{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T02:10:55Z","timestamp":1772503855799,"version":"3.50.1"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.lfs.2021.119506","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T22:43:52Z","timestamp":1618526632000},"page":"119506","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Phosphodiesterase (1, 3 & 5) inhibitors attenuate diclofenac-induced acute kidney toxicity in rats"],"prefix":"10.1016","volume":"277","author":[{"given":"Walaa","family":"Wadie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nermeen S.","family":"Abdel-Razek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hesham A.","family":"Salem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2021.119506_bb0005","first-page":"134","article-title":"Evaluation of random urine sample protein-cretinine ratio as an index of quantitative proteinuria","volume":"6","author":"Garg","year":"2004","journal-title":"JK Sci."},{"key":"10.1016\/j.lfs.2021.119506_bb0010","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.phrs.2016.12.039","article-title":"Vinpocetine reduces diclofenac-induced acute kidney injury through inhibition of oxidative stress, apoptosis, cytokine production, and NF-\u03baB activation in mice","volume":"120","author":"Fattori","year":"2017","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.lfs.2021.119506_bb0015","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1093\/ndt\/gfm113","article-title":"N-acetylcysteine attenuates NSAID-induced rat renal failure by restoring intrarenal prostaglandin synthesis","volume":"22","author":"Efrati","year":"2007","journal-title":"Nephrology Dialysis Transplantation"},{"key":"10.1016\/j.lfs.2021.119506_bb0020","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/BF02737826","article-title":"Signaling role of PDE Isozymes in pathobiology of glomerular mesangial cells studies in vitro and in vivo","volume":"29","author":"Dousa","year":"1998","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.lfs.2021.119506_bb0025","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1046\/j.1523-1755.1999.00233.x","article-title":"Cyclic-3 \u0408, 5 \u0408-nucleotide phosphodiesterase isozymes in cell biology and pathophysiology of the kidney","volume":"55","author":"Dousa","year":"1999","journal-title":"Kidney Int."},{"key":"10.1016\/j.lfs.2021.119506_bb0030","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1043-2760(01)00523-9","article-title":"Cyclic nucleotide phosphodiesterases and their role in endocrine cell signaling","volume":"13","author":"Mehats","year":"2002","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2021.119506_bb0035","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0022-2143(97)90125-6","article-title":"Inhibitors of cyclic nucleotide phosphodiesterase isozymes block renal tubular cell proliferation induced by folic acid","volume":"130","author":"Matousovic","year":"1997","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.lfs.2021.119506_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2334-9-80","article-title":"The role of phosphodiesterase 3 in endotoxin-induced acue kidney injury","volume":"9","author":"Choi","year":"2009","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.lfs.2021.119506_bb0045","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1093\/ndt\/gfs391","article-title":"Selective phosphodiesterase-5 (PDE-5) inhibitor vardena fi l ameliorates renal damage in type 1 diabetic rats by restoring cyclic 3 0, 5 0 guanosine monophosphate (cGMP) level in podocytes","volume":"28","author":"Fang","year":"2013","journal-title":"Nephrology Dialysis Transplantation"},{"key":"10.1016\/j.lfs.2021.119506_bb0050","first-page":"1148","article-title":"Phosphodiesterase inhibitors: their role and implications","volume":"1","author":"Ghosh","year":"2009","journal-title":"International Journal of Pharmtech Research"},{"key":"10.1016\/j.lfs.2021.119506_bb0055","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1046\/j.1468-1331.2000.00116.x","article-title":"Effects of the non-selective phosphodiesterase inhibitor pentoxifylline on regional cerebral blood flow and large arteries in healthy subjects","volume":"7","author":"Kruuse","year":"2000","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.lfs.2021.119506_bb0060","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/0006-2952(94)90477-4","article-title":"Phosphodiesterase inhibitory profile of some related xanthine derivatives pharmacologically active on the peripheral microcirculation","volume":"47","author":"Lagarde","year":"1994","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.lfs.2021.119506_bb0065","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/00005344-199500252-00020","article-title":"Effects of pentoxifylline on adherence of polymorphnuclear neutrophils to oxidant-stimulated human endothelial cells: involvement of cyclic AMP","volume":"25","author":"Franzini","year":"1995","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.lfs.2021.119506_bb0070","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/S0006-291X(88)81271-3","article-title":"Cellular and molecular regulation on tumore necrosis factor-alpha production by pentoxifylline","volume":"155","author":"Strieter","year":"1988","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2021.119506_bb0075","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1081\/JDI-120026026","article-title":"Beneficial effect of pentoxifylline on cisplatin-induced acute renal failure in rabbits","volume":"25","author":"Kim","year":"2003","journal-title":"Ren. Fail."