression of glutathione redox system genes in the hippocampus and cerebellum in Alzheimer's disease, Neurosci. Lett. 302 (2001) 141\u2013145.","DOI":"10.1016\/S0304-3940(01)01636-6"},{"key":"10.1016\/j.lfs.2021.119386_bb0260","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0076-6879(81)77046-0","article-title":"Glutathione peroxidase","volume":"77","author":"Wendel","year":"1981","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.lfs.2021.119386_bb0265","unstructured":"S. Marklund, Pyrogallol autoxidation. In: Greenwald RA (ed) Handbook of Methods for Oxygen Radical Research, 4th ed., CRC Press, Boca Raton, 1985."},{"key":"10.1016\/j.lfs.2021.119386_bb0270","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzym."},{"key":"10.1016\/j.lfs.2021.119386_bb0275","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0009-8981(85)90135-4","article-title":"Differential investigation of the capacity of succinate oxidation in human skeletal muscle","volume":"153","author":"Fischer","year":"1985","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.lfs.2021.119386_bb0280","doi-asserted-by":"crossref","unstructured":"P. Rustin, D. Chretien, T. Bourgeron, B. Grard, A. Riitig, J.M. Saudubray, A. Munnich, U, Biochemical and molecular investigations in respiratory chain deficiencies, Clin. Chim. Acta 228 (1994) 35\u201351. doi:https:\/\/doi.org\/10.1016\/0009-8981(94)90055-8.","DOI":"10.1016\/0009-8981(94)90055-8"},{"key":"10.1016\/j.lfs.2021.119386_bb0285","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.lfs.2021.119386_bb0290","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.lfs.2021.119386_bb0295","first-page":"265","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"Readings"},{"key":"10.1016\/j.lfs.2021.119386_bb0300","doi-asserted-by":"crossref","unstructured":"A. Moustafa, D. Hewedi, A. Eissa, D. Frydecka, M. Blazej, Homocysteine levels in neurological disorders, in: T. Farooqui, A.A. Farooqui (Eds.), Diet Exerc. Cogn. Funct. Neurol. Dis., First Edit, John Wiley & Sons, Inc., 2015: pp. 73\u201381.","DOI":"10.1002\/9781118840634.ch7"},{"key":"10.1016\/j.lfs.2021.119386_bb0305","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fncel.2016.00011","article-title":"Adducin at the neuromuscular junction in amyotrophic lateral sclerosis: hanging on for dear life","volume":"10","author":"Krieger","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.lfs.2021.119386_bb0310","series-title":"Incorporation of Homocysteine Into Protein in Humans","first-page":"1462","volume":"41","author":"Jakubowski","year":"2003"},{"key":"10.1016\/j.lfs.2021.119386_bb0315","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/life7010006","article-title":"Homocysteine editing, thioester chemistry, coenzyme A, and the origin of coded peptide synthesis \u2020","volume":"7","author":"Jakubowski","year":"2017","journal-title":"Life"},{"key":"10.1016\/j.lfs.2021.119386_bb0320","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s11011-013-9451-x","article-title":"Development of an animal model for gestational hypermethioninemia in rat and its effect on brain Na+,K+-ATPase\/Mg2+-ATPase activity and oxidative status of the offspring","volume":"29","author":"Schweinberger","year":"2014","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.lfs.2021.119386_bb0325","first-page":"80","article-title":"The multifaceted role of Nrf2 in mitochondrial function","volume":"2","author":"Holmstr\u00f6m","year":"2017","journal-title":"Curr. Opin. Toxicol."},{"key":"10.1016\/j.lfs.2021.119386_bb0330","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/glia.20947","article-title":"Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson\u2019s disease","volume":"58","author":"Rojo","year":"2010","journal-title":"Glia"},{"key":"10.1016\/j.lfs.2021.119386_bb0335","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1089\/ars.2017.7342","article-title":"Transcriptional regulation by Nrf2","volume":"29","author":"Tonelli","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.lfs.2021.119386_bb0340","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s11010-011-1141-6","article-title":"Chronic mild hyperhomocysteinemia alters ectonucleotidase activities and gene expression of ecto-5\u2032-nucleotidase\/CD73 in rat lymphocytes","volume":"361","author":"Scherer","year":"2012","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.lfs.2021.119386_bb0345","doi-asserted-by":"crossref","DOI":"10.1007\/s11302-020-09746-7","article-title":"P2X7 receptor deletion attenuates oxidative stress and liver damage in sepsis","author":"Larrouyet-Sarto","year":"2020","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.lfs.2021.119386_bb0350","doi-asserted-by":"crossref","unstructured":"C.A. Feghali, T.M. Wright, Cytokines in acute and chronic inflammation., Front. Biosci. 2 (1997) d12\u201326. doi:https:\/\/doi.org\/10.2741\/a171.","DOI":"10.2741\/A171"},{"key":"10.1016\/j.lfs.2021.119386_bb0355","series-title":"5-Manipulating Inflammation to Improve Healing","first-page":"117","author":"Urao","year":"2016"},{"key":"10.1016\/j.lfs.2021.119386_bb0360","doi-asserted-by":"crossref","first-page":"627","DOI":"10.14202\/vetworld.2018.627-635","article-title":"The crucial roles of inflammatory mediators in inflammation: a review","volume":"11","author":"Abdulkhaleq","year":"2018","journal-title":"Vet. World."},{"key":"10.1016\/j.lfs.2021.119386_bb0365","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s10620-014-3379-9","article-title":"Homocysteine promotes intestinal fibrosis in rats with trinitrobenzene sulfonic acid-induced colitis","volume":"60","author":"Ding","year":"2015","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.lfs.2021.119386_bb0370","first-page":"65","article-title":"Dynamic changes of TGF-\u03b1 and TGF-\u03b21 in rats with liver cirrhosis induced by multiple pathogenic factors","volume":"32","author":"Tian","year":"2016","journal-title":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese J. Appl. Physiol."