},{"key":"10.1016\/j.lfs.2021.119506_bb0080","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0006-2952(84)90240-5","article-title":"Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle","volume":"33","author":"Hagiwara","year":"1984","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.lfs.2021.119506_bb0085","doi-asserted-by":"crossref","first-page":"9795","DOI":"10.1073\/pnas.0914414107","article-title":"Vinpocetine inhibits NF-kB \u2013 dependent inflammation via an IKK-dependent but PDE-independent mechanism","volume":"107","author":"Jeon","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2021.119506_bb0090","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4196\/kjpp.2011.15.4.203","article-title":"Cilostazol inhibits vascular smooth muscle cell proliferation and reactive oxygen species production through activation of amp-activated protein kinase induced by heme oxygenase-1","volume":"15","author":"Kim","year":"2011","journal-title":"The Korean Journal of Physiology and Pharmacology"},{"key":"10.1016\/j.lfs.2021.119506_bb0095","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1271\/bbb.90938","article-title":"Cilostazol ameliorates nephropathy in type 1 diabetic rats involving improvement in oxidative stress and regulation of TGF-\u03b2 and NF- \u03baB. Bioscience","volume":"74","author":"Lee","year":"2010","journal-title":"Biotechnology, and Biochemistry"},{"key":"10.1016\/j.lfs.2021.119506_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0095313","article-title":"Cilostazol renoprotective effect: modulation of PPAR-\u03b3, NGAL, Kim-1 and IL-18 underlies its novel effect in a model of ischemia-reperfusion","volume":"9","author":"Ragab","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2021.119506_bb0105","first-page":"309","article-title":"Sildenafil a novel inhibitor of phosphodiesterase type 5 in human corpus cavernosum smooth muscle cells","volume":"62","author":"Morelandl","year":"1998","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2021.119506_bb0110","series-title":"PDE5 Inhibitor","author":"Dhaliwal","year":"2020"},{"key":"10.1016\/j.lfs.2021.119506_bb0115","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.molimm.2013.06.021","article-title":"Gender-specific immunological effects of the phosphodiesterase 5 inhibitor sildenafil in healthy mice","volume":"56","author":"Karakhanova","year":"2013","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.lfs.2021.119506_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/489382","article-title":"Sildenafil ameliorates gentamicin-induced nephrotoxicity in rats: role of iNOS and eNOS","volume":"2014","author":"Morsy","year":"2014","journal-title":"Journal of Toxicology"},{"issue":"5","key":"10.1016\/j.lfs.2021.119506_bb0125","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.3390\/jcm9051284","article-title":"Current concepts on the reno-protective effects of phosphodiesterase 5 inhibitors in acute kidney injury: systematic search and review","volume":"9","author":"Georgiadis","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.lfs.2021.119506_bb0130","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1139\/cjpp-2016-0115","article-title":"Pentoxifylline abrogates cardiotoxicity induced by the administration of a single high dose or multiple low doses of doxorubicin in rats","volume":"94","author":"Elshazly","year":"2016","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.lfs.2021.119506_bb0135","first-page":"1","article-title":"Evaluation of therapeutic efficacy of vinpocetine in adjuvant induced arthritis model in rats","volume":"2","author":"Ali","year":"2016","journal-title":"Journal of Pain Management & Medicine"},{"key":"10.1016\/j.lfs.2021.119506_bb0140","first-page":"687","article-title":"Protective effect of sitagliptin against renal ischemia reperfusion injury in protective effect of sitagliptin against renal ischemia reperfusion injury in rats","volume":"37","author":"Nuransoy","year":"2015","journal-title":"Informa Healthcare"},{"key":"10.1016\/j.lfs.2021.119506_bb0145","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/01.shk.0000175555.95676.34","article-title":"Olprinone reduces ischemia\/reperfusion-induced acute renal injury in rats through enhancement of cAMP","volume":"24","author":"Mizutani","year":"2005","journal-title":"SHOCK"},{"key":"10.1016\/j.lfs.2021.119506_bb0150","first-page":"546","article-title":"Hypoxia-induced increased permeability of endothelial monolayers occurs through lowering of cellular CAMP levels","volume":"262","author":"Ogawa","year":"1992","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.lfs.2021.119506_bb0155","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1634\/stemcells.2007-0885","article-title":"Transformation by retroviral vectors of bone marrow-derived mesenchymal cells induces mitochondria-dependent camp-sensitive