},{"key":"10.1016\/j.lfs.2021.119386_bb0375","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3389\/fphys.2019.00192","article-title":"Ganoderma triterpenes protect against hyperhomocysteinemia induced endothelial-mesenchymal transition via TGF-\u03b2 signaling inhibition","volume":"10","author":"He","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.lfs.2021.119386_bb0380","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.bbadis.2013.06.015","article-title":"Involvement of hydrogen sulfide and homocysteine transsulfuration pathway in the progression of kidney fibrosis after ureteral obstruction","volume":"1832","author":"Jung","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.lfs.2021.119386_bb0385","doi-asserted-by":"crossref","first-page":"9421","DOI":"10.1002\/jcb.28217","article-title":"The immunomodulatory mechanism of brain injury induced by hyperhomocysteinemia in spontaneously hypertensive rats","volume":"120","author":"Zhang","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.lfs.2021.119386_bb0390","unstructured":"G.C. Rom\u00e1n, Vascular dementia. Advances in nosology, diagnosis, treatment and prevention., Panminerva Med. 46 (2004) 207\u2013215."},{"key":"10.1016\/j.lfs.2021.119386_bb0395","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s10571-006-9114-0","article-title":"Homocysteine thiolactone and human cholinesterases","volume":"27","author":"Darvesh","year":"2007","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.lfs.2021.119386_bb0400","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22091499","article-title":"Human erythrocyte acetylcholinesterase in health and disease","volume":"22","author":"Saldanha","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.lfs.2021.119386_bb0405","doi-asserted-by":"crossref","DOI":"10.1016\/0028-3908(84)90100-X","article-title":"Neurotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer-type dementia and depression, and suicides","volume":"23","author":"Crow","year":"1984","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.lfs.2021.119386_bb0410","series-title":"Inhibitors of acetylcholinesterase and butyrylcholinesterase Meet Immunity","author":"Pohanka","year":"2014"},{"key":"10.1016\/j.lfs.2021.119386_bb0415","series-title":"Acetylcholinesterase and ATPases in Motor Neuron Degenerative Diseases","first-page":"430","author":"Rasool","year":"1983"},{"key":"10.1016\/j.lfs.2021.119386_bb0420","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijdevneu.2019.03.004","article-title":"Prenatal hyperhomocysteinemia induces oxidative stress and accelerates \u201caging\u201d of mammalian neuromuscular synapses","volume":"75","author":"Khuzakhmetova","year":"2019","journal-title":"Int. J. Dev. Neurosci. Off. J. Int. Soc. Dev. Neurosci."},{"key":"10.1016\/j.lfs.2021.119386_bb0425","doi-asserted-by":"crossref","DOI":"10.3390\/biom10070995","article-title":"Hydrogen sulfide alleviates anxiety, motor, and cognitive dysfunctions in rats with maternal hyperhomocysteinemia via mitigation of oxidative stress","volume":"10","author":"Yakovleva","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.lfs.2021.119386_bb0430","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2174\/157016106777698414","article-title":"Hyperhomocysteinemia in movement disorders: current evidence and hypotheses","volume":"4","author":"Zoccolella","year":"2006","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.lfs.2021.119386_bb0435","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1007\/s12640-018-9979-y","article-title":"Postnatal administration of homocysteine induces cerebellar damage in rats: protective effect of folic acid","volume":"35","author":"Koohpeyma","year":"2019","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.lfs.2021.119386_bb0440","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/cbf.2938","article-title":"Homocysteine induces energy imbalance in rat skeletal muscle: is creatine a protector?","volume":"31","author":"Kolling","year":"2013","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.lfs.2021.119386_bb0445","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2014.05.005","article-title":"Creatine prevents the imbalance of redox homeostasis caused by homocysteine in skeletal muscle of rats","volume":"545","author":"Kolling","year":"2014","journal-title":"Gene"},{"key":"10.1016\/j.lfs.2021.119386_bb0450","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.nbd.2019.03.012","article-title":"Hyperhomocysteinemia leads to exacerbation of ischemic brain damage: role of GluN2A NMDA receptors","volume":"127","author":"Jindal","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.lfs.2021.119386_bb0455","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neuint.2016.10.001","article-title":"Oxidative stress and mitochondrial dysfunction are the underlying events of dopaminergic neurodegeneration in homocysteine rat model of Parkinson\u2019s disease","volume":"101","author":"Bhattacharjee","year":"2016","journal-title":"Neurochem. Int."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521003714?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521003714?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:47:57Z","timestamp":1758401277000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320521003714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":91,"alternative-id":["S0024320521003714"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119386","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyperhomocysteinemia alters cytokine gene expression, cytochrome c oxidase activity and oxidative stress in striatum and cerebellum of rodents","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119386","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"119386"}}