reactive oxygen species production","volume":"26","author":"Piccoli","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.lfs.2021.119506_bb0160","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.freeradbiomed.2005.12.025","article-title":"Protective effect of cyclic AMP against cisplatin-induced nephrotoxicity","volume":"40","author":"Mishima","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.lfs.2021.119506_bb0165","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s10741-007-9016-3","article-title":"Natriuretic peptides and therapeutic applications","volume":"12","author":"Lee","year":"2007","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.lfs.2021.119506_bb0170","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1124\/jpet.113.208017","article-title":"cGMP-selective phosphodiesterase inhibitors stimulate mitochondrial biogenesis and promote recovery from acute kidney injury","volume":"347","author":"Whitaker","year":"2013","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2021.119506_bb0175","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1111\/j.1523-1755.2004.00861.x","article-title":"Early detection of acute renal failure by serum cystatin C","volume":"66","author":"Herget-Rosenthal","year":"2004","journal-title":"Kidney Int."},{"key":"10.1016\/j.lfs.2021.119506_bb0180","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.etp.2010.06.008","article-title":"Cytoprotective effect of vitamin C against gentamicin-induced acute kidney injury in rats","volume":"64","author":"Stojiljkovic","year":"2012","journal-title":"Experimental & Toxicologic Pathology"},{"key":"10.1016\/j.lfs.2021.119506_bb0185","first-page":"37","article-title":"Structural basis for the proinflammatory cytokine activity of high mobility group box 1","author":"Jianhua","year":"2003","journal-title":"Mol. Med."},{"key":"10.1016\/j.lfs.2021.119506_bb0190","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature00858","article-title":"Release of chromatin protein HMGB1 by necrotic cells triggers inflammation","volume":"418","author":"Scaffidi","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2021.119506_bb0195","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.apsb.2016.02.004","article-title":"The role of high mobility group box 1 (HMGB1) in the pathogenesis of kidney diseases","volume":"6","author":"Chen","year":"2016","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.lfs.2021.119506_bb0200","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/apm.12568","article-title":"The damage-associated molecular pattern HMGB1 is elevated in human alcoholic hepatitis, but does not seem to be a primary driver of inflammation","volume":"124","author":"Laursen","year":"2016","journal-title":"APMIS"},{"key":"10.1016\/j.lfs.2021.119506_bb0205","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.molimm.2013.07.008","article-title":"RAGE and TLRs: relatives, friends or neighbours?","volume":"56","author":"Ibrahim","year":"2013","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.lfs.2021.119506_bb0210","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.biopha.2017.12.028","article-title":"Diclofenac-induced renal toxicity in female Wistar albino rats is protected by the pre-treatment of aqueous leaves extract of Madhuca longifolia through suppression of inflammation, oxidative stress and cytokine formation","volume":"98","author":"Peter","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.lfs.2021.119506_bb0215","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1681\/ASN.2009101048","article-title":"HMGB1 contributes to kidney ischemia reperfusion injury","volume":"21","author":"Wu","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.lfs.2021.119506_bb0220","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/ki.2013.475","article-title":"Preconditioning with recombinant high-mobility group box 1 protein protects the kidney against ischemia \u2013 reperfusion injury in mice","volume":"85","author":"Wu","year":"2014","journal-title":"Kidney Int."},{"key":"10.1016\/j.lfs.2021.119506_bb0225","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0891-5849(01)00560-3","article-title":"Diclofenac induced in vivo nephrotoxicity may involve oxidative stress-mediated massive genomic DNA fragmentation and apoptotic cell death","volume":"31","author":"Hickey","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.lfs.2021.119506_bb0230","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/sj.cdd.4401843","article-title":"Signals from within: the DNA-damage-induced NF-kB response","volume":"13","author":"Janssens","year":"2006","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.lfs.2021.119506_bb0235","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.bbrc.2006.07.089","article-title":"Action of diclofenac on kidney mitochondria and cells","volume":"348","author":"Ng","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2021.119506_bb0240","first-page":"2105","article-title":"Protective effects of icariin on cisplatin-induced acute renal injury in mice","volume":"7","author":"Ma","year":"2015","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.lfs.2021.119506_bb0245","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1080\/08860220802595492","article-title":"Effects of pentoxifylline on amikacin-induced nephrotoxicity in rats","volume":"31","author":"Ozer","year":"2009","journal-title":"Ren. Fail."},{"key":"10.1016\/j.lfs.2021.119506_bb0250","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1097\/01.ASN.0000034909.10994.8A","article-title":"Pentoxifylline attenuated the renal disease progression in rats with remnant kidney","volume":"13","author":"Lin","year":"2002","journal-title":"Journal of American Society of Nephrology"},{"key":"10.1016\/j.lfs.2021.119506_bb0255","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/pr.2017.41","article-title":"Pentoxifylline modulates LPS-induced hyperinflammation in monocytes of preterm infants in vitro","volume":"82","author":"Schuller","year":"2017","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.lfs.2021.119506_bb0260","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ejphar.2017.08.027","article-title":"Vinpocetine mitigates proteinuria and podocytes injury in a rat model of diabetic nephropathy","volume":"814","author":"Wadie","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2021.119506_bb0265","doi-asserted-by":"crossref","first-page":"80315","DOI":"10.18632\/oncotarget.20699","article-title":"Vinpocetine alleviate cerebral ischemia\/reperfusion injury by","volume":"8","author":"Wu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.lfs.2021.119506_bb0270","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1007\/s11255-020-02485-z","article-title":"Vinpocetine reduces cisplatin-induced acute kidney injury through inhibition of NF\u2013\u03baB pathway and activation of Nrf2\/ARE pathway in rats","volume":"52","author":"Song","year":"2020","journal-title":"Int. Urol. Nephrol."},{"key":"10.1016\/j.lfs.2021.119506_bb0275","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.etp.2016.01.002","article-title":"Cilostazol attenuates gentamicin-induced nephrotoxicity in rats","volume":"68","author":"Abdelsameea","year":"2016","journal-title":"Exp. Toxicol. Pathol."},{"issue":"9","key":"10.1016\/j.lfs.2021.119506_bb0280","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0203837","article-title":"Cilostazol disrupts TLR-4, Akt\/GSK-3\u03b2\/CREB, and IL-6\/JAK-2\/STAT-3\/SOCS-3 crosstalk in a rat model of Huntington\u2019s disease","volume":"13","author":"El-Abhar","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2021.119506_bb0285","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.intimp.2018.06.021","article-title":"International immunopharmacology anti-inflammatory properties of cilostazol: its interruption of DNA binding activity of NF-\u03baB from the Toll-like receptor signaling pathways","volume":"62","author":"Sakamoto","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.lfs.2021.119506_bb0290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0113598","article-title":"Sildenafil citrate for prophylaxis of nephropathy in an animal model of contrast-induced acute kidney injury","volume":"9","author":"Lauver","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2021.119506_bb0295","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1183\/09031936.00055908","article-title":"Effect of sildenafil on acrolein-induced airway inflammation and mucus production in rats","volume":"33","author":"Wang","year":"2009","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.lfs.2021.119506_bb0300","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.vph.2016.08.009","article-title":"Elevated serum HMGB1 in pulmonary arterial hypertension secondary to congenital heart disease","volume":"85","author":"Huangmd","year":"2016","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.lfs.2021.119506_bb0305","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1159\/000343414","article-title":"Renoprotective effects of sildenafil in DOCA-salt hypertensive rats","volume":"36","author":"Bae","year":"2012","journal-title":"Kidney Blood Press. Res."},{"key":"10.1016\/j.lfs.2021.119506_bb9000","doi-asserted-by":"crossref","first-page":"45e","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.lfs.2021.119506_bb8000","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.lfs.2021.119506_bb7000","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.placenta.2015.07.133","article-title":"Sildenafil (Viagra\u00ae) blocks inflammatory injury in LPS-induced mouse abortion: A potential prophylactic treatment against acute pregnancy loss","volume":"36","author":"Luna","year":"2015","journal-title":"Placenta"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521004914?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320521004914?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:52:58Z","timestamp":1758401578000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320521004914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":64,"alternative-id":["S0024320521004914"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119506","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phosphodiesterase (1, 3 & 5) inhibitors attenuate diclofenac-induced acute kidney toxicity in rats","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2021.119506","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"119506"}}